Препарат применяют для терапии острого болевого синдрома различной этиологии, в том числе: Головная боль, мигрень и мигренеподобная боль. Зубная боль. Боли в мышцах и суставах, ревматические боли. Альгодисменорея. Кроме того, препарат применяется как жаропонижающее средство, в том числе у пациентов с гриппоподобными состояниями (лихорадка, боль в мышцах, ...
Повышенная индивидуальная чувствительность к компонентам препарата и другим лекарственным средствам группы нестероидных противовоспалительных средств. Препарат не применяют для терапии женщин в период беременности и лактации, а также для лечения детей в возрасте младше 12 лет. Препарат противопоказан пациентам, страдающим тяжелыми нарушениями функции ...
Парацетамола 200мг; Пропифеназона 200мг; Кофеина 50мг; Вспомогательные вещества, в том числе лактоза.
Фармакологические свойства
Новалгин – комбинированный обезболивающий препарат, обладающий выраженным анальгетическим и антипиретическим действием. Кроме того, препарат обладает некоторой противовоспалительной активностью, стимулирует центральную нервную систему. В состав препарата входят три активных компонента – парацетамол, пропифеназон и кофеин. Механизм действия и терапевтические эффекты препарата основаны на фармакологических свойствах активных компонентов входящих в его состав. Парацетамол и пропифеназон лекарственные вещества группы нестероидных противовоспалительных средств, за счет угнетения активности фермента циклооксигеназы снижают синтез простагландинов, простациклинов и тромбоксана из арахидоновой кислоты. За счет снижения количества простагландинов в центральной нервной системе реализуется анальгетический эффект парацетамола и пропифеназона. Вещества оказывают непосредственное влияние на центр терморегуляции в гипоталамусе, вследствие чего отмечается снижение повышенной температуры тела. Пропифеназон обладает противовоспалительным эффектом, угнетая синтез простагландинов в очаге воспаления.
Показания к применению
Препарат применяют для терапии острого болевого синдрома различной этиологии, в том числе: Головная боль, мигрень и мигренеподобная боль. Зубная боль. Боли в мышцах и суставах, ревматические боли. Альгодисменорея. Кроме того, препарат применяется как жаропонижающее средство, в том числе у пациентов с гриппоподобными состояниями (лихорадка, боль в мышцах, головная боль).
Противопоказания
Повышенная индивидуальная чувствительность к компонентам препарата и другим лекарственным средствам группы нестероидных противовоспалительных средств. Препарат не применяют для терапии женщин в период беременности и лактации, а также для лечения детей в возрасте младше 12 лет. Препарат противопоказан пациентам, страдающим тяжелыми нарушениями функции почек и/или печени, нарушениями функции кроветворения, а также пациентам с дефицитом глюкозо-6-фосфатдегидрогеназы, лактазной недостаточностью и язвенными поражениями желудка и двенадцатиперстной кишки. Препарат следует с осторожностью назначать пациентам, страдающим заболеваниями печени и/или почек, доброкачественной гипербилирубинемией. Кроме того, следует соблюдать осторожность при назначении препарата Новалгин пациентам пожилого возраста. При применении препарата в рекомендованных дозах влияния на способность к управлению потенциально опасными механизмами и вождению автомобиля отмечено не было.
Применение при беременности и в период грудного вскармливания
Препарат противопоказан к применению в период беременности и грудного вскармливания.
Способ применения и дозы
Препарат принимают перорально, таблетку рекомендуется глотать целиком, не разжевывая и не измельчая, запивая необходимым количеством воды. Препарат рекомендуется принимать после приема пищи. Длительность курса лечения и дозы препарата определяет лечащий врач индивидуально для каждого пациента. Взрослым обычно назначают по 1-2 таблетки препарата 1-3 раза в сутки. Возможен также однократный прием препарата при острой боли. Детям в возрасте от 12 до 16 лет обычно назначают по 1 таблетке препарата 1-3 раза в сутки. Максимальная суточная доза для взрослых – 6 таблеток. Максимальная суточная доза для детей в возрасте от 12 до 16 лет – 3 таблетки. Не рекомендуется принимать препарат более 10 дней подряд. В случае если длительность курса лечения превышает 5 дней, следует контролировать функцию печени и картину периферической крови.
Побочное действие
При применении препарата у пациентов отмечалось развитие таких побочных эффектов: Со стороны желудочно-кишечного тракта: тошнота, рвота, боли в эпигастральной области. Со стороны системы кроветворения: лейкопения, тромбоцитопения, агранулоцитоз, метгемоглобинемия, гемолитическая анемия. Аллергические реакции: кожная сыпь, зуд, крапивница, отек Квинке.
Передозировка
При применении завышенных доз препарата у пациентов отмечается развитие лейкопении, агранулоцитоза, гемолитической анемии, а также поражения почек и печени вплоть до печеночной недостаточности. При дальнейшем увеличении дозы возможно развитие метгемоглобинемии. При передозировке показано промывание желудка, прием энтеросорбентов и проведение симптоматической терапии. При отравлении парацетамолом показано введение N-ацетилцистеина и прием метионина.
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