Синтетический аналог гистамина. Является слабым агонистом ги... Инструкция
Показания к применению
Водянка лабиринта внутреннего уха. Вестибулярные и лабиринтные нарушения: головокружение, шум и боль в ушах, головная боль, тошнота, рвота, снижение слуха. Вестибулярный неврит, лабиринтит, доброкачественное позиционное головокружение (в т.ч. После нейрохирургических операций), болезнь меньера. В составе комплексной терапии: Вертебробазилярная недостаточность. ...
Гиперчувствительность. Феохромоцитома. Бронхиальная астма. Язвенная болезнь желудка и двенадцатиперстной кишки в фазе обострения. Беременность (i триместр). С осторожностью: Язвенная болезнь желудка или двенадцатиперстной кишки (в анамнезе). Беременность (ii–iii триместр). Детский возраст.
Таблетки 1 табл. бетагистина дигидрохлорид 8 мг, вспомогательные вещества: повидон K90, МКЦ, лактозы моногидрат, кремния диоксид коллоидный, кросповидон, стеариновая кислота, вода очищенная (не содержится в готовом препарате)
Фармакологические свойства
Синтетический аналог гистамина. Является слабым агонистом гистаминовых H1-рецепторов и довольно мощным антагонистом гистаминовых H3-рецепторов. Оказывает гистаминоподобное и вазодилатирующее действие. Воздействует на кохлеарный кровоток и центральный вестибулярный аппарат. Действие препарата включает в себя вазодилатацию во внутреннем ухе (опосредованно через гистаминовые H3- и H1-рецепторы), ингибирующий эффект в отношении вестибулярных ядер (через гистаминовые H3-рецепторы) и импульсной активности ампулярных рецепторов. Путем прямого агонистического воздействия на гистаминовые H1-рецепторы сосудов внутреннего уха и прекапиллярные сфинктеры микроциркуляторного русла, расположенные в сосудистой полоске (stria vascularis), а также опосредованно через гистаминовые H3-рецепторы, улучшает микроциркуляцию и проницаемость капилляров внутреннего уха, нормализует давление эндолимфы в лабиринте и улитке, увеличивает кровоток в базилярной артерии. Обладает выраженным центральным эффектом, являясь антагонистом гистаминовых H3-рецепторов ядер вестибулярного нерва. Нормализует проводимость в полисинаптических нейронах вестибулярных ядер на уровне ствола головного мозга. Опосредованно воздействуя на гистаминовые H3-рецепторы, повышает в стволе головного мозга содержание серотонина, снижающего активность вестибулярных ядер. Способствует устранению нарушений как со стороны вестибулярного, так и кохлеарного аппарата: снижает частоту и интенсивность головокружений, уменьшает шум в ушах, способствует улучшению слуха в случаях его снижения. Бетагистин стимулирует гистаминовые H1-рецепторы, поэтому не оказывает седативного эффекта и не вызывает сонливости.
Показания к применению
Водянка лабиринта внутреннего уха. Вестибулярные и лабиринтные нарушения: головокружение, шум и боль в ушах, головная боль, тошнота, рвота, снижение слуха. Вестибулярный неврит, лабиринтит, доброкачественное позиционное головокружение (в т.ч. После нейрохирургических операций), болезнь меньера. В составе комплексной терапии: Вертебробазилярная недостаточность. Посттравматическая энцефалопатия. Атеросклероз сосудов головного мозга.
Противопоказания
Гиперчувствительность. Феохромоцитома. Бронхиальная астма. Язвенная болезнь желудка и двенадцатиперстной кишки в фазе обострения. Беременность (i триместр). С осторожностью: Язвенная болезнь желудка или двенадцатиперстной кишки (в анамнезе). Беременность (ii–iii триместр). Детский возраст.
Применение при беременности и в период грудного вскармливания
Препарат противопоказан к применению в I триместре беременности. С осторожностью следует назначать препарат во II и III триместрах беременности.
Способ применения и дозы
Внутрь, во время еды, не разжевывая, запивая небольшим количеством жидкости. Таблетки с дозировкой 8 и 16 мг: по 8–16 мг 2–4 раза в день. Лечение длительное.
Побочное действие
Диспепсия (тошнота, рвота), кожная сыпь, отек Квинке.
Передозировка
Симптомы: головная боль, гиперемия кожи лица, головокружение, тахикардия, снижение АД, бронхоспазм.
Особые указания
Терапевтический эффект препарата в ряде случаев появляется лишь спустя несколько месяцев от начала лечения.
Для описания товара использована информация от партнера 36.6
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