Ректальные суппозитории "Артрозилен" - НПВП. Оказывает противовоспалительное, анальгезирующее и жаропонижающее действие. Ингибируя ЦОГ-1 и ЦОГ-2, угнетает синтез простагландинов. Обладает антибрадикининовой активностью, стабилизирует лизосомальные мембраны и задерживает высвобождение из них ферментов, способствующих разрушению тканей при хроническом воспалении. Снижает выделение цитокинов, тормозит активность нейтрофилов. Уменьшает утреннюю скованность и припухлость суставов, увеличивает объем движений. Кетопрофена лизиновая соль, в отличие от кетопрофена, является быстрорастворимым соединением с нейтральной рН, за счет чего почти не раздражает ЖКТ. После приема внутрь максимальный терапевтический эффект наблюдается на протяжении от 4 до 24 ч. При наружном применении Артрозилен уменьшает проявления воспаления и болевые ощущения в области пораженных суставов, сухожилий, связок, мышц. При суставном синдроме вызывает ослабление болей в суставах в покое и при движении, уменьшение утренней скованности и припухлости суставов. Кетопрофена лизиновая соль не оказывает катаболического влияния на суставной хрящ.
Показания к применению
Ревматоидный артрит, внесуставной ревматизм, остеоартроз, суставной синдром при обострении подагры, неспецифические спондилоартриты (анкилозирующий спондилит, псориатический артрит). Болевой синдром различного генеза: у онкологических больных, послеоперационные боли, невралгия, миалгия, тендинит, бурсит, радикулит, травматическое воспаление мягких тканей и опорно-двигательного аппарата, аднексит, дисальгоменорея, отит, головная боль, зубная боль (в т.ч. при лечении и удалении зубов), почечная колика.
Применение при беременности и в период грудного вскармливания
Применение препарата Артрозилен в III триместре беременности противопоказано. В I и II триместрах беременности применять препарат Артрозилен следует с осторожностью и под контролем врача. При необходимости применения препарата в период лактации грудное вскармливание следует прекратить. Женщинам, планирующим беременность, следует воздержаться от приема препарата Артрозилен, т.к. на фоне его приема может снижаться вероятность имплантации яйцеклетки.
Способ применения и дозы
Ректально назначают по 1 суппозиторию 2-3 раза/сут. Максимальная суточная доза - 480 мг. Пациентам пожилого возраста не следует назначать более 2 суппозиториев в сутки.
Побочное действие
Со стороны пищеварительной системы: боли в животе, диарея, стоматит, эзофагит, гастрит, дуоденит, эрозивно-язвенные поражения ЖКТ, гематомезис, мелена, повышение уровня билирубина, повышение активности печеночных ферментов, гепатит, печеночная недостаточность, увеличение размеров печени. Со стороны ЦНС и периферической нервной системы: головокружение, гиперкинезия, тремор, вертиго, перепады настроения, тревожность, галлюцинации, раздражительность, общее недомогание, нарушение зрения. Аллергические реакции: крапивница, ангионевротический отек, многоформная экссудативная эритема (в т.ч. синдром Стивенса-Джонсона), анафилактоидные реакции (отек слизистой оболочки полости рта, отек глотки, периорбитальный отек). Дерматологические реакции: эритематозная экзантема, зуд, макуло-папулезная сыпь. Со стороны мочевыделительной системы: болезненное мочеиспускание, цистит, отеки, гематурия. Со стороны системы кроветворения: лейкоцитопения, лейкоцитоз, лимфангит, уменьшение протромбинового времени, тромбоцитопения, тромбоцитопеническая пурпура, увеличение размеров селезенки, васкулит. Со стороны дыхательной системы: бронхоспазм, диспноэ, ощущение спазма гортани, ларингоспазм, отек гортани, ринит. Со стороны сердечно-сосудистой системы: гипертензия, гипотензия, тахикардия, боль в грудной клетке, синкопальные состояния, периферические отеки, бледность. Прочие: конъюнктивит, нарушение менструального цикла, усиление потоотделения. Местные реакции при ректальном применении: жжение, зуд, тяжесть в аноректальной области, обострение геморроя. Местные реакции при наружном применении: кожные проявления аллергических реакций, фотосенсибилизация. При длительном применении на обширных поверхностях кожи возможно развитие системных побочных эффектов. Кетопрофена лизиновая соль гораздо реже вызывает побочные эффекты по сравнению с кетопрофеном.
Передозировка
В настоящее время о случаях передозировки препаратом Артрозилен не сообщалось. В случае передозировки следует проводить симптоматическую терапию, мониторинг дыхательной и сердечно-сосудистой деятельности. Специфического антидота не существует. Гемодиализ малоэффективен.
Особые указания
Противопоказания к применению: "аспириновая триада", III триместр беременности, период лактации, повышенная чувствительность к кетопрофену или другим компонентам препарата, ацетилсалициловой кислоте или другим НПВС. Для системного применения: язвенная болезнь желудка и двенадцатиперстной кишки в фазе обострения, язвенный колит в фазе обострения, болезнь Крона, дивертикулит, пептическая язва, нарушения свертывания крови (в т.ч. гемофилия), хроническая почечная недостаточность, детский и подростковый возраст до 18 лет. Для наружного применения: мокнущие дерматозы, экзема, нарушение целостности кожных покровов, детский возраст до 6 лет. С осторожностью следует назначать препарат в I и II триместрах беременности, а также пациентам пожилого возраста. При системном применении следует проявлять осторожность при анемии, бронхиальной астме, алкоголизме, табакокурении, алкогольном циррозе печени, гипербилирубинемии, печеночной недостаточности, сахарном диабете, дегидратации, сепсисе, хронической сердечной недостаточности, отеках, артериальной гипертензии, заболеваниях крови (в т.ч. лейкопении), дефиците глюкозо-6-фосфатдегидрогеназы, стоматите, при наружном применении - при обострении печеночной порфирии, эрозивно-язвенных поражениях ЖКТ, тяжелых нарушениях функции печени и почек, хронической сердечной недостаточности, бронхиальной астме, а также у детей в возрасте до 12 лет. Во время лечения препаратом Артрозилен необходимо проводить периодический контроль картины периферической крови и функционального состояния печени и почек. При необходимости определения 17-кетостероидов препарат следует отменить за 48 ч до исследования. Прием Артрозилена может маскировать признаки инфекционного заболевания. Применение Артрозилена при бронхиальной астме может спровоцировать приступ удушья. При наружном применении препарат следует наносить только на неповрежденную кожу. Следует избегать попадания в глаза и на слизистую оболочку. Во избежание проявлений повышенной чувствительности и фоточувствительности, рекомендуется избегать воздействия на кожу солнечных лучей в течение курса лечения. Водные растворы кетопрофена лизиновой соли, а также гель для наружного применения могут быть использованы при физиотерапевтическом лечении (ионофорезе, мезотерапии): при ионофорезе препарат наносят на отрицательный полюс. Влияние на способность к вождению автотранспорта и управлению механизмамиВ период применения препарата следует воздержаться от потенциально опасных видов деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций.
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В I и II триместрах беременности применять препарат Артрозилен следует с осторожностью и под контролем врача. При необходимости применения препарата в период лактации грудное вскармливание следует прекратить. Женщинам, планирующим беременность, следует воздержаться от приема препарата Артрозилен, т.к. на фоне его приема может снижаться вероятность имплантации яйцеклетки."}}]},{"id":5,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Ректально назначают по 1 суппозиторию 2-3 раза/сут. Максимальная суточная доза - 480 мг. 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Дерматологические реакции: эритематозная экзантема, зуд, макуло-папулезная сыпь. Со стороны мочевыделительной системы: болезненное мочеиспускание, цистит, отеки, гематурия. Со стороны системы кроветворения: лейкоцитопения, лейкоцитоз, лимфангит, уменьшение протромбинового времени, тромбоцитопения, тромбоцитопеническая пурпура, увеличение размеров селезенки, васкулит. Со стороны дыхательной системы: бронхоспазм, диспноэ, ощущение спазма гортани, ларингоспазм, отек гортани, ринит. Со стороны сердечно-сосудистой системы: гипертензия, гипотензия, тахикардия, боль в грудной клетке, синкопальные состояния, периферические отеки, бледность. Прочие: конъюнктивит, нарушение менструального цикла, усиление потоотделения. Местные реакции при ректальном применении: жжение, зуд, тяжесть в аноректальной области, обострение геморроя. Местные реакции при наружном применении: кожные проявления аллергических реакций, фотосенсибилизация. 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Для системного применения: язвенная болезнь желудка и двенадцатиперстной кишки в фазе обострения, язвенный колит в фазе обострения, болезнь Крона, дивертикулит, пептическая язва, нарушения свертывания крови (в т.ч. гемофилия), хроническая почечная недостаточность, детский и подростковый возраст до 18 лет. Для наружного применения: мокнущие дерматозы, экзема, нарушение целостности кожных покровов, детский возраст до 6 лет. С осторожностью следует назначать препарат в I и II триместрах беременности, а также пациентам пожилого возраста. 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Применение Артрозилена при бронхиальной астме может спровоцировать приступ удушья. При наружном применении препарат следует наносить только на неповрежденную кожу. Следует избегать попадания в глаза и на слизистую оболочку. Во избежание проявлений повышенной чувствительности и фоточувствительности, рекомендуется избегать воздействия на кожу солнечных лучей в течение курса лечения. Водные растворы кетопрофена лизиновой соли, а также гель для наружного применения могут быть использованы при физиотерапевтическом лечении (ионофорезе, мезотерапии): при ионофорезе препарат наносят на отрицательный полюс. 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