КомплигамВ Раствор, ампулы, 10 шт, 2 мл, для внутримышечного введения

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В связи с отсутствием значительных запасов витамина в организме он должен поступать в организм ежедневно."}},{"type":"paragraph","data":{"text":"Тиамин проникает через гематоэнцефалический и плацентарный барьеры, обнаруживается в материнском молоке. Тиамин выводится с мочой в альфа-фазе через 0,15 часа, в бета-фазе - через 1 час и в терминальной фазе - в течение 2 дней. Основными метаболитами являются: тиаминкарбоновая кислота, пирамин и некоторые неизвестные метаболиты. Из всех витаминов тиамин сохраняется в организме в наименьших количествах. Организм взрослого человека содержит около 30 мг тиамина в виде: 80 % в виде тиамина пирофосфата, 10 % тиамина трифосфата и остальное количество в виде тиамина монофосфата."}},{"type":"paragraph","data":{"text":"После внутримышечной инъекции пиридоксин быстро абсорбируется в кровяное русло и распределяется в организме, выполняя роль коэнзима после фосфорилирования группы СН2ОН в 5-ом положении. Около 80 % витамина связывается с белками плазмы крови. Пиридоксин распределяется по всему организму, проникает через плаценту, обнаруживается в материнском молоке."}},{"type":"paragraph","data":{"text":"Депонируется в печени и окисляется до 4-пиридоксиновой кислоты, которая экскретируется с мочой, максимум через 2-5 часов после абсорбции. В человеческом организме содержится 40-150 мг витамина В6, его ежедневная скорость элиминации составляет около 1,7 - 3,6 мг при скорости восполнения 2,2 - 2,4%."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"В качестве патогенетического и симптоматического средства при лечении заболеваний и синдромов нервной системы различного происхождения:"}},{"type":"list","data":{"style":"ordered","items":["нейропатии и полинейропатии (диабетическая, алкогольная и другие);"]}},{"type":"list","data":{"style":"ordered","items":["неврит и полиневрит, в т.ч. ретробульбарный неврит;"]}},{"type":"list","data":{"style":"ordered","items":["периферические парезы, в т.ч. лицевого нерва;"]}},{"type":"list","data":{"style":"ordered","items":["невралгия, в т.ч. тройничного нерва и межреберных нервов;"]}},{"type":"list","data":{"style":"ordered","items":["болевой синдром (корешковый, миалгия);"]}},{"type":"list","data":{"style":"ordered","items":["ночные мышечные судороги, особенно у лиц старших возрастных групп;"]}},{"type":"list","data":{"style":"ordered","items":["плексопатии, ганглиониты (включая опоясывающий герпес);"]}},{"type":"list","data":{"style":"ordered","items":["неврологические проявления остеохондроза позвоночника (радикулопатия, люмбоишалгия, мышечно-тонические синдромы)."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["тяжелые и острые формы декомпенсированной хронической сердечной недостаточности;","детский возраст (из-за отсутствия исследований);","повышенная чувствительность к компонентам препарата."]}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Не рекомендуется применять препарат Комплигам В при беременности и в период лактации (грудного вскармливания)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eВ/м (глубоко).\u003c/i\u003e При выраженном болевом синдроме лечение целесообразно начинать с 2 мл препарата ежедневно, в течение 5–10 дней, с переходом в дальнейшем либо на прием внутрь, либо на более редкие инъекции (2–3 раза в неделю в течение 2–3 нед).  "}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции: кожные реакции в виде зуда, крапивницы; редко - реакции повышенной чувствительности к препарату, в т.ч. сыпь, затрудненное дыхание, ангионевротический отек, анафилактический шок."}},{"type":"paragraph","data":{"text":"Прочие: в отдельных случаях - повышенное потоотделение, тахикардия, угревая сыпь."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e в случаях очень быстрого введения препарата могут возникнуть системные реакции (головокружение, аритмия, судороги), они также могут явиться результатом передозировки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e симптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Пиридоксин не назначают одновременно с леводопой, поскольку ослабляется действие последней."}},{"type":"paragraph","data":{"text":"Принимая во внимание наличие в составе препарата лидокаина, в случае дополнительного применения эпинефрина и норэпинефрина возможно усиление побочного действия на сердце. В случае передозировки местноанестезирующих средств не следует дополнительно применять эпинефрин и норэпинефрин."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФармацевтическое взаимодействие\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Тиамин полностью распадается в растворах, содержащих сульфиты."}},{"type":"paragraph","data":{"text":"Тиамин нестабилен в щелочном и нейтральном растворах; назначение с карбонатами, цитратами, барбитуратами, препаратами меди не рекомендовано."}},{"type":"paragraph","data":{"text":"Цианокобаламин несовместим с аскорбиновой кислотой, солями тяжелых металлов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В случаях очень быстрого введения препарата возможно развитие системных реакций (головокружение, аритмия, судороги)."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Информация о предостережении относительно применения препарата водителями транспортных средств и лицами, работающими с потенциально опасными механизмами, отсутствует."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eРаствор для внутримышечного введения.\u003c/i\u003e По 2 мл в ампулах светозащитного стекла. По 5 амп. в контурной ячейковой упаковке из пленки ПВХ и фольги алюминиевой или без фольги. 1 или 2 контурные ячейковые упаковки в пачке картонной.  "}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте, при температуре 2–8 °C. Не допускается хранение и транспортирование при температуре ниже 2 °C."}},{"type":"paragraph","data":{"text":"\u003ci\u003eХранить в недоступном для детей месте.\u003c/i\u003e"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЗАО «ФармФирма «Сотекс». "}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО «ФармФирма «Сотекс». "}}]}],"source":null},"description_toggle":false,"short_description":"Фармгруппа:Комплекс витаминов группы В.Фармдействие:КомплигамВ - комбинированный препарат, содержащий витамины группы В и лидокаин. Нейротропные витамины группы В оказывают благоприятное действие на воспалительные и дегенеративные заболевания нервов и двигательного аппарата. Они применяются не для устранения дефицитных состояний, а в высоких дозах обладают анальгетическими свойствами, способствуют усилению кровотока, нормализуют работу нервной системы и процесс кроветворения (витамин B12). Тиамин (В1) играет ключевую роль в процессах углеводного обмена, имеющих решающее значение в обменных процессах нервной ткани, а также в цикле Кребса с последующим участием в синтезе ТПФ (тиамин пирофосфат) и АТФ (аденозин трифосфат). Пиридоксин (B6) участвует в метаболизме белков, и частично, в метаболизме углеводов и жиров. Физиологической функцией обоих витаминов (B1, B6) является потенцирование действия друг друга, проявляющееся в положительном влиянии на нервную, нейромышечную и сердечно-сосудистую системы. Цианокобаламин (В12) участвует в синтезе миелиновой оболочки, стимулирует гемопоэз, уменьшает болевые ощущения, связанные с поражением периферической нервной системы, стимулирует нуклеиновый обмен через активацию фолиевой кислоты.Фармакокинетика:После внутримышечного введения КомплигамВ тиамин быстро абсорбируется из места инъекции и поступает в кровь (484 нг/мл через 15 мин в первый день введения дозы 50 мг) и распределяется неравномерно в организме при содержании его в лейкоцитах 15 %, эритроцитах 75 % и в плазме крови 10 %. В связи с отсутствием значительных запасов витамина в организме он должен поступать в организм ежедневно. Тиамин проникает через гематоэнцефалический и плацентарный барьеры, обнаруживается в материнском молоке. Тиамин выводится с мочой в альфа-фазе через 0,15 часа, в бета-фазе - через 1 час и в терминальной фазе - в течение 2 дней. Основными метаболитами являются: тиаминкарбоновая кислота, пирамин и некоторые неизвестные метаболиты. Из всех витаминов тиамин сохраняется в организме в наименьших количествах. Организм взрослого человека содержит около 30 мг тиамина в виде: 80 % в виде тиамина пирофосфата, 10 % тиамина трифосфата и остальное количество в виде тиамина монофосфата. После внутримышечной инъекции пиридоксин быстро абсорбируется в кровяное русло и распределяется в организме, выполняя роль коэнзима после фосфорилирования группы СН2ОН в 5-ом положении. Около 80 % витамина связывается с белками плазмы крови. Пиридоксин распределяется по всему организму, проникает через плаценту, обнаруживается в материнском молоке. Депонируется в печени и окисляется до 4-пиридоксиновой кислоты, которая экскретируется с мочой, максимум через 2-5 часов после абсорбции. В человеческом организме содержится 40-150 мг витамина В6, его ежедневная скорость элиминации составляет около 1,7 - 3,6 мг при скорости восполнения 2,2 - 2,4%.","substance":[{"id":816,"title":"Пиридоксин","title_latin":"Pyridoxinum","slug":"piridoksin_816"},{"id":1178,"title":"Цианокобаламин","title_latin":"Cyanocobalaminum","slug":"tsianokobalamin_1178"},{"id":1608,"title":"Тиамин","title_latin":"Thiaminum","slug":"tiamin_1608"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"КомплигамВ","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/14039/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/14039/share_default/"}},"diseases":[{"id":"563","title":"Невралгия тройничного нерва","slug":"563-nevralgiya_troynichnogo_nerva"},{"id":"564","title":"Поражения лицевого нерва","slug":"564-porazheniya_litsevogo_nerva"},{"id":"569","title":"Наследственная и идиопатическая невропатия","slug":"569-nasledstvennaya_i_idiopaticheskaya_nevropatiya"},{"id":"570","title":"Воспалительная полиневропатия","slug":"570-vospalitelnaya_polinevropatiya"},{"id":"573","title":"Алкогольная полиневропатия","slug":"573-alkogolnaya_polinevropatiya"},{"id":"678","title":"Неврит зрительного нерва","slug":"678-nevrit_zritelnogo_nerva"},{"id":"1034","title":"Остеохондроз позвоночника","slug":"1034-osteohondroz_pozvonochnika"},{"id":"1039","title":"Радикулопатия","slug":"1039-radikulopatiya"},{"id":"1040","title":"Ишиас","slug":"1040-ishias"},{"id":"1041","title":"Люмбаго с ишиасом","slug":"1041-lyumbago_s_ishiasom"},{"id":"1057","title":"Миалгия","slug":"1057-mialgiya"},{"id":"1058","title":"Невралгия и неврит неуточненные","slug":"1058-nevralgiya_i_nevrit_neutochnennye"},{"id":"1262","title":"Судорога и спазм","slug":"1262-sudoroga_i_spazm"}],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Аналоги","type":"analogs","products":[{"id":152926,"title":"Ларигама","subtitle":{"full":"Раствор, ампулы, 10 шт, 2 мл, для внутримышечного введения","short":"Раствор, 10 шт, 2 мл","package":"10 шт, 2 мл"},"prescription":true,"catalog_section_id":100283,"manufacturer":{"id":2347,"title":"Гротекс","slug":"groteks_2347","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Раствор","slug":"152926-larigama","attributes":{"count":"10 шт","dose":"","volume":"2 мл","spf":"","size":""},"image":{"isTouch":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/62208/phoneMedium_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/62208/phoneMedium_default/"},"isFromTablet":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/62208/tabletLarge_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/62208/tabletLarge_default/"}},"image_thumb":{"isTouch":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/62208/previewTouch_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/62208/previewTouch_default/"},"isFromTablet":{"retina":"https://vseapteki.ru/cropping/thumbnails/101/62208/previewDesktopMedium_retina/","default":"https://vseapteki.ru/cropping/thumbnails/101/62208/previewDesktopMedium_default/"}},"available":true,"price":{"min":"369","max":"466"},"counters":null},{"id":92669,"title":"Нейромультивит","subtitle":{"full":"Раствор, ампулы, 5 шт, 2 мл, для внутримышечного введения, для взрослых","short":"Раствор, 5 шт, 2 мл","package":"5 шт, 2 мл"},"prescription":true,"catalog_section_id":100283,"manufacturer":{"id":5283,"title":"G.L. 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