Блокатор м-холинорецепторов. Полагают, что расширение бронхо... Инструкция
Показания к применению
Для ингаляционного применения: лечение и профилактика хронических обструктивных заболеваний дыхательных путей: хронический бронхит с бронхообструктивным синдромом (с эмфиземой или без нее), бронхиальная астма легкой и средней степени тяжести, особенно с сопутствующими заболеваниями сердечно-сосудистой системы, бронхоспазм при хирургических операциях. ...
Раствор для ингаляций Ипратропиум-Натив эффективно предупреждает сужение бронхов, возникающее в результате вдыхания сигаретного дыма, холодного воздуха, действия различных бронхоспазмирующих веществ, а также угнетает спазм бронхов, связанный с влиянием блуждающего нерва. При ингаляционном применении практически не оказывает резорбтивного действия.
Фармакологические свойства
Блокатор м-холинорецепторов. Полагают, что расширение бронхов, вызываемое ипратропия бромидом, обусловлено конкурентным связыванием с м-холинорецепторами гладких мышц бронхов. Уменьшает секрецию желез (в т.ч. бронхиальных и пищеварительных). Предупреждает сужение бронхов, возникающее в результате вдыхания сигаретного дыма, холодного воздуха, действия различных бронхоконстрикторных веществ. При ингаляционном применении практически не оказывает резорбтивного действия. При системном применении вызывает увеличение ЧСС, улучшает AV-проводимость, в отличие от атропина не влияет на ЦНС.
Показания к применению
Для ингаляционного применения: лечение и профилактика хронических обструктивных заболеваний дыхательных путей: хронический бронхит с бронхообструктивным синдромом (с эмфиземой или без нее), бронхиальная астма легкой и средней степени тяжести, особенно с сопутствующими заболеваниями сердечно-сосудистой системы, бронхоспазм при хирургических операциях. Подготовка дыхательных путей перед введением в аэрозолях антибиотиков, муколитических средств, ГКС, кромогликата натрия. Для интраназального применения: хронические риниты с гиперсекрецией. Для введения внутрь и в/в введения: синусовая брадикардия, обусловленная преимущественно влиянием блуждающего нерва, брадиаритмии с синоатриальной блокадой, AV-блокада II степени, брадисистолическая форма мерцания предсердий.
Способ применения и дозы
Препарат Ипратропиум-натив предназначен только для ингаляционного введения путем вдыхания через рот с помощью небулайзера. Препарат Ипратропиум-натив не предназначен для инъекций или для приема внутрь! В 20 каплях препарата Ипратропиум-натив (около 1 мл) содержится 0,250 мг ипратропия бромида, соответственно 1 капля препарата содержит 0,0125 мг ипратропия бромида. Режим дозирования подбирается индивидуально. Препарат Ипратропиум-натив необходимо применять под наблюдением врача только с помощью небулайзера любой конструкции, который превращает раствор препарата в аэрозоль для ингаляций. Так как многие небулайзеры действуют только при наличии постоянного потока воздуха, не исключено, что распыляемый препарат будет попадать в окружающую среду. Учитывая это, препарат Ипратропиум-натив следует применять в хорошо проветриваемых помещениях. Не следует превышать рекомендуемую суточную дозу как во время неотложной, так и поддерживающей терапии! Если лечение не приводит к существенному улучшению или если состояние пациента ухудшается (неожиданно или быстро усиливается одышка (затруднение дыхания)), необходимо немедленно проконсультироваться с врачом. Если врачом не назначено иначе, рекомендуется следующий режим дозирования. Поддерживающее лечение: взрослые (в том числе пожилые): по 2,0 мл препарата Ипратропиум-натив (40 капель = 0,5 мг ипратропия бромида) 3 - 4 раза в день. Максимальная суточная доза - 8,0 мл препарата Ипратропиум-натив (2 мг ипратропия бромида). Острый бронхоспазм: взрослые (в том числе пожилые): по 2,0 мл препарата Ипратропиум-натив (40 капель = 0,5 мг ипратропия бромида), возможны повторные ингаляции до стабилизации состояния пациента, интервал между, ингаляциями определяется врачом. Ипратропиум-натив может применяться совместно с ингаляционными β2-адреномиметиками. Для обеспечения правильного применения препарата, пожалуйста, внимательно прочитайте эту инструкцию по применению. Рекомендуемую дозу препарата Ипратропиум-натив непосредственно перед использованием следует разбавить 0,9% раствором хлорид натрияа до достижения объема препарата 3-4 мл, залить в небулайзер и сделать ингаляцию. Оставшийся после ингаляции раствор не использовать повторно, вылить. Скорость и длительность ингаляции может зависеть от метода ингаляции и вида небулайзера. Длительность ингаляции следует контролировать по расходованию объема разведенного препарата Ипратропиум-натив. При использовании централизованнойкислородной системы раствор лучше применять при скорости потока 6 - 8 литров в минуту. Для ингаляций рекомендуется использовать небулайзеры с наконечником для рта (мундштуком). При использовании небулайзера с маской, следует использовать маскусоответствующего размера. Необходимо содержать небулайзер в чистоте.
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