Взрослые: Для профилактики и в составе комплексной терапии различных заболеваний сердечно-сосудистой системы:- хроническая сердечная недостаточность- дилатационная кардиомиопатия- ишемическая болезнь сердца, в том числе инфаркт миокарда (в период восстановительной терапии),- аритмии,- артериальная гипертензия,- период подготовки к проведению операций ...
Действующее вещество: Убидекаренон (Ubidecarenone)Концентрация действующего вещества (мг): 30
Фармакологические свойства
Препарат, нормализующий метаболизм миокарда, уменьшающий гипоксию тканей. Убидекаренон (коэнзим Q10, убихинон) - природное вещество, являющееся витаминоподобным коферментом. Убидекаренон является эндогенным субстратом, принимает участие в переносе электронов в транспортной цепочке окислительно- восстановительных процессов, в процессе обмена энергии, в реакции окислительного фосфорилирования в дыхательной цепи митохондрий клеток. Участвует в процессах клеточного дыхания, увеличивая синтез АТФ. Оказывает клинически значимое антиоксидантное действие. Предохраняет липиды клеточных мембран от перекисного окисления. Сокращает зону повреждения миокарда в условиях ишемии и реперфузии. Убидекаренон препятствует удлинению интервала QT, улучшает переносимость физической нагрузки. За счет эндогенного синтеза 100% удовлетворение потребности организма в коэнзиме Q10 происходит только до 20-летнего возраста. Концентрация коэнзима Q10 снижается у пациентов пожилого возраста, а также при различных заболеваниях как у взрослых, так и у детей.
Показания к применению
Взрослые: Для профилактики и в составе комплексной терапии различных заболеваний сердечно-сосудистой системы:- хроническая сердечная недостаточность- дилатационная кардиомиопатия- ишемическая болезнь сердца, в том числе инфаркт миокарда (в период восстановительной терапии),- аритмии,- артериальная гипертензия,- период подготовки к проведению операций на сердце (аортокоронарное шунтирование, при пороках сердца). Дети (с 1 года): Для профилактики и в составе комплексной терапии: заболеваний сердечно-сосудистой системы:- аритмии,- хроническая сердечная недостаточность,- дилатационная кардиомиопатия,- период подготовки к проведению операций на сердце (врожденные и приобретенные пороки); заболеваний желудочно-кишечного тракта:- хронический гастродуоденит; заболеваний почек:- хронический пиелонефрит,- метаболическая нефропатия; заболеваний нервной системы (в том числе наследственных нейродегенеративных заболеваний):- мигрень,- расстройства вегетативной нервной системы (нейро-циркуляторная дистония),- митохондриальная энцефаломиопатия (MELAS синдром), синдром Лейга,- туберозный склероз,- врожденные миопатии, мышечные дистрофии. В комплексной терапии заболеваний, связанных с нарушением обменных процессов:- астенический синдром- восстановительный период после тяжелых заболеваний и хирургических вмешательствВзрослые и дети (с 1 года):- для профилактики и восполнения недостаточности коэнзима Q10- для улучшения адаптации к повышенным физическим нагрузкам у спортсменов.
Противопоказания
Повышенная чувствительность к компонентам препарата. Детский возраст до 1 года.
Применение при беременности и в период грудного вскармливания
Препарат не рекомендуется назначать при беременности и в период грудного вскармливания в связи с отсутствием достаточного опыта клинического применения.
Способ применения и дозы
Взрослым и детям старше 14 лет по 10-11 капель (0,5 мл) 1 раз в день во время еды, предварительно растворив в небольшом количестве воды или иного напитка. Перед применением рекомендуется проконсультироваться с врачом.
Побочное действие
Возможны аллергические реакции. Очень редко: тошнота, диарея.
Передозировка
Случаев передозировки препарата Кудесан не наблюдалось.
Особые указания
Перед началом применения гормональной контрацепции и в последующем каждые 6 мес рекомендуется общемедицинское и гинекологическое обследование, включающее в себя цитологический анализ мазка с шейки матки, оценку состояния молочных желез, определение глюкозы крови, холестерина и других показателей функции печени, контроль АД, анализ мочи. Назначение Ригевидона женщинам с тромбоэмболическими заболеваниями в молодом возрасте и повышением свертываемости крови в семейном анамнезе не рекомендуется. Применение пероральной контрацепции допускается не ранее, чем через 6 мес после перенесенного вирусного гепатита при условии нормализации функций печени. При появлении резких болей в верхних отделах живота, гепатомегалии и признаков интраабдоминального кровотечения может возникнуть подозрение на наличие опухоли печени. В случае необходимости прием препарата следует прекратить. При нарушении функции печени во время приема Ригевидона необходима консультация терапевта. При появлении ациклических (межменструальных) кровотечений прием Ригевидона следует продолжать, т.к. в большинстве случаев эти кровотечения спонтанно прекращаются. Если ациклические (межменструальные) кровотечения не исчезают или повторяются, следует провести медицинское обследование для исключения органической патологии репродуктивной системы. В случае рвоты или диареи прием препарата следует продолжать, применяя другой, негормональный метод контрацепции. У курящих женщин, принимающих гормональные контрацептивы, имеется повышенный риск развития сердечно-сосудистых заболеваний с серьезными последствиями (инфаркт миокарда, инсульт). Риск увеличивается с возрастом и в зависимости от количества выкуриваемых сигарет (особенно у женщин старше 35 лет). Прием препарата следует прекратить в следующих случаях:- при появлении впервые или усилении мигренеподобной головной боли;- при появлении непривычно сильной головной боли;- при появлении ранних признаков флебита или флеботромбоза (непривычные боли или вздутие вен на ногах);- при возникновении желтухи или гепатита без желтухи;- при цереброваскулярных расстройствах;- при появлении колющих болей неясной этиологии при дыхании или кашле, боли и чувства стеснения в грудной клетке;- при остром ухудшении остроты зрения;- при подозрении на тромбоз или инфаркт;- при резком повышении АД;- при возникновении генерализованного зуда;- при учащении эпилептических припадков;- за 3 месяца до планируемой беременности;- ориентировочно за 6 недель до планируемого хирургического вмешательства;- при длительной иммобилизации;- при наступившей беременности. Влияние на способность к вождению автотранспорта и управлению механизмамиПрием препарата не влияет на способность к вождению транспортных средств и к управлению другими механизмами, работа с которыми связана с повышенным риском травматизма.
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