Но-шпа Таблетки, флакон, 60 шт, 40 мг, для приема внутрь, с дозатором

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Однако, при\nнеобходимости применения препарата Но-шпа® во время беременности, следует соблюдать\nосторожность, и назначать препарат только после оценки соотношения потенциальной\nпользы для матери и возможного риска для плода.\u003cbr /\u003e"}},{"type":"list","data":{"style":"unordered","items":["В связи с отсутствием исследований на животных и клинических данных, назначать"]}},{"type":"paragraph","data":{"text":"дротаверин в период грудного вскармливания не рекомендуется."}}]},{"id":7,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Взрослые\u003cbr /\u003e\nПо 1-2 таблетки на один прием 2-3 раза в день. 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В случаях, когда дротаверин применяется в качестве\nвспомогательной терапии, продолжительность лечения без консультации с врачом может быть\nбольше (2-3 дня). Если болевой синдром сохраняется, пациенту следует обратиться к врачу.\u003cbr /\u003e\nПри использовании флакона с полиэтиленовой пробкой, снабженной штучным дозатором:\u003cbr /\u003e\nперед использованием удалить защитную полоску с верхней части флакона и наклейку со дна\nфлакона. Расположить флакон в ладони таким образом, чтобы дозирующее отверстие на донышке\nне упиралось в ладонь. Затем надавить на верхнюю часть флакона, в результате чего одна таблетка\nвыпадет из дозирующего отверстия на донышке."}}]},{"id":8,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Ниже представлены неблагоприятные реакции, наблюдавшиеся в клинических исследованиях,\nразделенные по системам органов с указанием частоты их возникновения в соответствии со\nследующими градациями, рекомендованными Всемирной Организацией Здравоохранения: очень\nчасто (≥10 %); часто (≥1 %, \u003c10 %); нечасто (≥0,1 %, \u003c1 %); редко (≥0,01 %, \u003c0,1 %); очень редко, \nвключая отдельные сообщения (\u003c0,01 %); частота неизвестна (по имеющимся данным частоту\nопределить нельзя).\u003cbr /\u003e\nСо стороны нервной системы\u003cbr /\u003e\nРедкие: головная боль, головокружение, бессонница.\u003cbr /\u003e\nСо стороны сердечно-сосудистой системы\u003cbr /\u003e\nРедкие: ощущение сердцебиения, снижение артериального давления.\u003cbr /\u003e\nСо стороны желудочно-кишечного тракта\u003cbr /\u003e\nРедкие: тошнота, запор.\u003cbr /\u003e\nСо стороны иммунной системы\u003cbr /\u003e\nРедкие: аллергические реакции (ангионевротический отек, крапивница, сыпь, зуд) (см. раздел\n«Противопоказания»)."}}]},{"id":9,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Передозировка дротаверина ассоциировалась с нарушениями сердечного ритма и проводимости,\nвключая полную блокаду ножек пучка Гиса и остановку сердца, которая может быть фатальной.\nВ случае передозировки пациенты должны находиться под медицинским наблюдением, и при\nнеобходимости, им должно проводиться симптоматическое и направленное на поддержание\nосновных функций организма лечение, включая искусственное вызывание рвоты или промывание\nжелудка."}}]},{"id":10,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"С леводопой\u003cbr /\u003e\nИнгибиторы фосфодиэстеразы, подобные папаверину, снижают антипаркинсоническое действие\nлеводопы. При назначении дротаверина одновременно с леводопой возможно усиление\nригидности и тремора.\u003cbr /\u003e\nС другими спазмолитическими средствами, включая м-холиноблокаторы\nВзаимное усиление спазмолитического действия."}}]},{"id":11,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Каждая таблетка препарата Но-шпа® 40 мг содержит 52 мг лактозы моногидрата. Это может\nвызывать желудочно-кишечные жалобы у пациентов с непереносимостью лактозы. Данная форма\nнеприемлема для пациентов с дефицитом лактазы, галактоземией или синдромом нарушенной\nабсорбции глюкозы/галактозы (см. раздел «Противопоказания»)."}}]},{"id":12,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Для таблеток в блистерах Алюминий/Алюминий: 5 лет.\u003cbr /\u003e\nДля таблеток в блистерах ПВХ/Алюминий: 3 года.\u003cbr /\u003e\nДля таблеток во флаконах: 5 лет.\u003cbr /\u003e\nНе применять препарат после истечения срока годности, указанного на упаковке."}}]},{"id":13,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Для таблеток в блистерах Алюминий/Алюминий: хранить при температуре не выше 30 °С.\u003cbr /\u003e\nДля таблеток в блистерах ПВХ/Алюминий: хранить при температуре не выше 25 °С.\u003cbr /\u003e\nДля таблеток во флаконах: хранить в оригинальной упаковке при температуре от 15 С до 25 С.\u003cbr /\u003e\nХранить в недоступном для детей месте"}}]},{"id":14,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]}],"source":null},"description_toggle":false,"short_description":"Дротаверин представляет собой производное изохинолина, которое проявляет мощное спазмолитическое действие на гладкую мускулатуру за счет ингибирования фермента фосфодиэстеразы IV типа (ФДЭ IV). Ингибирование фермента ФДЭ IV приводит к повышению концентрации цАМФ, инактивации киназы легкой цепи миозина, что в дальнейшем вызывает расслабление гладкой мускулатуры. Снижающий концентрацию ионов Ca2+ эффект дротаверина через цАМФ объясняет антагонистический эффект дротаверина по отношению к ионам Ca2+ In vitro дротаверин ингибирует фермент ФДЭ IV без ингибирования ферментов ФДЭ III и ФДЭ V. Поэтому эффективность дротаверина зависит от концентраций ФДЭ IV в разных тканях. ФДЭ IV наиболее важна для подавления сократительной активности гладкой мускулатуры, в связи с чем селективное ингибирование ФДЭ IV может быть полезным для лечения гиперкинетических дискинезий и различных заболеваний, сопровождающихся спастическим состоянием желудочнокишечного тракта. Гидролиз цАМФ в миокарде и гладкой мускулатуре сосудов происходит, главным образом, с помощью фермента ФДЭ III, чем объясняется тот факт, что при высокой спазмолитической активности у дротаверина отсутствуют серьезные побочные эффекты со стороны сердца и сосудов и выраженные эффекты в отношении сердечно-сосудистой системы. Дротаверин эффективен при спазмах гладкой мускулатуры как нейрогенного, так и мышечного происхождения. Независимо от типа вегетативной иннервации, дротаверин расслабляет гладкую мускулатуру желудочно-кишечного тракта, желчевыводящих путей, мочеполовой системы. Вследствие своего сосудорасширяющего действия дротаверин улучшает кровоснабжение тканей. 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