Ливазо Таблетки, 28 шт, 4 мг, для приема внутрь

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До начала лечения и в процессе пациенты должны придерживаться гипохолестеринемической диеты.; Начальная доза препарата 1 мг/сут однократно. При необходимоcти дозу препарата увеличивают с интервалами не менее 4 недель до 2 мг/сут. Дозу следует подбирать индивидуально в соответствии с концентрациями ХС ЛПНП, целью лечения и ответом пациента на лечение. Большинству пациентов требуется доза 2 мг. Максимальная суточная доза - 1 мг.; Пациенты с легкими и умеренными нарушениями функции печени: рекомендована максимальная суточная доза 2 мг.; Пациенты с нарушением функции почек: при нарушении функции почек легкой степени гяжести (желательно объективно оценить данную степень с отражением КК или скорости клубочковой фильтрации), препарат Ливазо следует применять с осторожностью. Данные по применению максимальной суточной дозы препарата 4 мг при нарушениях функции почек любой степени тяжести ограничены, поэтому назначать максимальную суточную дозу 4 мг необходимо только при тщательном контроле функции почек после постепенного повышения дозы. Не рекомендуется пациентам с тяжелыми нарушениями функции почек назначать максимальную суточную дозу в 4 мг; рекомендуется рассмотреть ограничение максимальной суточной дозы до 2 мг при тяжелой почечной недостаточности.; Пациенты пожилого возрасте: коррекция дозы не требуется."}}]},{"id":6,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В контролируемых клинических исследованиях при приеме рекомендованных доз менее 4% пациентов, получавших лечение препаратом Лнвазо. было исключено из исследования в связи с развитием нежелательных реакций. Наиболее распространенной была миапгия.; В зависимости от частоты возникновения выделяют следующие нежелательные реакции в соответствии с классификацией ВОЗ: очень часто: ≥10, часто: от ≥1/100 до \u003c1/10, нечасто: от ≥1/1000 до \u003c1/100, редко: от ≥1/10000 до \u003c1/10000, очень редко: \u003c1/10000 н частота неизвестна (имеющиеся данные не позволяют определить частоту).; Со стороны органов кроветворения: нечасто - анемия.; Со стороны обмена веществ: нечасто - анорексия.; Нарушение психики: часто - бессонница.; Со стороны нервной системы: часто - головная боль; нечасто - головокружение, нарушение вкуса, сонливость.; Со стороны органов чувств: нечасто - звон в ушах; редко - снижение остроты зрения.; Со стороны кожных покровов: нечасто - кожный зуд, супь; редко - крапивница, эритема.; Со стороны опорно-двигательного аппарата: часто - миалгия, артралгия; нечасто - мышечные спазмы.; Со стороны мочевыделительной системы: нечасто - поллакиурия.; Со стороны пищеварительной системы: часто - запор, диарея, диспепсия, тошнота; нечасто - боли в животе, сухость слизистой оболочки полости рта, рвота; редко - глоссодиния, острый панкреатит, холестатическая желтуха.; Лабораторные показатели: нечасто - понышенне активности \"печеночных\" трансаминаз ACT, АЛТ, повышение активности креатинфосфокиназы (КФК).; В клинических исследований после приема Ливазо наблюдалось повышение активности КФК в 3 раза выше ВГН у 49 пациентов из 2800 (1.8%). Уровни превышения ВГН в 10 раз и более с сопутствующими мышечными симптомами отмечались редко, и наблюдались только у одного пациента из 2406 пациентов, получавших 4 мг Ливазо (0.04%) в программе клинических исследований.; Прочие: нечасто - астении, недомогание, повышенная утомляемость, периферические отеки.; Опыт постмаркетингового применения; Двухлетнее проспективное исследование пострегистрационного наблюдения было проведено приблизительно у 20000 пациентов в Японии. Подавляющее большинство из этих пациентов получали питавастатин в дозе 1 или 2 мг, а не 4 мг. У 10.4 % пациентов были зарегистрированы нежелательные реакции, у которых нельзя исключить причинную связь с питавастатином, и 7.4% пациентов прекратили лечение в связи с развитием нежелательных реакций. Частота возникновнения миалгии составляла 1.08%. Большинство нежелательных реакций были легкими. На протяжении 2-х лет частота нежелательных реакций была выще у пациентов, имевших в анамнезе лекарственную аллергию (20.4%) или заболевание печени или почек (13.5%).; Нежелательные реакции и частота их возникновения, наблюдавшиеся в проспективном исследовании пострегистрационного наблюдения, но не в международных контролируемых клинических исследованиях при применении препарата и рекомендуемых дозах приведены ниже.; Со стороны печени и желчевыводящих путей: редко - нарушение функции печени.; Со стороны опорно-двигательного аппарата: редко - миопатия, рабдомиолиз.; В исследовании пострегистрационного наблюдения имелись два сообщения о рабдомиолизе, при котором пациенты нуждались в госпитализации (0.01% пациентов).; Кроме того, имеются спонтанные сообщения об эффектах со стороны опорно-двигательного аппарата, включающие миалгию и миопатию у пациентов, лечившихся Ливазо во всех рекомендуемых дозах. Были также получены сообщения о рабдомиолизе с острой почечной недостаточностью и без нее, в т.ч., о рабдомиолизе с летальным исходом.; Были также получены спонтанные сообщения о следующих нежелательных реакциях (частота основана на случаях, наблюдаемых в пострегистрационных исследованиях).; Со стороны нервной системы: нечасто - гипестезия.; Со стороны пищеварительной системы: редко - абдомиальный дискомфорт.; Нежелательные явления при применении других статинов:;- нарушение сна, включая кошмарные сновидения; - амнезия; - сексуальная дисфункция; - депрессия; - интеретициальное заболевание легких; - сахарный диабет: частота нозникновения зависит от наличия или отсутсвия факторов риска (концентрация глюкозы в крови натощак ≥5 ммоль/л, ИМТ\u003e30 кг/м2, повышенная концентрация ТГ, артериальная гипертензия в анамнезе); - повышение гликозилированного гемоглобина."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Питавастатин - конкурентный ингибитор ГМГ-КоА (З-гидрокси-З-метилглютарилкоэнзим А) редуктазы, фермента, катализирующего начальную стадию синтеза холестерина образование мевалоновой кислоты из ГМГ-КоА. Поскольку превращение ГМГ-КоА и мевалоновую кислоту представляет собой начальную стадию синтеза холестерина, то применение питавастатина не вызывает накопления в организме потенциально токсичных стеролов. ГМГ-КоА легко метаболизируется до ацетил-КоА. который участвует во многих процессах синтеза в организме. Клинические исследования показали эффективность препарата Ливазо в отношении снижения концентрации общего холестерина (ОХС) в плазме крови, холестерина липопротеинов низкой плотности (ХС ЛПНП), холестерина липопротеинов очень низкой плотности (ХС ЛПОНП). триглицеридов (ТГ) и аполипопротеина В (Аро-В), а также повышения концентрации холестерина липопротеинов высокой плотности (ХС ЛПВП) и аполипопротеина А1 (Аро-Al).","substance":[{"id":968,"title":"Питавастатин","title_latin":"Pitavastatinum","slug":"pitavastatin_968"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Ливазо - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/14728/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/14728/share_default/"}},"diseases":[],"other_packages":[{"id":99523,"title":"Ливазо","subtitle":{"full":"Таблетки, 28 шт, 1 мг","short":"Таблетки, 28 шт, 1 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