Тиоктовая кислота (-липоевая кислота) - кофермент митохондриальных мультиферментных комплексов, участвующий в окислительном декарбоксилировании пировиноградной кислоты и -кетокислот. Является эндогенным антиоксидантом: связывает свободные радикалы, восстанавливает внутриклеточный уровень глутатиона, повышает активность супероксиддисмутазы. Улучшает трофику нейронов и аксональную проводимость. По характеру биохимического действия тиоктовая кислота сходна с витаминами группы В.; Играет важную роль в энергетическом обмене. Участвует в регулировании липидного и углеводного обменов,; стимулирует обмен холестерина. Способствует снижению содержания глюкозы в крови, увеличению содержания гликогена в печени, снижению инсулинорезистентности.; Обладает липотропным эффектом, улучшает функцию печени. Оказывает дезинтоксикационное действие при отравлении солями тяжелых металлов и при других интоксикациях.
Показания к применению
Диабетическая полиневропатия
Алкогольная полиневропатия
Противопоказания
Беременность
Период лактации (грудного вскармливания)
Детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены)
Гиперчувствительность к тиоктовой кислоте и компонентам препарата
Применение при беременности и в период грудного вскармливания
Применение препарата при беременности противопоказано в связи с отсутствием достаточного клинического опыта применения тиоктовой кислоты у беременных женщин. Исследования репродуктивной токсичности не выявили рисков в отношении фертильности, влияния на развитие плода и каких-либо эмбриотоксических свойств препарата.; Применение препарата Октолипен; в период лактации противопоказано ввиду отсутствия данных о проникновении тиоктовой кислоты в грудное молоко.
Способ применения и дозы
Препарат принимают внутрь, натощак, за 30 мин до приема пищи. Таблетки следует проглатывать целиком, не разжевывая, запивая достаточным количеством жидкости.; Рекомендуемая доза - по 1 таб. (600 мг) 1 раз/сут.; Возможно проведение ступенчатой терапии: пероральный прием препарата начинают после 2-4-недельного курса парентерального введения тиоктовой кислоты. Максимальный курс приема таблеток - 3 мес. В некоторых случаях терапия препаратом Октолипен; предполагает более длительное применение. Продолжительность приема определяет лечащий врач.
Побочное действие
Возможные побочные эффекты при применении препарата Октолипен; приведены по нисходящей частоте возникновения: очень часто (1≥1/10), часто (≥1/100, <1/10), нечасто (≥1/1000, <1/100), редко (≥1/10 000, <1/1000), очень редко (<1/10 000). Корреляции частоты возникновения побочных эффектов с полом и возрастом пациентов не наблюдается.; Со стороны ЦНС: очень редко - изменение или нарушение вкусовых ощущений.; Со стороны пищеварительной системы: очень редко - тошнота, рвота, изжога, боль в животе, диарея.; Со стороны обмена веществ: очень редко - снижение содержания глюкозы в крови (из-за улучшения усвоения глюкозы); возможно развитие гипогликемии, симптомы которой включают головокружение, повышенное потоотделение, головную боль, нарушение зрения.; Со стороны иммунной системы: очень редко - аллергические реакции, такие как кожная сыпь, крапивница, зуд.
Передозировка
Симптомы: головная боль, тошнота, рвота. В тяжелых случаях (при приеме тиоктовой кислоты в дозе 10-40 г или более 10 таб. по 600 мг для взрослых, или в дозе >50 мг/кг массы тела у детей): психомоторное возбуждение или помутнение сознания, генерализованные судороги, выраженные нарушения кислотно-щелочного равновесия с лактацидозом, гипогликемия (вплоть до развития комы), острый некроз скелетных мышц, гемолиз, ДВС-синдром, подавление деятельности костного мозга, полиорганная недостаточность.; Лечение: при подозрении на существенную передозировку препарата рекомендуется немедленная госпитализация и применение мер в соответствии с общими принципами, принятыми при случайном отравлении (вызов рвоты, промывание желудка, прием активированного угля и т.д.). Лечение генерализованных судорог, лактацидоза и других угрожающих жизни последствий интоксикации - симптоматическое, его следует проводить в соответствии с принципами современной интенсивной терапии. Специфического антидота нет. Гемодиализ, гемоперфузия или методы фильтрации с принудительным выведением тиоктовой кислоты из организма не эффективны.
Особые указания
В период лечения (особенно на начальной стадии) необходим регулярный контроль содержания глюкозы в крови у пациентов с сахарным диабетом. В отдельных случаях может возникнуть необходимость уменьшения дозы инсулина или перорального гипогликемического препарата во избежание развития гипогликемии.; Пациентам, принимающим препарат Октолипен;, следует воздерживаться от употребления алкоголя.; Одновременный прием пищи может препятствовать абсорбции лекарственного препарата.; При приеме препарата Октолипен; употребление молочных продуктов не рекомендуется (из-за содержания в них кальция). Интервал между приемами должен составлять не менее 2 ч.; Влияние на способность к вождению автотранспорта и управлению механизмами; Влияние на способность к управлению транспортными средствами и механизмами специально не изучалось. Необходимо; соблюдать осторожность при управлении транспортными средствами и занятиях потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
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Является эндогенным антиоксидантом: связывает свободные радикалы, восстанавливает внутриклеточный уровень глутатиона, повышает активность супероксиддисмутазы. Улучшает трофику нейронов и аксональную проводимость. По характеру биохимического действия тиоктовая кислота сходна с витаминами группы В.; Играет важную роль в энергетическом обмене. Участвует в регулировании липидного и углеводного обменов,; стимулирует обмен холестерина. Способствует снижению содержания глюкозы в крови, увеличению содержания гликогена в печени, снижению инсулинорезистентности.; Обладает липотропным эффектом, улучшает функцию печени. 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Исследования репродуктивной токсичности не выявили рисков в отношении фертильности, влияния на развитие плода и каких-либо эмбриотоксических свойств препарата.; Применение препарата Октолипен; в период лактации противопоказано ввиду отсутствия данных о проникновении тиоктовой кислоты в грудное молоко."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь, натощак, за 30 мин до приема пищи. Таблетки следует проглатывать целиком, не разжевывая, запивая достаточным количеством жидкости.; Рекомендуемая доза - по 1 таб. (600 мг) 1 раз/сут.; Возможно проведение ступенчатой терапии: пероральный прием препарата начинают после 2-4-недельного курса парентерального введения тиоктовой кислоты. Максимальный курс приема таблеток - 3 мес. В некоторых случаях терапия препаратом Октолипен; предполагает более длительное применение. 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Корреляции частоты возникновения побочных эффектов с полом и возрастом пациентов не наблюдается.; Со стороны ЦНС: очень редко - изменение или нарушение вкусовых ощущений.; Со стороны пищеварительной системы: очень редко - тошнота, рвота, изжога, боль в животе, диарея.; Со стороны обмена веществ: очень редко - снижение содержания глюкозы в крови (из-за улучшения усвоения глюкозы); возможно развитие гипогликемии, симптомы которой включают головокружение, повышенное потоотделение, головную боль, нарушение зрения.; Со стороны иммунной системы: очень редко - аллергические реакции, такие как кожная сыпь, крапивница, зуд."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: головная боль, тошнота, рвота. 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