Бифоназол, активное вещество раствора Микоспор, является производным имидазола и обладает широким спектром антимикотического действия. Бифоназол обладает фунгицидным действием в отношении дерматофитов (в частности, в отношении Trichophyton spp.). Полный фунгицидный эффект достигается при концентрации бифоназола 5 мкг/мл и продолжительности воздействия не менее 6 часов. Бифоназол обладает фунгистатическим действием в отношении дрожжевых и плесневых грибов, а также Malassezia furfur. При поражении дрожжевыми грибам и, например, Candida species, при концентрации 1-4 мкг/мл отмечается преимущественно фунгистатический эффект бифоназола; для фунгицидного эффекта необходима концентрация бифоназола 20 мкг/мл. Бифоназол также активен в отношении Corynebacterium minutissimum (МПК от 0.5 до 2 мкг/мл), грамположительных кокков, за исключением энтерококков (МПК от 4 до 16 мкг/мл). Резистентные штаммы грибов встречаются очень редко. Исследования не подтвердили развитие вторичной устойчивости у первично чувствительных штаммов. Бифоназол подавляет биосинтез эргостерола на двух различных уровнях, что отличает его от других противогрибковых препаратов и других производных азола. Такое двойное действие приводит к структурным и функциональным повреждениям цитоплазматической мембраны грибов.
Показания к применению
Грибковые заболевания кожи, вызванные дерматофитами, дрожжеподобными, плесневыми грибами, а также Malassezia furfur и Corynebacterium minutissimum:- микозы стоп (дерматофития кожи стоп и межпальцевая дерматофития стоп); - микозы кистей рук (дерматофития кожи рук и межпальцевая дерматофития); - дерматофития гладкой кожи тела; - дерматофития паховой области; - поверхностный кандидоз кожи; - отрубевидный лишай; - эритразма.
Противопоказания
повышенная чувствительность к бифоназолу или любому другому компоненту препарата. С осторожностью:- беременность и период лактации; - детский возраст.
Применение при беременности и в период грудного вскармливания
БеременностьАбсорбция бифоназола при наружном применении препарата незначительна. Данные исследований показывают, что бифоназол не оказывает какого-либо отрицательного действия на организм матери и плода. Однако применение препарата в этот период возможно, если потенциальная польза для матери превосходит потенциальный риск для плода или ребенка. ЛактацияНеизвестно, проникает ли бифоназол в грудное молоко у женщин. Абсорбция бифоназола при наружном применении препарата незначительна. Однако применение препарата в этот период возможно, если потенциальная польза для матери превосходит потенциальный риск для плода или ребенка. ФертильностьДанные по безопасности, полученные из доклинических исследований, дают основания предположить, что применение бифоназола не оказывает какого-либо отрицательного влияния на мужскую и женскую фертильность.
Способ применения и дозы
Наружно, раствор наносят тонким слоем на пораженные участки кожи 1 раз в день, желательно на ночь, и осторожно втирают. Для достижения удовлетворительного результата лечение должно быть непрерывным. Длительность терапии обычно составляет:- при микозах стоп (дерматофития кожи стоп и межпальцевая дерматофития стоп): 3 недели,- при микозах кистей рук (дерматофития кожи рук и межпальцевая дерматофития), кожи тела (дерматофития гладкой кожи) и складок кожи (паховая дерматофития): 2-3 недели,- при отрубевидном лишае, эритразме: 2 недели,- при поверхностном кандидозе кожи: 2-4 недели. Для обработки поверхности, приблизительно равной площади ладони, достаточно нескольких капель раствора (примерно 3-х капель).
Побочное действие
Общие нарушения и местные реакции: боль в месте нанесения, периферические отеки (в месте нанесения). Нарушения со стороны кожи и подкожных тканей: контактный дерматит, аллергический дерматит, эритема, зуд, сыпь, крапивница, волдыри, шелушение и сухость кожи, экзема, раздражение кожи, мацерация, чувство жжения кожи. Побочные эффекты обратимы и исчезают после отмены препарата.
Передозировка
Симптомы: возможны диарея, боль в животе и рвота. У пациентов из группы риска прием препарата в высоких дозах может вызывать или усугублять обструкцию кишечника или кишечную непроходимость.
Особые указания
Применять с осторожностью у пациентов, имеющих повышенную чувствительность к другим противогрибковым лекарственным средствам из группы производным имидазола (эконазол, клотримазол, миконазол). Избегать попадания раствора в глаза. Использование в педиатрииОтдельных исследований у детей не проводилось. На основании обзора клинических данных не выявлено свидетельств развития неблагоприятных побочных эффектов при применении препарата у детей. Однако, у детей младше 1 года Микоспор раствор следует использовать только под контролем врача.
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Бифоназол также активен в отношении Corynebacterium minutissimum (МПК от 0.5 до 2 мкг/мл), грамположительных кокков, за исключением энтерококков (МПК от 4 до 16 мкг/мл). Резистентные штаммы грибов встречаются очень редко. Исследования не подтвердили развитие вторичной устойчивости у первично чувствительных штаммов. Бифоназол подавляет биосинтез эргостерола на двух различных уровнях, что отличает его от других противогрибковых препаратов и других производных азола. Такое двойное действие приводит к структурным и функциональным повреждениям цитоплазматической мембраны грибов."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Грибковые заболевания кожи, вызванные дерматофитами, дрожжеподобными, плесневыми грибами, а также Malassezia furfur и Corynebacterium minutissimum:- микозы стоп (дерматофития кожи стоп и межпальцевая дерматофития стоп); - микозы кистей рук (дерматофития кожи рук и межпальцевая дерматофития); - дерматофития гладкой кожи тела; - дерматофития паховой области; - поверхностный кандидоз кожи; - отрубевидный лишай; - эритразма."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["повышенная чувствительность к бифоназолу или любому другому компоненту препарата. 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