Цетиризин является метаболитом гидроксизина, относится к группе конкурентных антагонистов гистамина, блокирует гистаминовые Н1-рецепторы.
В дополнение к антигистаминному эффекту цетиризин предупреждает развитие и облегчает течение аллергических реакций: в дозе 10 мг 1 или 2 раза/сут ингибирует позднюю фазу агрегации эозинофилов в коже и конъюнктиве пациентов, имеющих аллергические реакции.
Клиническая эффективность и безопасность
Исследования с участием здоровых добровольцев показали, что цетиризин в дозах 5 или 10 мг значительно ингибирует реакцию в виде сыпи и покраснения на введение в кожу гистамина в высокой концентрации, однако корреляция с эффективностью не установлена.
В 6-недельном плацебо-контролируемом исследовании с участием 186 пациентов с аллергическим ринитом и сопутствующей бронхиальной астмой легкого и среднетяжелого течения, показано, что прием цетиризина в дозе 10 мг 1 раз/сут уменьшает симптомы ринита и не влияет на функцию легких.
Результаты данного исследования подтверждают безопасность применения цетиризина у пациентов, страдающих аллергией и бронхиальной астмой легкого и среднетяжелого течения.
В плацебо-контролируемом исследовании показано, что прием цетиризина в дозе 60 мг/сут в течение 7 дней не вызывал клинически значимого удлинения интервала QT.
Прием цетиризина в рекомендуемой дозе показал улучшение качества жизни пациентов с круглогодичным и сезонным аллергическими ринитами.
В клинических исследованиях показано, что цетиризин начинает действовать через 20 мин после приема, его эффект сохраняется в течение 24 ч.
Дети
В 35-дневном исследовании с участием пациентов в возрасте 5-12 лет не выявлено признаков невосприимчивости к антигистаминному эффекту цетиризина. Нормальная реакция кожи на гистамин восстанавливалась в течение 3 дней после отмены препарата при его неоднократном применении.
Фармакотерапевтическая группа
Противоаллергическое средство - локатор H1 гистаминовых рецепторов
Фармакологические свойства
Блокатор гистаминовых Н1-рецепторов. Цетиризин является конкурентным антагонистом гистамина, практически не оказывает антихолинергического и антисеротонинового действия. Обладает выраженным противоаллергическим действием, предупреждает развитие и облегчает течение аллергических реакций. Обладает противозудным и противоэкссудативным эффектом. Влияет на раннюю стадию аллергических реакций, а также уменьшает миграцию клеток воспаления; угнетает выделение медиаторов, участвующих в поздней аллергической реакции. Уменьшает проницаемость капилляров, предупреждает развитие отека тканей, снимает спазм гладкой мускулатуры. Устраняет кожную реакцию на введение гистамина, специфических аллергенов, а также на охлаждение (при холодовой крапивнице). В терапевтических дозах практически не оказывает седативного эффекта. На фоне курсового приема толерантность не развивается.; Действие препарата начинается через 20 мин (у 50% больных), через 1 ч (у 95% больных) и сохраняется в течение 24 ч.
Показания к применению
Сезонный и круглогодичный аллергический ринит и конъюнктивит
Зудящие аллергические дерматозы
Поллиноз (сенная лихорадка)
Крапивница (в т.ч. хроническая идиопатическая)
Отек Квинке
Противопоказания
Терминальная стадия почечной недостаточности (КК<10 мл/мин) (для приема таблеток)
Наследственная непереносимость галактозы, недостаточность лактазы или синдром глюкозо-галактозной мальабсорбции (для приема таблеток)
Детский возраст до 6 лет (для приема таблеток)
Детский возраст до 1 года (для приема капель)
Беременность
Период лактации (грудного вскармливания)
Повышенная чувствительность к компонентам препарата
С осторожностью: хроническая почечная недостаточность средней степени тяжести (требуется коррекция режима дозирования), пожилой возраст (возможно снижение клубочковой фильтрации). При приеме таблеток: хронические заболевания печени (гепатоцеллюлярный, холестатический или билиарный цирроз печени) (коррекция дозы требуется только при сопутствующем снижении скорости клубочковой фильтрации).
Применение при беременности и в период грудного вскармливания
Противопоказано применение при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Зодак назначают внутрь, независимо от приема пищи. Перед приемом капли растворить в воде. Таблетки, покрытые оболочкой, следует проглатывать целиком, запивая небольшим количеством воды.
Взрослым и детям старше 12 лет - по 10 мг цетиризина (1 таблетка, 20 капель или 2 мерные ложки сиропа).
Детям от 6 до 12 лет - по 10 мг цетиризина (1 таблетка, 20 капель или 2 мерные ложки сиропа) 1 раз в сутки или по 5 мг цетиризина (10 капель или 1 мерная ложка сиропа) 2 раза в сутки, утром и вечером.
Детям от 2 до 6 лет - по 5 мг цетиризина (1/2 таблетки, 10 капель или 1 мерная ложка сиропа) 1 раз в сутки или 2.5 мг цетиризина (5 капель или 1/2 мерной ложки сиропа) 2 раза в сутки, утром и вечером.
Детям от 1 до 2 лет - по 2.5 мг (5 капель) 2 раза в сутки.
Побочное действие
Препарат, как правило, хорошо переносится. Побочные реакции возникают редко и имеют преходящий характер. Определение частоты побочных реакций: очень часто (≥1/10), часто (≥1/100, <1/10), нечасто (≥1/1000, <1/100), редко (≥1/10 000, <1/1000), очень редко (< 1/10 000), частота неизвестна (по имеющимся данным определить частоту встречаемости побочного эффекта не представляется возможным).; Со стороны системы кроветворения: очень редко - тромбоцитопения.; Со стороны иммунной системы: редко - реакции гиперчувствительности; очень редко - анафилактический шок.; Со стороны нервной системы: часто - головная боль, сонливость, повышенная утомляемость, головокружение; нечасто - парестезии; редко - судороги, нарушения двигательной функции; очень редко - извращения вкуса, дискинезия, дистония, обморок, тремор, тик; частота неизвестна - нарушение памяти, в т.ч. амнезия.; Нарушения психики: нечасто - возбуждение; редко - агрессия, спутанность сознания, депрессия, галлюцинации, нарушение сна; частота неизвестна - суицидальные идеи.; Со стороны органа зрения: очень редко - нарушения аккомодации, нечеткость зрения, нистагм.; Со стороны органа слуха и равновесия: частота неизвестна - вертиго.; Со стороны пищеварительной системы: часто - сухость во рту, тошнота; нечасто - диарея, боль в животе.; Со стороны сердечно-сосудистой системы: редко - тахикардия.; Со стороны дыхательной системы: часто - ринит, фарингит.; Со стороны обмена веществ: редко - увеличение массы тела.; Со стороны мочевыделительной системы: очень редко - дизурия, энурез; частота неизвестна - задержка мочи.; Со стороны лабораторных показателей: редко - изменение функциональных проб печени (повышение активности печеночных трансаминаз, ЩФ, ГГТ и концентрации билирубина); очень редко - тромбоцитопения.; Со стороны кожи и подкожных тканей: нечасто - сыпь, зуд; очень редко - стойкая эритема.; Аллергические реакции: редко - крапивница; очень редко - ангионевротический отек.; Общие реакции: нечасто - астения, недомогание; редко - периферические отеки; частота неизвестна - повышение аппетита.
Передозировка
Симптомы: возможны спутанность сознания, головокружение, сонливость, заторможенность, ступор, слабость, беспокойство, повышенная раздражительность, седативный эффект повышенная утомляемость, головная боль, мидриаз, зуд, тахикардия, тремор, задержка мочеиспускания, сухость во рту, диарея, запор (чаще всего при приеме 50 мг цетиризина в сут), недомогание.; Лечение: промывание желудка, назначение активированного угля, проведение симптоматической терапии. Специфический антидот не известен. Гемодиализ неэффективен.
Взаимодействие с другими лекарственными средствами
На основании анализа фармакодинамики, фармакокинетики цетиризина, взаимодействие с другими лекарственными препаратами маловероятно.
Не было отмечено значимого взаимодействия с псевдоэфедрином и теофиллином (в дозе 400 мг/сут) в специальных исследованиях лекарственного взаимодействия.
Одновременное применение цетиризина с этанолом и препаратами, угнетающими ЦНС, может способствовать дальнейшему снижению концентрации внимания и быстроты реакций, хотя цетиризин не усиливает эффект этанола (при его концентрации в крови 0.5 г/л).
Особые указания
Пациентам с нарушением функции почек, печени и пациентам пожилого возраста необходимо перед приемом препарата проконсультироваться с врачом.; Не рекомендуется одновременное употребление лекарственных средств, угнетающих ЦНС, алкоголя.; Указание для больных сахарным диабетом; Капли не содержат сахара, поэтому их можно назначать больным сахарным диабетом.; Влияние на способность к вождению автотранспорта и управлению механизмами; В период лечения пациентам необходимо воздерживаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Условия хранения
Препарат следует хранить в недоступном для детей месте при температуре не выше 25°С.
Срок годности
Срок годности - 3 года. Не применять по истечении срока годности, указанного на упаковке.
Условия отпуска
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Н\u003csub\u003e1\u003c/sub\u003e-рецепторы."}},{"type":"paragraph","data":{"text":"В дополнение к антигистаминному эффекту цетиризин предупреждает развитие и облегчает течение аллергических реакций: в дозе 10 мг 1 или 2 раза/сут ингибирует позднюю фазу агрегации эозинофилов в коже и конъюнктиве пациентов, имеющих аллергические реакции."}},{"type":"paragraph","data":{"text":"\u003ci\u003eКлиническая эффективность и безопасность\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Исследования с участием здоровых добровольцев показали, что цетиризин в дозах 5 или 10 мг значительно ингибирует реакцию в виде сыпи и покраснения на введение в кожу гистамина в высокой концентрации, однако корреляция с эффективностью не установлена."}},{"type":"paragraph","data":{"text":"В 6-недельном плацебо-контролируемом исследовании с участием 186 пациентов с аллергическим ринитом и сопутствующей бронхиальной астмой легкого и среднетяжелого течения, показано, что прием цетиризина в дозе 10 мг 1 раз/сут уменьшает симптомы ринита и не влияет на функцию легких."}},{"type":"paragraph","data":{"text":"Результаты данного исследования подтверждают безопасность применения цетиризина у пациентов, страдающих аллергией и бронхиальной астмой легкого и среднетяжелого течения."}},{"type":"paragraph","data":{"text":"В плацебо-контролируемом исследовании показано, что прием цетиризина в дозе 60 мг/сут в течение 7 дней не вызывал клинически значимого удлинения интервала QT."}},{"type":"paragraph","data":{"text":"Прием цетиризина в рекомендуемой дозе показал улучшение качества жизни пациентов с круглогодичным и сезонным аллергическими ринитами."}},{"type":"paragraph","data":{"text":"В клинических исследованиях показано, что цетиризин начинает действовать через 20 мин после приема, его эффект сохраняется в течение 24 ч."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В 35-дневном исследовании с участием пациентов в возрасте 5-12 лет не выявлено признаков невосприимчивости к антигистаминному эффекту цетиризина. Нормальная реакция кожи на гистамин восстанавливалась в течение 3 дней после отмены препарата при его неоднократном применении."}}]},{"name":"Фармакотерапевтическая группа","slug":"","id":13,"body":[{"type":"paragraph","data":{"text":"Противоаллергическое средство - локатор H1 гистаминовых рецепторов"}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Блокатор гистаминовых Н1-рецепторов. Цетиризин является конкурентным антагонистом гистамина, практически не оказывает антихолинергического и антисеротонинового действия. Обладает выраженным противоаллергическим действием, предупреждает развитие и облегчает течение аллергических реакций. Обладает противозудным и противоэкссудативным эффектом. Влияет на раннюю стадию аллергических реакций, а также уменьшает миграцию клеток воспаления; угнетает выделение медиаторов, участвующих в поздней аллергической реакции. Уменьшает проницаемость капилляров, предупреждает развитие отека тканей, снимает спазм гладкой мускулатуры. Устраняет кожную реакцию на введение гистамина, специфических аллергенов, а также на охлаждение (при холодовой крапивнице). В терапевтических дозах практически не оказывает седативного эффекта. На фоне курсового приема толерантность не развивается.; Действие препарата начинается через 20 мин (у 50% больных), через 1 ч (у 95% больных) и сохраняется в течение 24 ч."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Сезонный и круглогодичный аллергический ринит и конъюнктивит","Зудящие аллергические дерматозы","Поллиноз (сенная лихорадка)","Крапивница (в т.ч. хроническая идиопатическая)","Отек Квинке"]}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Терминальная стадия почечной недостаточности (КК\u003c10 мл/мин) (для приема таблеток)","Наследственная непереносимость галактозы, недостаточность лактазы или синдром глюкозо-галактозной мальабсорбции (для приема таблеток)","Детский возраст до 6 лет (для приема таблеток)","Детский возраст до 1 года (для приема капель)","Беременность","Период лактации (грудного вскармливания)","Повышенная чувствительность к компонентам препарата"]}},{"type":"paragraph","data":{"text":"С осторожностью: хроническая почечная недостаточность средней степени тяжести (требуется коррекция режима дозирования), пожилой возраст (возможно снижение клубочковой фильтрации). При приеме таблеток: хронические заболевания печени (гепатоцеллюлярный, холестатический или билиарный цирроз печени) (коррекция дозы требуется только при сопутствующем снижении скорости клубочковой фильтрации)."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Противопоказано применение при беременности и в период лактации (грудного вскармливания)."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Зодак назначают внутрь, независимо от приема пищи. Перед приемом капли растворить в воде. Таблетки, покрытые оболочкой, следует проглатывать целиком, запивая небольшим количеством воды."}},{"type":"paragraph","data":{"text":"Взрослым и детям старше 12 лет - по 10 мг цетиризина (1 таблетка, 20 капель или 2 мерные ложки сиропа)."}},{"type":"paragraph","data":{"text":"Детям от 6 до 12 лет - по 10 мг цетиризина (1 таблетка, 20 капель или 2 мерные ложки сиропа) 1 раз в сутки или по 5 мг цетиризина (10 капель или 1 мерная ложка сиропа) 2 раза в сутки, утром и вечером."}},{"type":"paragraph","data":{"text":"Детям от 2 до 6 лет - по 5 мг цетиризина (1/2 таблетки, 10 капель или 1 мерная ложка сиропа) 1 раз в сутки или 2.5 мг цетиризина (5 капель или 1/2 мерной ложки сиропа) 2 раза в сутки, утром и вечером."}},{"type":"paragraph","data":{"text":"Детям от 1 до 2 лет - по 2.5 мг (5 капель) 2 раза в сутки."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат, как правило, хорошо переносится. Побочные реакции возникают редко и имеют преходящий характер. Определение частоты побочных реакций: очень часто (≥1/10), часто (≥1/100, \u003c1/10), нечасто (≥1/1000, \u003c1/100), редко (≥1/10 000, \u003c1/1000), очень редко (\u003c 1/10 000), частота неизвестна (по имеющимся данным определить частоту встречаемости побочного эффекта не представляется возможным).; Со стороны системы кроветворения: очень редко - тромбоцитопения.; Со стороны иммунной системы: редко - реакции гиперчувствительности; очень редко - анафилактический шок.; Со стороны нервной системы: часто - головная боль, сонливость, повышенная утомляемость, головокружение; нечасто - парестезии; редко - судороги, нарушения двигательной функции; очень редко - извращения вкуса, дискинезия, дистония, обморок, тремор, тик; частота неизвестна - нарушение памяти, в т.ч. амнезия.; Нарушения психики: нечасто - возбуждение; редко - агрессия, спутанность сознания, депрессия, галлюцинации, нарушение сна; частота неизвестна - суицидальные идеи.; Со стороны органа зрения: очень редко - нарушения аккомодации, нечеткость зрения, нистагм.; Со стороны органа слуха и равновесия: частота неизвестна - вертиго.; Со стороны пищеварительной системы: часто - сухость во рту, тошнота; нечасто - диарея, боль в животе.; Со стороны сердечно-сосудистой системы: редко - тахикардия.; Со стороны дыхательной системы: часто - ринит, фарингит.; Со стороны обмена веществ: редко - увеличение массы тела.; Со стороны мочевыделительной системы: очень редко - дизурия, энурез; частота неизвестна - задержка мочи.; Со стороны лабораторных показателей: редко - изменение функциональных проб печени (повышение активности печеночных трансаминаз, ЩФ, ГГТ и концентрации билирубина); очень редко - тромбоцитопения.; Со стороны кожи и подкожных тканей: нечасто - сыпь, зуд; очень редко - стойкая эритема.; Аллергические реакции: редко - крапивница; очень редко - ангионевротический отек.; Общие реакции: нечасто - астения, недомогание; редко - периферические отеки; частота неизвестна - повышение аппетита."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: возможны спутанность сознания, головокружение, сонливость, заторможенность, ступор, слабость, беспокойство, повышенная раздражительность, седативный эффект повышенная утомляемость, головная боль, мидриаз, зуд, тахикардия, тремор, задержка мочеиспускания, сухость во рту, диарея, запор (чаще всего при приеме 50 мг цетиризина в сут), недомогание.; Лечение: промывание желудка, назначение активированного угля, проведение симптоматической терапии. Специфический антидот не известен. Гемодиализ неэффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"На основании анализа фармакодинамики, фармакокинетики цетиризина, взаимодействие с другими лекарственными препаратами маловероятно."}},{"type":"paragraph","data":{"text":"Не было отмечено значимого взаимодействия с псевдоэфедрином и теофиллином (в дозе 400 мг/сут) в специальных исследованиях лекарственного взаимодействия."}},{"type":"paragraph","data":{"text":"Одновременное применение цетиризина с этанолом и препаратами, угнетающими ЦНС, может способствовать дальнейшему снижению концентрации внимания и быстроты реакций, хотя цетиризин не усиливает эффект этанола (при его концентрации в крови 0.5 г/л)."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Пациентам с нарушением функции почек, печени и пациентам пожилого возраста необходимо перед приемом препарата проконсультироваться с врачом.; Не рекомендуется одновременное употребление лекарственных средств, угнетающих ЦНС, алкоголя.; Указание для больных сахарным диабетом; Капли не содержат сахара, поэтому их можно назначать больным сахарным диабетом.; Влияние на способность к вождению автотранспорта и управлению механизмами; В период лечения пациентам необходимо воздерживаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"name":"Условия хранения","slug":"storage","id":18,"body":[{"type":"paragraph","data":{"text":"Препарат следует хранить в недоступном для детей месте при температуре не выше 25°С."}}]},{"name":"Срок годности","slug":"expiry_date","id":19,"body":[{"type":"paragraph","data":{"text":"Срок годности - 3 года. Не применять по истечении срока годности, указанного на упаковке."}}]},{"name":"Условия отпуска","slug":"release_condition","id":20,"body":[{"type":"paragraph","data":{"text":"Без рецепта "}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Блокатор гистаминовых Н1-рецепторов. Цетиризин является конкурентным антагонистом гистамина, практически не оказывает антихолинергического и антисеротонинового действия. Обладает выраженным противоаллергическим действием, предупреждает развитие и облегчает течение аллергических реакций. Обладает противозудным и противоэкссудативным эффектом. Влияет на раннюю стадию аллергических реакций, а также уменьшает миграцию клеток воспаления; угнетает выделение медиаторов, участвующих в поздней аллергической реакции. Уменьшает проницаемость капилляров, предупреждает развитие отека тканей, снимает спазм гладкой мускулатуры. Устраняет кожную реакцию на введение гистамина, специфических аллергенов, а также на охлаждение (при холодовой крапивнице). В терапевтических дозах практически не оказывает седативного эффекта. На фоне курсового приема толерантность не развивается.; Действие препарата начинается через 20 мин (у 50% больных), через 1 ч (у 95% больных) и сохраняется в течение 24 ч.","substance":[{"id":197,"title":"Цетиризин","title_latin":"Cetirizinum","slug":"tsetirizin_197"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Зодак - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70911/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70911/share_default/"}},"diseases":[{"id":"615","title":"Острый атопический (аллергический) конъюнктивит","slug":"615-ostryy_atopicheskiy_allergicheskiy_konyunktivit"},{"id":"811","title":"Вазомоторный и аллергический ринит","slug":"811-vazomotornyy_i_allergicheskiy_rinit"},{"id":"813","title":"Аллергический ринит, вызванный пыльцой 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