Под влиянием препарата происходит изменение флоры толстой ки... Инструкция
Показания к применению
Хронический запор, регулирование стула при геморрое, необходимости хирургической операции на толстой кишке и в области анального отверстия, в послеоперационном периоде, печеночная прекома и кома, печеночная энцефалопатия, гипераммониемия, дисбактериоз, сальмонеллез (за исключением генерализованных форм).
Противопоказания
Гиперчувствительность, непереносимость галактозы или фруктозы, галактоземия, непроходимость кишечника, ректальные кровотечения, коло-, илеостома, подозрение на аппендицит.
100 г содержит: Активное вещество: лактулоза - 66.7 г. Вспомогательные вещества: лимонная кислота - 0.05 г, ароматизатор сливочный (No7 бис) - 0.06 г, вода очищенная - до 100 мл. Состав ароматизатора: пропиленгликоль, дигидрокумарин, ванилин.
Описание
Сироп "Нормазе" - слабительное средство. Оказывает гиперосмотическое, гипоаммониемическое, слабительное действие, стимулирует перистальтику кишечника, улучшает всасывание фосфатов и солей кальция.
Фармакологические свойства
Под влиянием препарата происходит изменение флоры толстой кишки (увеличение количества лактобацилл), что приводит к повышению кислотности в просвете толстой кишки и стимулирует перистальтику. Наряду с этим увеличивается объем и происходит размягчение каловых масс. В результате препарат оказывает слабительный эффект, не влияя при этом непосредственно на слизистую оболочку и гладкую мускулатуру толстой кишки. Под действием препарата аммиак переходит из крови в кишечник, при этом уменьшается образование азотосодержащих токсических веществ в его проксимальном отделе и, соответственно, всасывание их в систему полой вены. Действие может наступать быстро или быть отсроченным - через 24-48 ч. Обладает способностью ингибировать рост сальмонелл в толстой кишке. Не уменьшает абсорбцию витаминов и не вызывает привыкания.
Показания к применению
Хронический запор, регулирование стула при геморрое, необходимости хирургической операции на толстой кишке и в области анального отверстия, в послеоперационном периоде, печеночная прекома и кома, печеночная энцефалопатия, гипераммониемия, дисбактериоз, сальмонеллез (за исключением генерализованных форм).
Противопоказания
Гиперчувствительность, непереносимость галактозы или фруктозы, галактоземия, непроходимость кишечника, ректальные кровотечения, коло-, илеостома, подозрение на аппендицит.
Применение при беременности и в период грудного вскармливания
Лактулоза безопасна при применении при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Препарат следует принимать внутрь после еды. При запорах взрослым в первые 3 дня назначают 15-40 мл/сут, затем 10-25 мл/сут. Детям старше 6 лет – в первые 3 дня назначают 15 мл/сут, затем – 10 мл/сут, в возрасте 1-6 лет – 5-10 мл/сут, в возрасте до 1 года – 5 мл/сут. Продолжительность лечения от 4 недель до 3-4 мес. При печеночной коме, прекоме, энцефалопатии и гипераммониемии начальная доза составляет по 30-60 мл 3 раза/сут. Затем дозу подбирают так, чтобы мягкий стул был 2-3 раза/сут. Лечение может продолжаться до 3 мес и более. В послеоперационном периоде взрослым назначают по 10-30 мл 3 раза/сут, детям старше 1 года – по 5-10 мл 2-3 раза/сут, в возрасте до 1 года – по 5 мл 2-3 раза/сут. Препарат назначают через 18-24 ч после операции в течение 3-5 дней.
Данные по передозировке препарата Нормазе не предоставлены.
Особые указания
При длительном применении препарата (более 6 мес) следует регулярно контролировать содержание калия, хлора и углекислого газа в плазме крови. При гастрокардиальном синдроме следует постепенно увеличивать дозы, чтобы избежать метеоризма.
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