Действующее вещество: Метформина гидрохлорид, саксаглиптин; Концентрация действующего вещества (мг): 1002,5
Фармакологические свойства
Данные не предоставлены.
Показания к применению
Сахарный диабет 2 типа в сочетании с диетой и физическими упражнениями для улучшения гликемического контроля.
Противопоказания
Повышенная индивидуальная чувствительность к любому компоненту препарата
Серьезные реакции повышенной чувствительности (анафилаксия или ангионевротический отек) к ингибиторам ДПП-4
Сахарный диабет 1 типа (применение не изучено)
Применение совместно с инсулином (не изучено)
Врожденные непереносимость галактозы, лактазная недостаточность и глюкозо-галактозная мальабсорбция
Беременность, лактация
Возраст до 18 лет (безопасность и эффективность не изучены)
Нарушения функции почек (сывороточный креатинин ≥1,5мг/дл [мужчины], ≥1,4 мг/дл [женщины] или снижен клиренс креатинина), в том числе обусловленные острой сердечно-сосудистой недостаточностью (шоком), острым инфарктом миокарда и септицемией
Острые заболевания, при которых имеется риск развития нарушения функции почек: дегидратация (при рвоте, диарее), лихорадка, тяжелые инфекционные заболевания, состояния гипоксии (шок, сепсис, инфекции почек, бронхо-легочные заболевания)
Острый или хронический метаболический ацидоз, включая диабетический кетоацидоз, с комой или без комы
Клинически выраженные проявления острых и хронических заболеваний, которые могут привести к развитию тканевой гипоксии (дыхательная недостаточность, сердечная недостаточность, острый инфаркт миокарда)
Серьезные хирургические операции и травмы (когда показано проведение инсулинотерапии)
Нарушения функции печени
Хронический алкоголизм и острое отравление этанолом
Лактоацидоз (в т. ч. в анамнезе)
Период не менее 48 ч до и в течение 48 ч после проведения радиоизотопных или рентгенологических исследований с введением йодсодержащих контрастных средств
Соблюдение гипокалорийной диеты; С осторожностью; У лиц в возрасте старше 60 лет, выполняющих тяжелую физическую работу (повышенная опасность развития лактоацидоза) и пациентов с панкреатитом в анамнезе (связь между приемом препарата и повышенным риском развития панкреатита не установлена)
Применение при беременности и в период грудного вскармливания
Данные не предоставлены.
Способ применения и дозы
Внутрь, один раз в сутки во время ужина. Таблетки следует проглатывать целиком, не разжевывая, не измельчая и не разламывая. Дозу следует подбирать индивидуально. Обычно при терапии комбинированным препаратом, содержащим саксаглиптин и метформин, доза саксаглиптина составляет 5 мг один раз в сутки. Рекомендуемая начальная доза метформина модифицированного высвобождения является 500 мг один раз в сутки, ее можно повысить до 2000 мг один раз в сутки, что обеспечивается приемом 2 таблеток 2,5 мг/1000 мг, принятых 1 раз в сутки. Дозу метформина повышают постепенно, чтобы уменьшить риск побочных эффектов со стороны ЖКТ. Максимальная суточная доза: саксаглиптина 5 мг и метформина модифицированного высвобождения 2000 мг. ;
В настоящее время о случаях передозировки препарата не сообщалось.
Особые указания
Данные не предоставлены.
Для описания товара использована информация от партнера 36.6
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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