Лечение инфекций половых органов, вызванных вирусом Herpes simplex типа 2 (как при остром первичном, так и при рецидивирующем течении); лечение инфекций кожи, вызванных вирусом Varicella zoster (в составе комбинированной терапии); лечение инфекций кожи и слизистых оболочек, вызванных вирусом папилломы человека; лечение неспецифических вагинитов, кольпитов. ...
Действующим веществом препарата Эпиген Интим является активированная глицирризиновая кислота, получаемая путем экстракции из растительного сырья (корня солодки). Активированная глицирризиновая кислота обладает комплексным воздействием, включая иммуностимулирующее, противовирусное, противовоспалительное, противозудное и регенерирующее. Активированная глицирризиновая кислота индуцирует выработку собственных интерферонов. Иммуностимулирующий эффект проявляется повышением числа и активности Т-лимфоцитов, уменьшением концентрации IgG и увеличением концентрации IgА и IgМ. Активированная глицирризиновая кислота обладает противовирусным действием на разные типы ДНК и РНК вирусов in vitro и in vivo (Varicella zoster; вирус простого герпеса типов 1 и 2; ЦМВ, различные типы вируса папилломы человека, в т.ч. онкогенные). Активированная глицирризиновая кислота прерывает репликацию вирусов на ранних стадиях, вызывает выход вириона из капсида, тем самым не допуская его проникновение в клетки. Активированная глицирризиновая кислота инактивирует указанные вирусы в нетоксичных для нормально функционирующих клеток концентрациях. Мутантные штаммы вирусов, резистентные к ацикловиру и йодоуридину, также высокочувствительны к глицирризиновой кислоте, как и не мутантные штаммы. Противовоспалительная активность активированной глицирризиновой кислоты сочетается со стимулирующим влиянием на гуморальные и клеточные факторы иммунитета. Активированная глицирризиновая кислота существенно тормозит выброс кининов и синтез ПГ клетками соединительной ткани в зоне воспаления. Регенерирующее действие обусловлено улучшением репарации кожи и слизистых.
Показания к применению
Лечение инфекций половых органов, вызванных вирусом Herpes simplex типа 2 (как при остром первичном, так и при рецидивирующем течении); лечение инфекций кожи, вызванных вирусом Varicella zoster (в составе комбинированной терапии); лечение инфекций кожи и слизистых оболочек, вызванных вирусом папилломы человека; лечение неспецифических вагинитов, кольпитов. Профилактика распространенных вирусных инфекций, передаваемых половым путем.
Противопоказания
Повышенная чувствительность к глицирризиновой кислоте.
Применение при беременности и в период грудного вскармливания
Применение при беременности и в период лактации возможно по абсолютным показаниям. В экспериментальных исследованиях не установлено эмбриотоксического и тератогенного действия глицирризиновой кислоты.
Способ применения и дозы
Наружно, интравагинально, интрауретрально. Перед употреблением баллон встряхнуть. При применении баллон держать в вертикальном положении. При наружном применении препарат наносится на всю пораженную поверхность кожи с расстояния 4–5 см 1–2 нажатиями клапана, что является оптимальной терапевтической дозой. Для интравагинального применения препарата прилагается специальная насадка с распылителем. Снять клапан с баллона пульверизатора и надеть клапан насадки. Затем насадку ввести во влагалище и произвести впрыскивание путем 1–2 нажатий насадки, что является оптимальной терапевтической дозой. При герпесвирусной инфекции типа 1, опоясывающем лишае препарат рекомендуется применять 6 раз в день, на очаг поражения, в течение 5 дней. При герпесвирусной инфекции типа 2 (генитальный герпес), ЦМВ-инфекции рекомендуется применять 5 раз в день в течение 14 дней наружно и интравагинально. С целью профилактики рецидивов генитального герпеса и ЦМВ-инфекции препарат рекомендуется применять наружно и интравагинально с 18 — 20-го дня менструального цикла до окончания менструации, 2 раза в день, утром и вечером. В качестве профилактического противовирусного средства препарат рекомендуется применять до и после полового акта.
Побочное действие
Редко: аллергические реакции.
Особые указания
При лечении инфекций кожи, вызванных вирусом Varicella zoster, наружное применение глицирризиновой кислоты следует сочетать с приемом внутрь специфических противовирусных препаратов. При появлении признаков раздражения кожи или слизистых оболочек лечение следует прекратить.
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