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Comparison of the efficacy and skin permeability of topical NSAID preparations used in Europe // European Journal of Pharmaceutical Sciences. 2012. № 5 (47). C. 890–895. Комацу Т., Сакурада Т. Сравнение эффективности и проницаемости через кожу местных препаратов НПВП, используемых в Европе // Европейский журнал фармацевтических наук. 2012. № 5 (47). С. 890–895."}},{"type":"paragraph","data":{"text":"****Денисов Л.Н., Иванова О.Н., Сороцкая В.Н. Повышает ли комбинация нестероидных ментола эффективность локальной терапии? // Научно-практическая ревматология. 2006. (1). C. 34–39."}},{"type":"paragraph","data":{"text":"Описание"}},{"type":"paragraph","data":{"text":"прозрачный или полупрозрачный однородный гель от желтоватого до красновато-коричневого цвета с характерным запахом. Допускается наличие опалесценции и пузырьков воздуха.\n\n"}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/pharm-group/829\"\u003eНестероидное противовоспалительное средство для наружного применения\u003c/a\u003e"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"НПВС. При местном применении оказывает обезболивающее, противовоспалительное и противоотечное действие. Механизм действия связан с подавлением активности ферментов ЦОГ-1 и ЦОГ-2, регулирующих синтез простагландинов. При применении в виде геля обеспечивает местный лечебный эффект в отношении пораженных суставов, сухожилий, связок, мышц. При суставном синдроме уменьшает боль в суставах в покое и при движении, утреннюю скованность и припухлость суставов. Не оказывает повреждающего действия на суставной хрящ."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nОстрые и хронические воспалительные заболевания опорно-двигательного аппарата (воспалительное поражение связок и сухожилий, остеоартроз, остеохондроз с корешковым синдромом, радикулит, бурсит, ишиас, люмбаго, суставной синдром при обострении подагры);"}},{"type":"paragraph","data":{"text":"- мышечные боли ревматического и неревматического происхождения;"}},{"type":"paragraph","data":{"text":"- посттравматическое воспаление мягких тканей и опорно-двигательного аппарата (повреждения и разрывы связок, ушибы)."}},{"type":"paragraph","data":{"text":"Препарат предназначен для симптоматической терапии, уменьшения боли и воспаления на момент использования, на прогрессирование заболевания не влияет.\n\n"}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\n\n- индивидуальная повышенная чувствительность к кетопрофену или другим компонентам препарата;"}},{"type":"paragraph","data":{"text":"- повышенная чувствительность к ацетилсалициловой кислоте или другим нестероидным противовоспалительным препаратам (НПВП) (указание в анамнезе на бронхоспазм, крапивницу или ринит, вызванные приемом ацетилсалициловой кислоты), тиапрофеновой кислоте и фенофибрату;"}},{"type":"paragraph","data":{"text":"- полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа и околоносовых пазух, и непереносимости ацетилсалициловой кислоты или других НПВП"}},{"type":"paragraph","data":{"text":"(в т.ч. в анамнезе);"}},{"type":"paragraph","data":{"text":"- повышенная чувствительность кожи к воздействию солнечного излучения (фотосенсибилизация) в анамнезе;"}},{"type":"paragraph","data":{"text":"- кожная аллергия в анамнезе на солнцезащитные средства или парфюмерию;"}},{"type":"paragraph","data":{"text":"- воздействие солнечных лучей на обрабатываемые участки, включая солярий, в течение курса применения препарата и 2 недели после;"}},{"type":"paragraph","data":{"text":"- повреждение кожных покровов (мокнущие дерматозы, экзема, инфицированные ссадины, раны) в месте предполагаемого нанесения;"}},{"type":"paragraph","data":{"text":"- беременность (III триместр), период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"- детский возраст до 18 лет.\n\n"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\n\nЭрозивно-язвенное поражение желудочно-кишечного тракта, тяжелые нарушения функции почек и печени, печеночная порфирия, хроническая сердечная недостаточность, бронхиальная астма, пожилой возраст, беременность (I и II триместр)."}},{"type":"paragraph","data":{"text":"Если у Вас одно из перечисленных заболеваний/состояний, перед приемом препарата обязательно проконсультируйтесь с врачом.\n\n"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\n\nПрименение препарата противопоказано в III триместре беременности. В I и II триместрах беременности применение препарата возможно только после консультации с врачом, в том случае, если предполагаемая польза для матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"При необходимости применения препарата в период грудного вскармливания следует прекратить грудное вскармливание.\n\n"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nПрепарат предназначен для наружного применения."}},{"type":"paragraph","data":{"text":"Гель следует наносить на чистую сухую кожу. Небольшое количество геля (3-5 см) наносят тонким слоем, с последующим осторожным втиранием в воспаленные или болезненные участки тела."}},{"type":"paragraph","data":{"text":"Препарат следует наносить 2-3 раза в день."}},{"type":"paragraph","data":{"text":"Продолжительность курса лечения не должна превышать 14 дней.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nПобочные реакции перечислены с указанием частоты возникновения в соответствии с классификацией ВОЗ: очень часто (с частотой более 1/10), часто (с частотой не менее 1/100, но менее 1/10), нечасто (с частотой не менее 1/1000, но менее 1/100), редко (с частотой не менее 1/10000, но менее 1/1000), очень редко (с частотой менее 1/10000, включая единичные сообщения), частота неизвестна (не может быть установлена по имеющимся данным)."}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов:"}},{"type":"paragraph","data":{"text":"нечасто: эритема, зуд, экзема; редко: фотосенсибилизация, буллезный дерматит, крапивница; очень редко: контактный дерматит, ангионевротический отек."}},{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта:"}},{"type":"paragraph","data":{"text":"очень редко: пептическая язва, кровотечение, диарея."}},{"type":"paragraph","data":{"text":"Со стороны иммунной системы:"}},{"type":"paragraph","data":{"text":"очень редко: анафилактические реакции, реакции гиперчувствительности."}},{"type":"paragraph","data":{"text":"Со стороны мочевыделительной системы:"}},{"type":"paragraph","data":{"text":"очень редко: усугубление течения почечной недостаточности."}},{"type":"paragraph","data":{"text":"При появлении этих или других побочных эффектов необходимо прекратить применение препарата и обратиться к врачу.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nПри случайном применении препарата в дозе, превышающей рекомендованную, риск развития симптомов передозировки минимален в связи с крайне низкой системной абсорбцией кетопрофена при наружном применении."}},{"type":"paragraph","data":{"text":"При появлении местных побочных эффектов следует отменить препарат и промыть место нанесения."}},{"type":"paragraph","data":{"text":"При случайном проглатывании больших количеств геля возможно появление системных нежелательных реакций, характерных для НПВП. Необходимо промывание желудка, прием активированного угля.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nПрепарат может усиливать действие препаратов, вызывающих фотосенсибилизацию."}},{"type":"paragraph","data":{"text":"Несмотря на незначительную степень абсорбции кетопрофена через кожу, при частом и длительном применении могут появиться симптомы взаимодействия с другими препаратами (такие же, как при системном применении)."}},{"type":"paragraph","data":{"text":"При совместном применении с другими НПВП, глюкокортикоидами, этанолом, кортикотропином возможно образование язв в желудочно-кишечном тракте и развитие желудочно-кишечных кровотечений."}},{"type":"paragraph","data":{"text":"Пациентам, принимающим антикоагулянты кумаринового ряда, рекомендуется проводить регулярный контроль международного нормализованного отношения (МНО)."}},{"type":"paragraph","data":{"text":"При совместном применении кетопрофен усиливает токсичность метотрексата."}},{"type":"paragraph","data":{"text":"Входящий в состав вспомогательных веществ диметилсульфоксид усиливает проникновение лекарственных средств через кожу.\n\n"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nГель следует наносить только на неповрежденные участки кожи, избегая попадания на открытые раны, в глаза и на слизистые оболочки."}},{"type":"paragraph","data":{"text":"После нанесения препарата необходимо вымыть руки."}},{"type":"paragraph","data":{"text":"Допускается образование прозрачной пленки на коже в месте нанесения геля."}},{"type":"paragraph","data":{"text":"Не применять с окклюзионными повязками."}},{"type":"paragraph","data":{"text":"Можно использовать при фонофорезе."}},{"type":"paragraph","data":{"text":"При нанесении на кожу возможно ощущение чувства тепла и в редких случаях – жжения в области нанесения, которое может быть связано с разогревающим действием перца стручкового плодов настойки и камфоры."}},{"type":"paragraph","data":{"text":"Длительное применение местных средств может приводить к повышению чувствительности и появлению симптомов раздражения кожи в месте нанесения."}},{"type":"paragraph","data":{"text":"Во избежание проявлений фоточувствительности, рекомендуется избегать воздействия на кожу прямых солнечных лучей в течение курса лечения, а также по прошествии двух недель после последнего применения препарата (в том числе не посещать солярий)."}},{"type":"paragraph","data":{"text":"При длительном применении препарата в больших количествах в очень редких случаях возможно возникновение системных побочных эффектов (реакции гиперчувствительности, нарушения со стороны желудочно-кишечного тракта, усугубление течения почечной недостаточности)."}},{"type":"paragraph","data":{"text":"Пациентам с тяжелой почечной, сердечной или печеночной недостаточностью следует соблюдать осторожность при применении кетопрофена."}},{"type":"paragraph","data":{"text":"Риск возникновения системных побочных эффектов увеличивается в зависимости от количества наносимого геля, площади обрабатываемого участка кожи, состояния кожного покрова, длительности."}},{"type":"paragraph","data":{"text":"Следует прекратить применение препарата в случае возникновения любой кожной реакции, включая реакции при одновременном нанесении солнцезащитных или других косметических средств, содержащих органический солнцезащитный фильтр октокрилен.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не влияет на способность управлять транспортными средствами и работу с механизмами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Гель для наружного применения, 5 %."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nПри температуре не выше 25 ºС."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЗАО \"ЛЕККО\""}}]}],"source":null},"description_toggle":false,"short_description":"НПВС. При местном применении оказывает обезболивающее, противовоспалительное и противоотечное действие. Механизм действия связан с подавлением активности ферментов ЦОГ-1 и ЦОГ-2, регулирующих синтез простагландинов. При применении в виде геля обеспечивает местный лечебный эффект в отношении пораженных суставов, сухожилий, связок, мышц. При суставном синдроме уменьшает боль в суставах в покое и при движении, утреннюю скованность и припухлость суставов. Не оказывает повреждающего действия на суставной хрящ.","substance":[{"id":94,"title":"Кетопрофен","title_latin":"Ketoprophenum","slug":"ketoprofen_94"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Пенталгин экстра-гель - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60828/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60828/share_default/"}},"diseases":[],"other_packages":[{"id":106948,"title":"Пенталгин экстра-гель","subtitle":{"full":"Гель, туба, 30 г, 5 %, для наружного применения","short":"Гель, 30 г, 5 %","package":"30 г, 5 %"},"prescription":false,"catalog_section_id":78,"manufacturer":{"id":5310,"title":"Лекко","slug":"lekko_5310","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Гель","slug":"106948-pentalgin_ekstragel","attributes":{"count":"30 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