Доксазозина мезилат 4.85 мг,; что соответствует содержанию доксазозина 4 мг; Вспомогательные вещества: гипромеллоза, кальция гидрофосфат безводный, лактозы моногидрат, магния стеарат.; Состав оболочки: краситель Opadry белый (гипромеллоза, титана диоксид /Е171/), макрогол 400.
Фармакологические свойства
Альфа1-адреноблокатор. Доксазозин является селективным конкурентным блокатором постсинаптических 1-адренорецепторов. За счет снижения тонуса мышц сосудов доксазозин уменьшает ОПСС, что приводит к снижению АД.; После однократного приема препарата максимум антигипертензивного действия наблюдается в период от 2 до 6 ч, а в целом гипотензивный эффект сохраняется в течение 24 ч. В период лечения доксазозином у больных артериальной гипертензией отсутствуют различия значений АД в положении стоя и лежа.; Препарат эффективен при артериальной гипертензии, в т.ч. сопровождающейся метаболическими нарушениями (ожирение, снижение толерантности к глюкозе).; Снижает риск развития ИБС.; Применение препарата у лиц с нормальным АД не сопровождается снижением АД. При длительном применении доксазозина у пациентов не наблюдается изменения толерантности к терапевтическому антигипертензивному действию.; В период лечения доксазозином наблюдается снижение содержания в плазме крови ТГ, общего холестерина (Хс). Отмечается некоторый рост коэффициента ЛПВП/Хс - на 4-13%.; При длительном лечении доксазозином наблюдается регрессия гипертрофии левого желудочка, подавление агрегации тромбоцитов и повышение содержания в тканях активного плазминогена.; В связи с тем, что доксазозин блокирует 1-адренорецепторы, расположенные в строме и капсуле предстательной железы и в шейке мочевого пузыря, происходит снижение сопротивления и давления в мочеиспускательном канале, уменьшается сопротивление внутреннего сфинктера. Поэтому назначение доксазозина пациентам с симптомами доброкачественной гиперплазии предстательной железы приводит к значительному улучшению показателей уродинамики и уменьшению проявлений симптомов заболевания.; Начало действия - через 1-2 недели лечения, максимум - после 14 недель, эффект сохраняется в течение длительного времени. При сравнении с доксазозином в форме обычных таблеток препарат в форме таблеток с модифицированным высвобождением улучшает соотношение между эффективностью и безопасностью.
Показания к применению
Лечение мягкой или умеренной артериальной гипертензии (в сочетании с другими антигипертензивными средствами - тиазидными диуретиками, бета-адреноблокаторами, блокаторами медленных кальциевых каналов, ингибиторами АПФ)
Возраст до 18 лет (эффективность и безопасность не установлены)
Повышенная чувствительность к доксазозину и другим компонентам препарата
Повышенная чувствительность к другим производным хиназолина (празозин, теразозин)
С осторожностью следует применять препарат при аортальном и митральном стенозе, у пациентов с нарушением функции печени и/или почек, при ортостатической артериальной гипотензии.
Применение при беременности и в период грудного вскармливания
Применение Камирена ХЛ при беременности возможно только по жизненным показаниям в том случае, когда предполагаемая польза для матери превосходит потенциальный риск для плода.; Безопасность применения Камирена ХЛ для грудных детей не установлена, поэтому при необходимости назначения препарата в период лактации следует решить вопрос о прекращении грудного вскармливания.
Способ применения и дозы
Назначают внутрь 1 раз/сут, утром или вечером, независимо от приема пищи, не разжевывая и запивая достаточным количеством воды.; Артериальная гипертензия; Средняя доза Камирена ХЛ составляет 4 мг (1 таб.)/сут. Действие препарата может проявляться уже в первый день лечения, терапевтический эффект наступает через 4 недели после начала лечения. Через 4 недели, в случае хорошей переносимости препарата и при недостаточной эффективности, возможно повышение дозы. Максимальная рекомендуемая суточная доза Камирена ХЛ составляет 8 мг (2 таб.) в 1 прием.; Если терапевтическое действие недостаточно, то можно одновременно назначать другие антигипертензивные средства: бета-адреноблокаторы, диуретики, блокаторы медленных кальциевых каналов, ингибиторы АПФ.; После достижения стойкого терапевтического эффекта дозу обычно несколько снижают (средняя терапевтическая доза при поддерживающей терапии обычно составляет 2-4 мг/сут).; Доброкачественная гиперплазия предстательной железы у пациентов с нормальным АД; Камирен; ХЛ назначают в дозе 4 мг (1 таб.)/сут. Первую дозу препарата следует принимать вечером перед сном. В зависимости от эффективности лечения дозу можно постепенно увеличивать с интервалом 1-2 недели до 8 мг 1 раз/сут. Как правило, суточная доза составляет 2-4 мг. Максимальная суточная доза составляет 8 мг.; Доброкачественная гиперплазия предстательной железы у пациентов с артериальной гипертензией АД; Дозы препарата такие же, как при артериальной гипертензии у пациентов без доброкачественной гиперплазии предстательной железы.; Препарат применяется длительно. Продолжительность лечения врач устанавливает индивидуально.; Дозу препарата следует корректировать в зависимости от эффективности или возможных побочных реакций у конкретных больных.; Пациентам с печеночной недостаточностью требуются меньшие дозы вследствие замедленного метаболизма препарата.; Если пациент забыл принять Камирен; ХЛ в обычное время, то препарат следует принять как можно скорее в соответствующей дозе. Если наступает время для приема следующей дозы, то ее следует принять не удваивая. Важно принимать препарат регулярно. Если пациент не принимал препарат в течение нескольких дней, то новый терапевтический курс следует начинать с наименьшей дозы.
Побочное действие
Артериальная гипертензия; В клинических исследованиях наиболее часто наблюдались, особенно в начале лечения, ортостатическая гипотензия, которая в редких случаях может привести к обмороку.; Со стороны сердечно-сосудистой системы: отеки, обморок.; Со стороны ЦНС и периферической нервной системы: головокружение, головная боль, сонливость.; Со стороны пищеварительной системы: тошнота, рвота, диарея, гастрит.; Со стороны дыхательной системы: ринит.; Общие реакции: астения, утомляемость, недомогание.; Доброкачественная гиперплазия предстательной железы; У пациентов с доброкачественной гиперплазией предстательной железы те же побочные эффекты, что и у больных с артериальной гипертензией, а также:; Со стороны сердечно-сосудистой системы: снижение АД, ортостатическая гипертензия.; Со стороны ЦНС и периферической нервной системы: сухость во рту, приапизм, гипестезия, парестезии, тремор, импотенция, бессонница, повышенная возбудимость.; Со стороны эндокринной системы: гинекомастия.; Со стороны пищеварительной системы: боли в животе, запор, диарея, диспепсия, метеоризм, потеря аппетита, тошнота, повышение активности печеночных трансаминаз, холестаз, желтуха, гепатит.; Со стороны органов кроветворения: лейкопения, пурпура, тромбоцитопения.; Со стороны костно-мышечной системы: артралгия, мышечные судороги, слабость в мышцах, миалгия.; Со стороны дыхательной системы: бронхоспазм, кашель, одышка, носовое кровотечение.; Дерматологические реакции: алопеция.; Со стороны органов чувств: нечеткость зрительного восприятия, шум в ушах.; Со стороны мочевыделительной системы: дизурия, гематурия, нарушение мочеиспускания, никтурия, полиурия, недержание мочи.; Аллергические реакции: кожная сыпь, крапивница.; Прочие: боль в спине, ощущение жара (приливы крови в коже лица).; Также отмечались следующие побочные эффекты у пациентов с артериальной гипертензией (причинно-следственная связь с приемом препарата не установлена): брадикардия, тахикардия, ощущение сердцебиения, боль в груди, стенокардия, инфаркт миокарда, нарушение мозгового кровообращения, аритмия.
Передозировка
Симптомы: выраженное снижение АД, иногда сопровождающееся обмороком.; Лечение: пациента необходимо немедленно перевести в горизонтальное положение на спину с низким изголовьем. Проведение симптоматической терапии. Диализ неэффективен.
Особые указания
Особую осторожность следует соблюдать при назначении Камирена ХЛ пациентам с нарушением функции печени, особенно при одновременном применении препаратов, которые могут отрицательно повлиять на функции печени. В случае ухудшения показателей функционального состояния печени препарат следует немедленно отменить.; С целью предотвращения ортостатических реакций пациенты должны избегать неожиданных и резких изменений положения тела (переход из положения лежа в положение стоя).; Эффект первой дозы особенно выражен на фоне предшествующей терапии диуретиками и диеты с ограничением натрия.; Перед началом терапии необходимо исключить злокачественное перерождение предстательной железы.; При приеме алкоголя возможно усиление нежелательных эффектов доксазозина.; Использование в педиатрии; Безопасность и эффективность применения доксазозина у детей не установлена, поэтому применение в педиатрии противопоказано.; Влияние на способность к вождению автотранспорта и управлению механизмами; В связи с тем, что доксазозин способен вызывать ортостатические реакции в начале лечения и в период повышения дозы, пациентам целесообразно воздерживаться от потенциально опасных видов деятельности, в частности от управления транспортными средствами и работы с механизмами.
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мезилат 4.85 мг,; что соответствует содержанию доксазозина 4 мг; Вспомогательные вещества: гипромеллоза, кальция гидрофосфат безводный, лактозы моногидрат, магния стеарат.; Состав оболочки: краситель Opadry белый (гипромеллоза, титана диоксид /Е171/), макрогол 400."}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Альфа1-адреноблокатор. Доксазозин является селективным конкурентным блокатором постсинаптических 1-адренорецепторов. За счет снижения тонуса мышц сосудов доксазозин уменьшает ОПСС, что приводит к снижению АД.; После однократного приема препарата максимум антигипертензивного действия наблюдается в период от 2 до 6 ч, а в целом гипотензивный эффект сохраняется в течение 24 ч. В период лечения доксазозином у больных артериальной гипертензией отсутствуют различия значений АД в положении стоя и лежа.; Препарат эффективен при артериальной гипертензии, в т.ч. сопровождающейся метаболическими нарушениями (ожирение, снижение толерантности к глюкозе).; Снижает риск развития ИБС.; Применение препарата у лиц с нормальным АД не сопровождается снижением АД. При длительном применении доксазозина у пациентов не наблюдается изменения толерантности к терапевтическому антигипертензивному действию.; В период лечения доксазозином наблюдается снижение содержания в плазме крови ТГ, общего холестерина (Хс). Отмечается некоторый рост коэффициента ЛПВП/Хс - на 4-13%.; При длительном лечении доксазозином наблюдается регрессия гипертрофии левого желудочка, подавление агрегации тромбоцитов и повышение содержания в тканях активного плазминогена.; В связи с тем, что доксазозин блокирует 1-адренорецепторы, расположенные в строме и капсуле предстательной железы и в шейке мочевого пузыря, происходит снижение сопротивления и давления в мочеиспускательном канале, уменьшается сопротивление внутреннего сфинктера. Поэтому назначение доксазозина пациентам с симптомами доброкачественной гиперплазии предстательной железы приводит к значительному улучшению показателей уродинамики и уменьшению проявлений симптомов заболевания.; Начало действия - через 1-2 недели лечения, максимум - после 14 недель, эффект сохраняется в течение длительного времени. При сравнении с доксазозином в форме обычных таблеток препарат в форме таблеток с модифицированным высвобождением улучшает соотношение между эффективностью и безопасностью."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Лечение мягкой или умеренной артериальной гипертензии (в сочетании с другими антигипертензивными средствами - тиазидными диуретиками, бета-адреноблокаторами, блокаторами медленных кальциевых каналов, ингибиторами АПФ)","Симптоматическое лечение доброкачественной гиперплазии предстательной железы"]}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Возраст до 18 лет (эффективность и безопасность не установлены)","Повышенная чувствительность к доксазозину и другим компонентам препарата","Повышенная чувствительность к другим производным хиназолина (празозин, теразозин)"]}},{"type":"paragraph","data":{"text":"С осторожностью следует применять препарат при аортальном и митральном стенозе, у пациентов с нарушением функции печени и/или почек, при ортостатической артериальной гипотензии."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Применение Камирена ХЛ при беременности возможно только по жизненным показаниям в том случае, когда предполагаемая польза для матери превосходит потенциальный риск для плода.; Безопасность применения Камирена ХЛ для грудных детей не установлена, поэтому при необходимости назначения препарата в период лактации следует решить вопрос о прекращении грудного вскармливания."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Назначают внутрь 1 раз/сут, утром или вечером, независимо от приема пищи, не разжевывая и запивая достаточным количеством воды.; Артериальная гипертензия; Средняя доза Камирена ХЛ составляет 4 мг (1 таб.)/сут. Действие препарата может проявляться уже в первый день лечения, терапевтический эффект наступает через 4 недели после начала лечения. Через 4 недели, в случае хорошей переносимости препарата и при недостаточной эффективности, возможно повышение дозы. Максимальная рекомендуемая суточная доза Камирена ХЛ составляет 8 мг (2 таб.) в 1 прием.; Если терапевтическое действие недостаточно, то можно одновременно назначать другие антигипертензивные средства: бета-адреноблокаторы, диуретики, блокаторы медленных кальциевых каналов, ингибиторы АПФ.; После достижения стойкого терапевтического эффекта дозу обычно несколько снижают (средняя терапевтическая доза при поддерживающей терапии обычно составляет 2-4 мг/сут).; Доброкачественная гиперплазия предстательной железы у пациентов с нормальным АД; Камирен; ХЛ назначают в дозе 4 мг (1 таб.)/сут. Первую дозу препарата следует принимать вечером перед сном. В зависимости от эффективности лечения дозу можно постепенно увеличивать с интервалом 1-2 недели до 8 мг 1 раз/сут. Как правило, суточная доза составляет 2-4 мг. Максимальная суточная доза составляет 8 мг.; Доброкачественная гиперплазия предстательной железы у пациентов с артериальной гипертензией АД; Дозы препарата такие же, как при артериальной гипертензии у пациентов без доброкачественной гиперплазии предстательной железы.; Препарат применяется длительно. Продолжительность лечения врач устанавливает индивидуально.; Дозу препарата следует корректировать в зависимости от эффективности или возможных побочных реакций у конкретных больных.; Пациентам с печеночной недостаточностью требуются меньшие дозы вследствие замедленного метаболизма препарата.; Если пациент забыл принять Камирен; ХЛ в обычное время, то препарат следует принять как можно скорее в соответствующей дозе. Если наступает время для приема следующей дозы, то ее следует принять не удваивая. Важно принимать препарат регулярно. Если пациент не принимал препарат в течение нескольких дней, то новый терапевтический курс следует начинать с наименьшей дозы."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Артериальная гипертензия; В клинических исследованиях наиболее часто наблюдались, особенно в начале лечения, ортостатическая гипотензия, которая в редких случаях может привести к обмороку.; Со стороны сердечно-сосудистой системы: отеки, обморок.; Со стороны ЦНС и периферической нервной системы: головокружение, головная боль, сонливость.; Со стороны пищеварительной системы: тошнота, рвота, диарея, гастрит.; Со стороны дыхательной системы: ринит.; Общие реакции: астения, утомляемость, недомогание.; Доброкачественная гиперплазия предстательной железы; У пациентов с доброкачественной гиперплазией предстательной железы те же побочные эффекты, что и у больных с артериальной гипертензией, а также:; Со стороны сердечно-сосудистой системы: снижение АД, ортостатическая гипертензия.; Со стороны ЦНС и периферической нервной системы: сухость во рту, приапизм, гипестезия, парестезии, тремор, импотенция, бессонница, повышенная возбудимость.; Со стороны эндокринной системы: гинекомастия.; Со стороны пищеварительной системы: боли в животе, запор, диарея, диспепсия, метеоризм, потеря аппетита, тошнота, повышение активности печеночных трансаминаз, холестаз, желтуха, гепатит.; Со стороны органов кроветворения: лейкопения, пурпура, тромбоцитопения.; Со стороны костно-мышечной системы: артралгия, мышечные судороги, слабость в мышцах, миалгия.; Со стороны дыхательной системы: бронхоспазм, кашель, одышка, носовое кровотечение.; Дерматологические реакции: алопеция.; Со стороны органов чувств: нечеткость зрительного восприятия, шум в ушах.; Со стороны мочевыделительной системы: дизурия, гематурия, нарушение мочеиспускания, никтурия, полиурия, недержание мочи.; Аллергические реакции: кожная сыпь, крапивница.; Прочие: боль в спине, ощущение жара (приливы крови в коже лица).; Также отмечались следующие побочные эффекты у пациентов с артериальной гипертензией (причинно-следственная связь с приемом препарата не установлена): брадикардия, тахикардия, ощущение сердцебиения, боль в груди, стенокардия, инфаркт миокарда, нарушение мозгового кровообращения, аритмия."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: выраженное снижение АД, иногда сопровождающееся обмороком.; Лечение: пациента необходимо немедленно перевести в горизонтальное положение на спину с низким изголовьем. Проведение симптоматической терапии. Диализ неэффективен."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Особую осторожность следует соблюдать при назначении Камирена ХЛ пациентам с нарушением функции печени, особенно при одновременном применении препаратов, которые могут отрицательно повлиять на функции печени. В случае ухудшения показателей функционального состояния печени препарат следует немедленно отменить.; С целью предотвращения ортостатических реакций пациенты должны избегать неожиданных и резких изменений положения тела (переход из положения лежа в положение стоя).; Эффект первой дозы особенно выражен на фоне предшествующей терапии диуретиками и диеты с ограничением натрия.; Перед началом терапии необходимо исключить злокачественное перерождение предстательной железы.; При приеме алкоголя возможно усиление нежелательных эффектов доксазозина.; Использование в педиатрии; Безопасность и эффективность применения доксазозина у детей не установлена, поэтому применение в педиатрии противопоказано.; Влияние на способность к вождению автотранспорта и управлению механизмами; В связи с тем, что доксазозин способен вызывать ортостатические реакции в начале лечения и в период повышения дозы, пациентам целесообразно воздерживаться от потенциально опасных видов деятельности, в частности от управления транспортными средствами и работы с механизмами."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Альфа1-адреноблокатор. 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Отмечается некоторый рост коэффициента ЛПВП/Хс - на 4-13%.; При длительном лечении доксазозином наблюдается регрессия гипертрофии левого желудочка, подавление агрегации тромбоцитов и повышение содержания в тканях активного плазминогена.; В связи с тем, что доксазозин блокирует 1-адренорецепторы, расположенные в строме и капсуле предстательной железы и в шейке мочевого пузыря, происходит снижение сопротивления и давления в мочеиспускательном канале, уменьшается сопротивление внутреннего сфинктера. Поэтому назначение доксазозина пациентам с симптомами доброкачественной гиперплазии предстательной железы приводит к значительному улучшению показателей уродинамики и уменьшению проявлений симптомов заболевания.; Начало действия - через 1-2 недели лечения, максимум - после 14 недель, эффект сохраняется в течение длительного времени. 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