Ципротерона ацетат обладает антиандрогенным, гестагенным и а... Инструкция
Показания к применению
— метастазирующий или неоперабельный рак предстательной железы (без и после орхиэктомии, а также в сочетании с агонистами гонадотропин - рилизинг гормона).
Противопоказания
Выраженные нарушения функции печени
Синдром Дубина-Джонсона и синдром Ротора
Опухоли печени, в т.ч. в анамнезе (за исключением метастатического поражения печени)
Ципротерона ацетат обладает антиандрогенным, гестагенным и антигонадотропным действием.; Ципротерона ацетат по конкурентному механизму угнетает действие андрогенов на их органы-мишени, а также обладает центральным антигонадотропным действием, приводящим к снижению синтеза тестостерона в яичках, и его содержания в сыворотке крови.
Показания к применению
— метастазирующий или неоперабельный рак предстательной железы (без и после орхиэктомии, а также в сочетании с агонистами гонадотропин - рилизинг гормона).
Противопоказания
Выраженные нарушения функции печени
Синдром Дубина-Джонсона и синдром Ротора
Опухоли печени, в т.ч. в анамнезе (за исключением метастатического поражения печени)
Тяжелые хронические депрессивные состояния
Текущие тромбоэмболические процессы
Кахексия (если она не связана с раком предстательной железы)
Повышенная чувствительностью к ципротерону или к другим составным компонентам препарата
Следует применять с осторожностью при следующих заболеваниях: тромбоэмболические процессы в анамнезе, тяжелый сахарный диабет с сосудистыми осложнениями, серповидно-клеточная анемия.
Способ применения и дозы
Для лечения рака предстательной железы Андрокур назначается в дозе 200-300 мг/сут, разделенной на 2-3 приема, ежедневно длительно. При появлении признаков прогрессирования заболевания препарат следует отменить.; Таблетки Андрокура следует принимать после еды, запивая их небольшим количеством воды.
Побочное действие
В начале лечения могут отмечаться боли в животе, тошнота, повышенная утомляемость, сухость кожи, апатия, депрессивные состояния или состояние беспокойства, снижение способности концентрации внимания.; Редко могут наблюдаться аллергические реакции, увеличиваться или уменьшаться масса тела. Возможно появление гинекомастии и подавление сперматогенеза, обратимого снижения полового влечения и потенции. Длительное подавление выработки андрогенов в редких случаях может привести к возникновению остеопороза. В единичных случаях при применении высоких доз наблюдаются чувство нехватки воздуха и нарушения функции печени.
Передозировка
Ципротерон - практически нетоксичное средство. При непреднамеренном однократном приеме в дозе, многократно превышающей терапевтическую, ожидать острой интоксикации не следует.
Особые указания
Лечение Андрокуром следует проводить под контролем функции печени, коры надпочечников и картины периферической крови.; При наличии признаков гепатотоксичности прием препарата следует отменить.; У больных сахарным диабетом может потребоваться коррекция дозы инсулина или других гипогликемических препаратов (контроль уровня глюкозы должен проводиться чаще, чем обычно).; Негативного влияния Андрокура на фертильность после прекращения лечения не отмечено.; Влияние на способность к вождению автотранспорта и управлению механизмами; В период лечения необходимо воздерживаться от видов деятельности, требующих повышенного внимания.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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