Кратковременное лечение болевого синдрома различного происхождения
Симптоматическая терапия ревматических заболеваний (ревматоидный артрит, остеоартроз, анкилозирующий спондилит, суставной синдром при обострении подагры, ревматическое поражение мягких тканей)
Противопоказания
Полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других НПВП (в т.ч. в анамнезе)
Геморрагический диатез или нарушения свертываемости крови
Недавно перенесенные операции, сопряженные с риском кровотечения или неполного гемостаза
Период после проведения аортокоронарного шунтирования
НПВС. Оказывает выраженное обезболивающее и противовоспалительное действие. Лорноксикам обладает сложным механизмом действия, в основе которого лежит подавление синтеза простагландинов, обусловленное угнетением активности изоферментов ЦОГ. Кроме того, лорноксикам угнетает высвобождение свободных радикалов кислорода из активированных лейкоцитов. Анальгетический эффект лорноксикама не связан с наркотическим действием. Препарат Ксефокам не оказывает опиатоподобного действия на ЦНС и, в отличие от наркотических анальгетиков, не угнетает дыхания, не вызывает лекарственной зависимости.
Показания к применению
Кратковременное лечение болевого синдрома различного происхождения
Симптоматическая терапия ревматических заболеваний (ревматоидный артрит, остеоартроз, анкилозирующий спондилит, суставной синдром при обострении подагры, ревматическое поражение мягких тканей)
Противопоказания
Полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других НПВП (в т.ч. в анамнезе)
Геморрагический диатез или нарушения свертываемости крови
Недавно перенесенные операции, сопряженные с риском кровотечения или неполного гемостаза
Период после проведения аортокоронарного шунтирования
Эрозивно-язвенные изменения слизистой желудка или двенадцатиперстной кишки, активное желудочно-кишечное кровотечение
Цереброваскулярное или иное кровотечение
Рецидивирующая язва желудка или повторные ЖКТ кровотечения
ЖКТ кровотечения, связанные с приемом НПВП в анамнезе
Детский и подростковый возраст до 18 лет (из-за отсутствия клинических данных по его применению у этой возрастной группы)
Повышенная чувствительность/аллергия к лорноксикаму или к одному из компонентов препарата. С осторожностью: эрозивно-язвенные поражения и кровотечения из ЖКТ (в анамнезе)умеренно выраженная почечная недостаточность, КК менее 60 мл/минсостояния после хирургических вмешательствИБС, хроническая сердечная недостаточностьцереброваскулярные заболеваниядислипидемия/гиперлипидемиясахарный диабетзаболевания периферических артерийналичие инфекции Helicobacter pyloriдлительное применение НПВПтяжелые соматические заболеванияодновременное применение пероральных ГКС (в т.ч. преднизолона), антикоагулянтов (в т.ч. варфарина), антиагрегантов (в т.ч. клопидогрела), селективных ингибиторов обратного захвата серотонина (в т.ч. циталопрама, флуоксетина, пароксетина, сертралина)курение, алкоголизмвозраст старше 65 лет
Применение при беременности и в период грудного вскармливания
Применение препарата противопоказано при беременности и в период лактации.
Побочное действие
Со стороны пищеварительной системы: диспепсия, боль в животе, сухость во рту, стоматит, тошнота, рвота, изжога, диарея . эзофагит, гастрит, эрозивно-язвенные поражения слизистой оболочки желудка и кишечника в т.ч. с перфорацией и кровотечением, запор, метеоризм, мелена, нарушение функции печени, повышение уровня печеночных трансаминаз. Со стороны нервной системы: головная боль, головокружение, сонливость, нарушения сна, депрессия, возбуждение, тремор, асептический менингит, парестезии. Со стороны органов чувств: шум в ушах, нарушение зрения. Со стороны сердечно-сосудистой системы: развитие или усугубление сердечной недостаточности, тахикардия, повышение АД. Со стороны органов дыхания: фарингит, ринит, диспноэ, кашель, бронхоспазм. Со стороны мочевыделительной системы: дизурия, снижение клубочковой фильтрации, интерстициальный нефрит, гломерулонефрит, папиллярный некроз, нефротическнй синдром, периферические отеки, острая почечная недостаточность. Со стороны кожных покровов и подкожно-жировой клетчатки: отечный синдром, экхимозы, кожная сыпь, зуд, крапивница, алопеция, синдром Стивенса-Джонсона, синдром Лайелла, ангионевротический отек. Со стороны органов кроветворения и системы гемостаза: агранулоцитоз, лейкопения, анемия, тромбоцитопения, увеличение времени кровотечения. Прочие: анорексия, усиление потоотделения, изменение массы тела, артралгии, миалгии.
Особые указания
Со стороны пищеварительной системы: диспепсия, боль в животе, сухость во рту, стоматит, тошнота, рвота, изжога, диарея . эзофагит, гастрит, эрозивно-язвенные поражения слизистой оболочки желудка и кишечника в т.ч. с перфорацией и кровотечением, запор, метеоризм, мелена, нарушение функции печени, повышение уровня печеночных трансаминаз. Со стороны нервной системы: головная боль, головокружение, сонливость, нарушения сна, депрессия, возбуждение, тремор, асептический менингит, парестезии. Со стороны органов чувств: шум в ушах, нарушение зрения. Со стороны сердечно-сосудистой системы: развитие или усугубление сердечной недостаточности, тахикардия, повышение АД. Со стороны органов дыхания: фарингит, ринит, диспноэ, кашель, бронхоспазм. Со стороны мочевыделительной системы: дизурия, снижение клубочковой фильтрации, интерстициальный нефрит, гломерулонефрит, папиллярный некроз, нефротическнй синдром, периферические отеки, острая почечная недостаточность. Со стороны кожных покровов и подкожно-жировой клетчатки: отечный синдром, экхимозы, кожная сыпь, зуд, крапивница, алопеция, синдром Стивенса-Джонсона, синдром Лайелла, ангионевротический отек. Со стороны органов кроветворения и системы гемостаза: агранулоцитоз, лейкопения, анемия, тромбоцитопения, увеличение времени кровотечения. Прочие: анорексия, усиление потоотделения, изменение массы тела, артралгии, миалгии.
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