Оказывает антигипоксическое действие. Нормализует энергетиче... Инструкция
Показания к применению
Кардиология: ишемическая болезнь сердца — профилактика приступов стабильной стенокардии (в составе комбинированной терапии).
Оториноларингология: лечение кохлео-вестибулярных нарушений ишемической природы (таких как головокружение, шум в ушах, нарушение слуха).
Офтальмология: хориоретинальные сосудистые нарушения с ишемическим компонентом.
Противопоказания
Повышенная чувствительность к компонентам препарата, тяжёлая почечная недостаточность (клиренс креатинина менее 15 мл/мин), выраженные нарушения функции печени, беременность, период лактации, возраст до 18 лет (эффективность и безопасность не установлены).
таблетки круглой формы, двояковыпуклые, покрытые оболочкой розового цвета. На поперечном разрезе видны два слоя.
Фармакологические свойства
Оказывает антигипоксическое действие. Нормализует энергетический метаболизм клеток, подвергшихся гипоксии или ишемии. Непосредственно влияя на кардиомиоциты и нейроны головного мозга, оптимизирует их метаболизм и функцию. Цитопротективный эффект обусловлен повышением энергетического потенциала, активацией окислительного декарбоксилирования и рационализацией потребления кислорода (усиление аэробного гликолиза и замедление окисления жирных кислот за счет селективного ингибирования длинноцепочечной 3-кетоацил-КоА-тиолазы).
Триметазидин поддерживает сократимость миокарда, предотвращает снижение внутриклеточного содержания аденозинтрифосфорной кислоты (АТФ) и креатинфосфата.
В условиях ацидоза нормализует функционирование ионных каналов мембран, препятствует накоплению ионов кальция и натрия в кардиомиоцитах, нормализует внутриклеточную концентрацию ионов калия.
Уменьшает внутриклеточный ацидоз и повышенное содержание фосфатов, обусловленное ишемией миокарда и реперфузией. Препятствует повреждающему действию свободных радикалов, сохраняет целостность клеточных мембран, предотвращает активацию нейтрофилов в зоне ишемии, увеличивает продолжительность электрического потенциала, уменьшает выход креатинфосфокиназы из клеток и выраженность ишемических повреждений миокарда.
При стенокардии сокращает частоту приступов, уменьшает потребность в приеме нитратов, через 2 недели лечения повышает толерантность к физической нагрузке, снижаются резкие колебания артериального давления. Уменьшает головокружение и шум в ушах ишемической этиологии. При сосудистой патологии глаз восстанавливает функциональную активность сетчатки глаза. После приема внутрь триметазидин быстро и практически полностью абсорбируется в желудочно-кишечном тракте. Прием пищи не влияет на фармакокинетические свойства препарата. Биодоступность — 90%. Время достижения максимальной концентрации в плазме крови — 3-5 ч. В течение суток концентрация в плазме крови остается на уровне, превышающем 75% концентрации, определяемой через 11 ч после приёма одной таблетки препарата. Равновесная концентрация в плазме крови достигается примерно через 60 ч от начала лечения. Объем распределения составляет 4,8 л/кг, связь с белками плазмы крови 16%. Легко проникает через гистогематические барьеры. Выводится в неизмененном виде, преимущественно почками (около 60%). Период полувыведения — около 7 ч, у пациентов старше 65 лет — около 12 ч. Почечный клиренс триметазидина прямо коррелирует с клиренсом креатинина (КК), печеночный клиренс снижается с возрастом.
Показания к применению
Кардиология: ишемическая болезнь сердца — профилактика приступов стабильной стенокардии (в составе комбинированной терапии).
Оториноларингология: лечение кохлео-вестибулярных нарушений ишемической природы (таких как головокружение, шум в ушах, нарушение слуха).
Офтальмология: хориоретинальные сосудистые нарушения с ишемическим компонентом.
Противопоказания
Повышенная чувствительность к компонентам препарата, тяжёлая почечная недостаточность (клиренс креатинина менее 15 мл/мин), выраженные нарушения функции печени, беременность, период лактации, возраст до 18 лет (эффективность и безопасность не установлены).
Способ применения и дозы
Внутрь, во время приема пищи.
Римекор МВ применяют по 1 таблетке 2 раза в сутки (утром и вечером).
При пропуске одного приёма, при втором приёме не следует удваивать дозу препарата.
Курс лечения — по рекомендации врача.
Побочное действие
Частота побочных эффектов: очень часто (более 1/10); часто (более 1/100 и менее 1/10); нечасто (более 1/1000 и менее 1/100); редко (более 1/10000 и менее 1/1000); очень редко (более 1/10000), в том числе, отдельные сообщения.
Со стороны пищеварительной системы
Часто: боль в животе, диарея, диспепсия, тошнота, рвота.
Со стороны сердечно-сосудистой системы
Редко: ортостатическая гипотензия, «приливы» крови к коже лица.
Со стороны центральной нервной системы
Часто: головокружение, головная боль, астения.
Очень редко: экстрапирамидные расстройства (тремор, ригидность, акинезия), обратимые после отмены препарата.
Со стороны кожных покровов
Часто: кожная сыпь, зуд, крапивница.
Передозировка
Данные о случаях передозировки ограничены. В случае передозировки следует проводить симптоматическую терапию.
Взаимодействие с другими лекарственными средствами
Нет сведений.
Особые указания
Римекор МВ не предназначен для купирования приступов стенокардии и не показан для начального курса терапии нестабильной стенокардии или инфаркта миокарда, а также при подготовке к госпитализации или в первые ее дни!!!
В случае развития приступа стенокардии следует пересмотреть и адаптировать лечение.
Из-за отсутствия соответствующих клинических данных применение препарата Римекор МВ не рекомендуется пациентам с почечной недостаточностью с клиренсом креатинина менее 15 мл/мин, а также пациентам с тяжелыми нарушениями функции печени.
Влияние на способность к вождению автотранспорта и управлению механизмами
Рекомендуется соблюдать осторожность при управлении транспортными средствами и занятиях другими потенциально опасными видами деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций.
Условия хранения
При температуре от 15 до 25 °C.
Хранить в недоступном для детей месте!
Срок годности
2 года. Не использовать после истечения срока годности.
Условия отпуска
По рецепту врача.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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На поперечном разрезе видны два слоя."}}]},{"id":3,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Оказывает антигипоксическое действие. Нормализует энергетический метаболизм клеток, подвергшихся гипоксии или ишемии. Непосредственно влияя на кардиомиоциты и нейроны головного мозга, оптимизирует их метаболизм и функцию. Цитопротективный эффект обусловлен повышением энергетического потенциала, активацией окислительного декарбоксилирования и рационализацией потребления кислорода (усиление аэробного гликолиза и замедление окисления жирных кислот за счет селективного ингибирования длинноцепочечной 3-кетоацил-КоА-тиолазы).\nТриметазидин поддерживает сократимость миокарда, предотвращает снижение внутриклеточного содержания аденозинтрифосфорной кислоты (АТФ) и креатинфосфата.\nВ условиях ацидоза нормализует функционирование ионных каналов мембран, препятствует накоплению ионов кальция и натрия в кардиомиоцитах, нормализует внутриклеточную концентрацию ионов калия.\nУменьшает внутриклеточный ацидоз и повышенное содержание фосфатов, обусловленное ишемией миокарда и реперфузией. Препятствует повреждающему действию свободных радикалов, сохраняет целостность клеточных мембран, предотвращает активацию нейтрофилов в зоне ишемии, увеличивает продолжительность электрического потенциала, уменьшает выход креатинфосфокиназы из клеток и выраженность ишемических повреждений миокарда.\nПри стенокардии сокращает частоту приступов, уменьшает потребность в приеме нитратов, через 2 недели лечения повышает толерантность к физической нагрузке, снижаются резкие колебания артериального давления. Уменьшает головокружение и шум в ушах ишемической этиологии. При сосудистой патологии глаз восстанавливает функциональную активность сетчатки глаза. После приема внутрь триметазидин быстро и практически полностью абсорбируется в желудочно-кишечном тракте. Прием пищи не влияет на фармакокинетические свойства препарата. Биодоступность — 90%. Время достижения максимальной концентрации в плазме крови — 3-5 ч. В течение суток концентрация в плазме крови остается на уровне, превышающем 75% концентрации, определяемой через 11 ч после приёма одной таблетки препарата. Равновесная концентрация в плазме крови достигается примерно через 60 ч от начала лечения. Объем распределения составляет 4,8 л/кг, связь с белками плазмы крови 16%. Легко проникает через гистогематические барьеры. Выводится в неизмененном виде, преимущественно почками (около 60%). Период полувыведения — около 7 ч, у пациентов старше 65 лет — около 12 ч. Почечный клиренс триметазидина прямо коррелирует с клиренсом креатинина (КК), печеночный клиренс снижается с возрастом."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Кардиология: ишемическая болезнь сердца — профилактика приступов стабильной стенокардии (в составе комбинированной терапии).\nОториноларингология: лечение кохлео-вестибулярных нарушений ишемической природы (таких как головокружение, шум в ушах, нарушение слуха).\nОфтальмология: хориоретинальные сосудистые нарушения с ишемическим компонентом."}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к компонентам препарата, тяжёлая почечная недостаточность (клиренс креатинина менее 15 мл/мин), выраженные нарушения функции печени, беременность, период лактации, возраст до 18 лет (эффективность и безопасность не установлены)."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь, во время приема пищи.\nРимекор МВ применяют по 1 таблетке 2 раза в сутки (утром и вечером).\nПри пропуске одного приёма, при втором приёме не следует удваивать дозу препарата.\nКурс лечения — по рекомендации врача."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота побочных эффектов: очень часто (более 1/10); часто (более 1/100 и менее 1/10); нечасто (более 1/1000 и менее 1/100); редко (более 1/10000 и менее 1/1000); очень редко (более 1/10000), в том числе, отдельные сообщения.\nСо стороны пищеварительной системы\nЧасто: боль в животе, диарея, диспепсия, тошнота, рвота.\nСо стороны сердечно-сосудистой системы\nРедко: ортостатическая гипотензия, «приливы» крови к коже лица.\nСо стороны центральной нервной системы\nЧасто: головокружение, головная боль, астения.\nОчень редко: экстрапирамидные расстройства (тремор, ригидность, акинезия), обратимые после отмены препарата.\nСо стороны кожных покровов\nЧасто: кожная сыпь, зуд, крапивница."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Данные о случаях передозировки ограничены. В случае передозировки следует проводить симптоматическую терапию."}}]},{"id":9,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Нет сведений."}}]},{"id":10,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Римекор МВ не предназначен для купирования приступов стенокардии и не показан для начального курса терапии нестабильной стенокардии или инфаркта миокарда, а также при подготовке к госпитализации или в первые ее дни!!!\nВ случае развития приступа стенокардии следует пересмотреть и адаптировать лечение.\nИз-за отсутствия соответствующих клинических данных применение препарата Римекор МВ не рекомендуется пациентам с почечной недостаточностью с клиренсом креатинина менее 15 мл/мин, а также пациентам с тяжелыми нарушениями функции печени.\nВлияние на способность к вождению автотранспорта и управлению механизмами\nРекомендуется соблюдать осторожность при управлении транспортными средствами и занятиях другими потенциально опасными видами деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":11,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При температуре от 15 до 25 °C.\nХранить в недоступном для детей месте!"}}]},{"id":12,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"2 года. 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