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Препарат активен в отношении грамположительных и\nграмотрицательных бактерий \u003ci\u003eEscherichia coli\u003c/i\u003e,\u003ci\u003e\nProteus spp.\u003c/i\u003e,\u003ci\u003e Staphylococcus spp.\u003c/i\u003e,\u003ci\u003e Klebsiella spp\u003c/i\u003e."}},{"type":"paragraph","data":{"text":"Бактерицидные\nсвойства мази обусловлены активностью ионов серебра, которые высвобождаются в\nране в результате диссоциации серебряной соли сульфадиазина; высвобождение\nионов серебра идет постепенно (умеренная диссоциация), обеспечивая постоянство противомикробного\nэффекта. Бактерицидная активность ионов серебра дополняется бактериостатическим\nэффектом сульфадиазина (также высвобождающегося в процессе диссоциации\nсеребряной соли сульфадиазина)."}},{"type":"paragraph","data":{"text":"Препарат\u003cb\u003e \u003c/b\u003eхарактеризуется умеренной осмотической активностью и не обладает\nнекролитическими свойствами."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"При нанесении на\nраневую поверхность в периферический и системный кровоток абсорбируется около\n10 %\nсульфадиазина и 1 % серебра. Нанесение на обширную раневую поверхность\nсопровождается повышением концентрации сульфадиазина в крови до 10-20 мкг/мл."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Лечение\nинфицированных поверхностных ран и ожоговых поверхностей со слабой экссудацией, пролежней, ссадин, кожных\nязв, пересаженных участков кожи; а также профилактика их инфицирования. 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После хирургической обработки раны и удаления некротических тканей\nна поврежденную поверхность наносят тонким слоем (2-4 мм) мази (под\nповязку или открытым способом) 1-2 раза в день. "}},{"type":"paragraph","data":{"text":"Применение на кожу мази\u003csup\u003e \u003c/sup\u003eявляется безболезненным, мазь не\nпачкает одежду и белье.\u003csup\u003e \u003c/sup\u003e"}},{"type":"paragraph","data":{"text":"Максимальная разовая доза –\n300 г. Период лечения индивидуален и зависит от характера болезни и\nэффективности применяемого лечения, в общих случаях длится до 3-х недель."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли Вы забыли применить препарат\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Если Вы забыли применить\nпрепарат, используйте как можно быстрее и продолжайте применение как обычно. Не\nприменяйте двойную дозу, если предыдущее время применения препарата было\nпропущено."}},{"type":"paragraph","data":{"text":"При сохранении симптомов заболевания или ухудшении состояния на фоне\nприема препарата, следует сообщить об этом лечащему врачу."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Частота развития\nнежелательных реакций классифицирована согласно рекомендациям Всемирной\nорганизации здравоохранения: очень часто (> 1/10), часто (≥ 1/100, < 1/10), нечасто (≥ 1/1000, < 1/100),\nредко (≥ 1/10000, < 1/1000), очень редко, в том числе отдельные сообщения (< 1/10000)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со\nстороны крови и лимфатической системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: лейкопения, которая характеризуется в основном снижением числа\nнейтрофилов. Максимальное снижение числа лейкоцитов наблюдается на 2-4 сут\nпосле начала лечения; нормализация числа лейкоцитов наблюдается на 2-4 сут, при\nэтом продолжение лечения препаратом не оказывает влияния на процесс восстановления\nчисла лейкоцитов. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны кожи и подкожных тканей\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко: кожные аллергические\nреакции, нарушение пигментации кожи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие расстройства и нарушения в месте введения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: жжение и зуд в месте\nнанесения."}},{"type":"paragraph","data":{"text":"При длительном применении на больших раневых поверхностях: системные\nпобочные эффекты, характерные для сульфаниламидных ЛС. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со\nстороны иммунной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко: аллергические реакции."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны крови и лимфатической системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко: нарушение кроветворения (агранулоцитоз, апластическая и\nгемолитическая анемия, тромбоцитопения, лейкопения)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны желудочно-кишечного тракта\u003c/i\u003e "}},{"type":"paragraph","data":{"text":"Часто: диспепсия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения\u003c/i\u003e\u003ci\u003e со стороны печени и желчевыводящих путей\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко: гепатит, гепатоцеллюлярный\nнекроз."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны почек и мочевыделительной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко: токсический нефроз."}},{"type":"paragraph","data":{"text":"Имеются отдельные сообщения о \u003ci\u003eнарушениях\nфункций центральной нервной системы\u003c/i\u003e, \u003ci\u003eнарушениях\nсо стороны почек и мочевыделительной системы \u003c/i\u003e(интерстициальный нефрит), \u003ci\u003eнарушениях cо стороны кожи и подкожных\nтканей\u003c/i\u003e (некроз кожи, мультиформная эритема, синдром Стивенса-Джонсона и\nэксфолиативный дерматит)."}},{"type":"paragraph","data":{"text":"Степень абсорбции препарата зависит от размера ожоговой поверхности и\nстепени повреждения тканей."}},{"type":"paragraph","data":{"text":"При появлении побочных эффектов, не описанных в данной инструкции,\nследует прекратить прием препарата и сообщить об этом лечащему врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При\nпродолжительном лечении обширных ожоговых поверхностей сульфаниламиды могут достигнуть таких же\nзначений концентрации в плазме крови, как и при системном лечении, что определяет симптомы\nпередозировки: тошноту, нарушение функции печени, кристаллурию, нарушение\nфункции почек, лейкопению. Лечение\nсимптоматическое."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Действующее вещество мази сульфадиазин серебра может инактивировать\nферментные препараты, применяемые для очищения раны, поэтому одновременное\nприменение этих препаратов нежелательно."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При лечении пациентов с\nпеченочной и/или почечной недостаточностью необходимо регулярно проводить\nконтроль концентрации сульфаниламидов в плазме."}},{"type":"paragraph","data":{"text":"\nСоли серебра, вступая в реакции с кислородом воздуха, металлами и др.\nхимическими компонентами, особенно при катализирующем тепловом воздействии,\nтемнеют, поэтому препарат должен храниться в закрытой таре и вдали от источников\nтепла."}},{"type":"paragraph","data":{"text":"\nЧасти тела, обработанные препаратом, рекомендуется предохранять от действия\nпрямых солнечных лучей."}},{"type":"paragraph","data":{"text":"При применении препарата\nнеобходимо избегать его попадания в глаза."}},{"type":"paragraph","data":{"text":"Не следует утилизировать\nнеиспользованный препарат и упаковку с помощью сточных вод или вместе с\nбытовыми отходами. Попадание лекарственных препаратов в окружающую среду должно\nбыть сведено к минимуму."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не влияет на способность управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций"}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Мазь для наружного\nприменения 1 %. "}},{"type":"paragraph","data":{"text":"По 15 г,\n30 г и 50 г (для\nпроизводителя АО Таллиннский фармацевтический завод) или по 50 г (для\nпроизводителя АО «Гриндекс») в тубе алюминиевой с внутренней поверхностью,\nпокрытой лаком, с защитной алюминиевой мембраной на горловине и конусообразным\nприспособлением для прокола мембраны в навинчивающемся бушоне из пластмассы. Тубу\nвместе с инструкцией по применению помещают в пачку из\nкартона коробочного.\nНа пачке может быть нанесен стикер для контроля первого вскрытия."}},{"type":"paragraph","data":{"text":"Для\nстационаров по 800 г\n(для производителя АО Таллиннский фармацевтический завод) в банке\nпластмассовой, закрытой\nнавинчивающейся крышкой с внутренней прокладкой из картона с ламинированной\nповерхностью. На банке может быть нанесен стикер для контроля первого\nвскрытия. Банки с инструкциями по применению помещают в групповую упаковку."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Мазь в тубах хранить при температуре не выше 25 °С. "}},{"type":"paragraph","data":{"text":"Не замораживать."}},{"type":"paragraph","data":{"text":"Мазь в плотно закрытых банках хранить в защищенном от света месте при\nтемпературе не выше 25 °С. "}},{"type":"paragraph","data":{"text":"Не замораживать."}},{"type":"paragraph","data":{"text":"Хранить\nв недоступном для детей месте. "}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. "}},{"type":"paragraph","data":{"text":"Не применять по\nистечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО Таллиннский\nфармацевтический завод. Тонди 33, 11316 Таллинн, Эстония"}},{"type":"paragraph","data":{"text":"Телефон: +372 6120 201"}},{"type":"paragraph","data":{"text":"Электронная\nпочта: farma@tft.ee"}},{"type":"paragraph","data":{"text":"АО «Гриндекс». Ул. Крустпилс, 53, Рига, LV-1057, Латвия"}},{"type":"paragraph","data":{"text":"Телефон: +371 67083 205"}},{"type":"paragraph","data":{"text":"Факс: +371 67083 505"}},{"type":"paragraph","data":{"text":"Электронная\nпочта: \u003ca href=\"mailto:grindeks@grindeks.lv\"\u003egrindeks@grindeks.lv\u003c/a\u003e"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Гриндекс Рус»."}},{"type":"paragraph","data":{"text":"Россия, 117556, г. Москва,\nВаршавское шоссе, д. 74, корп. 3, 5 этаж."}},{"type":"paragraph","data":{"text":"Телефон: + 7 (495) 7716505"}},{"type":"paragraph","data":{"text":"Факс: +7 (499) 6103963"}},{"type":"paragraph","data":{"text":"Электронная почта: office@grindeks.ru"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаСульфадиазин-противомикробное бактерицидное средство широкого спектра действия, относящееся к группе сульфаниламидов. Препарат активен в отношении грамположительных и грамотрицательных бактерийEscherichia coli,Proteus spp.,Staphylococcus spp.,Klebsiella spp. Бактерицидные свойства мази обусловлены активностью ионов серебра, которые высвобождаются в ране в результате диссоциации серебряной соли сульфадиазина; высвобождение ионов серебра идет постепенно (умеренная диссоциация), обеспечивая постоянство противомикробного эффекта. Бактерицидная активность ионов серебра дополняется бактериостатическим эффектом сульфадиазина (также высвобождающегося в процессе диссоциации серебряной соли сульфадиазина). Препаратхарактеризуется умеренной осмотической активностью и не обладает некролитическими свойствами.ФармакокинетикаПри нанесении на раневую поверхность в периферический и системный кровоток абсорбируется около 10 % сульфадиазина и 1 % серебра. Нанесение на обширную раневую поверхность сопровождается повышением концентрации сульфадиазина в крови до 10-20 мкг/мл.","substance":[{"id":454,"title":"Сульфадиазин","title_latin":"Sulfadiazinum","slug":"sulfadiazin_454"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":{"count":16,"url":"/review/8902-sulfargin/"},"image_alt":"Сульфаргин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/89857/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/89857/share_default/"}},"diseases":[{"id":"774","title":"Варикозное расширение вен нижних конечностей с язвой и воспалением","slug":"774-varikoznoe_rasshirenie_ven_nizhnih_konechnostey_s_yazvoy_i_vospaleniem"},{"id":"1000","title":"Декубитальная язва (пролежень)","slug":"1000-dekubitalnaya_yazva_prolezhen"},{"id":"1306","title":"Термические и химические ожоги неуточненной 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