Лиофилизат для приготовления раствора для в/в и в/м введения 1 фл. цитохром С 10 мг.
Фармакологические свойства
Цитопротектор. Представляет собой высокомолекулярное железопорфириновое соединение, которое выделяют в виде очищенного кристаллического вещества, например, из миокарда крупного рогатого скота. Представляет собой конъюгированный белок, по структуре близкий к гемоглобину, состоит из гема и одиночной пептидной цепи (апоцитохром С). Цитохром С играет важнейшую роль в биохимических окислительно-восстановительных процессах практически у всех аэробных организмов. Эти реакции происходят с участием двух митохондриальных ферментов: цитохромоксидазы и цитохромредуктазы. Гем проявляет свойства либо донора, либо акцептора электронов. Он обладает высокой химической активностью в отношении утилизации кислородных радикалов, таких как супероксид или перекись водорода, которая является сильным окислителем. Метаболиты гема действуют как "ловушки" для пероксидного радикала. Установлено, что в хрусталике, пораженном катарактой, концентрация цитохрома С снижена. Цитохром С не способен в достаточных количествах проникать в роговицу в виде целой молекулы. Это становится возможным только после расщепления пептидной цепи до гем-содержащего нанопептида, который свободно проникает в роговицу. Ингибирование окислительных процессов во всех тканях, находящихся спереди от хрусталика (в т.ч. роговицы и внутриглазной жидкости), имеет большое значение для подавления развития катаракты, поскольку ультрафиолетовое излучение вызывает в этих тканях цепные реакции с образованием свободных кислородных радикалов, которые, как доказано, могут привести к помутнению хрусталика. Гем-содержащий цитохром С обладает способностью к нейтрализации свободных кислородных радикалов в определенных окислительно-восстановительных процессах и таким образом предотвращать развитие катаракты.
Показания к применению
Состояния, сопровождающиеся гипоксией тканей (отравления снотворными средствами, окисью углерода, светильным газом . ишемические, дистрофические, инфекционно-воспалительные, токсические поражения миокарда . хроническая недостаточность кровообращения, нарушения мозгового и периферического кровообращения, пневмония, дыхательная недостаточность . профилактика повреждений тканей при наркозе, для поддержки организма в пред- и послеоперационный периоды при операциях на грудной клетке . лечение катаракты (в составе комбинированной терапии).
Противопоказания
Повышенная чувствительность к лошадиной сыворотке, беременность, лактация (грудное вскармливание).
Применение при беременности и в период грудного вскармливания
В/в введение цитохрома С противопоказано при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Индивидуальный, в зависимости от показаний и применяемой лекарственной формы.
Побочное действие
Аллергические реакции: при быстром в/в введении - гиперемия кожи лица, зуд, крапивница, озноб, гипертермия . при местном применении в офтальмологии - гиперемия конъюнктивы, кратковременное жжение.
Особые указания
Аллергические реакции: при быстром в/в введении - гиперемия кожи лица, зуд, крапивница, озноб, гипертермия . при местном применении в офтальмологии - гиперемия конъюнктивы, кратковременное жжение.
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