Препарат, стимулирующий моторику ЖКТ. Итоприд усиливает моторику ЖКТ за счет антагонизма в отношении допаминовых D2-рецепторов и ингибирования ацетилхолинэстеразы. Итоприд активирует высвобождение ацетилхолина и подавляет его разрушение. Итоприд обладает противорвотным эффектом за счет взаимодействия с D2-рецепторами, расположенными в триггерной зоне. Вызывает дозозависимое подавление рвоты, вызванной апоморфином.; Итоприд активирует пропульсивную моторику желудка за счет антагонизма с D2-рецепторами и дозозависимого ингибирования активности ацетилхолинэстеразы.; Итоприд оказывает специфическое действие на верхние отделы ЖКТ, ускоряет транзит по желудку, улучшает его опорожнение.; Не оказывает влияния на сывороточные концентрации гастрина.
Показания к применению
Симптоматическое лечение функциональной неязвенной диспепсии (хронического гастрита) в т.ч.:
Вздутие живота (метеоризм)
Боль или ощущение дискомфорта в эпигастральной области (гастралгия)
Анорексия
Изжога
Тошнота, рвота
Чувство быстрого насыщения
Противопоказания
Повышенная чувствительность к итоприду или любому вспомогательному веществу препарата
Желудочно-кишечные кровотечения
Механическая обструкция и перфорация органов ЖКТ
Детский возраст до 16 лет
Беременность
Период лактации (грудного вскармливания)
С осторожностью: в связи с наличием в составе препарата лактозы, итоприд применяют с осторожностью при врожденном дефиците лактазы, непереносимости лактозы, глюкозо-галактозной мальабсорбции и в гериатрии у пациентов пожилого возраста с нарушением функции печени и почек.
Применение при беременности и в период грудного вскармливания
Препарат Итопра; противопоказан при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Внутрь, до еды, по 50 мг 3 раза/сут.; Рекомендуемая суточная доза составляет 150 мг.; Указанная доза может быть снижена с учетом возраста пациента.
Побочное действие
Со стороны системы кроветворения: лейкопения, тромбоцитопения.; Аллергические реакции: гиперемия кожи, кожный зуд, сыпь, анафилактический шок.; Со стороны эндокринной системы: гинекомастия, повышение уровня пролактина.; Со стороны пищеварительной системы: повышенное слюноотделение, тошнота, диарея, запор, боль в животе, желтуха.; Со стороны нервной системы: головная боль, головокружение, тремор.; Лабораторные показатели: повышение активности ACT, АЛТ, ГГТ, ЩФ, уровня билирубина.
Передозировка
Случаи передозировки у человека не описаны.; Лечение: при возможной передозировке показано промывание желудка и симптоматическая терапия.
Особые указания
С осторожностью следует применять препарат Итопра; у пациентов, для которых появление холинергических побочных реакций (связанных с усилением действия ацетилхолина под влиянием препарата), может усугубить течение основного заболевания.; При отмене препарата Итопра; признаков возникновения синдрома отмены не описано.; Специальных мер предосторожности при уничтожении неиспользованного лекарственного препарата не требуется.; Влияние на способность к вождению автотранспорта и управлению механизмами; Действие компонентов препарата не приводит к нарушению психомоторных реакций. Однако в связи с возможными побочными эффектами (головокружение, тремор) нельзя исключить снижение концентрации внимания и влияние на способность к вождению автотранспорта и управлению механизмами.
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