Пассажикс Таблетки, 30 шт, 10 мг, жевательные

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Поэтому если мать принимает Пассажикс кормление грудью не рекомендуется за исключением случаев когда ожидаемая польза оправдывает потенциальный риск."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"1. Хроническая диспепсия."}},{"type":"paragraph","data":{"text":"Взрослые: по 10 мг (1 таблетка) 3 раза в сутки за 15-30 мин до еды и в случае необходимости перед сном."}},{"type":"paragraph","data":{"text":"Дети старше 5 лет: по 25 мг на 10 кг массы тела. 3 раза в сутки до еды и в случае необходимости перед сном."}},{"type":"paragraph","data":{"text":"При необходимости указанную дозировку можно удвоить."}},{"type":"paragraph","data":{"text":"2. Острые и подострые состояния (прежде всего тошнота и рвота)."}},{"type":"paragraph","data":{"text":"Взрослые: по 20 мг (2 таблетки) 3-4 раза в сутки до еды и перед сном."}},{"type":"paragraph","data":{"text":"Дети старше 5 лет: по 5 мг на 10 кг массы тела 3-4 раза в сутки перед едой и перед сном."}},{"type":"paragraph","data":{"text":"Примечания"}},{"type":"paragraph","data":{"text":"Рекомендуется пероральное применение Пассажикса до еды. При приеме препарата после еды абсорбция несколько замедляется."}},{"type":"paragraph","data":{"text":"При почечной недостаточности рекомендуется уменьшение частоты приема препарата (см. раздел \"Особые указания\")."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Побочные эффекты наблюдаются редко отмечались исключительные случаи преходящих спазмов кишечника."}},{"type":"paragraph","data":{"text":"Экстрапирамидные явления наблюдаются у детей и при повышенной проницаемости гематоэнцефалического барьера. Эти явления полностью обратимы и спонтанно исчезают после прекращения лечения."}},{"type":"paragraph","data":{"text":"Так как гипофиз находится вне гематоэнцефалического барьера Пассажикс может индуцировать повышение уровня пролактина в плазме. В редких случаях эта гиперпролактинемия может стимулировать появление галактореи гинекомастии и дисменореи."}},{"type":"paragraph","data":{"text":"Отмечались редкие аллергические реакции такие как сыпь и крапивница."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомами передозировки могут быть сонливость дезориентация и экстрапирамидные реакции особенно у детей."}},{"type":"paragraph","data":{"text":"Лечение: в случае передозировки рекомендуется применение активированного угля и тщательное наблюдение. Антихолинергические средства препараты применяемые для лечения паркинсонизма или антигистаминные препараты могут оказаться эффективными при возникновении экстрапирамидных реакций."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении антихолинергические препараты могут нейтрализовать действие Пассажикса."}},{"type":"paragraph","data":{"text":"При одновременном применении с Пассажиксом антацидные и антисекреторные препараты снижают его биодоступность. Н"}},{"type":"paragraph","data":{"text":"а основании исследований in vitro можно предположить что при одновременном применении с Пассажиксом лекарственных препаратов значительно ингибирующих фермент цитохром CYP3A4 (противогрибковые препарата группы азолов антибиотики из группы макролидов ингибиторы ВИЧ-протеазы антидепрессант нефазодон) может наблюдаться повышение уровня домперидона в плазме."}},{"type":"paragraph","data":{"text":"Препарат не влияет на уровень парацетамола и дигоксина в крови."}},{"type":"paragraph","data":{"text":"Не исключено что Пассажикс может влиять на всасывание применяемых одновременно внутрь препаратов с замедленным высвобождением активного вещества или покрытых кишечнорастворимой оболочкой."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При сочетанном применении Пассажикса с антацидными или антисекреторными препаратами последние следует принимать после еды а не до еды т.е. их не следует принимать одновременно с Пассажиксом."}},{"type":"paragraph","data":{"text":"Применение при заболеваниях печени"}},{"type":"paragraph","data":{"text":"Учитывая метаболизм домперидона в печени следует с осторожностью назначать Пассажикс больным с печеночной недостаточностью."}},{"type":"paragraph","data":{"text":"Применение при заболеваниях почек"}},{"type":"paragraph","data":{"text":"У больных тяжелой почечной недостаточностью (сывороточный креатинин > 6 мг/100 мл т.е > 06 ммоль/л) период полувыведения домперидона увеличивался с 74 до 208 часов но концентрации препарата в плазме были ниже чем у здоровых добровольцев. Так как очень небольшой процент препарата выводится почками в неизмененном виде то едва ли необходима коррекция разовой дозы у больных с почечной недостаточностью. Однако при повторном назначении частота введения должна быть снижена до 1-2 раз в сутки в зависимости от тяжести недостаточности также может возникнуть необходимость снижений дозы. При длительной терапии больные должны находиться под регулярным наблюдением."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Домперидон не нарушает быстроту психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки жевательные 10 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом защищенном от света недоступном для детей месте при температуре не выше 25 °С."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Акционерное общество \"Фармацевтическое предприятие \"Оболенское\" (АО \"ФП \"Оболенское\"), 142279, Московская обл., Серпуховский район, пос. Оболенск, корп. 7-8, корп. 39, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"ФП \"Оболенское\""}}]}],"source":null},"description_toggle":false,"short_description":"Увеличивает продолжительность перистальтических сокращений антрального отдела желудка и двенадцатиперстной кишки ускоряет опорожнение желудка в случае замедления этого процесса повышает тонус нижнего пищеводного сфинктера устраняет развитие тошноты и рвоты. Домперидон слабо проникает через гематоэнцефалический барьер поэтому применение домперидона редко сопровождается экстрапирамидными побочными эффектами особенно у взрослых но домперидон стимулирует выделение пролактина из гипофиза. Его противорвотное действие возможно обусловлено сочетанием периферического (гастрокинетического) действия и антагонизма к рецепторам дофамина в триггерной зоне хеморецепторов. Домперидон не оказывает действия на желудочную секрецию. Всасывание После приема препарата внутрь домперидон быстро всасывается. Обладает низкой биодоступностью (около 15%). Снижение кислотности желудочного сока уменьшает абсорбцию домперидона. Максимальная концентрация в плазме достигается через 1 ч. Распределение Домперидон широко распределяется в различных тканях в тканях мозга его концентрация невелика. Связь с белками плазмы составляет 91-93%. Метаболизм Подвергается интенсивному метаболизму в стенке кишечника и печени. Выведение Выводится через кишечник (66%) и почками (33%) в неизмененном виде выводится соответственно 10% и 1% от величины дозы. 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