Всасывание и метаболизм: После приема внутрь изосорбид-5-мон... Инструкция
Показания к применению
Профилактика и длительная терапия стенокардии III-IV функциональных классов. Восстановительное лечение после перенесенного инфаркта миокарда. Лечение хронической сердечной недостаточности (в составе комбинированной терапии).
Противопоказания
Острые нарушения кровообращения (шок, сосудистый коллапс). Геморрагический инсульт. Острая стадия инфаркта миокарда. Одновременный прием ингибиторов фосфодиэстераз (силденафил). Выраженная артериальная гипотензия (систолическое ад<90 мм рт.ст., диастолическое ад<60 мм рт.ст.). Состояния после черепно-мозговой травмы. Закрытоугольная глаукома. Дефицит ...
Всасывание и метаболизм: После приема внутрь изосорбид-5-мононитрат быстро и полностью всасывается из ЖКТ. Биодоступность препарата при приеме внутрь составляет от 90 до 100%. Cmax в плазме крови достигается через 1-1.5 ч после приема. Не подвергается эффекту первого прохождения через печень. Выведение: Изосорбид-5-мононитрат выводится почками исключительно в виде метаболитов. Приблизительно 2% выводится в неизмененном виде. T1/2 составляет приблизительно 5 ч, что примерно в 8 раз выше, чем у изосорбида динитрата.
Показания к применению
Профилактика и длительная терапия стенокардии III-IV функциональных классов. Восстановительное лечение после перенесенного инфаркта миокарда. Лечение хронической сердечной недостаточности (в составе комбинированной терапии).
Противопоказания
Острые нарушения кровообращения (шок, сосудистый коллапс). Геморрагический инсульт. Острая стадия инфаркта миокарда. Одновременный прием ингибиторов фосфодиэстераз (силденафил). Выраженная артериальная гипотензия (систолическое ад<90 мм рт.ст., диастолическое ад<60 мм рт.ст.). Состояния после черепно-мозговой травмы. Закрытоугольная глаукома. Дефицит глюкозо-6-фосфатдегидрогеназы. Возраст до 18 лет. Повышенная чувствительность к органическим нитратам.
Применение при беременности и в период грудного вскармливания
При беременности препарат может быть назначен только по строгим показаниям, когда ожидаемый терапевтический эффект для матери превышает потенциальный риск для плода. Если существует необходимость применения препарата в период лактации, то грудное вскармливание необходимо прекратить.
Способ применения и дозы
Моночинкве ретард назначают по 50 мг (1 капс.) 1 раз/сут утром после еды, не разжевывая и запивая небольшим количеством жидкости. Дозу следует корректировать в зависимости от состояния пациента.
Побочное действие
При приеме Моночинкве ретард в рекомендуемой дозе Побочное эффекты не описаны. Однако, как и при применении других нитратов, возможно: Со стороны сердечно-сосудистой системы в начале лечения - нитратная головная боль, которая обычно уменьшается через несколько дней при продолжении терапии. после первого приема или после увеличения дозы - артериальная (в т.ч. ортостатическая) гипотензия, сопровождающаяся тахикардией, головокружением, слабостью. Со стороны пищеварительной системы очень редко - тошнота, рвота. Дерматологические реакции очень редко – покраснение лица и кожные аллергические реакции.
Передозировка
О случаях передозировки не сообщалось. Однако при возникновении симптомов передозировки рекомендуются общепринятые меры: вызвать рвоту, промыть желудок. Необходимо контролировать, не принимал ли пациент одновременно еще какие-либо лекарства, следить за параметрами гемодинамики.
Особые указания
Препарат не применяют для купирования приступов стенокардии. При артериальной гипертензии препарат применятся только под контролем врача. Препарат назначают как в виде монотерапии, так и в комбинации с бета-адреноблокаторами, блокаторами кальциевых каналов, ингибиторами АПФ, сердечными гликозидами или диуретиками. Влияние на способность к вождению автотранспорта и управлению механизмами: При приеме препарата возможно снижение способности к концентрации внимания и быстроты психомоторных реакций, в связи с чем не рекомендуется управление транспортными средствами и занятия другими потенциально опасными видами деятельности.
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