Комбинированный препарат с выраженным антигипоксическим, ноотропным и сосудорасширяющим действием. Компоненты взаимно потенцируют снижение сопротивления сосудов мозга и способствуют повышению в них кровотока. Пирацетам – ноотропное средство. Активирует метаболические процессы в головном мозге посредством усиления энергетического и белкового обмена, ускорения утилизации глюкозы клетками и повышения их устойчивости к гипоксии. Улучшает межнейрональную передачу в ЦНС и регионарный кровоток в ишемизированной зоне. Циннаризин – селективный блокатор медленных кальциевых каналов и антагонист гистаминовых H1-рецепторов. Установлено, что он ингибирует поступление в клетки ионов кальция и уменьшает их содержание в депо плазмолеммы. Снижает тонус гладкой мускулатуры артериол, уменьшает их реакцию на биогенные сосудосуживающие вещества (катехоламины, ангиотензин и вазопрессин). Обладает сосудорасширяющим действием (особенно в отношении сосудов головного мозга, усиливая антигипоксическое действие пирацетама), не оказывая существенного влияния на АД. Проявляет умеренную антигистаминную активность, уменьшает возбудимость вестибулярного аппарата, повышает тонус симпатической нервной системы. Повышает эластичность мембран эритроцитов, их способность к деформации, снижает вязкость крови.
Показания к применению
Нарушения мозгового кровообращения, вследствие инсульта, атеросклероза сосудов, ЧМТ. Нарушения когнитивных функций: памяти, мышления, внимания. Снижение настроения, раздражительность. Энцефалопатии различного происхождения. Лабиринтопатии. Болезнь Меньера. Мигрень. Комплексная терапия артериальной гипертензии. Комплексная терапия тугоухости. Комплексная терапия НЦД. Комплексная терапия нарушения зрения при: миопии, макулодистрофии, закрытоугольной глаукоме (после стабилизации внутриглазного давления). Нарушения памяти и внимания у детей, в том числе и со сниженным интеллектом. Астения.
Противопоказания
Непереносимость одного из компонентов препарата. Тяжелая почечная недостаточность. Период беременности(1 триместр). Паркинсонизм. Возраст до 5 лет.
Применение при беременности и в период грудного вскармливания
Несмотря на отсутствие данных о наличии тератогенного действия пирацетама и циннаризина Фезам противопоказан к применению при беременности. Пирацетам выделяется с грудным молоком, поэтому при необходимости применения препарата в период лактации грудное вскармливание следует прекратить.
Способ применения и дозы
Взрослым: в зависимости от тяжести заболевания - 1-2 капсулы 3 раза в день. Детям: в зависимости от тяжести заболевания - 1-2 капсулы 1-2 раза в день. Курс лечения 1-3 месяца.
Фезам хорошо переносится пациентами, в случае передозировки не наблюдается серьезных побочных эффектов, требующих отмены препарата. Симптомы: возможна боль в животе. Лечение: следует провести промывание желудка, вызвать рвоту; проведение симптоматической терапии; при необходимости - гемодиализ. Специфического антидота нет.
Особые указания
С осторожностью назначать пациентам с заболеваниями печени и/или почек. При почечной недостаточности легкой и средней степени тяжести (КК менее 60 мл/мин) следует снизить терапевтическую дозу или увеличить интервал между приемами препарата. У пациентов с нарушениями функции печени необходимо контролировать содержание печеночных ферментов. Пациентам следует избегать употребления алкоголя во время приема Фезама. Препарат усиливает активность гормонов щитовидной железы и может вызвать тремор и беспокойство. Влияние на способность к вождению автотранспорта и управлению механизмами: Во время приема препарата Фезам пациентам следует соблюдать осторожность при управлении транспортными средствами и работе с машинами и оборудованием, поскольку в начале лечения циннаризин может вызывать сонливость.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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