ГКС для наружного применения. Подавляет функции лейкоцитов и тканевых макрофагов. Ограничивает миграцию лейкоцитов в область воспаления. Нарушает способность макрофагов к фагоцитозу, а также к образованию интерлейкина-1. Способствует стабилизации лизосомальных мембран, снижая тем самым концентрацию протеолитических ферментов в области воспаления. Уменьшает ...
Применяют наружно 1 раз/сут тонким слоем на пораженную область, слегка втирая. Возможно использование с окклюзионной повязкой. Обычно курс лечения составляет для взрослых не более 12 недель, а для детей - не более 4 недель. В течение года возможно проведение нескольких курсов терапии.
100 г метилпреднизолона ацепонат (в пересчете на 100% вещество) 0.1 г. Вспомогательные вещества: этанол 96% - 100 мг, натрия хлорид - 4.35 мг, динатрия эдетата дигидрат - 0.5 мг, 1М раствор натрия гидроксида или раствор хлористоводородной кислоты - до рН 7.4-7.5, вода д/и - до 1 мл.
Фармакологические свойства
Фармакокинетика
Показания к применению
ГКС для наружного применения. Подавляет функции лейкоцитов и тканевых макрофагов. Ограничивает миграцию лейкоцитов в область воспаления. Нарушает способность макрофагов к фагоцитозу, а также к образованию интерлейкина-1. Способствует стабилизации лизосомальных мембран, снижая тем самым концентрацию протеолитических ферментов в области воспаления. Уменьшает проницаемость капилляров, обусловленную высвобождением гистамина. Подавляет активность фибробластов и образование коллагена. Ингибирует активность фосфолипазы А2, что приводит к подавлению синтеза простагландинов и лейкотриенов. Подавляет высвобождение ЦОГ (главным образом ЦОГ-2), что также способствует уменьшению выработки простагландинов. Уменьшает число циркулирующих лимфоцитов (T- и B-клеток), моноцитов, эозинофилов и базофилов вследствие их перемещения из сосудистого русла в лимфоидную ткань . подавляет образование антител. Метилпреднизолон ацепонат подавляет высвобождение гипофизом АКТГ и β .-липотропина, но не снижает уровень циркулирующего β .-эндорфина. Угнетает секрецию ТТГ и ФСГ. При непосредственной аппликации на сосуды вызывает вазоконстрикторный эффект. При наружном и местном применении терапевтическая активность метилпреднизолона обусловлена противовоспалительным, противоаллергическим и антиэкссудативным (благодаря вазоконстрикторному эффекту) действием.
Противопоказания
Применяют наружно 1 раз/сут тонким слоем на пораженную область, слегка втирая. Возможно использование с окклюзионной повязкой. Обычно курс лечения составляет для взрослых не более 12 недель, а для детей - не более 4 недель. В течение года возможно проведение нескольких курсов терапии.
Применение при беременности и в период грудного вскармливания
Не рекомендуется применять при наличии розовых угрей на лице. При бактериальных дерматозах или дерматомикозах необходима одновременная терапия антибактериальными или противогрибковыми средствами. Не следует одновременно проводить физиотерапию. С особой осторожностью применять при беременности. Следует избегать попадания в глаза и использовать на обширных поверхностях кожи.
Побочное действие
Специфические поражения кожи (туберкулез, сифилис, ветряная оспа), кожные реакции на вакцинацию, вирусные заболевания.
Особые указания
Специфические поражения кожи (туберкулез, сифилис, ветряная оспа), кожные реакции на вакцинацию, вирусные заболевания.
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