Длительная терапия пациентов с ожирением или пациентов с избыточной массой тела в том числе имеющих ассоциированные с ожирением факторы риска, в сочетании с умерено гипокалорийной диетой. В комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) или умеренно гипокалорийной диетой у пациентов с сахарным диабетом ...
Повышенная чувствительность к орлистату или другим компонентам препарата, синдром мальабсорбции, холестаз, одновременный прием с циклоспорином, беременность и кормление грудью, возраст до 12 лет.
Ксеналтен - препарат для снижения и поддержания массы тела. Компоненты препарата воздействуют на организм, снижая скорость химических реакций липаз желудочного и панкреатического типа, которые заняты в деле расщепления липидов, Таким образом, Ксеналтен блокирует процесс всасывания жиров во время пищеварительного процесса. Человек, принимающий препарат, получает с привычной пищей гораздо меньше калорий.
Фармакологические свойства
Специфический ингибитор желудочно-кишечных липаз. Образует ковалентную связь с активным сериновым участком желудочной и панкреатической липаз в просвете желудка и тонкого кишечника. Инактивированный фермент теряет способность расщеплять жиры пищи, поступающие в форме триглицеридов (ТГ). Нерасщепленные ТГ не всасываются, и возникающее вследствие этого уменьшение поступления калорий в организм приводит к уменьшению массы тела. Увеличивает концентрацию жира в каловых массах через 24–48 ч после приема. Обеспечивает эффективный контроль массы тела, уменьшение депо жира. Для проявления активности не требуется системная абсорбция орлистата, в рекомендуемой терапевтической дозе (120 мг 3 раза в сутки) он примерно на 30% ингибирует всасывание поступающих с пищей жиров.
Показания к применению
Длительная терапия пациентов с ожирением или пациентов с избыточной массой тела в том числе имеющих ассоциированные с ожирением факторы риска, в сочетании с умерено гипокалорийной диетой. В комбинации с гипогликемическими препаратами (метформин, производные сульфонилмочевины и/или инсулин) или умеренно гипокалорийной диетой у пациентов с сахарным диабетом 2 типа с избыточной массой тела или ожирением.
Противопоказания
Повышенная чувствительность к орлистату или другим компонентам препарата, синдром мальабсорбции, холестаз, одновременный прием с циклоспорином, беременность и кормление грудью, возраст до 12 лет.
Применение при беременности и в период грудного вскармливания
Противопоказано.
Способ применения и дозы
Внутрь, 120 мг 3 раза в сутки во время каждого приема пищи или не позднее чем через 1 час после еды (если пища не содержит жира, то прием можно пропустить).
Побочное действие
Со стороны ЖКТ: очень часто — маслянистые выделения из прямой кишки, выделение газов с некоторым количеством отделяемого, императивные позывы на дефекацию, стеаторея, учащение дефекации, жидкий стул, метеоризм, боли или дискомфорт в животе. Со стороны дыхательной системы, органов грудной клетки и средостения: очень часто — инфекции верхних дыхательных путей, часто — инфекции нижних дыхательных путей. Со стороны иммунной системы: редко — зуд, крапивница, сыпь, ангионевротический отек, бронхоспазм, анафилаксия. Со стороны нервной системы: очень часто — головные боли. Со стороны печени и желчевыводящих путей: очень редко — повышение активности трансаминаз и ЩФ, гепатит. Со стороны почек и мочевыводящих путей: часто — инфекции мочевыводящих путей. Прочие: очень часто — грипп, часто — дисменорея, тревога, слабость.
Передозировка
Однократный прием внутрь 800 мг орлистата или при его применении в дозе до 400 мг три раза в день в течение 15 дней людьми с нормальной массой тела и с ожирением не сопровождался значимыми нежелательными явлениями. Кроме того, у пациентов с ожирением есть опыт применения орлистата по 240 мг 3 раза в сутки в течение 6 месяцев, что не сопровождалось достоверным увеличением частоты нежелательных явлений. В случаях передозировки орлистата сообщалось либо об отсутствии нежелательных явлений, либо нежелательные явления не отличались от тех. которые наблюдаются при применение препарата в терапевтических дозах. В случае передозировки необходимо обратиться к врачу. При выраженной передозировке орлистата, следует наблюдать за состоянием пациента в течение 24 ч. По данным исследований у человека и животных, любые системные эффекты, которые можно связать с липазоингибирующими свойствами орлистата, должны быть быстро обратимы.
Особые указания
В период лечения необходимо соблюдать сбалансированную, низкокалорийную диету, содержащую не более 30% калоража в виде жиров и обогащенную фруктами и овощами.
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