Ипигрикс Таблетки, 50 шт, 20 мг

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Максимальная концентрация в плазме крови\nдостигается через один час. Около 40-55 % активного вещества связывается с\nпротеинами плазмы крови. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Препарат проникает через гематоэнцефалический\nбарьер. Ипидакрин быстро поступает в ткани, в равновесном состоянии в плазме\nнаходится только 2 % препарата. 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"}},{"type":"paragraph","data":{"text":"-       Лечение атонии кишечника."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"-       Гиперчувствительность\nк ипидакрину и/или к любому из вспомогательных веществ\nпрепарата."}},{"type":"paragraph","data":{"text":"-      \nЭпилепсия."}},{"type":"paragraph","data":{"text":"-      \nЭкстрапирамидные\nнарушения с гиперкинезами."}},{"type":"paragraph","data":{"text":"-      \nСтенокардия."}},{"type":"paragraph","data":{"text":"-      \nВыраженная\nбрадикардия."}},{"type":"paragraph","data":{"text":"-      \nБронхиальная\nастма."}},{"type":"paragraph","data":{"text":"-      \nВестибулярные\nнарушения."}},{"type":"paragraph","data":{"text":"-      \nОбострение\nязвы желудка или двенадцатиперстной кишки. "}},{"type":"paragraph","data":{"text":"-      \nМеханическая\nнепроходимость кишечника или мочевыводящих путей."}},{"type":"paragraph","data":{"text":"-      \nНепереносимость\nлактозы, дефицит лактазы, синдром глюкозо-галактозной мальабсорбции."}},{"type":"paragraph","data":{"text":"-      \nБеременность\nи период грудного вскармливания."}},{"type":"paragraph","data":{"text":"-      \nДети\nв возрасте до 18 лет (отсутствуют систематизированные данные о безопасности\nприменения)."}}]},{"id":28,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eпри\u003c/i\u003e\u003c/b\u003e\u003cb\u003e: \u003c/b\u003eязвенной\nболезни желудка и двенадцатиперстной кишки, тиреотоксикозе, заболеваниях\nсердечно-сосудистой системы, а также пациентам с обструктивными заболеваниями\nдыхательной системы в анамнезе или при острых заболеваниях дыхательных путей."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Ипидакрин усиливает тонус матки и может вызвать\nпреждевременную родовую деятельность, поэтому он противопоказан во время\nбеременности. Применение ипидакрина в период грудного вскармливания\nпротивопоказано."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблетки применяют\nвнутрь. Дозы и продолжительность лечения определяют индивидуально в зависимости\nот тяжести заболевания. "}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eПри заболеваниях периферической нервной системы\u003c/i\u003e\u003c/b\u003e\u003ci\u003e \u003c/i\u003eприменяют по 20 мг (1 таблетка) 1‑3 раза в день.\nПродолжительность курса лечения составляет 1‑2 месяца. При необходимости\nкурс лечения можно повторить несколько раз с перерывом между курсами в 1-2 месяца."}},{"type":"paragraph","data":{"text":"Для предотвращения миастенических кризов, при\nтяжелых нарушениях нервно-мышечной проводимости кратковременно парентерально\nвводят 1-2 мл (15-30 мг) раствора для внутримышечного и подкожного\nвведения, содержащего 15 мг ипидакрина в 1 мл, затем лечение\nпродолжают таблетками ипидакрина в дозе 20-40 мг (1-2 таблетки) 5 раз\nв день."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eПри заболеваниях центральной нервной системы\u003c/i\u003e\u003c/b\u003e\u003ci\u003e \u003c/i\u003eприменяют по 20 мг 2-3 раза в день. Курс\nлечения от 2 до 6 месяцев. При необходимости курс лечения повторяют."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eПри лечении атонии кишечника\u003c/i\u003e\u003c/b\u003e\u003ci\u003e \u003c/i\u003eприменяют по 20 мг 2‑3 раза в день в течение 1-2 недель."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПожилым\nпациентам и пациентам с нарушениями деятельности печени и/\u003c/i\u003e\u003ci\u003eили почек\n\u003c/i\u003eподбор доз не требуется."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза составляет 200 мг.\u003cb\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли Вы\nпропустили очередной прием препарата, примите его незамедлительно.\nНе применяйте двойную дозу для замены пропущенной. Продолжайте прием\nсогласно рекомендациям врача.\u003c/i\u003e"}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Обычно ипидакрин хорошо переносится.\nПобочные эффекты наблюдаются менее чем у 10 % больных и, главным образом,\nсвязаны со стимуляцией м-холинорецепторов."}},{"type":"paragraph","data":{"text":"В дальнейшем перечисленные побочные эффекты\nклассифицированы соответственно группам систем и органов с указанием частоты\nвстречаемости: часто (≥ 1/100 до < 1/10), нечасто (≥ 1/1000 до < 1/100), редко (≥ 1/10 000 до < 1/1000)."}},{"type":"paragraph","data":{"text":"Нарушения\nсо стороны желудочно-кишечного тракта"}},{"type":"paragraph","data":{"text":"Часто: гиперсаливация, тошнота."}},{"type":"paragraph","data":{"text":"Нечасто: рвота."}},{"type":"paragraph","data":{"text":"Редко: понос, боли в эпигастрии."}},{"type":"paragraph","data":{"text":"Неизвестно: диспепсия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны\nнервной системы"}},{"type":"paragraph","data":{"text":"Нечасто: головокружение, головные боли, сонливость, мышечный спазм,\nслабость."}},{"type":"paragraph","data":{"text":"Нарушения сердечной\nфункции\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: сердцебиения, брадикардия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны\nорганов зрения"}},{"type":"paragraph","data":{"text":"Неизвестно: миоз."}},{"type":"paragraph","data":{"text":"Нарушения со стороны\nдыхательной системы, груди и средостения"}},{"type":"paragraph","data":{"text":"Нечасто: увеличение\nбронхиальной секреции, бронхоспазм."}},{"type":"paragraph","data":{"text":"Нарушения со стороны\nскелетно-мышечной системы и соединительной ткани"}},{"type":"paragraph","data":{"text":"Неизвестно: тремор,\nсудороги, повышение тонуса матки."}},{"type":"paragraph","data":{"text":"Нарушения со стороны\nкожи и подкожных тканей"}},{"type":"paragraph","data":{"text":"Часто: потливость."}},{"type":"paragraph","data":{"text":"Нечасто: аллергические\nреакции (зуд, высыпания), обычно при применении больших доз препарата."}},{"type":"paragraph","data":{"text":"Общие нарушения и\nреакции в месте введения"}},{"type":"paragraph","data":{"text":"Неизвестно: гипотермия,\nболи в грудной клетке, желтуха."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри\nпоявлении перечисленных побочных \u003c/i\u003e\u003ci\u003eэффектов, а также при появлении побочно\u003c/i\u003e\u003ci\u003eго \u003c/i\u003e\u003ci\u003eэффекта, не\u003c/i\u003e\u003ci\u003e упомянуто\u003c/i\u003e\u003ci\u003eго в инструкции, необходимо обратиться к врачу.\u003c/i\u003e\u003ci\u003e\u003c/i\u003e"}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: при тяжелой передозировке возможно развитие\nхолинергического криза (снижение аппетита, бронхоспазм, слезотечение, усиленное\nпотоотделение, сужение зрачков, нистагм, усиленная перистальтика ЖКТ,\nспонтанная дефекация и мочеиспускание, рвота, желтуха, брадикардия, нарушение внутрисердечной\nпроводимости, аритмии, артериальная гипотензия, беспокойство, тревога,\nвозбуждение, чувство страха, атаксия, судороги, кома, нарушение речи,\nсонливость, общая слабость)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e: проводят симптоматическую терапию, применяют\nм-холинолитические вещества (в том числе атропин, циклодол, метацин и др.)."}}]},{"id":29,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Ипидакрин ослабляет угнетающее действие на\nнервно-мышечную передачу и проведение возбуждения по периферическим нервам\nместных анестетиков, аминогликозидов и калия хлорида."}},{"type":"paragraph","data":{"text":"Седативный эффект лекарственных средств,\nугнетающих ЦНС, в том числе этанола, а также действие других ингибиторов\nхолинэстеразы и м‑холиномиметических веществ под влиянием ипидакрина\nусиливаются."}},{"type":"paragraph","data":{"text":"При одновременном применении других\nхолинергических лекарственных средств ипидакрин увеличивает риск\nхолинергического криза у больных миастенией."}},{"type":"paragraph","data":{"text":"Бета-адренолитические вещества усиливают\nвыраженность брадикардии, вызываемой ипидакрином."}},{"type":"paragraph","data":{"text":"Церебролизин потенцирует действие ипидакрина."}},{"type":"paragraph","data":{"text":"Алкоголь усиливает нежелательные побочные эффекты\nипидакрина."}}]},{"id":9,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Отсутствуют систематизированные данные о\nприменении у детей."}},{"type":"paragraph","data":{"text":"На время лечения следует исключить алкоголь,\nкоторый усиливает побочные эффекты ипидакрина."}},{"type":"paragraph","data":{"text":"Ипидакрин может обострить течение эпилепсии,\nа также усилить отрицательное воздействие алкоголя на организм."}},{"type":"paragraph","data":{"text":"У пациентов с депрессиями ипидакрин может усилить\nпроявление симптомов депрессии."}},{"type":"paragraph","data":{"text":"В связи с возможным риском брадикардии при\nприменении ипидакрина следует контролировать деятельность сердца."}}]},{"id":30,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Ипидакрин может оказывать седативное действие,\nпоэтому пациентам, подверженным данному воздействию, при применении ипидакрина следует\nсоблюдать осторожность при управлении транспортными средствами и работе с\nмеханизмами."}}]},{"id":31,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки 20 мг."}},{"type":"paragraph","data":{"text":"По 25 таблеток в контурной ячейковой упаковке\nиз фольги алюминиевой и пленки поливинилхлоридной."}},{"type":"paragraph","data":{"text":"По 2 контурные ячейковые упаковки вместе с\nинструкцией по применению помещают в пачку из картона. "}},{"type":"paragraph","data":{"text":"На пачке может быть нанесен стикер для контроля\nпервого вскрытия."}}]},{"id":32,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 \u003csup\u003eо\u003c/sup\u003eС."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":33,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности,\nуказанного на упаковке."}}]},{"id":34,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":36,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Гриндекс Рус»."}},{"type":"paragraph","data":{"text":"Россия, 117556, Москва, Варшавское\nшоссе, д. 74, корп. 3, 5 этаж."}},{"type":"paragraph","data":{"text":"Телефон: +7 (495) 7716505*"}},{"type":"paragraph","data":{"text":"Факс: +7 (499) 6103963"}},{"type":"paragraph","data":{"text":"Электронная почта: office@grindeks.ru"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаИпидакрин – обратимый ингибитор холинэстеразы. Непосредственно стимулирует проведение импульсов по нервным волокнам, межнейрональным и нервно-мышечным синапсам периферической и центральной нервной системы (ЦНС). Фармакологическое действие ипидакрина основано на сочетании двух механизмов действия: - блокада калиевых каналов мембраны нейронов и мышечных клеток, - обратимое ингибирование холинэстеразы в синапсах. Ипидакрин усиливает действие на гладкие мышцы не только ацетилхолина, но и адреналина, серотонина, гистамина и окситоцина. Обладает следующими фармакологическими эффектами: - восстановление и стимуляция нервно-мышечного проведения; - восстановление проведения импульса в периферической нервной системе после блокады, вызванной некоторыми факторами (например, травма, воспаление, действие местных анестетиков, антибиотиков, токсинов и калия хлорида); - усиление сократимости и тонуса гладкой мускулатуры внутренних органов; - специфическая умеренная стимуляция ЦНС в комбинации с отдельными проявлениями седативного действия; - улучшение памяти. При доклиническом изучении ипидакрин не оказывал тератогенного, эмбриотоксического, мутагенного, канцерогенного и иммунотоксического действий, не влиял на эндокринную систему. Достаточные данные клинических исследований безопасности применения ипидакрина у детей отсутствуют.ФармакокинетикаАбсорбцияПосле применения внутрь ипидакрин быстро всасывается из желудочно-кишечного тракта. Максимальная концентрация в плазме крови достигается через один час. Около 40-55 % активного вещества связывается с протеинами плазмы крови.РаспределениеПрепарат проникает через гематоэнцефалический барьер. Ипидакрин быстро поступает в ткани, в равновесном состоянии в плазме находится только 2 % препарата. Период полураспределения составляет 40 минут.Метаболизм и выведениеПрепарат метаболизируется в печени. Выведение ипидакрина осуществляется ренально (через почки) и экстраренально (через желудочно-кишечный тракт), преобладает выведение с мочой (главным образом путем канальцевой секреции, только ⅓ дозы выводится путем клубочковой фильтрации). 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