Противогрибковый препарат для наружного применения, обладающ... Инструкция
Показания к применению
Профилактика и лечение грибковых инфекций кожи:
микозы стоп (tinea pedis); ороговелости, трещины, зуд и шелушение кожи, вызванные грибком стопы; паховая эпидермофития (tinea craris), грибковые поражения гладкой кожи тела (tinea corporis), вызванные такими дерматофитами, как Trichophyton (в т.ч. Т. rubrum, T. mentagrophytes, Т. verrucosum, Т. violaceum), Microsporum canis и Epidermophyton floccosum;
дрожжевые инфекции кожи, в основном те, которые вызываются грибами рода Candida (например, Candida albicans), в частности опрелость;
Ламизил® Спрей применяется для лечения грибка стопы, грибка на теле, разноцветного лишая, кандидоза кожи.
Ламизил Спрей удобно наносить на области, пораженные грибком. Нет необходимости прикасаться к инфицированным областям, поэтому после обработки руки остаются чистыми.
Активное вещество спрея Ламизил тербинафин обладает фунгицидным действием, при помощи которого борется с инфекцией, вызывающей грибок (микоз) стопы.
Противогрибковый препарат для наружного применения, обладающий широким спектром противогрибковой активности. В небольших концентрациях тербинафин оказывает фунгицидное действие в отношении дерматофитов (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), плесневых (в основном Candida albicans) и некоторых диморфных грибов (Pityrosporum orbiculare). Активность в отношении дрожжевых грибов, в зависимости от их вида, может быть фунгицидной или фунгистатической.
Тербинафин специфическим образом изменяет ранний этап биосинтеза стеролов, происходящего в грибах. Это ведет к дефициту эргостерола и к внутриклеточному накоплению сквалена, что вызывает гибель клетки гриба. Действие тербинафина осуществляется путем ингибирования фермента скваленэпоксидазы, расположенного на клеточной мембране гриба.
Тербинафин не оказывает влияния на систему цитохрома Р450 у человека и, соответственно, на метаболизм гормонов или других лекарственных препаратов.
Показания к применению
Профилактика и лечение грибковых инфекций кожи:
микозы стоп (tinea pedis); ороговелости, трещины, зуд и шелушение кожи, вызванные грибком стопы; паховая эпидермофития (tinea craris), грибковые поражения гладкой кожи тела (tinea corporis), вызванные такими дерматофитами, как Trichophyton (в т.ч. Т. rubrum, T. mentagrophytes, Т. verrucosum, Т. violaceum), Microsporum canis и Epidermophyton floccosum;
дрожжевые инфекции кожи, в основном те, которые вызываются грибами рода Candida (например, Candida albicans), в частности опрелость;
повышенная чувствительность к тербинафину или к любому из неактивных ингредиентов, входящих в состав препарата;
период грудного вскармливания;
детский возраст до 18 лет (спрей Ламизил).
С осторожностью
С осторожностью назначают препарат пациентам с печеночной и/или почечной недостаточностью, больным хроническим алкоголизмом, при угнетении костномозгового кроветворения, опухолях, болезнях обмена веществ, окклюзионных заболеваниях сосудов конечностей.
Применение при беременности и в период грудного вскармливания
Поскольку клинический опыт применения крема Ламизил у беременных женщин очень ограничен, его не следует применять, кроме случаев крайней необходимости. При беременности препарат применяют только в случае, если предполагаемая польза для матери превышает потенциальный риск для плода. Необходимо проконсультироваться с врачом.
В экспериментальных исследованиях тератогенных свойств тербинафина выявлено не было. До настоящего времени не сообщалось о каких-либо пороках развития при применении препарата Ламизил.
Тербинафин выделяется с грудным молоком, поэтому препарат не следует назначать кормящим матерям. Не следует допускать контакта младенца с любой поверхностью кожи, обработанной препаратом Ламизил.
Способ применения и дозы
У взрослых спрей Ламизил можно применять 1 или 2 раза/сут, в зависимости от показаний. Перед применением препарата необходимо тщательно очистить и подсушить пораженные участки. Препарат распыляют на пораженные участки в количестве, достаточном для их тщательного увлажнения, и, кроме того, наносят на прилегающие участки, как пораженной, так и интактной кожи.
При обширных грибковых поражениях тела рекомендуется применять спрей во флаконах по 30 мл.
Кратность применения препарата и продолжительность лечения: дерматомикоз туловища, голеней - 1 раз/сут в течение 1 недели; дерматомикоз стоп - 1 раз/сут в течение 1 недели; разноцветный лишай - 2 раза/сут в течение 1 недели; паховая эпидермофития, опрелость - 1 раз/сут в течение 1 недели.
Побочное действие
Определение частоты побочных эффектов (ВОЗ): очень часто (≥1/10), часто (≥1/100 и <1/10), нечасто (≥1/1000 и <1/100), редко (≥1/10 000 и <1/1000), очень редко (<1/10 000), включая отдельные сообщения.
Со стороны иммунной системы: отдельные сообщения - реакции гиперчувствительности (сыпь).
Со стороны органа зрения: редко - раздражение глаз.
Со стороны кожных покровов: часто - шелушение кожи, зуд; нечасто - повреждение кожи, образование корки, поражение кожи, нарушение пигментации, эритема, ощущение жжения кожи; редко - ощущение сухости кожи, контактный дерматит, экзема; отдельные сообщения - сыпь.
Местные реакции: нечасто - боль, боль в месте нанесения, раздражение в месте нанесения; редко - обострение симптомов заболевания. В местах нанесения препарата возможны наблюдаться зуд, шелушение кожи, болевые ощущения, раздражение, изменение пигментации кожи, жжение, эритема, корки. Эти незначительные симптомы следует отличать от реакций гиперчувствительности, таких как сыпь, возникающих в редких случаях и требующих отмены терапии. В редких случаях течение грибковой инфекции может обостряться.
Если любые из указанных побочных эффектов усугубляются, или пациент заметил любые другие побочные эффекты, следует сообщить об этом врачу.
Передозировка
О случаях передозировки препарата Ламизил не сообщалось.
Симптомы: случайный прием внутрь 30 мл спрея Ламизил с содержанием 300 мг тербинафина гидрохлорида сравним с приемом 1 таблетки препарата Ламизил с дозировкой 250 мг (разовая доза для взрослого человека). При случайном приеме большего количества спрея Ламизил внутрь можно ожидать развития таких же побочных явлений, как и при передозировке таблеток Ламизил (головная боль, тошнота, боли в эпигастрии и головокружение). Следует также учитывать, что спрей содержит этиловый спирт (28.87% (об./об.).
Лечение: активированный уголь, при необходимости проводят симптоматическую терапию.
Взаимодействие с другими лекарственными средствами
В настоящее время лекарственное взаимодействие препарата Ламизил неизвестно.
Особые указания
Уменьшение выраженности клинических проявлений обычно отмечается в первые дни лечения. В случае нерегулярного применения или преждевременного его прекращения имеется риск рецидива инфекции.
Препарат предназначен только для наружного применения.
Следует избегать попадания препарата в глаза, т.к. он может вызвать раздражение. При случайном попадании глаза следует немедленно промыть проточной водой, а в случае развития стойких явлений раздражения необходимо обратиться к врачу.
При развитии аллергических реакций необходимо отменить препарат.
Крем Ламизил для наружного применения содержит цетиловый и стеариловый спирты, что может вызвать в местах нанесения местные аллергические реакции (контактный дерматит).
Следует соблюдать осторожность при нанесении спрея Ламизил на поврежденные участки кожи, т.к. этанол, входящий в его состав, может вызвать раздражение. Спрей Ламизил предназначен только для наружного применения. Не следует применять спрей Ламизил для нанесения на кожу лица. Если спрей Ламизил был случайно введен в дыхательные пути при ингаляции, то, в случае появления каких-либо симптомов и особенно при их стойком сохранении, необходимо проконсультироваться с врачом. Спрей Ламизил содержит пропиленгликоль, который в некоторых случаях может вызывать раздражение кожи. Следует также, учитывать, что препарат содержит этанол 96%.
Влияние на способность управлять автомобилем и движущимися механизмами
Не влияет.
Форма выпуска
Спрей для наружного применения в виде прозрачной, бесцветной или светло-желтой жидкости с характерным запахом.
Условия хранения
Препарат следует хранить в недоступном для детей месте при температуре не выше 30°С. Не замораживать (для спрея).
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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N016003/02"}}]},{"id":2,"name":"Торговое название препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Ламизил"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"Спрей д/наружн. прим. 10 мг/1 г"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"\u003ci\u003e1 г спрея содержит:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eАктивное вещество:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"10 мг тербинафина гидрохлорида;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"макрогол цетостеариловый эфир,"}},{"type":"paragraph","data":{"text":"этанол,"}},{"type":"paragraph","data":{"text":"вода очищенная,"}},{"type":"paragraph","data":{"text":"пропиленгликоль,"}},{"type":"paragraph","data":{"text":"азот."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"\n\nЛамизил® Спрей применяется для лечения грибка стопы, грибка на теле, разноцветного лишая, кандидоза кожи."}},{"type":"paragraph","data":{"text":"Ламизил Спрей удобно наносить на области, пораженные грибком. Нет необходимости прикасаться к инфицированным областям, поэтому после обработки руки остаются чистыми."}},{"type":"paragraph","data":{"text":"Активное вещество спрея Ламизил тербинафин обладает фунгицидным действием, при помощи которого борется с инфекцией, вызывающей грибок (микоз) стопы.\n\n"}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/pharm-group/453\"\u003eПротивогрибковое средство\u003c/a\u003e"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Противогрибковый препарат для наружного применения, обладающий широким спектром противогрибковой активности. В небольших концентрациях тербинафин оказывает фунгицидное действие в отношении дерматофитов (Trychophyton rubrum, Trychophyton mentagrophytes, Trychophyton verrucosum, Trychophyton violaceum, Trychophyton tonsurans, Microsporum canis, Epidermophyton floccosum), плесневых (в основном Candida albicans) и некоторых диморфных грибов (Pityrosporum orbiculare). Активность в отношении дрожжевых грибов, в зависимости от их вида, может быть фунгицидной или фунгистатической."}},{"type":"paragraph","data":{"text":"Тербинафин специфическим образом изменяет ранний этап биосинтеза стеролов, происходящего в грибах. Это ведет к дефициту эргостерола и к внутриклеточному накоплению сквалена, что вызывает гибель клетки гриба. Действие тербинафина осуществляется путем ингибирования фермента скваленэпоксидазы, расположенного на клеточной мембране гриба."}},{"type":"paragraph","data":{"text":"Тербинафин не оказывает влияния на систему цитохрома Р450 у человека и, соответственно, на метаболизм гормонов или других лекарственных препаратов."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Профилактика и лечение грибковых инфекций кожи:"}},{"type":"list","data":{"style":"ordered","items":["микозы стоп (tinea pedis); ороговелости, трещины, зуд и шелушение кожи, вызванные грибком стопы; паховая эпидермофития (tinea craris), грибковые поражения гладкой кожи тела (tinea corporis), вызванные такими дерматофитами, как Trichophyton (в т.ч. Т. rubrum, T. mentagrophytes, Т. verrucosum, Т. violaceum), Microsporum canis и Epidermophyton floccosum;","дрожжевые инфекции кожи, в основном те, которые вызываются грибами рода Candida (например, Candida albicans), в частности опрелость;","разноцветный лишай (Pityriasis versicolor), вызываемый Pityrosporum orbiculare (Malassezia furfur)."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["повышенная чувствительность к тербинафину или к любому из неактивных ингредиентов, входящих в состав препарата;","период грудного вскармливания;","детский возраст до 18 лет (спрей Ламизил)."]}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eС осторожностью\u003c/i\u003e назначают препарат пациентам с печеночной и/или почечной недостаточностью, больным хроническим алкоголизмом, при угнетении костномозгового кроветворения, опухолях, болезнях обмена веществ, окклюзионных заболеваниях сосудов конечностей. "}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Поскольку клинический опыт применения крема Ламизил у беременных женщин очень ограничен, его не следует применять, кроме случаев крайней необходимости. При беременности препарат применяют только в случае, если предполагаемая польза для матери превышает потенциальный риск для плода. Необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"В \u003ci\u003eэкспериментальных исследованиях\u003c/i\u003e тератогенных свойств тербинафина выявлено не было. До настоящего времени не сообщалось о каких-либо пороках развития при применении препарата Ламизил."}},{"type":"paragraph","data":{"text":"Тербинафин выделяется с грудным молоком, поэтому препарат не следует назначать кормящим матерям. Не следует допускать контакта младенца с любой поверхностью кожи, обработанной препаратом Ламизил."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"У \u003cb\u003eвзрослых\u003c/b\u003e спрей Ламизил можно применять 1 или 2 раза/сут, в зависимости от показаний. Перед применением препарата необходимо тщательно очистить и подсушить пораженные участки. Препарат распыляют на пораженные участки в количестве, достаточном для их тщательного увлажнения, и, кроме того, наносят на прилегающие участки, как пораженной, так и интактной кожи."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eобширных грибковых поражениях тела\u003c/i\u003e рекомендуется применять спрей во флаконах по 30 мл."}},{"type":"paragraph","data":{"text":"Кратность применения препарата и продолжительность лечения: \u003ci\u003eдерматомикоз туловища, голеней\u003c/i\u003e - 1 раз/сут в течение 1 недели; \u003ci\u003eдерматомикоз стоп\u003c/i\u003e - 1 раз/сут в течение 1 недели; \u003ci\u003eразноцветный лишай\u003c/i\u003e - 2 раза/сут в течение 1 недели; \u003ci\u003eпаховая эпидермофития, опрелость\u003c/i\u003e - 1 раз/сут в течение 1 недели."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Определение частоты побочных эффектов (ВОЗ): очень часто (≥1/10), часто (≥1/100 и <1/10), нечасто (≥1/1000 и <1/100), редко (≥1/10 000 и <1/1000), очень редко (<1/10 000), включая отдельные сообщения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны иммунной системы: \u003c/i\u003eотдельные сообщения - реакции гиперчувствительности (сыпь)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органа зрения: \u003c/i\u003eредко - раздражение глаз."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны кожных покровов: \u003c/i\u003eчасто - шелушение кожи, зуд; нечасто - повреждение кожи, образование корки, поражение кожи, нарушение пигментации, эритема, ощущение жжения кожи; редко - ощущение сухости кожи, контактный дерматит, экзема; отдельные сообщения - сыпь."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМестные реакции: \u003c/i\u003eнечасто - боль, боль в месте нанесения, раздражение в месте нанесения; редко - обострение симптомов заболевания. В местах нанесения препарата возможны наблюдаться зуд, шелушение кожи, болевые ощущения, раздражение, изменение пигментации кожи, жжение, эритема, корки. Эти незначительные симптомы следует отличать от реакций гиперчувствительности, таких как сыпь, возникающих в редких случаях и требующих отмены терапии. В редких случаях течение грибковой инфекции может обостряться."}},{"type":"paragraph","data":{"text":"Если любые из указанных побочных эффектов усугубляются, или пациент заметил любые другие побочные эффекты, следует сообщить об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"О случаях передозировки препарата Ламизил не сообщалось."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e случайный прием внутрь 30 мл спрея Ламизил с содержанием 300 мг тербинафина гидрохлорида сравним с приемом 1 таблетки препарата Ламизил с дозировкой 250 мг (разовая доза для взрослого человека). При случайном приеме большего количества спрея Ламизил внутрь можно ожидать развития таких же побочных явлений, как и при передозировке таблеток Ламизил (головная боль, тошнота, боли в эпигастрии и головокружение). Следует также учитывать, что спрей содержит этиловый спирт (28.87% (об./об.)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e активированный уголь, при необходимости проводят симптоматическую терапию."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":" В настоящее время лекарственное взаимодействие препарата Ламизил неизвестно. "}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Уменьшение выраженности клинических проявлений обычно отмечается в первые дни лечения. В случае нерегулярного применения или преждевременного его прекращения имеется риск рецидива инфекции."}},{"type":"paragraph","data":{"text":"Препарат предназначен только для наружного применения."}},{"type":"paragraph","data":{"text":"Следует избегать попадания препарата в глаза, т.к. он может вызвать раздражение. При случайном попадании глаза следует немедленно промыть проточной водой, а в случае развития стойких явлений раздражения необходимо обратиться к врачу."}},{"type":"paragraph","data":{"text":"При развитии аллергических реакций необходимо отменить препарат."}},{"type":"paragraph","data":{"text":"Крем Ламизил для наружного применения содержит цетиловый и стеариловый спирты, что может вызвать в местах нанесения местные аллергические реакции (контактный дерматит)."}},{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при нанесении спрея Ламизил на поврежденные участки кожи, т.к. этанол, входящий в его состав, может вызвать раздражение. Спрей Ламизил предназначен только для наружного применения. Не следует применять спрей Ламизил для нанесения на кожу лица. Если спрей Ламизил был случайно введен в дыхательные пути при ингаляции, то, в случае появления каких-либо симптомов и особенно при их стойком сохранении, необходимо проконсультироваться с врачом. Спрей Ламизил содержит пропиленгликоль, который в некоторых случаях может вызывать раздражение кожи. Следует также, учитывать, что препарат содержит этанол 96%."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не влияет."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eСпрей для наружного применения\u003c/b\u003e\u003c/i\u003e в виде прозрачной, бесцветной или светло-желтой жидкости с характерным запахом. 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