Ампициллин - антибиотик группы полусинтетических пенициллино... Инструкция
Показания к применению
Инфекционно-воспалительные заболевания, вызванные чувствительными к ампициллину микроорганизмами, в т.ч.:– инфекции дыхательных путей (в т.ч. бронхит, пневмония, абсцесс легкого),– инфекции ЛОР-органов (в т.ч. тонзиллит),– инфекции желчевыводящих путей (в т.ч. холецистит, холангит),– инфекции мочевыводящих путей (в т.ч. пиелит, пиелонефрит, цистит),– ...
– повышенная чувствительность к антибиотикам из группы пенициллина и другим беталактамным антибиотикам,– выраженные нарушения функции печени (для парентерального применения).
1 таблетка содержит: Активное вещество: эторикоксиб 120 мг. Вспомогательные вещества: кальция гидрофосфат, целлюлоза микрокристаллическая, кроскармеллоза натрия, магния стеарат. Состав оболочки: опадрай II зеленый 39К11529, воск карнаубский. Состав пленочной оболочки: лактозы моногидрат, гипромеллоза, титана диоксид, триацетин, алюминиевый лак на основе красителя индигокармина (Е132), краситель железа оксид желтый (Е172).
Описание
Ампициллин — противомикробное средство, антибиотик, полусинтетический пенициллин. Ампициллин является полусинтетическим антибиотиком широкого спектра действия, применяется при заболеваниях, вызванных смешанной инфекцией.
Фармакологические свойства
Ампициллин - антибиотик группы полусинтетических пенициллинов широкого спектра действия. Оказывает бактерицидное действие за счет подавления синтеза клеточной стенки бактерий. Активен в отношении грамположительных аэробных бактерий: Staphylococcus spp. (за исключением штаммов, продуцирующих пенициллиназу), Streptococcus spp. (в т.ч. Enterococcus spp.), Listeria monocytogenes, грамотрицательных аэробных бактерий: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, некоторых штаммов Haemophilus influenzae. Разрушается под действием пенициллиназы. Кислотоустойчив.
Показания к применению
Инфекционно-воспалительные заболевания, вызванные чувствительными к ампициллину микроорганизмами, в т.ч.:– инфекции дыхательных путей (в т.ч. бронхит, пневмония, абсцесс легкого),– инфекции ЛОР-органов (в т.ч. тонзиллит),– инфекции желчевыводящих путей (в т.ч. холецистит, холангит),– инфекции мочевыводящих путей (в т.ч. пиелит, пиелонефрит, цистит),– инфекции ЖКТ (в т.ч. сальмонеллоносительство),– гинекологические инфекции,– инфекции кожи и мягких тканей,– перитонит,– сепсис, септический эндокардит,– менингит,– ревматизм,– рожа,– скарлатина,– гонорея.
Противопоказания
– повышенная чувствительность к антибиотикам из группы пенициллина и другим беталактамным антибиотикам,– выраженные нарушения функции печени (для парентерального применения).
Применение при беременности и в период грудного вскармливания
Возможно применение препарата при беременности по показаниям в тех случаях, когда польза для матери превышает потенциальный риск для плода. Ампициллин выделяется с грудным молоком в низких концентрациях. При необходимости применения препарата в период лактации следует решить вопрос о прекращении грудного вскармливания.
Способ применения и дозы
Устанавливают индивидуально в зависимости от тяжести течения, локализации инфекции и чувствительности возбудителя. При приеме внутрь разовая доза для взрослых составляет 250-500 мг, суточная доза - 1-3 г. Максимальная суточная доза составляет - 4 г. Детям препарат назначают в суточной дозе 50-100 мг/кг, детям с массой тела до 20 кг - 12.5-25 мг/кг. Суточную дозу делят на 4 приема. Продолжительность лечения зависит от тяжести инфекции и эффективности лечения. Таблетки принимают внутрь независимо от приема пищи.
Побочное действие
Аллергические реакции: кожная сыпь, крапивница, отек Квинке, зуд, эксфолиативный дерматит, мультиформная эритема, в редких случаях - анафилактический шок. Со стороны пищеварительной системы: тошнота, рвота, диарея, глоссит, стоматит, псевдомембранозный колит, кишечный дисбактериоз, повышение активности печеночных трансаминаз. Со стороны системы кроветворения: анемия, лейкопения, тромбоцитопения, агранулоцитоз. Эффекты, обусловленные химиотерапевтическим действием: кандидоз полости рта, вагинальный кандидоз.
Передозировка
Проявляется токсическим действием на ЦНС (особенно у больных с почечной недостаточностью). Лечение: симптоматическое.
Особые указания
С осторожностью и на фоне одновременного применения десенсибилизирующих средств следует назначать препарат при бронхиальной астме, сенной лихорадке и других аллергических заболеваниях. В процессе применения Ампициллина необходим систематический контроль функции почек, печени и картины периферической крови. При печеночной недостаточности препарат следует применять только под контролем функции печени. Пациентам с нарушениями функции почек требуется коррекция режима дозирования в зависимости от КК. При применении препарата в высоких дозах у пациентов с почечной недостаточностью возможно токсическое действие на ЦНС. При применении препарата для лечения сепсиса возможна реакция бактериолиза (реакция Яриша-Герксгеймера). При появлении аллергических реакций на фоне применения Ампициллина препарат следует отменить и назначить десенсибилизирующую терапию. У ослабленных пациентов при длительном применении препарата может развиться суперинфекция, вызванная устойчивыми к ампициллину микроорганизмами. Для профилактики развития кандидоза одновременно с Ампициллином следует назначить нистатин или леворин, а также витамины группы В и С.
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