Через механизмы аллостерической модуляции препарат сенситизи... Инструкция
Показания к применению
Длительная терапия пациентов с избыточной массой тела или ожирением I-II степени (индекс массы тела более 25 кг/м2) в сочетании с умеренно гипокалорийной диетой.
Противопоказания
Повышенная индивидуальная чувствительность к компонентам препарата. Диетресса не рекомендуется для применения у детей в возрасте до 18-ти лет в связи с недостаточностью данных по эффективности и безопасности для этого возраста.
Инструкция
Состав
Активные вещества:
Антитела к каннабиноидному рецептору 1 типа аффинно очищенные - 0,006 г.
Вспомогательные вещества: лактозы моногидрат, целлюлоза микрокристаллическая, магния стеарат.
Описание
Диетресса – препарат для длительной терапии пациентов с избыточной массой тела или ожирением 1 степени. Действует на пищевой центр в гипоталамусе. В сочетании с гипокалорийной диетой, Диетресса способствует снижению массы тела, уменьшая чувство голода и повышая чувство насыщения при употреблении небольшой порции низкокалорийной пищи. Диетресса снимает психологическое напряжение в период изменения пищевого поведения. Препарат не вызывает привыкания, лекарственной зависимости.
Рекомендуемая схема приема: 6 таблеток в день по 1-2 таблетки, за 15-30 минут до еды держать во рту до полного растворения. Принимать длительно – до трех месяцев. При необходимости курс может быть возобновлён.
С более полной информацией можно ознакомиться в инструкции по применению препарата Диетресса.
Фармакологические свойства
Через механизмы аллостерической модуляции препарат сенситизирует каннабиноидный рецептор I типа, что сопровождается повышением его чувствительности к эндогенным каннабиноидным нейропептидам. Вследствие этого нормализуется эндоканнабиноидная регуляция мезолимбической системы, в том числе пищевого центра в гипоталамусе.
Экспериментально показано, что при введении препарата животным происходит отказ от самостимуляции латерального гипоталамуса, свидетельствующий о насыщении системы позитивного эмоционального подкрепления, уменьшении эйфоригенной значимости пищи, снижение прироста массы тела в условиях высокожировой диеты.
Прием препарата сопровождается тормозящим влиянием на процессы ожирения: уменьшением потребления пищи и снижением веса, не вызывая как тормозящего, так и стимулирующего влияния на высшую нервную деятельность.
Эффект снижения веса обусловлен не только центральными, но и периферическими механизмами – за счет модуляции каннабиноидных рецепторов адипоцитов (жировых клеток), активации в них основного обмена.
Препарат не вызывает привыкания, лекарственной зависимости, не оказывает наркогенного действия.
Показания к применению
Длительная терапия пациентов с избыточной массой тела или ожирением I-II степени (индекс массы тела более 25 кг/м2) в сочетании с умеренно гипокалорийной диетой.
Противопоказания
Повышенная индивидуальная чувствительность к компонентам препарата. Диетресса не рекомендуется для применения у детей в возрасте до 18-ти лет в связи с недостаточностью данных по эффективности и безопасности для этого возраста.
Применение при беременности и в период грудного вскармливания
Безопасность применения Диетрессы у беременных и в период лактации не изучалась. При необходимости приема препарата следует учитывать соотношение риск/польза.
Способ применения и дозы
Внутрь. Рекомендуется прием 6 таблеток в день по 1-2 таблетки (держать во рту до полного растворения) за 15-30 минут до еды. Желательно сочетать лечение с умеренно гипокалорийной диетой. Принимать длительно - до трех месяцев. При необходимости курс может быть возобновлен.
Побочное действие
При использовании препарата по указанным показаниям и в указанных дозировках побочного действия не выявлено. Возможны реакции повышенной индивидуальной чувствительности к компонентам препарата.
Передозировка
Случаев передозировки до настоящего времени не зарегистрировано. При случайной передозировке возможны диспепсические явления, обусловленные входящими в состав препарата наполнителями.
Взаимодействие с другими лекарственными средствами
Случаев несовместимости с другими лекарственными средствами до настоящего времени не зарегистрировано.
Особые указания
В состав препарата входит лактозы моногидрат, в связи с чем его не рекомендуется назначать пациентам с врожденной галактоземией, синдромом мальабсорбции глюкозы или галактозы, либо при врожденной лактазной недостаточности.
Диетресса не оказывает влияния на способность управления транспортными средствами и другими потенциально опасными механизмами.
В небольшом количестве случаев в начале курса терапии Диетрессой может наблюдаться временное (от двух до восьми суток) незначительное повышение аппетита, не вызывающее увеличения веса и не требующее отмены препарата.
Условия хранения
В защищенном от света месте, при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не применять по истечении срока годности.
Условия отпуска
Без рецепта.
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