Гидрокортизон - глюкокортикостероид, оказывает противовоспал... Инструкция
Показания к применению
Аллергические заболевания глаз (дерматиты век, бпефариты, конъюнктивиты и кератоконъюнктивиты); воспалительные заболевания переднего отдела глаза при отсутствии нарушения целостности эпителия роговицы (бпефариты, конъюнктивиты и кератоконъюнктивиты); термический и химический ожог глаз (после полной эпитепизации дефектов роговицы).
Противопоказания
Повышенная чувствительность к компонентам препарата;
метилларагидроксибензоат — 2,0 мг, вазелин белый — до 1,0 г
Описание
Противовоспалительное, противоаллергическое, противоотечное, противозудное. Воспалительные заболевания роговицы, склеры и конъюнктивы глаз; аллергические заболевания глаз и краев век; состояние после травмы или оперативного вмешательства на глазном яблоке (не ранее, чем через 7 дней после операции или травмы); асептический ожог (химический, термический или вызванный излучением) глаз. Конъюнктивально, 2-3 раза в сутки в небольшом количестве в течение 2 нед.
Фармакотерапевтическая группа
Глюкокортикостероид.
Фармакологические свойства
Гидрокортизон - глюкокортикостероид, оказывает противовоспалительное, противоаллергическое действие. Уменьшает воспалительные клеточные инфильтраты, снижает миграцию лейкоцитов, в т.ч. лимфоцитов в область воспаления. Стабилизирует клеточные и субклеточные, в том числе лизосомальные мембраны и мембраны тучных клеток. Уменьшает связывание иммуноглобулинов с рецепторами на поверхности клеток и тормозит синтез или высвобождение цитокинов (интерлейкинов и интерферонов) из лимфоцитов и макрофагов. Уменьшает освобождение арахидоновой кислоты из фосфолипидов и синтез ее метаболитов (простагландинов, лейкотриенов, тромбоксана). Уменьшает экссудативнуюреакцию, способствует уменьшению проницаемости капилляров. Снижает выраженность раннего иммунологического ответа. Обладает антиметаболическим действием и тормозит развитие соединительной ткани и рубцевание.
Фармакокинетика
Гидрокортизон плохо проникает через роговицу во внутриглазную жидкость. Гидрокортизон проникает в эпидермис и эпителий слизистой оболочки, может незначительно всасываться в системный кровоток и оказывать системное действие. Гидрокортизон метаболизируется непосредственно в эпидермисе и эпителии слизистой оболочки, в дальнейшем незначительное его количество после абсорбции попадает в общий кровоток и биотрансформируется в печени. В крови 80% связывается с транскортином и 10% c альбуминами. Метаболиты гидрокортизона выводятся через почки и кишечник.
Показания к применению
Аллергические заболевания глаз (дерматиты век, бпефариты, конъюнктивиты и кератоконъюнктивиты); воспалительные заболевания переднего отдела глаза при отсутствии нарушения целостности эпителия роговицы (бпефариты, конъюнктивиты и кератоконъюнктивиты); термический и химический ожог глаз (после полной эпитепизации дефектов роговицы).
Противопоказания
Повышенная чувствительность к компонентам препарата;
гнойные,
вирусные,
туберкулезные,
грибковые заболевания глаз;
глаукома;
трахома;
период вакцинации;
нарушения целостности оболочек глаза;
возраст до 18 лет.
Способ применения и дозы
Местно.
В конъюнктивальный мешок вводят 1 см глазной мази 2-3 раза в сутки.
Курс лечения 1 - 2 недели. По рекомендации врача курс лечения может быть продлен.
При длительном применении более 10 дней может наблюдаться:
— повышение внутриглазного давления c возможным последующим развитием стероидной глаукомы с поражением зрительного нерва и нарушением полей зрения (поэтому при применении препаратов, содержащих глюкокортикостероиды, более 10 дней следует регулярно измерять внутриглазное давление);
— образование задней субкапсулярной катаракты;
— замедление процесса заживления ран (при заболеваниях, вызывающих истончение роговицы, возможна ее перфорация).
Вторичная бактериальная инфекция может возникнуть как следствие подавления защитной реакции организма больного.
При острых гнойных заболеваниях глаза гпюкокортикостероиды могут замаскировать или усилить имеющийся инфекционный процесс.
Грибковое поражение роговицы имеет тенденцию особенно часто возникать при длительном применении гпюкокортикостероидов. Появление на роговице незаживающих язв после длительного печения гпюкокортикостероидами может свидетельствовать o развитии грибковой инвазии.
Передозировка
Передозировка отмечается крайне редко.
Симптомы передозировки: возможно возникновение местных побочных эффектов. При отмене препарата явления передозировки проходят самостоятельно.
Взаимодействие с другими лекарственными средствами
Взаимодействие с другими лекарственными средствами
При длительном применении препарата при возможной резорбции препарата в общий кровоток, гидрокортизон снижает эффективность инсулина, пероральных гипогпикемических препаратов, гипотензивных средств, антикоагулянтов, снижает концентрацию салицилатов в крови, уменьшает концентрацию празиквантела в сыворотке крови. Повышают риск развития побочных эффекгов гидрокортизона: андрогены, эстрогены, пероральные контрацептивы, анаболические стероиды (гирсутизм, угревая сыпь); антипсихотические средства, карбутамид, азатиоприн (катаракга); холиноблокаторы, антигистаминные препараты, трициклические антидепрессанты, нитраты (глаукома); диуретики (гипокапиемия).
При применении с сердечными гликозидами возможно развитие гликозидной интоксикации.
Одновременное применение с препаратами свинца и серебра приводит к взаимной инактивации.
Особые указания
Во время лечения не рекомендуется ношение контактных линз.
При использовании глазных капель интервал времени между их инстилляцией и нанесением мази - не менее 15 мин.
При применении более 10 дней и наличии в анамнезе открыто- ипи закрытоугопьной глаукомы необходим контроль внутриглазного давления.
Влияние на способность управлять автомобилем и движущимися механизмами
Если у пациента nocлe применения препарата временно снижается четкость зрения, до её восстановления нерекомендуется управлять автомобилем и заниматься видами деятельности, требующими повышенного внимания.
Форма выпуска
Мазь.
Условия хранения
Хранить при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
2 года. Не использовать после истечения срока годности.
Срок годности после вскрытия тубы - 4 недели.
Условия отпуска
Без рецепта.
Производитель
JELFA. Страна производства: Польша.
Для описания товара использована информация от партнера ЭркаФарм
Мобильное приложение «Все аптеки»
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Воспалительные заболевания роговицы, склеры и конъюнктивы глаз; аллергические заболевания глаз и краев век; состояние после травмы или оперативного вмешательства на глазном яблоке (не ранее, чем через 7 дней после операции или травмы); асептический ожог (химический, термический или вызванный излучением) глаз. Конъюнктивально, 2-3 раза в сутки в небольшом количестве в течение 2 нед."}}]},{"name":"Фармакотерапевтическая группа","slug":"","id":12,"body":[{"type":"paragraph","data":{"text":"Глюкокортикостероид."}}]},{"name":"Фармакологические свойства","slug":"pharmacologic_effects","id":13,"body":[{"type":"paragraph","data":{"text":"Гидрокортизон - глюкокортикостероид, оказывает противовоспалительное, противоаллергическое действие. Уменьшает воспалительные клеточные инфильтраты, снижает миграцию лейкоцитов, в т.ч. лимфоцитов в область воспаления. Стабилизирует клеточные и субклеточные, в том числе лизосомальные мембраны и мембраны тучных клеток. Уменьшает связывание иммуноглобулинов с рецепторами на поверхности клеток и тормозит синтез или высвобождение цитокинов (интерлейкинов и интерферонов) из лимфоцитов и макрофагов. Уменьшает освобождение арахидоновой кислоты из фосфолипидов и синтез ее метаболитов (простагландинов, лейкотриенов, тромбоксана). Уменьшает экссудативнуюреакцию, способствует уменьшению проницаемости капилляров. Снижает выраженность раннего иммунологического ответа. Обладает антиметаболическим действием и тормозит развитие соединительной ткани и рубцевание."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"Гидрокортизон плохо проникает через роговицу во внутриглазную жидкость. Гидрокортизон проникает в эпидермис и эпителий слизистой оболочки, может незначительно всасываться в системный кровоток и оказывать системное действие. Гидрокортизон метаболизируется непосредственно в эпидермисе и эпителии слизистой оболочки, в дальнейшем незначительное его количество после абсорбции попадает в общий кровоток и биотрансформируется в печени. В крови 80% связывается с транскортином и 10% c альбуминами. Метаболиты гидрокортизона выводятся через почки и кишечник."}}]},{"name":"Показания к применению","slug":"indications","id":14,"body":[{"type":"paragraph","data":{"text":"Аллергические заболевания глаз (дерматиты век, бпефариты, конъюнктивиты и кератоконъюнктивиты); воспалительные заболевания переднего отдела глаза при отсутствии нарушения целостности эпителия роговицы (бпефариты, конъюнктивиты и кератоконъюнктивиты); термический и химический ожог глаз (после полной эпитепизации дефектов роговицы)."}}]},{"name":"Противопоказания","slug":"contraindications","id":15,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к компонентам препарата; "}},{"type":"paragraph","data":{"text":"гнойные, "}},{"type":"paragraph","data":{"text":"вирусные, "}},{"type":"paragraph","data":{"text":"туберкулезные, "}},{"type":"paragraph","data":{"text":"грибковые заболевания глаз;"}},{"type":"paragraph","data":{"text":"глаукома;"}},{"type":"paragraph","data":{"text":"трахома;"}},{"type":"paragraph","data":{"text":"период вакцинации;"}},{"type":"paragraph","data":{"text":"нарушения целостности оболочек глаза;"}},{"type":"paragraph","data":{"text":"возраст до 18 лет."}}]},{"name":"Способ применения и дозы","slug":"dosage","id":18,"body":[{"type":"paragraph","data":{"text":"Местно."}},{"type":"paragraph","data":{"text":"В конъюнктивальный мешок вводят 1 см глазной мази 2-3 раза в сутки."}},{"type":"paragraph","data":{"text":"Курс лечения 1 - 2 недели. По рекомендации врача курс лечения может быть продлен."}}]},{"name":"Побочное действие","slug":"side_effects","id":19,"body":[{"type":"paragraph","data":{"text":"Аллергические реакции, жжение, инъецированность склер, кратковременное затуманивание зрения."}},{"type":"paragraph","data":{"text":"При длительном применении более 10 дней может наблюдаться:"}},{"type":"paragraph","data":{"text":"— повышение внутриглазного давления c возможным последующим развитием стероидной глаукомы с поражением зрительного нерва и нарушением полей зрения (поэтому при применении препаратов, содержащих глюкокортикостероиды, более 10 дней следует регулярно измерять внутриглазное давление);"}},{"type":"paragraph","data":{"text":"— образование задней субкапсулярной катаракты;"}},{"type":"paragraph","data":{"text":"— замедление процесса заживления ран (при заболеваниях, вызывающих истончение роговицы, возможна ее перфорация)."}},{"type":"paragraph","data":{"text":"Вторичная бактериальная инфекция может возникнуть как следствие подавления защитной реакции организма больного."}},{"type":"paragraph","data":{"text":"При острых гнойных заболеваниях глаза гпюкокортикостероиды могут замаскировать или усилить имеющийся инфекционный процесс."}},{"type":"paragraph","data":{"text":"Грибковое поражение роговицы имеет тенденцию особенно часто возникать при длительном применении гпюкокортикостероидов. Появление на роговице незаживающих язв после длительного печения гпюкокортикостероидами может свидетельствовать o развитии грибковой инвазии."}}]},{"name":"Передозировка","slug":"overdose","id":20,"body":[{"type":"paragraph","data":{"text":"Передозировка отмечается крайне редко."}},{"type":"paragraph","data":{"text":"Симптомы передозировки: возможно возникновение местных побочных эффектов. 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Повышают риск развития побочных эффекгов гидрокортизона: андрогены, эстрогены, пероральные контрацептивы, анаболические стероиды (гирсутизм, угревая сыпь); антипсихотические средства, карбутамид, азатиоприн (катаракга); холиноблокаторы, антигистаминные препараты, трициклические антидепрессанты, нитраты (глаукома); диуретики (гипокапиемия)."}},{"type":"paragraph","data":{"text":"При применении с сердечными гликозидами возможно развитие гликозидной интоксикации."}},{"type":"paragraph","data":{"text":"Одновременное применение с препаратами свинца и серебра приводит к взаимной инактивации."}}]},{"name":"Особые указания","slug":"","id":22,"body":[{"type":"paragraph","data":{"text":"Во время лечения не рекомендуется ношение контактных линз."}},{"type":"paragraph","data":{"text":"При использовании глазных капель интервал времени между их инстилляцией и нанесением мази - не менее 15 мин."}},{"type":"paragraph","data":{"text":"При применении более 10 дней и наличии в анамнезе открыто- ипи закрытоугопьной глаукомы необходим контроль внутриглазного давления."}}]},{"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","id":23,"body":[{"type":"paragraph","data":{"text":"Если у пациента nocлe применения препарата временно снижается четкость зрения, до её восстановления нерекомендуется управлять автомобилем и заниматься видами деятельности, требующими повышенного внимания."}}]},{"name":"Форма выпуска","slug":"","id":24,"body":[{"type":"paragraph","data":{"text":"Мазь."}}]},{"name":"Условия хранения","slug":"storage","id":25,"body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"name":"Срок годности","slug":"expiry_date","id":26,"body":[{"type":"paragraph","data":{"text":"2 года. 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