Оксалиплатин медак Лиофилизат, флакон, 1 шт, 100 мг, для раствора для инфузий

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Со стороны обмена веществ: очень часто - анорексия, гипергликемия, гипокалиемия, гипернатриемия, часто - дегидратация, нечасто - метаболический ацидоз. Со стороны дыхательной системы, органов грудной клетки и средостения: очень часто - одышка, кашель, носовое кровотечение, часто - икота, эмболия легочной артерии, редко - фиброз легких, острое интерстициальное поражение легких, иногда со смертельным исходом. Со стороны сердечно-сосудистой системы: часто - кровотечение, \"приливы\", тромбоз глубоких вен, повышение артериального давления. Со стороны мочевыделительной системы: часто - гематурия, дизурия, очень редко - острый тубулярный некроз, острый интерстициальный нефрит и острая почечная недостаточность, частота не может быть оценена - гемолитико-уремический синдром. Со стороны кожи и подкожных тканей: очень часто - алопеция, кожные высыпания, часто - шелушение кожи ладоней и стоп (например, ладонно-подошвенный синдром), эритематозные высыпания, сыпь, повышенная потливость, изменения со стороны ногтей. Со стороны органа зрения: часто - конъюнктивит, нарушения зрения, редко - транзиторное снижение остроты зрения, выпадение полей зрения, неврит зрительного нерва, преходящая потеря зрения, обратимая после прекращения лечения. Со стороны органа слуха: нечасто - ототоксичность, редко - снижение слуха, неврит слухового нерва, глухота. Со стороны иммунной системы: очень часто аллергические реакции, возникающие, главным образом, во время инфузии (кожная сыпь, в частности крапивница, конъюнктивит, ринит), часто анафилактические реакции, включая бронхоспазм, ангионевротический отек, снижение артериального давления и анафилактический шок. Инфекционные и паразитарные заболевания: очень часто - инфекции, часто - ринит, инфекции верхних дыхательных путей, нейтропенический сепсис. Местные реакции: очень часто - боль, покраснение, отек и тромбоз в месте введения препарата. Экстравазация также может приводить к появлению локальных болей и воспаления вплоть до некроза, особенно при введении оксалиплатина в периферическую вену. Со стороны лабораторных показателей: очень часто - повышение концентрации щелочной фосфатазы, активности \"печеночных\" ферментов, содержания билирубина, лактатдегидрогеназы, изменения содержания натрия и глюкозы в сыворотке крови, часто - повышение концентрации креатинина. Прочие: очень часто - озноб, повышение температуры тела из-за развития инфекций (с фебрильной нейтропенией или без нее) или вследствие возможного иммунного механизма, повышенная усталость, слабость, боль, повышение массы тела (при адъювантной терапии), часто - снижение массы тела (при терапии диссеминированного колоректального рака)."}}]},{"id":9,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: более выраженное проявление побочных эффектов. Лечение: антидот к оксалиплатину не известен. Рекомендуется мониторинг гематологических показателей и симптоматическая терапия."}}]},{"id":10,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Лечение Оксалиплатином медак следует проводить только в специализированных онкологических отделениях и под наблюдением онколога, имеющего опыт применения цитотоксических препаратов. Постоянный контроль за возможными токсическими эффектами при терапии оксалиплатином обязателен. Ввиду ограниченной информации по безопасности применения препарата у пациентов с нарушением функции почек средней степени тяжести, применение препарата должно осуществляться только после оценки соотношения польза/риск для конкретного пациента. В этом случае необходимо тщательно контролировать функцию почек и корректировать дозу с учетом токсического воздействия. Необходимо тщательное наблюдение за состоянием пациентов при наличии аллергических реакций на другие соединения платины в анамнезе. В случае развития анафилактической реакции на оксалиплатин, инфузию следует немедленно прервать и назначить соответствующее симптоматическое лечение. Дальнейшее применение препарата Оксалиплатин медак в случае развития аллергических реакций противопоказано. Поступали сообщения о случаях перекрестных реакций, в том числе летальных, со всеми соединениями платины. В случае экстравазации инфузию следует немедленно прекратить и начать местное симптоматическое лечение. Оставшуюся дозу препарата следует ввести в другую вену. Регулярно (раз в неделю), а также перед каждым введением препарата Оксалиплатин медак следует проводить контроль форменных элементов периферической крови и показателей функции почек и печени. Должен осуществляться тщательный контроль в отношении нейротоксичности, особенно в случае одновременного применения с другими лекарственными препаратами, обладающими неврологической токсичностью. Перед началом каждого цикла терапии препаратом Оксалиплатин медак следует проводить неврологическое обследование на предмет выявления признаков нейротоксичности. Рекомендации по коррекции дозы и режима введения оксалиплатина при нейротоксичности, гематологических и желудочно-кишечных проявлениях токсичности. Пациентов следует проинформировать о возможности устойчивых симптомов периферической сенсорной нейропатии после окончания курса лечения. Локализованные умеренные парестезии с функциональными нарушениями могут сохраняться до 3 лет после окончания лечения по схеме адъювантного применения препарата."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Оксалиплатин обладает широким спектром цитотоксического действия. Он также проявляет активность in vitro и in vivo на различных моделях опухолей, устойчивых к цисплатину. В комбинации с фторурацилом наблюдается синергичное цитотоксическое действие. Изучение механизма действия оксалиплатина подтверждает гипотезу о том, что биотрансформированные, водные производные оксалиплатина, взаимодействуя с ДНК путем образования меж- и внутритяжевых мостиков, подавляют синтез ДНК, что ведет к цитотоксическому и противоопухолевому эффектам.","substance":[{"id":753,"title":"Оксалиплатин","title_latin":null,"slug":"oksaliplatin_753"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Оксалиплатин медак - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/9382/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/9382/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[{"id":94735,"title":"Оксалиплатин медак","subtitle":{"full":"Раствор, флакон, 1 шт, 50 мг","short":"Раствор, 1 шт, 50 мг","package":"1 шт, 50 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