Экседрин Таблетки, пачка, 20 шт, для приема внутрь, для взрослых

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Быстро ослабляет боль, особенно вызванную воспалительным процессом, а также умеренно угнетает агрегацию тромбоцитов и замедляет процесс тромбообразования, улучшая микроциркуляцию в очаге воспаления."}},{"type":"paragraph","data":{"text":"\u003ci\u003eКофеин\u003c/i\u003e повышает рефлекторную возбудимость спинного мозга, возбуждает дыхательный и сосудодвигательный центры, расширяет кровеносные сосуды скелетных мышц, головного мозга, сердца, почек, снижает агрегацию тромбоцитов. Уменьшает сонливость, чувство усталости, повышает умственную и физическую работоспособность. В данной комбинации кофеин в малой дозе практически не оказывает стимулирующего действия на ЦНС, однако способствует нормализации тонуса сосудов головного мозга и ускорению кровотока в нем."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Болевой синдром средней и легкой интенсивности различного происхождения:"}},{"type":"list","data":{"style":"ordered","items":["головная боль;","мигрень;","зубная боль;","невралгия;","артралгия и миалгия (боли в мышцах и суставах);","альгодисменорея (боли при менструации)."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["гиперчувствительность к любому из компонентов в составе препарата;","эрозивно-язвенные поражения ЖКТ в фазе обострения;","желудочно-кишечное кровотечение;","полное или неполное сочетание бронхиальной астмы, рицидивирующего полипноза носа и околоносовых пазух и непереносимости ацетилсалициловой кислоты или др. нестероидных противовоспалительных препаратов (в т.ч. в анамнезе);","хирургические вмешательства, сопровождающиеся кровотечением;","гемофилия;","геморрагический диатез;","гипопротромбинемия;","выраженная артериальная гипертензия;","портальная гипертензия;","тяжелое течение ИБС;","глаукома;","авитаминоз К;","почечная недостаточность;","одновременное применение других препаратов, содержащих парацетамол, ацетилсалициловую кислоту или другое нестероидное противовоспалительное средство;","дефицит глюкозо-6-фосфатдегидрогеназы;","беременность;","лактация;","повышенная возбудимость;","нарушения сна;","детский возраст до 15 лет (риск развития синдрома Рейе у детей с гипертермией на фоне вирусных заболеваний)."]}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eС осторожностью\u003c/i\u003e применять препарат при подагре, заболеваниях печени, головных болях, связанных с травмой головы, приеме антикоагулянтов, гипогликемических средств, подагре или артрите, а также при одновременном приеме препаратов, содержащих ацетилсалициловую кислоту или другие обезболивающие и жаропонижающие компоненты.  "}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Несмотря на то, что ацетилсалициловую кислоту можно применять во II триместре беременности, безопасность данной комбинации у беременных и кормящих грудью не изучалась, поэтому препарат противопоказан у беременных (во всех триместрах) и кормящих грудью."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь во время или после еды."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eВзрослые и подростки с 15 лет\u003c/i\u003e:\u003c/b\u003e по 1 таблетке через каждые 4-6 ч."}},{"type":"paragraph","data":{"text":"При первых признаках мигрени принимают 2 таблетки."}},{"type":"paragraph","data":{"text":"Средняя суточная доза составляет 3-4 таблетки в день, максимальная суточная доза - 6 таблеток в день."}},{"type":"paragraph","data":{"text":"После приема 2 таблеток облегчение головной и других видов боли обычно наступает быстро - через 15 мин, при мигрени облегчение наступает обычно через 30 мин."}},{"type":"paragraph","data":{"text":"При болевом синдроме препарат не следует принимать более 5 дней без консультации с врачом. При мигрени препарат не следует принимать более 3 дней без консультации с врачом."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Гастралгия, тошнота, рвота, гепатотоксичность, нефротоксичность, эрозивноязвенные поражения ЖКТ, аллергические реакции, тахикардия, повышение артериального давления, бронхоспазм."}},{"type":"paragraph","data":{"text":"При длительном применении - головокружение, головная боль, нарушения зрения, шум в ушах, снижение агрегации тромбоцитов, гипокоагуляция, геморрагический синдром (носовое кровотечение, кровоточивость десен, пурпура и др.), поражение почек с папиллярным некрозом, глухота, злокачественная экссудативная эритема (синдром Стивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла), синдром Рейе у детей (гиперпирексия, метаболический ацидоз, нарушения со стороны нервной системы и психики, рвота, нарушения функции печени)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы, обусловленные наличием парацетамола (при приеме в дозах более 10-15 г/сут): в течение первых 24 ч бледность кожных покровов, тошнота, рвота, анорексия, абдоминальная боль, нарушение метаболизма глюкозы, метаболический ацидоз. Симптомы нарушения функции печени могут появиться через 12-48 ч после передозировки. При тяжелой передозировке -печеночная недостаточность с прогрессирующей энцефалопатией, кома, смерть; острая почечная недостаточность с тубулярным некрозом (в т.ч. при отсутствии тяжелого поражения печени); аритмия, панкреатит. Гепато-токсический эффект у взрослых проявляется при приеме 10 г и более."}},{"type":"paragraph","data":{"text":"Симптомы, обусловленные наличием ацетилсалициловой кислоты (при приеме в дозах более 150 мг/кг): при легких интоксикациях - тошнота, рвота, шум в ушах, нарушение зрения, головокружение, сильная головная боль. При тяжелых отравлениях - гипервентиляция легких центрального генеза (одышка, удушье, цианоз, холодный липкий пот, паралич дыхания), респираторный ацидоз. Наибольший риск развития хронической интоксикации отмечается у детей и лиц пожилого возраста при приеме в течение нескольких суток более 100 мг/кг/сут. При отравлении средней и тяжелой степени необходима госпитализация."}},{"type":"paragraph","data":{"text":"Симптомы, обусловленные наличием кофеина (при приеме в дозах более 300 мг/сут): гастралгия, ажитация, тревожность, возбуждение, двигательное беспокойство, спутанность сознания, делирий, обезвоживание, тахикардия, аритмия, гипертермия, учащенное мочеиспускание, головная боль, повышенная тактильная или болевая чувствительность, тремор или мышечные подергивания; тошнота и рвота, иногда с кровью; звон в ушах, эпилептические припадки (при острой передозировке - тонико-клонические). Лечение: контроль за кислотно-основным состоянием и электролитным балансом. Взависимости от состояния обмена веществ - введение натрия гидрокарбоната, натрия цитрата или натрия лактата. Повышающаяся щелочность усиливает выведение ацетилсалициловой кислоты за счет защелачивания мочи. Промывание желудка в первые 4 ч, провокация рвоты, прием активированного угля, слабительных лекарственных средств, введение донаторов SH-групп и предшественников синтеза глутатиона метионина в течение 8-9 ч после передозировки и ацетилцистеина - в течение 8 ч."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Препарат может усиливать действие гепарина, непрямых коагулянтов, резерпина, стероидных гормонов и гипогликемических лекарственных средств."}},{"type":"paragraph","data":{"text":"Одновременное применение с другими НПВП, метотрексатом увеличивает риск развития побочных эффектов. Уменьшает эффективность спиронолактона, фуросемида, гипотензивных лекарственных средств, а также противоподагрических препаратов, способствующих выведению мочевой кислоты. Барбитураты, рифампицин, салициламид, противоэпилептические препараты и другие индукторы микросомальных ферментов печени способствуют образованию токсичных метаболитов парацетамола, влияющих на функцию печени. Метоклопрамид ускоряет всасывание парацетамола. Под воздействием парацетамола период полувыведения хлорамфеникола увеличивается в 5 раз. При повторном приеме парацетамол может усилить действие антикоагулянтов (производных кумарина)."}},{"type":"paragraph","data":{"text":"Одновременный прием парацетамола, ацетилсалициловой кислоты и алкогольных напитков повышает риск развития гепатотоксических эффектов. Кофеин ускоряет всасывание эрготамина."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Если после приема препарата симптомы сохраняются, наблюдается ухудшение или возникают новые симптомы, следует незамедлительно обратиться к врачу. При приеме препарата в рекомендованной дозе в организм поступает столько же кофеина, сколько содержится в одной чашке кофе, поэтому следует сократить потребление кофеинсодержащих продуктов при лечении данным препаратом во избежание развития нервного возбуждения, раздражительности, бессонницы и учащенного сердцебиения на фоне передозировки кофеина. При подозрении на передозировку следует незамедлительно обратиться за медицинской помощью, даже если симптомы отсутствуют. Следует воздержаться от употребления алкоголя при приеме препарата в связи с повышением риска поражения печени и желудочно-кишечного кровотечения. Поскольку ацетилсалициловая кислота замедляет свертывание крови, то пациент, которому предстоит хирургическое вмешательство, должен заранее предупредить врача о приеме препарата. Ацетилсалициловая кислота в низких дозах уменьшает выведение мочевой кислоты, в связи с чем у пациентов с предрасположенностью препарат может спровоцировать приступ подагры. При продолжительном применении препарата необходим контроль периферической крови и функционального состояния печени."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не сообщалось о влиянии препарата на способность управлять автомобилем и работать с механизмами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eТаблетки, покрытые пленочной оболочкой\u003c/b\u003e\u003c/i\u003e белого цвета, продолговатые, с гравировкой \"Е\" на одной стороне; на поперечном разрезе - ядро белого или почти белого цвета.  "}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Препарат следует хранить в недоступном для детей месте при температуре не выше 25°С."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"Срок годности - 2 года."}},{"type":"paragraph","data":{"text":"Не использовать после даты истечения срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Препарат разрешен к применению в качестве средства безрецептурного отпуска."}},{"type":"paragraph","data":{"text":"\u003ci\u003eNR15MU0542 май 2015 г\u003c/i\u003e"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/firm/4838\"\u003eГлаксоСмитКляйн Хелскер, АО\u003c/a\u003e (Россия)  "}}]}],"source":null},"description_toggle":false,"short_description":"Экседрин - комбинированный препарат, содержащий парацетамол, ацетилсалициловую кислоту и кофеин.Парацетамолобладает обезболивающим, жаропонижающим и крайне слабым противовоспалительным действием, что связано с его влиянием на центр терморегуляции в гипоталамусе и слабовыраженной способностью ингибировать синтез простагландинов в периферических тканях.Ацетилсалициловая кислотаобладает обезболивающим, жаропонижающим и противовоспалительным действием. Быстро ослабляет боль, особенно вызванную воспалительным процессом, а также умеренно угнетает агрегацию тромбоцитов и замедляет процесс тромбообразования, улучшая микроциркуляцию в очаге воспаления.Кофеинповышает рефлекторную возбудимость спинного мозга, возбуждает дыхательный и сосудодвигательный центры, расширяет кровеносные сосуды скелетных мышц, головного мозга, сердца, почек, снижает агрегацию тромбоцитов. Уменьшает сонливость, чувство усталости, повышает умственную и физическую работоспособность. В данной комбинации кофеин в малой дозе практически не оказывает стимулирующего действия на ЦНС, однако способствует нормализации тонуса сосудов головного мозга и ускорению кровотока в нем.","substance":[{"id":24,"title":"Ацетилсалициловая кислота","title_latin":"Acidum acetylsalicylicum","slug":"atsetilsalitsilovaya_kislota_24"},{"id":605,"title":"Парацетамол","title_latin":"Paracetamolum","slug":"paratsetamol_605"},{"id":1078,"title":"Кофеин","title_latin":"Coffeinum","slug":"kofein_1078"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":{"count":27,"url":"/review/30422-excedrin/"},"image_alt":"Экседрин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60407/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60407/share_default/"}},"diseases":[{"id":"554","title":"Мигрень","slug":"554-migren"},{"id":"853","title":"Другие уточненные изменения зубов и их 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