Ибупрофен-Хемофарм Таблетки, 30 шт, 400 мг, в пленочной оболочке

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Неизбирательно блокирует циклооксигеназу 1 (ЦОГ-1) и циклооксигеназу II (ЦОГ-2), вследствие чего тормозит синтез простагландинов. Оказывает быстрое направленное действие против боли (обезболивающее), противовоспалительное и жаропонижающее действие. Кроме того, ибупрофен обратимо ингибирует агрегацию тромбоцитов."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Абсорбция — высокая, быстро и практически полностью всасывается из желудочно-кишечного тракта (ЖКТ). После приема препарата натощак максимальная концентрация (С\u003csub\u003emах\u003c/sub\u003e) ибупрофена в плазме крови достигается через 30-35 минут. Прием препарата вместе с пищей может увеличивать время достижения максимальной концентрации (ТС\u003csub\u003emах\u003c/sub\u003e). Связь с белками плазмы крови более 90 %. Медленно проникает в полость суставов, задерживается в синовиальной жидкости, создавая в ней большие концентрации, чем в плазме крови. После абсорбции около 60 % фармакологически неактивной R-формы медленно трансформируется в активную S-форму. Подвергается метаболизму в печени. Период полувыведения (Т1/2) — 2 часа. Выводится почками (в неизмененном виде не более 1 %) и, в меньшей степени, с желчью. У пожилых людей не обнаруживалось значимых различий в фармакокинетическом профиле ибупрофена по сравнению с более молодыми людьми."}},{"type":"paragraph","data":{"text":"В ограниченных исследованиях ибупрофен обнаруживался в грудном молоке в очень низких концентрациях."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Головная боль, зубная боль, мигрень, болезненные менструации, невралгия, боль в спине, боль в суставах, мышечная и ревматическая боль, лихорадочное состояние при гриппе и простудных заболеваниях."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["гиперчувствительность к ибупрофену или любому из компонентов, входящих в состав препарата;","полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа и околоносовых пазух и непереносимости ацетилсалициловой кислоты (АСК) или других НПВП (в том числе в анамнезе);","эрозивно-язвенные заболевания органов желудочно-кишечного тракта (в том числе язвенная болезнь желудка и двенадцатиперстной кишки, болезнь Крона, язвенный колит) или язвенное кровотечение в активной фазе или в анамнезе (два или более подтвержденных эпизода язвенной болезни или язвенного кровотечения);","кровотечение или перфорация язвы желудочно-кишечного тракта в анамнезе, спровоцированные применением НПВП;","тяжелая сердечная недостаточность (класс IV по классификации Нью-Йоркской Ассоциации кардиологов (NYHA));","тяжелая печеночная недостаточность или заболевание печени в активной фазе;","почечная недостаточность тяжелой степени тяжести (клиренс креатинина < 30 мл/мин), подтвержденная гиперкалиемия;","декомпенсированная сердечная недостаточность, период после проведения аортокоронарного шунтирования;","цереброваскулярное или иное кровотечение;","гемофилия и другие нарушения свертываемости крови (в том числе гипокоагуляция), геморрагические диатезы;","беременность (III триместр);","детский возраст до 12 лет."]}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"При наличии состояний, указанных в данном разделе, перед применением препарата следует проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Одновременный прием других НПВП, наличие в анамнезе однократного эпизода язвенной болезни желудка и двенадцатиперстной кишки или язвенного кровотечения ЖКТ; гастрит, энтерит, колит, наличие инфекции Helicobacter pylori, язвенный колит; бронхиальная астма или аллергические заболевания в стадии обострения или в анамнезе — возможно развитие бронхоспазма; системная красная волчанка или смешанное заболевание соединительной ткани (синдром Шарпа) — повышен риск асептического менингита; ветряная оспа; почечная недостаточность, в том числе при обезвоживании (клиренс креатинина менее 30-60 мл/мин), нефротический синдром, печеночная недостаточность, цирроз печени с портальной гипертензией, гипербилирубинемия, артериальная гипертензия и/или сердечная недостаточность, цереброваскулярные заболевания, заболевания крови неясной этиологии (лейкопения и анемия), тяжелые соматические заболевания, дислипидемия/гиперлипидемия, сахарный диабет, заболевания периферических артерий, курение, частое употребление алкоголя, одновременное применение лекарственных средств, которые могут увеличить риск возникновения язв или кровотечения, в частности, пероральных глюкокортикостероидов (в том числе преднизолона), антикоагулянтов (в том числе варфарина), селективных ингибиторов обратного захвата серотонина (в том числе циталопрама, флуоксетина, пароксетина, сертралина) или антиагрегантов (в том числе АСК, клопидогрела), беременность I-II триместр, период грудного вскармливания, пожилой возраст."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказано применение препарата в III триместре беременности."}},{"type":"paragraph","data":{"text":"Следует избегать применения препарата в I-II триместрах беременности, при необходимости приема препарата следует проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Имеются данные о том, что ибупрофен в незначительных количествах может проникать в грудное молоко без каких-либо отрицательных последствий для здоровья грудного ребенка, поэтому обычно при кратковременном приеме необходимости в прекращении грудного вскармливания не возникает. При необходимости длительного применения препарата следует обратиться к врачу для решения вопроса о прекращении грудного вскармливания на период применения препарата."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Для приема внутрь. Пациентам с повышенной чувствительностью желудка рекомендуется принимать препарат во время еды."}},{"type":"paragraph","data":{"text":"Только для кратковременного применения. Внимательно прочтите инструкцию перед приемом препарата."}},{"type":"paragraph","data":{"text":"Взрослым и детям старше 12 лет внутрь по 1 таблетке (400 мг) до 3 раз в сутки. Таблетки следует запивать водой."}},{"type":"paragraph","data":{"text":"Интервал между приемом таблеток должен составлять не менее 6 часов."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза составляет 1200 мг (3 таблетки). Максимальная суточная доза для детей от 12 до 18 лет составляет 800 мг (2 таблетки)."}},{"type":"paragraph","data":{"text":"Если при приеме препарата в течение 2-3 дней симптомы сохраняются или усиливаются, необходимо прекратить лечение и обратиться к врачу."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Риск возникновения побочных эффектов можно свести к минимуму, если принимать препарат коротким курсом, в минимальной эффективной дозе, необходимой для устранения симптомов."}},{"type":"paragraph","data":{"text":"У людей пожилого возраста наблюдается повышенная частота побочных реакций на фоне применения НПВП, особенно желудочно-кишечных кровотечений и перфораций, в некоторых случаях с летальным исходом."}},{"type":"paragraph","data":{"text":"Побочные эффекты преимущественно являются дозозависимыми."}},{"type":"paragraph","data":{"text":"Нижеперечисленные побочные реакции отмечались при кратковременном приеме ибупрофена в дозах, не превышающих 1200 мг/сутки (6 таблеток). При лечении хронических состояний и при длительном применении возможно появление других побочных реакций."}},{"type":"paragraph","data":{"text":"Частота нежелательных реакций (НР), указанных ниже, приведена в соответствии со следующей классификацией: очень частые (≥ 10 %), частые (≥ 1 %, но < 10 %), нечастые (≥ 0,1 %, но < 1 %), редкие (≥ 0,01 %, но < 0,1 %), очень редкие (< 0,01 %), частота неизвестна — невозможно оценить частоту на основании доступных данных."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны крови и лимфатической системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редкие:\u003c/i\u003e нарушения кроветворения (анемия, лейкопения, апластическая анемия, гемолитическая анемия, тромбоцитопения, панцитопения, агранулоцитоз). Первыми симптомами таких нарушений являются лихорадка, боль в горле, поверхностные язвы в полости рта, гриппоподобные симптомы, выраженная слабость, кровотечения из носа и подкожные кровоизлияния, кровотечения и кровоподтеки неизвестной этиологии."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны иммунной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eНечастые: \u003c/i\u003eреакции гиперчувствительности — неспецифические аллергические реакции и анафилактические реакции, реакции со стороны дыхательных путей (бронхиальная астма, в том числе ее обострение, бронхоспазм, одышка, диспноэ), кожные реакции (зуд, крапивница, пурпура, отек Квинке, эксфолиативные и буллезные дерматозы, в том числе токсический эпидермальный некролиз (синдром Лайелла), синдром Стивенса-Джонсона, мультиформная эритема), аллергический ринит, эозинофилия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редкие:\u003c/i\u003e тяжелые реакции гиперчувствительности, в том числе отек лица, языка и гортани, одышка, тахикардия, артериальная гипотензия (анафилаксия, отек Квинке или тяжелый анафилактический шок)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны желудочно-кишечного тракта\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eНечастые:\u003c/i\u003e боль в животе, тошнота, диспепсия (в том числе изжога, вздутие живота)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРедкие:\u003c/i\u003e диарея, метеоризм, запор, рвота."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редкие:\u003c/i\u003e пептическая язва, перфорация или желудочно-кишечное кровотечение, мелена, кровавая рвота, в некоторых случаях с летальным исходом, особенно у пациентов пожилого возраста, язвенный стоматит, гастрит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЧастота неизвестна:\u003c/i\u003e обострение колита и болезни Крона."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны печени и желчевыводящих путей\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редкие: \u003c/i\u003eнарушения функции печени (особенно при длительном применении), повышение активности «печеночных» трансаминаз, гепатит и желтуха."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны почек и мочевыводящих путей\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редкие:\u003c/i\u003e острая почечная недостаточность (компенсированная и декомпенсированная) особенно при длительном применении, в сочетании с повышением концентрации мочевины в плазме крови и появлением отеков, гематурии и протеинурии, нефритический синдром, нефротический синдром, папиллярный некроз, интерстициальный нефрит, цистит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны нервной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eНечастые:\u003c/i\u003e головная боль."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редкие:\u003c/i\u003e асептический менингит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сердечно-сосудистой системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЧастота неизвестна:\u003c/i\u003e сердечная недостаточность, периферические отеки, при длительном применении повышен риск тромботических осложнений (например, инфаркт миокарда), повышение артериального давления."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны дыхательной системы и органов средостения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЧастота неизвестна:\u003c/i\u003e бронхиальная астма, бронхоспазм, одышка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛабораторные показатели\u003c/i\u003e"}},{"type":"list","data":{"style":"ordered","items":["гематокрит или гемоглобин (могут уменьшаться);","время кровотечения (может увеличиваться);","концентрация глюкозы в плазме крови (может снижаться);","клиренс креатинина (может уменьшаться);","плазменная концентрация креатинина (может увеличиваться);","активность «печеночных» трансаминаз (может повышаться)."]}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.\u003c/i\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"У детей симптомы передозировки могут возникать после приема дозы, превышающей 400 мг/кг массы тела. У взрослых дозозависимый эффект передозировки менее выражен. Период полувыведения препарата при передозировке составляет 1,5-3 часа."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e тошнота, рвота, боль в эпигастральной области или, реже, диарея, шум в ушах, головная боль и желудочно-кишечное кровотечение. В более тяжелых случаях наблюдаются проявления со стороны центральной нервной системы: сонливость, редко — возбуждение, судороги, дезориентация, кома. В случаях тяжелого отравления может развиваться метаболический ацидоз и увеличение протромбинового времени, почечная недостаточность, повреждение ткани печени, снижение артериального давления, угнетение дыхания и цианоз. У пациентов с бронхиальной астмой возможно обострение этого заболевания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e симптоматическое, с обязательным обеспечением проходимости дыхательных путей, мониторингом электрокардиограммы и основных показателей жизнедеятельности вплоть до нормализации состояния пациента. Рекомендуется пероральное применение активированного угля или промывание желудка в течение 1 часа после приема потенциально токсической дозы ибупрофена. Если ибупрофен уже абсорбировался, может быть назначено щелочное питье с целью выведения кислого производного ибупрофена почками, форсированный диурез. Частые или продолжительные судороги следует купировать внутривенным введением диазепама или лоразепама. При ухудшении бронхиальной астмы рекомендуется применение бронходилататоров."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Следует избегать одновременного применения ибупрофена со следующими лекарственными средствами:"}},{"type":"list","data":{"style":"ordered","items":["\u003ci\u003eАцетилсалициловая кислота:\u003c/i\u003e за исключением низких доз ацетилсалициловой кислоты (не более 75 мг в сутки), назначенных врачом, поскольку совместное применение может повысить риск возникновения побочных эффектов. При одновременном применении ибупрофен снижает противовоспалительное и антиагрегантное действие ацетилсалициловой кислоты (возможно повышение частоты развития острой коронарной недостаточности у пациентов, получающих в качестве антиагрегантного средства малые дозы ацетилсалициловой кислоты, после начала приема ибупрофена).","\u003ci\u003eДругие НПВП, в частности, селективные ингибиторы ЦОГ-2:\u003c/i\u003e следует избегать одновременного применения двух и более препаратов из группы НПВП из-за возможного увеличения риска возникновения побочных эффектов."]}},{"type":"paragraph","data":{"text":"С осторожностью применять одновременно со следующими лекарственными средствами:"}},{"type":"list","data":{"style":"ordered","items":["\u003ci\u003eАнтикоагулянты и тромболитические препараты:\u003c/i\u003e НПВП могут усиливать эффект антикоагулянтов, в частности, варфарина и тромболитических препаратов.","\u003ci\u003eАнтигипертензивные средства (ингибиторы ангиотензинпревращающего фермента (АПФ) и антагонисты ангиотензина II) и диуретики:\u003c/i\u003e НПВП могут снижать эффективность препаратов этих групп. У некоторых пациентов с нарушением почечной функции (например, у пациентов с обезвоживанием или у пациентов пожилого возраста с нарушением почечной функции) одновременное назначение ингибиторов АПФ или антагонистов ангиотензина II и средств, ингибирующих циклооксигеназу, может привести к ухудшению почечной функции, включая развитие острой почечной недостаточности (обычно обратимой). Эти взаимодействия следует учитывать у пациентов, принимающих коксибы одновременно с ингибиторами АПФ или антагонистами ангиотензина II. В связи с этим совместное применение вышеуказанных средств следует назначать с осторожностью, особенно у пожилых пациентов. Необходимо предотвращать обезвоживание у пациентов, а также рассмотреть возможность мониторинга почечной функции после начала такого комбинированного лечения и периодически — в дальнейшем. Диуретики и ингибиторы АПФ могут повышать нефротоксичность НПВП."]}},{"type":"list","data":{"style":"ordered","items":["\u003ci\u003eГлюкокортикостероиды:\u003c/i\u003e повышенный риск образования язв ЖКТ и желудочно-кишечного кровотечения.","\u003ci\u003eАнтиагреганты и селективные ингибиторы обратного захвата серотонина: \u003c/i\u003eповышенный риск возникновения желудочно-кишечного кровотечения.","\u003ci\u003eСердечные гликозиды:\u003c/i\u003e одновременное назначение НПВП и сердечных гликозидов может привести к усугублению сердечной недостаточности, снижению скорости клубочковой фильтрации и увеличению концентрации сердечных гликозидов в плазме крови.","\u003ci\u003eПрепараты лития:\u003c/i\u003e существуют данные о вероятности увеличения концентрации лития в плазме крови на фоне применения НПВП.","\u003ci\u003eМетотрексат:\u003c/i\u003e существуют данные о вероятности увеличения концентрации метотрексата в плазме крови на фоне применения НПВП.","\u003ci\u003eЦиклоспорин:\u003c/i\u003e увеличение риска нефротоксичности при одновременном назначении НПВП и циклоспорина.","\u003ci\u003eМифепристон: \u003c/i\u003eприем НПВП следует начать не ранее, чем через 8-12 дней после приема мифепристона, поскольку НПВП могут снижать эффективность мифепристона.","\u003ci\u003eТакролимус:\u003c/i\u003e при одновременном назначении НТТВП и такролимуса возможно увеличение риска нефротоксичности.","\u003ci\u003eЗидовудин:\u003c/i\u003e одновременное применение НПВП и зидовудина может привести к повышению гематотоксичности. Имеются данные о повышенном риске возникновения гемартроза и гематом у ВИЧ-положительных пациентов с гемофилией, получавших совместное лечение зидовудином и ибупрофеном.","\u003ci\u003eАнтибиотики хинолонового ряда:\u003c/i\u003e у пациентов, получающих совместное лечение НПВП и антибиотиками хинолонового ряда, возможно увеличение риска возникновения судорог.","\u003ci\u003eМиелотоксические препараты:\u003c/i\u003e усиление гематотоксичности.","\u003ci\u003eЦефамандол, цефоперазон, цефотетан, вальпроевая кислота, пликамицин: \u003c/i\u003eувеличение частоты развития гипопротромбинемии.","\u003ci\u003eЛекарственные средства, блокирующие канальцевую секрецию:\u003c/i\u003e снижение выведения и повышение плазменной концентрации ибупрофена.","\u003ci\u003eИндукторы микросомального окисления (фенитоин, этанол, барбитураты, рифампицин, фенилбутазон, трициклические антидепрессанты):\u003c/i\u003e увеличение продукции гидроксилированных активных метаболитов, увеличение риска развития тяжелых интоксикаций.","\u003ci\u003eИнгибиторы микросомального окисления:\u003c/i\u003e снижение риска гепатотоксического действия.","\u003ci\u003eПероральные гипогликемические лекарственные средства и инсулин, производные сульфонилмочевины:\u003c/i\u003e усиление действия препаратов.","\u003ci\u003eАнтациды и колестирамин: \u003c/i\u003eснижение абсорбции.","\u003ci\u003eУрикозурические препараты:\u003c/i\u003e снижение эффективности препаратов.","\u003ci\u003eЭстрогены, этанол:\u003c/i\u003e повышенный риск возникновения побочных эффектов.","\u003ci\u003eКофеин:\u003c/i\u003e усиление анальгезирующего эффекта."]}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Рекомендуется принимать препарат максимально возможным коротким курсом и в минимальной эффективной дозе, необходимой для устранения симптомов. В случае необходимости приема препарата более 10 дней, необходимо обратиться к врачу."}},{"type":"paragraph","data":{"text":"У пациентов с бронхиальной астмой или аллергическим заболеванием в стадии обострения, а также у пациентов с анамнезом бронхиальной астмы/аллергического заболевания препарат может спровоцировать бронхоспазм."}},{"type":"paragraph","data":{"text":"Применение препарата у пациентов с системной красной волчанкой или смешанным заболеванием соединительной ткани связано с повышенным риском развития асептического менингита."}},{"type":"paragraph","data":{"text":"Во время длительного лечения необходим контроль картины периферической крови и функционального состояния печени и почек. При появлении симптомов гастропатии показан тщательный контроль, включающий проведение эзофагогастродуоденоскопии, общий анализ крови (определение гемоглобина), анализ кала на скрытую кровь."}},{"type":"paragraph","data":{"text":"При необходимости определения 17-кетостероидов препарат следует отменить за 48 часов до исследования."}},{"type":"paragraph","data":{"text":"В период лечения не рекомендуется прием этанола."}},{"type":"paragraph","data":{"text":"Пациентам с почечной недостаточностью необходимо проконсультироваться с врачом перед применением препарата, поскольку существует риск ухудшения функционального состояния почек."}},{"type":"paragraph","data":{"text":"Пациентам с гипертонией, в том числе в анамнезе и/или хронической сердечной недостаточностью, необходимо проконсультироваться с врачом перед применением препарата, поскольку препарат может вызывать задержку жидкости, повышение артериального давления н отеки."}},{"type":"paragraph","data":{"text":"Пациентам с неконтролируемой артериальной гипертензией, застойной сердечной недостаточностью II-III класса по NYHA, ишемической болезнью сердца, заболеваниями периферических артерий и/или цереброваскулярными заболеваниями назначать ибупрофен следует только после тщательной оценки соотношения польза-риск, при этом следует избегать высоких доз ибупрофена (≥2400 мг/сутки)."}},{"type":"paragraph","data":{"text":"Применение НПВП у пациентов с ветряной оспой может быть связано с повышенным риском развития тяжелых гнойных осложнений инфекционно-воспалительных заболеваний кожи и подкожно-жировой клетчатки (например, некротизирующего фасциита). В связи с этим рекомендуется избегать применения препарата при ветряной оспе."}},{"type":"paragraph","data":{"text":"Информация для женщин, планирующих беременность: ибупрофен подавляет циклооксигеназу и синтез простагландинов, воздействует на овуляцию, нарушая женскую репродуктивную функцию (обратимо после отмены лечения)."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Пациентам, отмечающим головокружение, сонливость, заторможенность или нарушения зрения при приеме ибупрофена, следует избегать вождения автотранспорта или управления механизмами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой, 400 мг."}},{"type":"paragraph","data":{"text":"По 10 таблеток в блистер из пленки поливинилхлоридной и фольги алюминиевой. 1, 2, 3 или 5 блистеров с инструкцией по медицинскому применению лекарственного препарата в пачку картонную."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С в потребительской упаковке."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года. Не применять по истечении срока годности, указанного на упаковке"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Хемофарм д.о.о., Босния и Герцеговина"}},{"type":"paragraph","data":{"text":"78000, г. Баня-Лука, ул. Новаковичи, бб"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаМеханизм действия ибупрофена, производного пропионовой кислоты из группы нестероидных противовоспалительных препаратов (НПВП), обусловлен ингибированием синтеза простагландинов — медиаторов боли, воспаления и гипертермической реакции. Неизбирательно блокирует циклооксигеназу 1 (ЦОГ-1) и циклооксигеназу II (ЦОГ-2), вследствие чего тормозит синтез простагландинов. Оказывает быстрое направленное действие против боли (обезболивающее), противовоспалительное и жаропонижающее действие. Кроме того, ибупрофен обратимо ингибирует агрегацию тромбоцитов.ФармакокинетикаАбсорбция — высокая, быстро и практически полностью всасывается из желудочно-кишечного тракта (ЖКТ). После приема препарата натощак максимальная концентрация (Сmах) ибупрофена в плазме крови достигается через 30-35 минут. Прием препарата вместе с пищей может увеличивать время достижения максимальной концентрации (ТСmах). Связь с белками плазмы крови более 90 %. Медленно проникает в полость суставов, задерживается в синовиальной жидкости, создавая в ней большие концентрации, чем в плазме крови. После абсорбции около 60 % фармакологически неактивной R-формы медленно трансформируется в активную S-форму. Подвергается метаболизму в печени. Период полувыведения (Т1/2) — 2 часа. Выводится почками (в неизмененном виде не более 1 %) и, в меньшей степени, с желчью. У пожилых людей не обнаруживалось значимых различий в фармакокинетическом профиле ибупрофена по сравнению с более молодыми людьми. В ограниченных исследованиях ибупрофен обнаруживался в грудном молоке в очень низких концентрациях.","substance":[{"id":74,"title":"Ибупрофен","title_latin":"Ibuprophenum","slug":"ibuprofen_74"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Ибупрофен-Хемофарм - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/9010/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/9010/share_default/"}},"diseases":[{"id":"554","title":"Мигрень","slug":"554-migren"},{"id":"789","title":"Острый назофарингит","slug":"789-ostryy_nazofaringit"},{"id":"790","title":"Острый синусит","slug":"790-ostryy_sinusit"},{"id":"796","title":"Острая инфекция верхних отделов дыхательных путей неуточненная","slug":"796-ostraya_infektsiya_verhnih_otdelov_dyhatelnyh_putey_neutochnennaya"},{"id":"798","title":"Грипп, вызванный идентифицированным вирусом гриппа","slug":"798-gripp_vyzvannyy_identifitsirovannym_virusom_grippa"},{"id":"853","title":"Другие уточненные изменения зубов и их опорного аппарата (в т.ч. зубная боль)","slug":"853-drugie_utochnennye_izmeneniya_zubov_i_ih_opornogo_apparata_v_tch_zubnaya_bol"},{"id":"1012","title":"Серопозитивный ревматоидный артрит","slug":"1012-seropozitivnyy_revmatoidnyy_artrit"},{"id":"1013","title":"Псориатические и энтеропатические артропатии","slug":"1013-psoriaticheskie_i_enteropaticheskie_artropatii"},{"id":"1014","title":"Юношеский [ювенильный] артрит","slug":"1014-yunosheskiy_yuvenilnyy_artrit"},{"id":"1015","title":"Подагра","slug":"1015-podagra"},{"id":"1016","title":"Полиартроз","slug":"1016-poliartroz"},{"id":"1020","title":"Боль в суставе","slug":"1020-bol_v_sustave"},{"id":"1035","title":"Анкилозирующий спондилит","slug":"1035-ankiloziruyuschiy_spondilit"},{"id":"1037","title":"Спондилез","slug":"1037-spondilez"},{"id":"1039","title":"Радикулопатия","slug":"1039-radikulopatiya"},{"id":"1040","title":"Ишиас","slug":"1040-ishias"},{"id":"1041","title":"Люмбаго с ишиасом","slug":"1041-lyumbago_s_ishiasom"},{"id":"1045","title":"Синовиты и теносиновиты","slug":"1045-sinovity_i_tenosinovity"},{"id":"1046","title":"Другие поражения синовиальных оболочек и сухожилий","slug":"1046-drugie_porazheniya_sinovialnyh_obolochek_i_suhozhiliy"},{"id":"1048","title":"Болезни мягких тканей, связанные с нагрузкой, перегрузкой и давлением","slug":"1048-bolezni_myagkih_tkaney_svyazannye_s_nagruzkoy_peregruzkoy_i_davleniem"},{"id":"1049","title":"Другие бурсопатии","slug":"1049-drugie_bursopatii"},{"id":"1056","title":"Ревматизм неуточненный","slug":"1056-revmatizm_neutochnennyy"},{"id":"1057","title":"Миалгия","slug":"1057-mialgiya"},{"id":"1058","title":"Невралгия и неврит 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