Ипигрикс Раствор, 10 шт, 1 мл, 15 мг/мл

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Усиливает действие на гладкую мускулатуру не только медиатора\nацетилхолина, но и адреналина, серотонина, гистамина и окситоцина."}},{"type":"paragraph","data":{"text":"Главные фармакологические эффекты\nипидакрина:"}},{"type":"paragraph","data":{"text":"- восстановление и\nстимуляция нервно-мышечного проведения;"}},{"type":"paragraph","data":{"text":"- восстановление проведения\nимпульса в периферической нервной системе после блокады, вызванной некоторыми\nфакторами (например, травма, воспаление, действие местных анестетиков,\nантибиотиков, токсинов и калия хлорида);"}},{"type":"paragraph","data":{"text":"- усиление сократимости и\nтонуса гладкой мускулатуры внутренних органов;"}},{"type":"paragraph","data":{"text":"- специфическая умеренная\nстимуляция ЦНС в комбинации с отдельными проявлениями седативного действия;"}},{"type":"paragraph","data":{"text":"- улучшение памяти."}},{"type":"paragraph","data":{"text":"При доклиническом изучении ипидакрин не оказывал\nтератогенного, эмбриотоксического, мутагенного, канцерогенного и\nиммунотоксического действий, не влиял на эндокринную систему."}},{"type":"paragraph","data":{"text":"Достаточные данные клинических исследований\nбезопасности применения ипидакрина у детей отсутствуют."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eАбсорбция\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"После применения внутрь ипидакрин быстро\nвсасывается из желудочно-кишечного тракта. Максимальная концентрация в плазме\nпосле подкожного или внутримышечного введения достигается в течение\n25-30 минут. Около 40-55 % активного вещества связывается с\nпротеинами плазмы. Терапевтический эффект проявляется через 15‑20 минут после парентерального введения. Продолжительность действия\nпрепарата составляет 3-5 часов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Препарат проникает через гематоэнцефалический\nбарьер. Ипидакрин быстро поступает в ткани, в равновесном состоянии в плазме\nнаходят только 2 % препарата."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм и выведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Препарат метаболизируется в печени. Выведение\nипидакрина осуществляется ренально и экстраренально (через желудочно-кишечный\nтракт), преобладает выведение с мочой. Период полувыведения ипидакрина\nсоставляет 40 мин. После парентерального введения 34,8 %\nот примененной дозы ипидакрина выводится в неизмененном виде с мочой. Это\nсвидетельствует о быстром метаболизме препарата в организме."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"- Заболевания периферической\nнервной системы (неврит, полиневрит, полинейропатия, полирадикулопатия, миастения\nи миастенический синдром различной этиологии)."}},{"type":"paragraph","data":{"text":"- Заболевания центральной нервной\nсистемы: бульбарные параличи и парезы."}},{"type":"paragraph","data":{"text":"- Период реконвалесценции после\nорганических поражений ЦНС, сопровождающихся двигательными нарушениями."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"-       Гиперчувствительность\nк ипидакрину и/или к любому из вспомогательных веществ\nпрепарата."}},{"type":"paragraph","data":{"text":"-      \nЭпилепсия."}},{"type":"paragraph","data":{"text":"-      \nЭкстрапирамидные\nнарушения с гиперкинезами."}},{"type":"paragraph","data":{"text":"-      \nСтенокардия."}},{"type":"paragraph","data":{"text":"-      \nВыраженная\nбрадикардия."}},{"type":"paragraph","data":{"text":"-      \nБронхиальная\nастма."}},{"type":"paragraph","data":{"text":"-      \nВестибулярные\nнарушения."}},{"type":"paragraph","data":{"text":"-      \nОбострение\nязвы желудка или двенадцатиперстной кишки."}},{"type":"paragraph","data":{"text":"-      \nМеханическая\nнепроходимость кишечника или мочевыводящих путей."}},{"type":"paragraph","data":{"text":"-      \nБеременность\nи период грудного вскармливания."}},{"type":"paragraph","data":{"text":"-       Дети в возрасте до 18 лет (отсутствуют\nсистематизированные данные о безопасности применения)."}}]},{"id":12,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eпри\u003c/i\u003e\u003c/b\u003e\u003cb\u003e: \u003c/b\u003eязвенной болезни желудка и\nдвенадцатиперстной кишки, тиреотоксикозе, заболеваниях сердечно-сосудистой\nсистемы, а также пациентам с обструктивными заболеваниями дыхательной системы в\nанамнезе или при острых заболеваниях дыхательных путей."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Ипидакрин усиливает тонус матки и может вызвать\nпреждевременную родовую деятельность, поэтому он противопоказан во время\nбеременности. Применение ипидакрина в период грудного вскармливания\nпротивопоказано."}}]},{"id":13,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутримышечно или подкожно. "}},{"type":"paragraph","data":{"text":"Дозы и продолжительность лечения\nопределяют индивидуально в зависимости от степени тяжести заболевания."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eЗаболевания периферической нервной системы\u003c/i\u003e\u003c/b\u003e "}},{"type":"paragraph","data":{"text":"·       \nМоно- и полинейропатии различного генеза: подкожно и внутримышечно 5-15 мг\n1-2 раза в сутки, курс 10-15 дней (в тяжелых случаях – до 30 дней);\nдалее переходят на прием ипидакрина в таблетках."}},{"type":"paragraph","data":{"text":"·       \nМиастения и миастенический синдром: подкожно и внутримышечно 5-30 мг 1‑3 раза в сутки; далее переходят\nна прием ипидакрина в таблетках. Общий курс лечения составляет 1‑2 месяца. При необходимости лечение можно повторить несколько раз с\nперерывом между курсами в 1-2 месяца."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eЗаболевания центральной нервной системы\u003c/i\u003e\u003c/b\u003e\u003cb\u003e \u003c/b\u003e"}},{"type":"paragraph","data":{"text":"·       \nБульбарные параличи и парезы: подкожно и внутримышечно 5-15 мг\n1-2 раза в сутки, курс 10-15 дней; далее переходят на прием\nипидакрина в таблетках."}},{"type":"paragraph","data":{"text":"·       \nРеабилитация при органических поражениях ЦНС: внутримышечно 10-15 мг 1‑2 раза в день, курс до 15 дней;\nдалее переходят на прием ипидакрина в таблетках."}}]},{"id":6,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Обычно ипидакрин хорошо переносится.\nПобочные эффекты главным образом связаны со стимуляцией м-холинорецепторов."}},{"type":"paragraph","data":{"text":"Нижеперечисленные побочные эффекты ипидакрина классифицированы по группам\nсистем и органов с указанием частоты встречаемости: часто (≥ 1/100 до < 1/10), нечасто (≥ 1/1000 до < 1/100), редко (≥ 1/10 000 до < 1/1000)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного\nтракта"}},{"type":"paragraph","data":{"text":"Часто: гиперсаливация, тошнота."}},{"type":"paragraph","data":{"text":"Нечасто: рвота."}},{"type":"paragraph","data":{"text":"Редко: понос, боли в эпигастрии."}},{"type":"paragraph","data":{"text":"Неизвестно: диспепсия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной\nсистемы"}},{"type":"paragraph","data":{"text":"Нечасто: головокружение, головные боли, сонливость, мышечный спазм,\nслабость."}},{"type":"paragraph","data":{"text":"Нарушения со сердечной\nфункции"}},{"type":"paragraph","data":{"text":"Часто: сердцебиение, брадикардия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны\nорганов зрения"}},{"type":"paragraph","data":{"text":"Неизвестно: миоз."}},{"type":"paragraph","data":{"text":"Нарушения со стороны дыхательной\nсистемы, груди и средостения"}},{"type":"paragraph","data":{"text":"Нечасто:\nувеличение бронхиальной секреции, бронхоспазм. "}},{"type":"paragraph","data":{"text":"Нарушения со стороны скелетно-мышечной\nсистемы и соединительной ткани"}},{"type":"paragraph","data":{"text":"Неизвестно: тремор,\nсудороги, повышение тонуса матки."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи\nи подкожных тканей"}},{"type":"paragraph","data":{"text":"Часто: потливость."}},{"type":"paragraph","data":{"text":"Нечасто:\nаллергические реакции (зуд, высыпания), обычно при применении больших доз\nпрепарата."}},{"type":"paragraph","data":{"text":"Общие нарушения и\nреакции в месте введения"}},{"type":"paragraph","data":{"text":"Неизвестно: гипотермия,\nболи в грудной клетке, желтуха."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри появлении перечисленных побочных\nэффектов, а также при появлении побочного эффекта, не упомянутого в инструкции,\nнеобходимо обратиться к врачу.\u003c/i\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: при тяжелой передозировке возможно развитие\nхолинергического криза (снижение аппетита, бронхоспазм, слезотечение, усиленное\nпотоотделение, сужение зрачков, нистагм, усиленная перистальтика желудочно-кишечного\nтракта, спонтанная дефекация и мочеиспускание, рвота, желтуха, брадикардия,\nнарушение внутрисердечной проводимости, аритмии, артериальная гипотензия,\nбеспокойство, тревога, возбуждение, чувство страха, атаксия, судороги, кома,\nнарушение речи, сонливость, общая слабость)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e: проводят симптоматическую терапию, применяют м-холинолитические\nвещества (в том числе атропин, циклодол, метацин)."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Ипидакрин ослабляет угнетающее действие на\nнервно-мышечную передачу и проведение возбуждения по периферическим нервам\nместных анестетиков, аминогликозидов и калия хлорида."}},{"type":"paragraph","data":{"text":"Седативный эффект лекарственных средств,\nугнетающих ЦНС, в том числе этанола, а также действие других ингибиторов\nхолинэстеразы и м-холиномиметических веществ под влиянием ипидакрина усиливаются."}},{"type":"paragraph","data":{"text":"При одновременном применении других\nхолинергических лекарственных средств ипидакрин увеличивает риск развития холинергического\nкриза у больных миастенией."}},{"type":"paragraph","data":{"text":"Бета-адренолитические вещества усиливают\nвыраженность брадикардии, вызываемой ипидакрином. "}},{"type":"paragraph","data":{"text":"Церебролизин потенцирует действие ипидакрина."}},{"type":"paragraph","data":{"text":"Алкоголь усиливает нежелательные\nпобочные эффекты ипидакрина."}},{"type":"paragraph","data":{"text":"Ипидакрин\nможно применять в комбинации с ноотропными препаратами."}}]},{"id":7,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Отсутствуют систематизированные данные о\nприменении у детей."}},{"type":"paragraph","data":{"text":"На время лечения следует исключить алкоголь,\nкоторый усиливает побочные эффекты ипидакрина."}},{"type":"paragraph","data":{"text":"Ипидакрин может обострить течение\nэпилепсии, а также усилить отрицательное воздействие алкоголя на организм."}},{"type":"paragraph","data":{"text":"У пациентов с депрессиями ипидакрин может усилить\nпроявление симптомов депрессии."}},{"type":"paragraph","data":{"text":"В связи с возможным риском брадикардии при\nприменении ипидакрина следует контролировать деятельность сердца."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Ипидакрин может оказывать седативное действие,\nпоэтому пациентам, подверженным данному воздействию при применении препарата, следует соблюдать\nосторожность при управлении транспортными средствами и работе с механизмами.\u003cb\u003e\u003c/b\u003e"}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутримышечного и подкожного введения\n5 мг/мл или 15 мг/мл."}},{"type":"paragraph","data":{"text":"По\u003cb\u003e \u003c/b\u003e1 мл\u003cb\u003e \u003c/b\u003eв ампуле из бесцветного стекла I гидролитического\nкласса с двумя маркировочными кольцами желтого и красного цвета (5 мг/мл) или зеленого и красного\nцвета (15 мг/мл) и с линией или точкой\nразлома."}},{"type":"paragraph","data":{"text":"По 5 ампул в ячейковой упаковке из\nполивинилхлоридной пленки без покрытия (поддон). "}},{"type":"paragraph","data":{"text":"По 2 ячейковые упаковки (поддона) вместе с инструкцией\nпо применению в пачке из картона.\u003cb\u003e\u003c/b\u003e"}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 \u003csup\u003eо\u003c/sup\u003eС.\nНе замораживать!"}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте!"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности,\nуказанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Эйч Би Эм Фарма с.р.о. "}},{"type":"paragraph","data":{"text":"Ул. Склабинска, 30,\nМартин, 036 80, Словакия"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"117556, Москва, Варшавское шоссе, д. 74, корп. 3, 5 этаж."}},{"type":"paragraph","data":{"text":"Тел. в Москве (495) 7716505"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаИпидакрин – обратимый ингибитор холинэстеразы. Непосредственно стимулирует проведение импульсов в центральной нервной системе (ЦНС) и нервно-мышечных синапсах, блокируя калиевые каналы мембран. Усиливает действие на гладкую мускулатуру не только медиатора ацетилхолина, но и адреналина, серотонина, гистамина и окситоцина. Главные фармакологические эффекты ипидакрина: - восстановление и стимуляция нервно-мышечного проведения; - восстановление проведения импульса в периферической нервной системе после блокады, вызванной некоторыми факторами (например, травма, воспаление, действие местных анестетиков, антибиотиков, токсинов и калия хлорида); - усиление сократимости и тонуса гладкой мускулатуры внутренних органов; - специфическая умеренная стимуляция ЦНС в комбинации с отдельными проявлениями седативного действия; - улучшение памяти. При доклиническом изучении ипидакрин не оказывал тератогенного, эмбриотоксического, мутагенного, канцерогенного и иммунотоксического действий, не влиял на эндокринную систему. Достаточные данные клинических исследований безопасности применения ипидакрина у детей отсутствуют.ФармакокинетикаАбсорбцияПосле применения внутрь ипидакрин быстро всасывается из желудочно-кишечного тракта. Максимальная концентрация в плазме после подкожного или внутримышечного введения достигается в течение 25-30 минут. Около 40-55 % активного вещества связывается с протеинами плазмы. Терапевтический эффект проявляется через 15‑20 минут после парентерального введения. Продолжительность действия препарата составляет 3-5 часов.РаспределениеПрепарат проникает через гематоэнцефалический барьер. Ипидакрин быстро поступает в ткани, в равновесном состоянии в плазме находят только 2 % препарата.Метаболизм и выведениеПрепарат метаболизируется в печени. Выведение ипидакрина осуществляется ренально и экстраренально (через желудочно-кишечный тракт), преобладает выведение с мочой. Период полувыведения ипидакрина составляет 40 мин. После парентерального введения 34,8 % от примененной дозы ипидакрина выводится в неизмененном виде с мочой. Это свидетельствует о быстром метаболизме препарата в организме.","substance":[{"id":266,"title":"Ипидакрин","title_latin":"Ipidacrinum","slug":"ipidakrin_266"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Ипигрикс - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/89870/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/89870/share_default/"}},"diseases":[{"id":"467","title":"Деменция при болезни Альцгеймера","slug":"467-dementsiya_pri_bolezni_altsgeymera"},{"id":"470","title":"Расстройства личности и поведения, обусловленные болезнью, повреждением или дисфункцией головного мозга","slug":"470-rasstroystva_lichnosti_i_povedeniya_obuslovlennye_boleznyu_povrezhdeniem_ili_disfunktsiey_golovnogo_mozga"},{"id":"541","title":"Дистония (в т.ч. дискинезия)","slug":"541-distoniya_v_tch_diskineziya"},{"id":"548","title":"Болезнь 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