Термикон Спрей, 30 г, 1 %

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В низких концентрациях тербинафин оказывает фунгицидное действие в отношении дерматофитов (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton floccosum), плесневых, определенных диморфных (Pityrosporum orbiculare) и дрожжевых грибов (в основном Сandida albicans)."}},{"type":"paragraph","data":{"text":"Активность в отношении дрожжевых грибов, в зависимости от их вида, может быть фунгицидной или фунгистатической."}},{"type":"paragraph","data":{"text":"Тербинафин специфическим образом изменяет ранний этап биосинтеза стеролов, происходящий в грибах. Это ведет к дефициту эргостерола и к внутриклеточному накоплению сквалена, что вызывает гибель клетки гриба."}},{"type":"paragraph","data":{"text":"Действие тербинафина осуществляется путем ингибирования фермента скваленэпоксидазы, расположенного на клеточной мембране гриба."}},{"type":"paragraph","data":{"text":"Тербинафин не оказывает влияния на систему цитохрoма P450 у человека и, соответственно, на метаболизм гормонов или других лекарственных препаратов.\n\n"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nПрофилактика и лечение грибковых инфекций кожи, в том числе:"}},{"type":"paragraph","data":{"text":"- микозов стоп («грибок» стопы),"}},{"type":"paragraph","data":{"text":"- паховой эпидермофитии,"}},{"type":"paragraph","data":{"text":"- грибковых поражений гладкой кожи тела, вызванных дерматофитами (трихофитии, микроспории, эпидермофитии, руброфитии)."}},{"type":"paragraph","data":{"text":"Разноцветный лишай, вызванный диморфными грибами."}},{"type":"paragraph","data":{"text":"Опрелость, вызванная плесневыми грибами.\n\n"}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к тербинафину или к вспомогательным веществам, входящим в состав препарата, детский возраст до 18 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Печеночная и/или почечная недостаточность, алкоголизм, угнетение костномозгового кроветворения, опухоли, болезни обмена веществ, окклюзионные заболевания сосудов конечностей."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\n\nВ экспериментальных исследованиях тератогенных свойств тербинафина выявлено не было. До настоящего времени не сообщалось о каких-либо пороках развития при применении Термикона  . Однако, поскольку клинический опыт применения Термикона  у беременных женщин очень ограничен, его следует применять только по строгим показаниям."}},{"type":"paragraph","data":{"text":"Тербинафин выделяется с грудным молоком. Однако, в случае применения кормящей матерью Термикона  спрея через кожу всасывается небольшое количество активного вещества, поэтому неблагоприятное воздействие на младенца маловероятно.\n\n"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nНаружно."}},{"type":"paragraph","data":{"text":"Взрослые. Термикон  спрей можно применять 1 или 2 раза в день, в зависимости от показаний. Перед применением препарата тщательно очистить и подсушить пораженные участки кожи."}},{"type":"paragraph","data":{"text":"Для обеспечения равномерного распыления содержимого предварительно произвести несколько кратковременных нажатий на насадку-распылитель."}},{"type":"paragraph","data":{"text":"Препарат наносят на пораженные участки кожи и прилегающие участки здоровой кожи в достаточном для их увлажнения количестве."}},{"type":"paragraph","data":{"text":"Кратность применения препарата и продолжительность лечения:"}},{"type":"paragraph","data":{"text":"– дерматомикоз туловища, голеней: 1 раз в сутки в течении 1 недели;"}},{"type":"paragraph","data":{"text":"– дерматомикоз стоп: 1 раз в сутки в течении 1 недели;"}},{"type":"paragraph","data":{"text":"– разноцветный лишай: 2 раза в сутки в течении 1 недели;"}},{"type":"paragraph","data":{"text":"– паховая эпидермофития, опрелость, вызванная плесневыми грибами: 1 раз в сутки в течении 1 недели.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nВ местах нанесения препарата может появиться покраснение, ощущение зуда или жжения."}},{"type":"paragraph","data":{"text":"Аллергические реакции.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nО случаях передозировки препарата не сообщалось. Если же случайно Термикон  спрей будет принят внутрь, можно ожидать развития таких же побочных явлений, как и при передозировке таблеток Термикон  (головная боль, тошнота, боли в эпигастрии и головокружение). Следует также учитывать содержание в препарате этилового спирта."}},{"type":"paragraph","data":{"text":"Лечение: активированный уголь, при необходимости – симптоматическая поддерживающая терапия.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Какие-либо лекарственные взаимодействия для спрея Термикон  не известны."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nУменьшение выраженности клинических проявлений обычно отмечается в первые дни лечения. В случае нерегулярного лечения или преждевременного его прекращения имеется риск рецидива инфекции. В том случае, если через неделю лечения не отмечается признаков улучшения, следует верифицировать диагноз."}},{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при нанесении спрея Термикон  на поврежденные участки кожи, так как спирт может вызвать раздражение."}},{"type":"paragraph","data":{"text":"Термикон  спрей предназначен только для наружного применения. Следует избегать попадания его в глаза, так как он может вызвать раздражение. При случайном попадании препарата в глаза, их следует немедленно промыть проточной водой, а в случае развития стойких явлений раздражения необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Если препарат был случайно введен в дыхательные пути при ингаляции, то, в случае появления каких-либо симптомов и особенно при их стойком сохранении, необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"При развитии аллергических реакций необходимо отменить препарат.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Данных о влиянии препарата на способность к управлению транспортными средствами или работе с другими механизмами нет."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Спрей для наружного применения 1%"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 30 °C. Не замораживать. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не использовать по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО \"Фармстандарт-Лексредства\""}}]}],"source":null},"description_toggle":false,"short_description":"Противогрибковый препарат для местного применения, обладающий широким спектром противогрибковой активности. В низких концентрациях тербинафин оказывает фунгицидное действие в отношении дерматофитов (Trychophyton rubrum, T. mentagrophytes, T. verrucosum, T. violaceum, T. tonsurans, Microsporum canis, Epidermophyton floccosum), плесневых, определенных диморфных (Pityrosporum orbiculare) и дрожжевых грибов (в основном Сandida albicans). Активность в отношении дрожжевых грибов, в зависимости от их вида, может быть фунгицидной или фунгистатической. Тербинафин специфическим образом изменяет ранний этап биосинтеза стеролов, происходящий в грибах. Это ведет к дефициту эргостерола и к внутриклеточному накоплению сквалена, что вызывает гибель клетки гриба. Действие тербинафина осуществляется путем ингибирования фермента скваленэпоксидазы, расположенного на клеточной мембране гриба. 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