Эспарокси Таблетки, пачка, 10 шт, 150 мг, для приема внутрь, для ЛОР органов, для взрослых

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У пациентов с врожденным удлинением интервала QT, с состояниями, способствующими возникновению нарушений сердечного ритма (нескорректированная гипокалиемия или гипомагниемия, клинически значимая брадикардия), и у пациентов, принимающих лекарственные препараты, которые приводят к развитию желудочковых нарушений ритма, в том числе желудочковой тахикардии типа «пируэт» (см. «Взаимодействие с другими лекарственными средствами»). При астеническом бульбарном параличе (myasthenia gravis) (как и при применении других макролидов, возможно утяжеление течения этого заболевания). При одновременном приеме антикоагулянтов непрямого действия, таких как варфарин, аценокумарол, флуиндион, фениндион (требуется регулярное определение Международного нормализованного отношения (МНО))."}},{"type":"paragraph","data":{"text":"При одновременном приеме дизопирамида (требуется регулярный контроль ЭКГ и сывороточных концентраций дизопирамида). При одновременном приеме дигоксина и других сердечных гликозидов (увеличение риска передозировки дигоксина и других сердечных гликозидов)."}},{"type":"paragraph","data":{"text":"При почечной недостаточности."}},{"type":"paragraph","data":{"text":"У лиц пожилого возраста (возможно замедление выведения рокситромицина из-за возрастного снижения функции печени и почек, возможны сопутствующие заболевания сердца, которые могут повысить риск возникновения нарушений ритма сердца). "}},{"type":"paragraph","data":{"text":"При одновременном приеме агонистов дофаминовых рецепторов – алкалоидов спорыньи, таких как бромокриптин, каберголин, лизурид, перголид."}},{"type":"paragraph","data":{"text":"При одновременном приеме циклоспорина (риск повышения плазменной концентрации циклоспорина)."}},{"type":"paragraph","data":{"text":"При одновременном приеме теофиллина (риск повышения плазменной концентрации теофиллина)."}},{"type":"paragraph","data":{"text":"При одновременном приеме лекарственных средств, преимущественно метаболизирующихся с помощью изофермента CYP3A (риск повышения их плазменных концентраций, см. раздел «Взаимодействие с другими лекарственными средствами»)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Рокситромицин противопоказан при беременности."}},{"type":"paragraph","data":{"text":"Рокситромицин в незначительных количествах проникает в грудное молоко. При необходимости применения препарата в период лактации следует решить вопрос о прекращении грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь. Препарат следует принимать за 15 мин до еды, запивая достаточным количеством жидкости."}},{"type":"paragraph","data":{"text":"Взрослые и дети с массой тела более 40 кг: 150 мг 2 раза в сутки, утром и вечером или 300 мг однократно."}},{"type":"paragraph","data":{"text":"При почечной недостаточности рокситромицин назначается в дозе 150 мг 2 раза в сутки."}},{"type":"paragraph","data":{"text":"При тяжелой печеночной недостаточности рокситромицин назначается в дозе 150 мг 1 раз в сутки."}},{"type":"paragraph","data":{"text":"Продолжительность приема препарата определяется индивидуально в зависимости от показания к применению, тяжести инфекционного процесса и активности возбудителя. Обычная продолжительность курса лечения 5-10 дней. При инфекциях, вызванных бета-гемолитическим стрептококком, курс лечения должен составлять не менее 10 дней. Продолжительность терапии не должна превышать 10 дней."}}]},{"id":1,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Лабораторные и инструментальные данные"}},{"type":"paragraph","data":{"text":"Повышение активности «печеночных» ферментов (аланинаминотрансферазы (АЛТ) и аспартатаминотрансферазы (АСТ) и/или щелочной фосфатазы)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны крови и лимфатической системы"}},{"type":"paragraph","data":{"text":"Эозинофилия, нейтропения, тромбоцитопения, агранулоцитоз."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной системы"}},{"type":"paragraph","data":{"text":"Головокружение, головная боль, парестезия; извращение вкуса (включая агевзию) и/или извращение обоняния (включая аносмию), как и при применении других макролидов."}},{"type":"paragraph","data":{"text":"Нарушения со стороны дыхательной системы, органов грудной клетки и средостения"}},{"type":"paragraph","data":{"text":"Бронхоспазм."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта"}},{"type":"paragraph","data":{"text":"Тошнота, рвота, боли в эпигастрии (диспепсия), диарея (иногда с кровью), панкреатит (большинство пациентов, у которых наблюдался панкреатит, принимало другие лекарственные препараты, для которых панкреатит является известной нежелательной реакцией), псевдомембранозный колит (см. «Особые указания»)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей"}},{"type":"paragraph","data":{"text":"Многоформная эритема, сыпь, крапивница, ангионевротический отек, пурпура, синдром Стивенса-Джонсона, токсический эпидермальный некролиз (см. «Особые указания»)."}},{"type":"paragraph","data":{"text":"Инфекционные и паразитарные заболевания (развитие суперинфекции)"}},{"type":"paragraph","data":{"text":"Как и при приеме других антибиотиков, при приеме рокситромицина, особенно длительном, возможно чрезмерное размножение нечувствительных к рокситромицину микроорганизмов. Необходимы повторные осмотры пациентов на предмет выявления суперинфекции с принятием соответствующих мер при ее возникновении."}},{"type":"paragraph","data":{"text":"Нарушения со стороны иммунной системы"}},{"type":"paragraph","data":{"text":"Анафилактический шок."}},{"type":"paragraph","data":{"text":"Нарушения со стороны печени и желчевыводящих путей"}},{"type":"paragraph","data":{"text":"Острые гепатиты (холестатический или гепатоцеллюлярный), иногда с развитием желтухи."}},{"type":"paragraph","data":{"text":"Психические нарушения"}},{"type":"paragraph","data":{"text":"Галлюцинации, спутанность сознания."}},{"type":"paragraph","data":{"text":"Нарушения со стороны органа слуха и лабиринтные нарушения"}},{"type":"paragraph","data":{"text":"Временная потеря слуха, гипоакузия (неполная потеря слуха), вертиго, шум в ушах."}},{"type":"paragraph","data":{"text":"Нарушение со стороны сердечно-сосудистой системы"}},{"type":"paragraph","data":{"text":"Удлинение интервала QT на ЭКГ, желудочковые нарушения ритма, такие как желудочковая тахикардия типа «пируэт», желудочковая тахикардия, которые могут привести к фибрилляции желудочков и остановке сердца (см. разделы «С осторожностью» и «Особые указания»)."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: возможно усиление дозозависимых побочных эффектов."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка, симптоматическая терапия. Специфического антидота не существует."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"См. инструкцию по применению."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Сообщалось о резко выраженном сужении сосудов («эрготизме») с возможным развитием некроза конечностей при сочетании приема макролидов с сосудосуживающими алколоидами спорыньи. Поэтому перед назначением рокситромицина следует обязательно выяснить у пациента, не принимает ли он эти алколоиды (см. «Взаимодействие с другими лекарственными средствами»)."}},{"type":"paragraph","data":{"text":"Тяжелые буллезные реакции"}},{"type":"paragraph","data":{"text":"При применении рокситромицина отмечались случаи тяжелых буллезных реакций, таких как синдром Стивенса-Джонсона или токсический эпидермальный некролиз (см. «Побочное действие»). При появлении симптомов или признаков синдрома Стивенса-Джонсона, или токсического эпидермального некролиза (например, прогрессирующей кожной сыпи, часто с появлением волдырей или повреждением слизистых оболочек) лечение препаратом ЭСПАРОКСИ® должно быть прекращено."}},{"type":"paragraph","data":{"text":"Влияние на продолжительность интервала QT"}},{"type":"paragraph","data":{"text":"При определенных условиях макролиды, включая рокситромицин, могут удлинять интервал QT. Поэтому рокситромицин следует применять с осторожностью у пациентов с врожденным удлинением интервала QT, у пациентов, имеющих состояния, способствующие развитию нарушений сердечного ритма, такие как нескорректированная гипокалиемия или гипомагниемия, клинически значимая брадикардия, и у пациентов, принимающих препараты, которые приводят к развитию желудочковых нарушений ритма, в том числе желудочковой тахикардии типа «пируэт» (см. «Взаимодействие с другими лекарственными средствами»). Следует скорректировать гипокалиемию и гипомагниемию до начала лечения рокситромицином, а лечение проводить под контролем ЭКГ."}},{"type":"paragraph","data":{"text":"Применение у пациентов с печеночной недостаточностью"}},{"type":"paragraph","data":{"text":"При применении препарата у пациентов с тяжелой печеночной недостаточностью (например, при циррозе печени с желтухой или асцитом) необходимо двукратное снижение суточной дозы рокситромицина (например, до 150 мг 1 раз в сутки у взрослых) (см. «Способ применения и дозы»)."}},{"type":"paragraph","data":{"text":"Применение у пациентов с почечной недостаточностью и пациентов пожилого возраста"}},{"type":"paragraph","data":{"text":"Почечная секреция рокситромицина и его метаболитов составляет приблизительно 10 % от принятой внутрь дозы. При применении препарата у пациентов с почечной недостаточностью, а также у пациентов пожилого возраста коррекции дозы не требуется."}},{"type":"paragraph","data":{"text":"Применение у пациентов с астеническим бульбарным параличом (myasthenia gravis)"}},{"type":"paragraph","data":{"text":"Как и другие макролиды, рокситромицин может утяжелять течение астенического бульбарного паралича, в связи с чем применение рокситромицина у таких пациентов требует особой осторожности и контроля за состоянием пациента."}},{"type":"paragraph","data":{"text":"Псевдомембранозный колит, вызываемый Clostridium diffi cile"}},{"type":"paragraph","data":{"text":"Диарея, особенно тяжелая, персистирующая и/или сопровождающаяся кровотечением во время лечения рокситромицином или после него, может быть симптомом псевдомембранозного колита (см. «Побочное действие»). При подозрении на псевдомембранозный колит прием рокситромицина должен быть немедленно прекращен. Нельзя применять лекарственные средства, тормозящие перестальтику кишечника."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при управлении транспортными средствами или занятии другими потенциально опасными видами деятельности, так как при применении препарата возможно возникновение головокружения, галлюцинаций, спутанности сознания. В случае возникновения таких побочных эффектов управление транспортными средствами или занятие другими потенциально опасными видами деятельности могут быть опасными для пациента, и от них следует временно (на время сохранения этих побочных эффектов) воздержаться."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой, 150 мг."}},{"type":"paragraph","data":{"text":"10 таблеток в блистер ПВХ/ПВДХ/алюминиевый. 1, 2 блистера в пачку картонную вместе с инструкцией по применению."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности, указанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Фарма Вернигероде ГмбХ, Дорнбергсвег 35, 38855 Вернигероде, Германия."}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"115114, г. Москва, ул. Летниковская, д. 16, оф. 306"}},{"type":"paragraph","data":{"text":"тел.: +7(499) 579-33-70"}},{"type":"paragraph","data":{"text":"факс: +7(499) 579-33-71"}},{"type":"paragraph","data":{"text":"e-mail: info@esparma-gmbh.ru"}}]}],"source":null},"description_toggle":false,"short_description":"круглые двояковыпуклые таблетки, покрытые пленочной оболочкой белого цвета. 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