ГКС для местного применения. В рекомендуемых дозах оказывает выраженное противовоспалительное, противоотечное и противоаллергическое действие.; Противовоспалительное действие обусловлено взаимодействием препарата с рецепторами ГКС. Подавляет пролиферацию тучных клеток, эозинофилов, лимфоцитов, макрофагов, нейтрофилов, снижает продукцию и высвобождение медиаторов воспаления и других биологически активных веществ (в т.ч. гистамина, простагландинов, лейкотриенов, цитокинов) во время ранней и поздней фазы аллергической реакции.; Противоаллергическое действие проявляется через 2-4 ч после первого применения. Уменьшает зуд в носу, чиханье, ринит, заложенность носа, неприятные ощущения в области придаточных пазух и ощущение давления вокруг носа и глаз. Облегчает глазные симптомы, связанные с аллергическим ринитом.; При применении в терапевтических дозах флутиказона пропионат не проявляет системного действия и практически не оказывает влияния на гипоталамо-гипофизарно-надпочечниковую систему.; Действие препарата сохраняется в течение 24 ч после однократного применения.
Показания к применению
Профилактика и лечение сезонного и круглогодичного аллергических ринитов.
Противопоказания
Детский возраст до 4 лет
Повышенная чувствительность к компонентам препарата
Применение при беременности и в период грудного вскармливания
Не рекомендуется назначать препарат при беременности. В случае необходимости следует учитывать предполагаемую пользу терапии для матери и потенциальный риск для плода.; Маловероятно, что флутиказона пропионат выделяется с грудным молоком. Тем не менее, на время применения препарата грудное вскармливание рекомендуется прекратить.
Способ применения и дозы
Препарат применяют интраназально.; Взрослым и детям 12 лет и старше назначают по 2 дозы (100 мкг) в каждый носовой ход 1 раз/сут, желательно утром. В некоторых случаях необходимо вводить по 2 дозы в каждый носовой ход 2 раза/сут (максимальная суточная доза - 400 мкг). После достижения терапевтического эффекта можно вводить поддерживающую дозу по 50 мкг/сут в каждый носовой ход (100 мкг). Максимальная суточная доза не должна превышать 400 мкг (по 4 дозы в каждый носовой ход).; Пациентам пожилого возраста не требуется коррекции дозы.; Детям в возрасте от 4 до 12 лет назначают по 1 дозе (50 мкг) 1 раз/сут в каждый носовой ход, желательно утром. Максимальная суточная доза не должна превышать 200 мкг в каждый носовой ход. Необходимо применять минимальную дозировку, обеспечивающую эффективное устранение симптомов.; Для достижения полного терапевтического эффекта препарат следует применять регулярно.; Правила использования препарата; Флакон с назальным спреем снабжен защитным колпачком, который предохраняет наконечник от попадания пыли и загрязнения.; При первом применении необходимо подготовить флакон, нажав на дозатор 6 раз. Распыляющий механизм разблокируется. Если препарат не использовался более одной недели, следует снова подготовить флакон и разблокировать распыляющий механизм.; Далее необходимо: — очистить полость носа; — закрыть один носовой ход и ввести наконечник в другой носовой ход; — наклонить голову немного вперед, продолжая держать флакон вертикально; — начать делать вдох через нос и, продолжая вдыхать, произвести однократное нажатие пальцами; — выдыхать через рот.; Далее таким же способом вводить препарат в другой носовой ход.; После использования следует промокнуть наконечник чистой салфеткой или носовым платком и закрыть его колпачком. Распылитель следует промывать не реже 1 раза в неделю. Для этого необходимо снять наконечник, промыть его в теплой воде, просушить и затем осторожно установить в верхней части флакона. Надеть защитный колпачок. Если отверстие наконечника засорилось, наконечник следует снять и оставить на некоторое время в теплой воде. Затем промыть под струей, просушить и снова надеть на флакон. Нельзя прочищать отверстие булавкой или другими острыми предметами.; После вскрытия упаковки препарат может использоваться до окончания срока годности.
Побочное действие
Определение частоты побочных реакций (согласно рекомендациям ВОЗ): очень часто (≥10%), часто (≥1%, но <10%), нечасто (≥0.1%, но <1%), редко (≥0.01%, но <0.1%), очень редко, включая единичные случаи (<0.01%).; Со стороны иммунной системы: редко - бронхоспазм, анафилактическая реакция; очень редко - реакция кожной гиперчувствительности, ангионевротический отек.; Со стороны нервной системы: часто - головная боль, нарушение вкусовых ощущений, нарушение обоняния.; Со стороны органа зрения: очень редко - повышение внутриглазного давления, глаукома, катаракта.; Со стороны дыхательной системы: очень часто - носовое кровотечение; часто - сухость и раздражение слизистой оболочки носоглотки; очень редко - перфорация носовой перегородки.; Со стороны кожи и подкожных тканей: очень редко - изъязвление подкожно-слизистого слоя.; Прочее: очень редко - задержка роста у детей, снижение функции коры надпочечников, остеопороз.
Передозировка
Симптомов острой и хронической передозировки не зарегистрировано. При интраназальном введении добровольцам по 2 мг флутиказона пропионата 2 раза/сут в течение 7 дней не обнаружено какого-либо влияния на гипоталамо-гипофизарно-надпочечниковую систему.
Особые указания
Одновременное применение с ингибиторами изофермента CYP3A4 (ритонавир, кетоназол) требует тщательного наблюдения за состоянием пациентов, поскольку эти препараты могут вызывать повышение концентрации флутиказона пропионата в плазме.; При назначении ГКС для интраназального применения в высоких дозах в течение длительного времени повышается риск развития системных эффектов ГКС. При длительном применении препарата Назарел необходим регулярный контроль функции коры надпочечников.; Т.к. ГКС для интраназального применения даже при применении в терапевтических дозах могут вызывать замедление роста детей при длительной терапии, необходимо регулярно контролировать рост ребенка и своевременно корректировать дозу препарата Назарел.; При лечении сезонного аллергического ринита Назарел достаточно эффективен, однако в случае особенно высокой концентрации в воздухе в летнее время аллергенов может потребоваться дополнительное лечение.; При назначении препарата Назарел пациентам с туберкулезом, инфекционным процессом, герпетическим кератитом, а также недавно перенесшим оперативное вмешательство на полости рта и носа, следует тщательно оценить соотношение возможного риска и ожидаемой пользы.
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Облегчает глазные симптомы, связанные с аллергическим ринитом.; При применении в терапевтических дозах флутиказона пропионат не проявляет системного действия и практически не оказывает влияния на гипоталамо-гипофизарно-надпочечниковую систему.; Действие препарата сохраняется в течение 24 ч после однократного применения."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Профилактика и лечение сезонного и круглогодичного аллергических ринитов."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Детский возраст до 4 лет","Повышенная чувствительность к компонентам препарата"]}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Не рекомендуется назначать препарат при беременности. В случае необходимости следует учитывать предполагаемую пользу терапии для матери и потенциальный риск для плода.; Маловероятно, что флутиказона пропионат выделяется с грудным молоком. Тем не менее, на время применения препарата грудное вскармливание рекомендуется прекратить."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат применяют интраназально.; Взрослым и детям 12 лет и старше назначают по 2 дозы (100 мкг) в каждый носовой ход 1 раз/сут, желательно утром. В некоторых случаях необходимо вводить по 2 дозы в каждый носовой ход 2 раза/сут (максимальная суточная доза - 400 мкг). После достижения терапевтического эффекта можно вводить поддерживающую дозу по 50 мкг/сут в каждый носовой ход (100 мкг). Максимальная суточная доза не должна превышать 400 мкг (по 4 дозы в каждый носовой ход).; Пациентам пожилого возраста не требуется коррекции дозы.; Детям в возрасте от 4 до 12 лет назначают по 1 дозе (50 мкг) 1 раз/сут в каждый носовой ход, желательно утром. Максимальная суточная доза не должна превышать 200 мкг в каждый носовой ход. Необходимо применять минимальную дозировку, обеспечивающую эффективное устранение симптомов.; Для достижения полного терапевтического эффекта препарат следует применять регулярно.; Правила использования препарата; Флакон с назальным спреем снабжен защитным колпачком, который предохраняет наконечник от попадания пыли и загрязнения.; При первом применении необходимо подготовить флакон, нажав на дозатор 6 раз. Распыляющий механизм разблокируется. 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Нельзя прочищать отверстие булавкой или другими острыми предметами.; После вскрытия упаковки препарат может использоваться до окончания срока годности."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Определение частоты побочных реакций (согласно рекомендациям ВОЗ): очень часто (≥10%), часто (≥1%, но \u003c10%), нечасто (≥0.1%, но \u003c1%), редко (≥0.01%, но \u003c0.1%), очень редко, включая единичные случаи (\u003c0.01%).; Со стороны иммунной системы: редко - бронхоспазм, анафилактическая реакция; очень редко - реакция кожной гиперчувствительности, ангионевротический отек.; Со стороны нервной системы: часто - головная боль, нарушение вкусовых ощущений, нарушение обоняния.; Со стороны органа зрения: очень редко - повышение внутриглазного давления, глаукома, катаракта.; Со стороны дыхательной системы: очень часто - носовое кровотечение; часто - сухость и раздражение слизистой оболочки носоглотки; очень редко - перфорация носовой перегородки.; Со стороны кожи и подкожных тканей: очень редко - изъязвление подкожно-слизистого слоя.; Прочее: очень редко - задержка роста у детей, снижение функции коры надпочечников, остеопороз."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомов острой и хронической передозировки не зарегистрировано. 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