Бромгексин 8 Берлин-Хеми Драже, 25 шт, 8 мг

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Возможно\nнитрозирование бромгексина в физиологических условиях в желудке."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Секретолитическая терапия при острых и хронических\nбронхолегочных заболеваниях, ассоциированных с нарушением секреции и\nтранспорта мокроты (например, острый и хронический бронхит, бронхоэктаз и\nдр.)."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"ordered","items":["повышенная чувствительность к бромгексину и другим\n компонентам препарата;","дефицит лактазы, редкая наследственная непереносимость\n галактозы или фруктозы, синдром глюкозо-галактозная мальабсорбции,\n сахаразо-изомальтазная недостаточность;","язвенная болезнь желудка и двенадцатиперстной кишки (в\n том числе в анамнезе);","беременность (I триместр);","детский возраст до 6 лет."]}}]},{"id":28,"name":"С осторожностью","slug":"cautions","body":[{"type":"list","data":{"style":"ordered","items":["при нарушении функции почек и/или\n заболеваниях печени;","при нарушении моторики бронхов, сопровождающемся\n чрезмерным скоплением секрета;"]}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Применение препарата во время беременности возможно во 2 и 3\nтриместре только в том случае, если предполагаемая польза для матери\nпревышает возможный риск для плода. Применение бромгексина в\nпериод грудного вскармливания противопоказано."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь, после еды, не разжевывая,\nзапивая достаточным количеством жидкости."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВзрослые и подростки старше 14 лет\u003c/i\u003e: по 1-2 драже 3 раза в сутки (24-48 мг/сутки)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети от 6 до 14 лет, а также пациенты с массой тела менее 50\nкг\u003c/i\u003e: по 1 драже 3 раза в сутки (24\nмг/сутки)."}},{"type":"paragraph","data":{"text":"При нарушении функции почек и/или печени следует увеличить\nинтервалы между приемами, либо уменьшить дозу. По данному вопросу необходимо\nпроконсультироваться с лечащим врачом."}},{"type":"paragraph","data":{"text":"Бромгексин не следует принимать более 4-5 дней без\nконсультации с лечащим врачом."}},{"type":"paragraph","data":{"text":"Длительность применения устанавливается в индивидуальном\nпорядке и зависит от показаний и течения болезни."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Обычно препарат Бромгексин 8 Берлин-Хеми переносится хорошо."}},{"type":"paragraph","data":{"text":"Возможные побочные эффекты приведены ниже по нисходящей\nчастоте возникновения: \u003ci\u003eочень\nчасто (> 1/10), часто (< 1/100, < 1/10), нечасто (< 1/1000 < 1/100),\nредко (< 1/10000 <1/1000), очень редко, включая отдельные\nсообщения (< 1/10000), неизвестно (не может быть оценена исходя из\nимеющихся данных)\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны иммунной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eРедко: \u003c/i\u003eреакции гиперчувствительности;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЧастота не установлена:\u003c/i\u003e анафилактические реакции, вплоть\nдо анафилактического шока; ангионевротический отек, кожный зуд."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны кожи и\nподкожных тканей\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eРедко:\u003c/i\u003e кожная сыпь, крапивница;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЧастота не установлена:\u003c/i\u003e тяжелые кожные реакции, включая мультиформную эритему,\nсиндром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром\nЛайелла), острый генерализованный экзантематозный пустулез (см. раздел \"Особые\nуказания\")."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны желудочно-кишечного\nтракта\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eНечасто:\u003c/i\u003e тошнота, рвота, боль в животе, диарея."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие нарушения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eНечасто:\u003c/i\u003e лихорадка."}},{"type":"paragraph","data":{"text":"При всех формах аллергических реакций\n(гиперчувствительность, анафилаксия) или в случае появления любого поражения кожи\nи/или слизистых оболочек необходимо прекратить прием данного лекарственного\nпрепарата и немедленно проинформировать об этом лечащего врача."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Опасные для жизни симптомы передозировки при применении\nпрепарата Бромгексин 8 Берлин-Хеми неизвестны."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e опасных случаев передозировки у человека до настоящего\nвремени не известно."}},{"type":"paragraph","data":{"text":"Опубликовано исследование случаев передозировки, согласно\nкоторому в 4 из 25 случаев передозировки наблюдалась рвота. У трех детей были\nотмечены такие явления, как рвота, а также оглушение сознания, атаксия,\nдиплопия, метаболический ацидоз легкой степени тяжести и тахипноэ. У детей\nсимптомы не возникали при приеме бромгексина в дозе до 40 мг, даже при\nотсутствии лечения."}},{"type":"paragraph","data":{"text":"Доказательства хронической токсичности бромгексина у\nчеловека отсутствуют."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e при выраженной передозировке показаны мониторинг\nкровообращения и, в случае необходимости, симптоматическое лечение. В связи с\nнизкой токсичностью бромгексина, как правило, нет необходимости в проведении\nинвазивных мероприятий, направленных на снижение его всасывания (принудительная\nрвота, промывание желудка) или на ускорение выведения. Кроме того, из-за\nособенностей фармакокинетики (высокий объем распределения, медленные процессы\nперераспределения и высокая степень связывания с белками), эффективного\nудаления бромгексина из организма путем диализа или форсированного диуреза не\nследует ожидать."}},{"type":"paragraph","data":{"text":"Поскольку у детей с 2-х лет даже после приема больших доз\nбромгексина ожидаются только легкие симптомы, при дозе бромгексина гидрохлорида\nдо 80 мг (например, 10 таблеток по 8 мг) детоксикацию можно не проводить. У\nдетей более младшего возраста соответствующий предел дозы составляет 60 мг\nбромгексина гидрохлорида (6 мг/кг массы тела)."}},{"type":"paragraph","data":{"text":"При передозировке возможно также развитие побочных эффектов,\nвызванных вспомогательными веществами."}}]},{"id":29,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Бромгексин не назначают одновременно с противокашлевыми\nсредствами (в том числе содержащими кодеин), т.к. из-за подавления рефлекса\nзатрудняется эвакуация разжиженной мокроты, что может привести к скоплению\nсекрета в дыхательных путях."}},{"type":"paragraph","data":{"text":"Бромгексин способствует проникновению антибиотиков\n(эритромицин, цефалексин, окситетрациклин, ампициллин, амоксициллин) в\nбронхиальный секрет в первые 4-5 дней противомикробной терапии. Клиническая\nзначимость данного возможного взаимодействия не доказана."}},{"type":"paragraph","data":{"text":"При одновременном применении с препаратами, оказывающими\nраздражающее действие на желудочно-кишечный тракт (например, некоторые\nнестероидные противовоспалительные препараты), возможно усиление раздражающего\nдействия последних на слизистую оболочку желудка."}}]},{"id":9,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В случаях нарушения моторики бронхов (например, при редком\nсиндроме первичной дискинезии ресничек) или при значительном объеме выделяемой\nмокроты, применение препарата Бромгексин 8 Берлин-Хеми требует\nосторожности, в связи с повышенным риском обструкции дыхательных путей."}},{"type":"paragraph","data":{"text":"При нарушении функции почек\nи при тяжелых заболеваниях печени препарат Бромгексин 8\nБерлин-Хеми следует применять с особой осторожностью (например, уменьшить\nдозу или увеличить интервал между приемами). При тяжелой почечной\nнедостаточности необходимо учитывать возможность кумуляции образующихся в\nпечени метаболитов."}},{"type":"paragraph","data":{"text":"Рекомендуется периодическое проведение мониторинга функции\nпечени, особенно при длительном лечении."}},{"type":"paragraph","data":{"text":"Имеются данные о возникновении в очень редких случаях\nтяжелых кожных реакций (таких как мультиформная эритема, синдром\nСтивенса-Джонсона, токсический эпидермальный некролиз, острый генерализованный\nэкзантематозный пустулез) на фоне приема бромгексина. При появлении\nаллергических реакций и/или признаков прогрессирующей кожной сыпи (иногда в\nсочетании с возникновением пузырей и поражением слизистых оболочек) следует\nнемедленно прекратить применение препарата и обратиться к врачу."}}]},{"id":30,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"При приеме в рекомендованных дозах препарат\nБромгексин 8 Берлин-Хеми не оказывает влияния на скорость психомоторных\nреакций."}}]},{"id":31,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Драже 8 мг."}},{"type":"paragraph","data":{"text":"По 25 драже в контурную ячейковую упаковку (блистер\nПВХ/фольга алюминиевая)."}},{"type":"paragraph","data":{"text":"По 1 блистеру вместе с инструкцией по применению\nпомещают в картонную пачку."}}]},{"id":32,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25ºС."}},{"type":"paragraph","data":{"text":"Лекарственное средство хранить в недоступном для детей\nместе!"}}]},{"id":33,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года"}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности, указанного на\nупаковке."}}]},{"id":34,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":35,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Берлин-Хеми АГ"}},{"type":"paragraph","data":{"text":"Темпельхофер Вег 83"}},{"type":"paragraph","data":{"text":"12347 Берлин, Германия"}}]},{"id":36,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Берлин-Хеми/А. Менарини\", Россия"}},{"type":"paragraph","data":{"text":"123112, г. Москва, Пресненская набережная, дом 10, БЦ\n\"Башня на набережной\", Блок , тел. (495) 785-01-00, факс (495)\n785-01-01."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаБромгексин оказывает муколитическое (секретолитическое) и отхаркивающее (секретомоторное) действие. Снижает вязкость мокроты, активирует мерцательный эпителий, увеличивает объем мокроты и улучшает ее отхождение. Стимулирует выработку эндогенного сурфактанта, обеспечивающего стабильность альвеолярных клеток в процессе дыхания. Эффект проявляется через 2-5 дней от начала лечения.ФармакокинетикаВсасывание.После приема внутрь бромгексин быстро и практически полностью всасывается из желудочно-кишечного тракта. Период полуабсорбции составляет около 0,4 ч. Максимальная концентрация в плазме крови после приема внутрь достигается через 1 ч.Распределение.Объем распределения составляет приблизительно 7 л/кг массы тела. Степень связывания с белками плазмы крови составляет 99%. Бромгексин проникает через гематоэнцефалический барьер и плацентарный барьер. Проникает в грудное молоко и спинномозговую жидкость. Бромгексин не подвергается кумуляции.Метаболизм.80% бромгексина подвергается эффекту \"первого прохождения\" через печень с образованием биологически активных метаболитов. При тяжелых заболеваниях печени отмечается снижение клиренса бромгексина.Выведение.Бромгексин выводится из организма, главным образом, в виде метаболитов. Полупериод достижения минимальной эффективной концентрации после достижения равновесия между процессами всасывания и выведения составляет приблизительно 1 ч. Конечный период полувыведения составляет около 16 ч за счет обратного распределения небольших количеств бромгексина из тканей. Выводится преимущественно почками в виде метаболитов, образующихся в печени. В связи с высокой степенью связывания с белками плазмы крови и высоким объемом распределения, а также медленным перераспределением из тканей в кровь, значительного выведения бромгексина с помощью диализа или форсированного диуреза ожидать не следует. При тяжелой почечной недостаточности не может быть исключено увеличение периода полувыведения метаболитов бромгексина. 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