Селектра Таблетки, коробка, 28 шт, 10 мг, для приема внутрь

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ЦНС: деперсонализация; головокружение; панические атаки; слабость; тревога; бессонница; повышенная раздражительность; сонливость; ажитация; судороги; расстройства зрения; тремор; спутанность сознания; двигательные нарушения; галлюцинации; серотониновый синдром (миоклонус, гипертермия, тремор, ажитация); маниакальные расстройства. ЖКТ: сухость в ротовой полости; диарея; тошнота; расстройства вкусовых ощущений; рвота; понижение аппетита; запор. Эндокринная система: галакторея; понижение секреции АДГ. Сердечно-сосудистая система: ортостатическая гипотензия. Мочеполовая система: аноргазмия (у женщин); понижение либидо; нарушение эякуляции; задержка мочи; импотенция. Кожные покровы: экхимоз; сыпь; пурпура; зуд; ангионевротический отек. Лабораторные показатели: изменение печеночной функции; гипонатриемия. Аллергические реакции: анафилактические проявления. Другие: гипертермия; повышенная потливость; синуситы; миалгия; артралгия; синдром отмены (при внезапном прекращении лечения)."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"C осторожностью следует применять у пациентов с почечной недостаточностью (КК менее 30 мл/мин), гипоманей, манией, при фармакологически неконтролируемой эпилепсии, при депрессии с суицидальными попытками, сахарном диабете, у пациентов пожилого возраста, при циррозе печени, при склонности к кровотечениям, одновременно с приемом лекарственных средств, снижающих порог судорожной готовности, вызывающих гипонатриемию, с этанолом, с препаратами, метаболизирующимися с участием изоферментов системы CYP2C19. Эсциталопрам следует назначать только через 2 нед. после отмены необратимых ингибиторов МАО и через 24 ч после прекращения терапии обратимым ингибитором МАО. Неселективные ингибиторы МАО можно назначать не ранее чем через 7 дней после отмены эсциталопрама. У некоторых пациентов с паническим расстройством в начале лечения эсциталопрамом может наблюдаться усиление тревоги, которая исчезает обычно в течение последующих 2 нед. лечения. Чтобы уменьшить вероятность возникновения тревоги, рекомендуется использовать низкие начальные дозы. Следует отменить эсциталопрам в случае развития эпилептических припадков или их учащении при фармакологически неконтролируемой эпилепсии. При развитии маниакального состояния эсциталопрам следует отменить. Эсциталопрам способен повышать концентрацию глюкозы в крови при сахарном диабете, что может потребовать коррекции доз гипогликемических препаратов. Клинический опыт применения эсциталопрама свидетельствует о возможном увеличении риска реализации суицидальных попыток в первые недели терапии, в связи с чем очень важно осуществлять тщательное наблюдение за пациентами в этот период. Гипонатриемия, связанная со снижением секреции АДГ, на фоне приема эсциталопрама возникает редко и обычно исчезает при его отмене. При развитии серотонинового синдрома эсциталопрам следует немедленно отменить и назначить симптоматическое лечение. Влияние на способность к вождению автотранспорта и управлению механизмамиВ период лечения пациентам следует избегать вождения автотранспорта и другой деятельности, требующей высокой концентрации внимания и скорости психомоторных реакций."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Антидепрессант. селективно ингибирует обратный захват серотонина; повышает концентрацию нейромедиатора в синаптической щели, усиливает и пролонгирует действие серотонина на постсинаптические рецепторы. эсциталопрам практически не связывается с серотониновыми (5-ht), допаминовыми (d1 и d2) рецепторами, α-адрено-, м-холинорецепторами, а также с бензодиазепиновыми и опиоидными рецепторами.антидепрессивный эффект обычно развивается через 2-4 нед. после начала лечения. максимальный терапевтический эффект лечения панических расстройств достигается примерно через 3 мес после начала 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