Ингибитор H+-K+-АТФ-азы. Блокирует заключительную стадию секреции хлороводородной (соляной) кислоты, снижает уровень базальной и стимулированной (независимо от вида раздражителя) секреции хлороводородной (соляной) кислоты в желудке. При язвенной болезни двенадцатиперстной кишки, ассоциированной с Helicobacter pylori, снижение желудочной секреции повышает чувствительность микроогранизма к антибиотикам.
Не влияет на моторику ЖКТ. Секреторная активность нормализуется через 3-4 дня после окончания приема препарата.
Показания к применению
язвенная болезнь желудка или двенадцатиперстной кишки в фазе обострения;
эрозивный гастрит (в т.ч. ассоциированный с Helicobacter pylori);
эрозивно-язвенные поражения желудка и двенадцатиперстной кишки, связанные с приемом НПВП;
рефлюкс-эзофагит.
Противопоказания
диспепсия невротического генеза;
злокачественные заболевания ЖКТ;
детский возраст (из-за отсутствия данных о применении препарата в педиатрической практике);
повышенная чувствительность к пантопразолу.
С осторожностью
С осторожностью назначают препарат при печеночной недостаточности.
Применение при беременности и в период грудного вскармливания
Опыт применения препарата при беременности и в период лактации ограничен. Препарат можно применять при беременности только в том случае, если польза для матери превышает возможный риск для плода.
Данных о выделении пантопразола с грудным молоком нет. Следует прекратить грудное вскармливание во время приема препарата.
В экспериментальных исследованиях репродуктивной функции отмечали незначительную эмбриотоксичность в дозах, превышающих 5 мг/кг.
Способ применения и дозы
При язвенной болезни желудка и двенадцатиперстной кишки, эрозивном гастрите препарат назначают по 40-80 мг/сут. Курс лечения при обострении язвенной болезни двенадцатиперстной кишки составляет 2 недели, а язвенной болезни желудка - 4-8 недель.
Для профилактики обострений язвенной болезни желудка и двенадцатиперстной кишки назначают по 20 мг/сут.
Для эрадикации Helicobacter pylori принимают по 40 мг 2 раза/сут в комбинации с противомикробными средствами. Курс терапии - 7-14 дней.
При эрозивно-язвенных поражениях желудка и двенадцатиперстной кишки, связанных с приемом НПВП, назначают по 40-80 мг/сут. Курс лечения - 4-8 недель. Для профилактики эрозивных поражений на фоне длительного применения НПВП - по 20 мг/сут.
При рефлюкс-эзофагите назначают по 20-40 мг/сут. Курс терапии составляет 4-8 недель. Для профилактики обострений принимают по 20 мг/сут.
У пациентов с выраженными нарушениями функции печени дозу следует снизить до 40 мг 1 раз в 2 дня, при этом необходимо контролировать биохимические показатели крови. При повышении активности печеночных ферментов препарат следует отменить.
Таблетки принимают внутрь целиком (не размельчая и не растворяя), запивая достаточным количеством жидкости. Препарат рекомендуют принимать за 1 ч до завтрака, при кратности приема 2 раза/сут вторую дозу - за 1 ч до ужина.
Побочное действие
Со стороны ЦНС: головная боль; очень редко - депрессия, слабость, головокружение, нарушение зрения.
Со стороны пищеварительной системы: диарея, тошнота, боли в верхней части живота, запор, метеоризм; в единичных случаях (1 случай на 106 пациентов) - тяжелое гепатоцеллюлярное поражение печени с желтухой, нарушения функции печени.
Аллергические реакции: кожная сыпь, зуд, гиперемия кожи, анафилактические реакции (вплоть до шока).
Взаимодействие с другими лекарственными средствами
Одновременное применение Санпраза может уменьшить всасывание препаратов, биодоступность которых зависит от рН среды желудка (в т.ч. кетоконазол, соли железа, ритонавир).
При совместном применении Санпраза с атазанавиром происходит снижение плазменных концентраций атазанавира и уменьшение его терапевтического эффекта.
При проведении специфических тестов Санпраза с такими препаратами как дигоксин, нифедипин, метопролол, амоксициллин, кларитромицин, пероральные контрацептивы (левоноргестрел/этинилэстрадиол), диклофенак, феназон, напроксен, пироксикам, глибенкламид, левотироксин натрия, диазепам, карбамазепин, фенитоин, циклоспорин, такролимус, цизаприд, мидазолам, метронидазол, теофиллин, кофеин, этанол клинически значимого взаимодействия не обнаружено.
Согласно постмаркетинговым данным при совместном приеме препарата с варфарином увеличивается протромбиновое время, что может привести к кровотечению, вплоть до летального исхода. Рекомендуется определять протромбиновое время.
Особые указания
Применение пантопразола при диспепсии неврогенного генеза не эффективно.
В присутствии какого-либо из тревожных симптомов (например, значимая непреднамеренная потеря веса, периодическая рвота, дисфагия, анемия или мелена) и в случае подозрения или наличия язвы желудка, следует исключить возможность злокачественного новообразования, т.к. лечение пантопразолом может уменьшить симптомы и отсрочить правильную постановку диагноза. Если симптомы сохраняются, несмотря на адекватное лечение, то следует провести дальнейшее обследование.
До и после лечения обязателен эндоскопический контроль для исключения возможности наличия злокачественных заболеваний желудка или пищевода, т. к. лечение может замаскировать симптоматику и отсрочить правильную диагностику.
Использование в педиатрии
Нет достаточного количества данных по применению препарата у детей до 18 лет.
Влияние на способность управлять автомобилем и движущимися механизмами
Применение препарата не оказывает влияния на способность пациента к выполнению работы, требующей повышенного внимания и быстроты психомоторных реакций.
Форма выпуска
Таблетки
Условия хранения
В сухом, защищенном от света месте, при температуре не выше 25 °C
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"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСостав оболочки:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"сополимер метакриловой кислоты и этилакрилата (1:1) - 11 мг, триэтилцитрат - 1.1 мг, коповидон - 7 мг, тальк - 10.7 мг, титана диоксид (Е171) - 0.8 мг, железа оксид желтый (Е172) - 0.2 мг, макрогол 6000 - 0.35 мг."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/pharm-group/539\"\u003eПротонового насоса ингибитор\u003c/a\u003e"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Ингибитор H\u003csup\u003e+\u003c/sup\u003e-K\u003csup\u003e+\u003c/sup\u003e-АТФ-азы. Блокирует заключительную стадию секреции хлороводородной (соляной) кислоты, снижает уровень базальной и стимулированной (независимо от вида раздражителя) секреции хлороводородной (соляной) кислоты в желудке. При язвенной болезни двенадцатиперстной кишки, ассоциированной с Helicobacter pylori, снижение желудочной секреции повышает чувствительность микроогранизма к антибиотикам."}},{"type":"paragraph","data":{"text":"Не влияет на моторику ЖКТ. Секреторная активность нормализуется через 3-4 дня после окончания приема препарата."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["язвенная болезнь желудка или двенадцатиперстной кишки в фазе обострения;","эрозивный гастрит (в т.ч. ассоциированный с Helicobacter pylori);","эрозивно-язвенные поражения желудка и двенадцатиперстной кишки, связанные с приемом НПВП;","рефлюкс-эзофагит."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["диспепсия невротического генеза;","злокачественные заболевания ЖКТ;","детский возраст (из-за отсутствия данных о применении препарата в педиатрической практике);","повышенная чувствительность к пантопразолу."]}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью назначают препарат при печеночной недостаточности."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Опыт применения препарата при беременности и в период лактации ограничен. Препарат можно применять при беременности только в том случае, если польза для матери превышает возможный риск для плода."}},{"type":"paragraph","data":{"text":"Данных о выделении пантопразола с грудным молоком нет. Следует прекратить грудное вскармливание во время приема препарата."}},{"type":"paragraph","data":{"text":"В экспериментальных исследованиях репродуктивной функции отмечали незначительную эмбриотоксичность в дозах, превышающих 5 мг/кг."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"При \u003ci\u003eязвенной болезни желудка и двенадцатиперстной кишки, эрозивном гастрите\u003c/i\u003e препарат назначают по 40-80 мг/сут. Курс лечения при обострении язвенной болезни двенадцатиперстной кишки составляет 2 недели, а язвенной болезни желудка - 4-8 недель."}},{"type":"paragraph","data":{"text":"Для \u003ci\u003eпрофилактики обострений язвенной болезни желудка и двенадцатиперстной кишки\u003c/i\u003e назначают по 20 мг/сут."}},{"type":"paragraph","data":{"text":"Для \u003ci\u003eэрадикации Helicobacter pylori\u003c/i\u003e принимают по 40 мг 2 раза/сут в комбинации с противомикробными средствами. Курс терапии - 7-14 дней."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eэрозивно-язвенных поражениях желудка и двенадцатиперстной кишки, связанных с приемом НПВП,\u003c/i\u003e назначают по 40-80 мг/сут. Курс лечения - 4-8 недель. Для \u003ci\u003eпрофилактики эрозивных поражений на фоне длительного применения НПВП\u003c/i\u003e - по 20 мг/сут."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eрефлюкс-эзофагите\u003c/i\u003e назначают по 20-40 мг/сут. Курс терапии составляет 4-8 недель. Для \u003ci\u003eпрофилактики обострений\u003c/i\u003e принимают по 20 мг/сут."}},{"type":"paragraph","data":{"text":"У \u003cb\u003eпациентов с выраженными нарушениями функции печени\u003c/b\u003e дозу следует снизить до 40 мг 1 раз в 2 дня, при этом необходимо контролировать биохимические показатели крови. При повышении активности печеночных ферментов препарат следует отменить."}},{"type":"paragraph","data":{"text":"Таблетки принимают внутрь целиком (не размельчая и не растворяя), запивая достаточным количеством жидкости. Препарат рекомендуют принимать за 1 ч до завтрака, при кратности приема 2 раза/сут вторую дозу - за 1 ч до ужина."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны ЦНС:\u003c/i\u003e головная боль; очень редко - депрессия, слабость, головокружение, нарушение зрения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e диарея, тошнота, боли в верхней части живота, запор, метеоризм; в единичных случаях (1 случай на 10\u003csup\u003e6 \u003c/sup\u003eпациентов) - тяжелое гепатоцеллюлярное поражение печени с желтухой, нарушения функции печени."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e кожная сыпь, зуд, гиперемия кожи, анафилактические реакции (вплоть до шока)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e болезненное напряжение молочных желез, гипертермия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Одновременное применение Санпраза может уменьшить всасывание препаратов, биодоступность которых зависит от рН среды желудка (в т.ч. кетоконазол, соли железа, ритонавир)."}},{"type":"paragraph","data":{"text":"При совместном применении Санпраза с атазанавиром происходит снижение плазменных концентраций атазанавира и уменьшение его терапевтического эффекта."}},{"type":"paragraph","data":{"text":"При проведении специфических тестов Санпраза с такими препаратами как дигоксин, нифедипин, метопролол, амоксициллин, кларитромицин, пероральные контрацептивы (левоноргестрел/этинилэстрадиол), диклофенак, феназон, напроксен, пироксикам, глибенкламид, левотироксин натрия, диазепам, карбамазепин, фенитоин, циклоспорин, такролимус, цизаприд, мидазолам, метронидазол, теофиллин, кофеин, этанол клинически значимого взаимодействия не обнаружено."}},{"type":"paragraph","data":{"text":"Согласно постмаркетинговым данным при совместном приеме препарата с варфарином увеличивается протромбиновое время, что может привести к кровотечению, вплоть до летального исхода. Рекомендуется определять протромбиновое время."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Применение пантопразола при диспепсии неврогенного генеза не эффективно."}},{"type":"paragraph","data":{"text":"В присутствии какого-либо из тревожных симптомов (например, значимая непреднамеренная потеря веса, периодическая рвота, дисфагия, анемия или мелена) и в случае подозрения или наличия язвы желудка, следует исключить возможность злокачественного новообразования, т.к. лечение пантопразолом может уменьшить симптомы и отсрочить правильную постановку диагноза. Если симптомы сохраняются, несмотря на адекватное лечение, то следует провести дальнейшее обследование."}},{"type":"paragraph","data":{"text":"До и после лечения обязателен эндоскопический контроль для исключения возможности наличия злокачественных заболеваний желудка или пищевода, т. к. лечение может замаскировать симптоматику и отсрочить правильную диагностику."}},{"type":"paragraph","data":{"text":"Использование в педиатрии"}},{"type":"paragraph","data":{"text":"Нет достаточного количества данных по применению препарата у детей до 18 лет."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Применение препарата не оказывает влияния на способность пациента к выполнению работы, требующей повышенного внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, при температуре не выше 25 °C"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/san_farmasyutikal_indastriz_ltd/\"\u003eСан Фармасьютикал Индастриз Лтд, Индия\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Ингибитор H+-K+-АТФ-азы. 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