Мотилак Таблетки, 30 шт, 10 мг, для приема внутрь

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Неизвестно оказывает ли этот уровень отрицательное воздействие на новорожденных. Поэтому если мать принимает Мотилак кормление грудью не рекомендуется за исключением случаев когда ожидаемая польза оправдывает потенциальный риск."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"1. 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Максимальная суточная доза - 80 мг."}},{"type":"paragraph","data":{"text":"Детям в возрасте от 5 до 12 лет назначают по 10 мг 3-4 раза в сутки до еды и перед сном."}},{"type":"paragraph","data":{"text":"Пациенты с тяжелой почечной недостаточностью (сывороточный креатинин > 6 мг/100 мл т.е. >06 ммоль/л): частота введения должна быть снижена до 1-2 раз в сутки а также может возникнуть необходимость снижения дозы."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта: преходящие спазмы кишечника."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: экстрапирамидные явления (у детей и лиц с повышенной проницаемости гематоэнцефалического барьера). Эти явления полностью обратимы и спонтанно исчезают после прекращения лечения."}},{"type":"paragraph","data":{"text":"Аллергические реакции: кожная сыпь крапивница."}},{"type":"paragraph","data":{"text":"Со стороны эндокринной системы:гиперпролактинемия (галакторея гинекомастия)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: сонливость дезориентация экстрапирамидные реакции особенно у детей."}},{"type":"paragraph","data":{"text":"Лечение: Рекомендуется применение активированного угля и тщательное наблюдение. Антихолинергические средства препараты применяемые для лечения паркинсонизма или антигистаминные препараты могут оказаться эффективными при возникновении экстрапирамидных реакций."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Антихолинергические и антацидные лекарственные препараты нейтрализуют действие домперидона."}},{"type":"paragraph","data":{"text":"Циметидин натрия гидрокарбонат снижают биодоступность домперидона."}},{"type":"paragraph","data":{"text":"Повышают концентрацию домперидона в плазме: противогрибковые лекарственные препараты азолового ряда антибиотики из группы макролидов ингибиторы ВИЧ- протеазы нефазодон (антидепрессант)."}},{"type":"paragraph","data":{"text":"Домперидон совместим с приемом антипсихотических лекарственных средств (нейролептиков) агонистами дофаминергических рецепторов (бромкриптин леводопа)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При сочетанном применении Мотилака с антацидными или антисекреторными препаратами последние рекомендуется принимать за 2 ч до или через 2 ч после приема Мотилака."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Мотилак не влияет на психомоторные реакции и способность управлять автомобилем."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки покрытые пленочной оболочкой 10 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 30 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Акционерное общество \"ВЕРОФАРМ\" (АО \"ВЕРОФАРМ\")"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"ВЕРОФАРМ\""}}]}],"source":null},"description_toggle":false,"short_description":"Увеличивает продолжительность перистальтических сокращений антрального отдела желудка и двенадцатиперстной кишки ускоряет опорожнение желудка в случае замедления этого процесса повышает тонус нижнего пищеводного сфинктера устраняет развитие тошноты и рвоты. Противорвотное действие домперидона возможно обусловлено сочетанием периферического (гастрокинетического) действия и антагонизма к рецепторам дофамина в триггерной зоне хеморецепторов. Применение домперидона редко сопровождается экстрапирамидными побочными эффектами особенно у взрослых. Домперидон стимулирует выделение пролактина из гипофиза. Домперидон не оказывает действия на желудочную секрецию. Всасывание После приема препарата внутрь домперидон быстро всасывается. Обладает низкой биодоступностью (около 15%). Пониженная кислотность желудочного содержимого уменьшает абсорбцию домперидона. Максимальная концентрация в плазме достигается через 1 ч. Распределение Домперидон широко распределяется в различных тканях в тканях мозга его концентрация невелика. Связывание с белками плазмы составляет 91-93%. Плохо проникает через гематоэнцефалический барьер. Метаболизм Подвергается интенсивному метаболизму в стенке кишечника и печени. Выведение Выводится через кишечник (66%) и почками (33%) в неизмененном виде выводится соответственно 10% и 1% от величины дозы. Период полувыведения составляет 7-9 ч при выраженной почечной недостаточности он удлиняется. 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