Панадол Таблетки, пачка, 12 шт, 500 мг, растворимые, для тела, шипучие

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Через 1-2 суток определяются признаки поражения печени (болезненность в области печени, повышение активности «печеночных» ферментов). Возможно развитие нарушения углеводного обмена и метаболического ацидоза. У взрослых пациентов поражение печени развивается после приема более 10 г парацетамола."}},{"type":"paragraph","data":{"text":"При наличии факторов, оказывающих влияние на токсичность парацетамола для печени, (см. раздел «Взаимодействие с другими препаратами», «Особые указания») поражение печени возможно после приема 5 и более грамм парацетамола. В тяжелых случаях передозировки в результате печеночной недостаточность может развиться энцефалопатия (нарушение функции мозга), кровотечения, гипогликемия, отек мозга, вплоть до летального исхода."}},{"type":"paragraph","data":{"text":"Возможно развитие острой почечной недостаточности с острым тубулярным некрозом, характерными признаками которого является боль в поясничной области, гематурия (примесь крови или эритроцитов в моче), протеинурия (повышенное содержание белка в моче), при этом тяжелое поражение печени может отсутствовать. Отмечались случаи нарушения сердечного ритма, панкреатита. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e При подозрении на передозировку, даже при отсутствии выраженных первых симптомов, необходимо прекратить применение препарата и немедленно обратиться за врачебной помощью. В течение 1 часа после передозировки рекомендуется промывание желудка и прием энтеросорбентов (активированный уголь, полифепан). Следует определить уровень парацетамола в плазме крови, но не ранее чем через 4 часа после передозировки (более ранние результаты недостоверны). Введение ацетилцистеина в течение 24 часов после передозировки."}},{"type":"paragraph","data":{"text":"Максимальное защитное действие обеспечивается в течение первых 8 часов после передозировки, со временем эффективность антидота резко падает. При необходимости вводят ацетилцистеин внутривенно. При отсутствии рвоты до поступления пациента в стационар возможно применение метионина. Необходимость в проведении дополнительных терапевтических мероприятий (дальнейшее введение метионина, в/в введение ацетилцистеина) определяется в зависимости от концентрации парацетамола в крови, а также от времени, прошедшего после его приема."}},{"type":"paragraph","data":{"text":"Лечение пациентов с серьезным нарушением функции печени через 24 часа после приема парацетамола должно проводиться совместно со специалистами токсикологического центра или специализированного отделения заболеваний печени.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении с индукторами микросомальных ферментов печени, средствами, обладающими гепатотоксическим действием, возникает риск усиления гепатотоксического действия парацетамола."}},{"type":"paragraph","data":{"text":"При одновременном применении с антикоагулянтами возможно небольшое или умеренно выраженное повышение протромбинового времени."}},{"type":"paragraph","data":{"text":"При одновременном применении с антихолинергическими средствами возможно уменьшение всасывания парацетамола."}},{"type":"paragraph","data":{"text":"При одновременном применении с пероральными контрацептивами ускоряется выведение парацетамола из организма и возможно уменьшение его анальгетического действия."}},{"type":"paragraph","data":{"text":"При одновременном применении с урикозурическими средствами снижается их эффективность."}},{"type":"paragraph","data":{"text":"При одновременном применении активированного угля снижается биодоступность парацетамола."}},{"type":"paragraph","data":{"text":"При одновременном применении с диазепамом возможно уменьшение экскреции диазепама."}},{"type":"paragraph","data":{"text":"Имеются сообщения о возможности усиления миелодепрессивного эффекта зидовудина при одновременном применении с парацетамолом. Описан случай тяжелого токсического поражения печени."}},{"type":"paragraph","data":{"text":"Описаны случаи проявлений токсического действия парацетамола при одновременном применении с изониазидом."}},{"type":"paragraph","data":{"text":"При одновременном применении с карбамазепином, фенитоином, фенобарбиталом, примидоном уменьшается эффективность парацетамола, что обусловлено повышением его метаболизма (процессов глюкуронизации и окисления) и выведения из организма. Описаны случаи гепатотоксичности при одновременном применении парацетамола и фенобарбитала."}},{"type":"paragraph","data":{"text":"При применении колестирамина в течение периода менее 1 ч после приема парацетамола возможно уменьшение абсорбции последнего."}},{"type":"paragraph","data":{"text":"При одновременном применении с ламотриджином умеренно повышается выведение ламотриджина из организма."}},{"type":"paragraph","data":{"text":"При одновременном применении с метоклопрамидом возможно увеличение абсорбции парацетамола и повышение его концентрации в плазме крови."}},{"type":"paragraph","data":{"text":"При одновременном применении с пробенецидом возможно уменьшение клиренса парацетамола; с рифампицином, сульфинпиразоном - возможно повышение клиренса парацетамола вследствие повышения его метаболизма в печени."}},{"type":"paragraph","data":{"text":"При одновременном применении с этинилэстрадиолом повышается всасывание парацетамола из кишечника."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"С осторожностью применяют у пациентов с нарушениями функции печени и почек, с доброкачественной гипербилирубинемией, а также у больных пожилого возраста."}},{"type":"paragraph","data":{"text":"При длительном применении парацетамола необходим контроль картины периферической крови и функционального состояния печени."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"По 2 таблетки в ламинированный стрип (крафт-беленая бумага/поли-этилен/фольга алюминиевая/полиэтилен или бумага со стеклянным покрытием/полиэтилен/фольга алюминиевая/сурлин)."}},{"type":"paragraph","data":{"text":"6 стрипов по 2 таблетки с инструкцией по применению в картонную коробку.\n\n"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nХранить при температуре не выше 25° С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/firm/4838\"\u003eГлаксоСмитКляйн Хелскер, АО\u003c/a\u003e (Россия)  "}}]}],"source":null},"description_toggle":false,"short_description":"Анальгетик-антипиретик. 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Механизм действия связан с ингибированием синтеза простагландинов, преимущественным влиянием на центр терморегуляции в гипоталамусе.","substance":[{"id":605,"title":"Парацетамол","title_latin":"Paracetamolum","slug":"paratsetamol_605"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Панадол - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60554/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60554/share_default/"}},"diseases":[{"id":"554","title":"Мигрень","slug":"554-migren"},{"id":"796","title":"Острая инфекция верхних отделов дыхательных путей неуточненная","slug":"796-ostraya_infektsiya_verhnih_otdelov_dyhatelnyh_putey_neutochnennaya"},{"id":"798","title":"Грипп, вызванный идентифицированным вирусом гриппа","slug":"798-gripp_vyzvannyy_identifitsirovannym_virusom_grippa"},{"id":"853","title":"Другие уточненные изменения зубов и их 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