Метрогил Гель, 30 г, 1 %

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Механизм действия заключается в биохимическом восстановлении 5-нитрогруппы метронидазола внутриклеточными транспортными протеинами анаэробных микроорганизмов и простейших. Восстановленная 5-нитрогруппа метронидазола взаимодействует с ДНК клетки микроорганизмов, ингибируя синтез их нуклеиновых кислот, что ведет к гибели бактерий."}},{"type":"paragraph","data":{"text":"Активен в отношении Trichomonas vaginalis, а также грамотрицательных анаэробов Bacteroides spp. (в т.ч. Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. и некоторых грамположительных микроорганизмов (чувствительные штаммы Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). МПК для этих штаммов составляет 0,125-6,25 мкг/мл. "}},{"type":"paragraph","data":{"text":"При наружном применении оказывает противоугревое действие, механизм которого точно неизвестен (не связано с действием на клеща Demodex folliculorum, обнаруживаемого в волосяных фолликулах и секрете сальных желез, и каким-либо влиянием на продукцию этого секрета)."}},{"type":"paragraph","data":{"text":"Метронидазол для наружного применения, возможно, обладает антиоксидантной активностью. Установлено, что он значительно снижает продукцию нейтрофилами активного кислорода, гидроксильных радикалов и водорода пероксида, которые являются потенциальными оксидантами, способными вызывать повреждение тканей в месте воспаления. Метронидазол для наружного применения неэффективен в отношении телеангиэктазий, отмечаемых при розовых угрях."}},{"type":"paragraph","data":{"text":"К метронидазолу нечувствительны аэробные микроорганизмы и факультативные анаэробы, но в присутствии смешанной флоры (аэробы и анаэробы) метронидазол действует синергично с антибиотиками, эффективными против обычных аэробов."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Розовые угри (в т.ч. постстероидные), вульгарные угри, инфекционные заболевания кожи, трофические язвы нижних конечностей (на фоне варикозного расширения вен, сахарного диабета), вялозаживающие раны, пролежни, ожог, экзема, себорейная экзема, жирная себорея, себорейный дерматит, геморрой, трещины заднего прохода. "}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к компонентам, входящим в состав препарата, а также к производным нитроимидазола."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Для наружного применения."}},{"type":"paragraph","data":{"text":"Наносят на предварительно очищенную кожу тонким слоем 2 раза в сутки, утром и вечером, в течение 3-9 нед."}},{"type":"paragraph","data":{"text":"При необходимости накладывают окклюзионную повязку."}},{"type":"paragraph","data":{"text":"Средняя продолжительность курса лечения составляет 3-4 мес, терапевтический эффект обычно отмечается уже после 3 недель лечения\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"При местном применении концентрация метронидазола в крови очень низкая, поэтому риск развития системных побочных эффектов невелик."}},{"type":"paragraph","data":{"text":"Редко могут наблюдаться: аллергические реакции (кожная сыпь, зуд, крапивница); гиперемия, шелушение и жжение кожи, слезотечение (если гель нанесен близко к глазам). \n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Случаев передозировки препарата при назначении в рекомендуемых дозах не наблюдалось."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении усиливает действие варфарина и других непрямых антикоагулянтов (увеличивает протромбиновое время)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не рекомендуется назначать препарат беременным женщинам в I триместре беременности."}},{"type":"paragraph","data":{"text":"В период лактации, при необходимости назначения препарата, следует решить вопрос о прекращении грудного вскармливания."}},{"type":"paragraph","data":{"text":"Сведения о возможном влиянии лекарственного препарата для медицинского применения на способность управлять транспортными средствами, механизмами."}},{"type":"paragraph","data":{"text":"Препарат не влияет на способность управлять автомобилем и обслуживать движущееся механическое оборудование."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Гель для наружного применения"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в защищенном от света, недоступном для детей месте при температуре не выше 30°С. "}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. 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