Гиперчувствительность к левофлоксацину, другим фторхинолонам или любому другому компоненту препарата, эпилепсия, псевдопаралитическая миастения (myasthenia gravis), поражения сухожилий при ранее проводившемся лечении хинолонами, нарушение функции почек (при КК менее 20 мл/мин), при нахождении на гемодиализе, дефицит лактазы, непереносимость лактозы ...
Таблетки Лефлобакт - синтетический противомикробный бактерицидный препарат широкого спектра действия из группы фторхинолонов. Назначается при ряде инфекционных заболеваниях, вызванных различными патогенными микроорганизмами. К примеру, хронический бронхит, пневмония, синусит и заболевания почек. Также Лефлобакт применяется при лечении простатита, атеромы с наличием в ней гноем, различных видов фурункулов, инфекции кожи, мочевыводящих путей, а также устойчивых к лекарствам форм туберкулеза.
Фармакологические свойства
Левофлоксацин – левовращающий изомер офлоксацина. Левофлоксацин блокирует ферменты ДНК-гиразу (топоизомеразу II) и топоизомеразу IV, нарушает суперспирализацию и сшивку разрывов ДНК, ингибирует синтез ДНК, вызывает глубокие морфологические изменения в цитоплазме, клеточной стенке и мембране бактерий. Активен в отношении большинства штаммов микроорганизмов, как в условиях in vitro, так и in vivo.
Показания к применению
Бактериальные инфекции, чувствительные к левофлоксацину, у взрослых: острый синусит, обострение хронического бронхита, внебольничная пневмония, неосложнённые инфекции мочевыводящих путей, осложнённые инфекции мочевыводящих путей (включая пиелонефрит), хронический бактериальный простатит, инфекции кожных покровов и мягких тканей, для комплексного лечения лекарственно-устойчивых форм туберкулеза, профилактика и лечение сибирской язвы при воздушно-капельном пути заражения.
Противопоказания
Гиперчувствительность к левофлоксацину, другим фторхинолонам или любому другому компоненту препарата, эпилепсия, псевдопаралитическая миастения (myasthenia gravis), поражения сухожилий при ранее проводившемся лечении хинолонами, нарушение функции почек (при КК менее 20 мл/мин), при нахождении на гемодиализе, дефицит лактазы, непереносимость лактозы или глюкозо-галактозная мальабсорбция.
Применение при беременности и в период грудного вскармливания
Противопоказано
Способ применения и дозы
Принимать до еды или в перерыве между приёмами пищи, не разжевывая, запивая достаточным количеством жидкости (от 0,5 до 1 стакана). Препарат следует принимать не менее чем за 2 часа до или через 2 часа после приёма препаратов, содержащих магний и/или алюминий, железо, цинк, или сукральфата. Если случайно пропущен приём препарата, следует как можно скорее принять очередную дозу и далее продолжать принимать препарат Лефлобакт согласно рекомендованному режиму его дозирования. Острый синусит – по 500мг 1 раз в сутки, в течение 10-14 дней. Обострение хронического бронхита – по 500мг 1 раз в сутки, в течение 7-10 дней. Внебольничная пневмония – по 500 мг 1-2 раза в сутки, в течение 7-14 дней. Неосложнённые инфекции мочевыводящих путей – по 250 мг 1 раз в сутки, в течение 3 дней. Осложнённые инфекции мочевыводящих путей – по 500 мг 1 раз в сутки, в течение 7-14 дней. Пиелонефрит – по 500 мг 1 раз в сутки, в течение 7-10 дней. Хронический бактериальный простатит – по 500 мг 1 раз в сутки, в течение 28 дней. Инфекции кожных покровов и мягких тканей – по 500 мг 1-2 раза в сутки, в течение 7- 14 дней. Комплексное лечение лекарственно-устойчивых форм туберкулеза – по 500 мг 1-2 раза в сутки - до 3-х месяцев. Профилактика и лечение сибирской язвы при воздушно-капельном пути заражения – по 500 мг 1 раз в сутки - до 8 недель.
Побочное действие
Головная боль, головокружение, диарея, рвота, тошнота, повышение активности «печеночных» ферментов в крови (например, аланинаминотрансферазы (АЛТ), аспартатаминотрансферазы (АСТ)), повышение активности щелочной фосфатазы (ЩФ) и гамма-глутамилтрансферазы (ГГТ), бессонница.
Может снижать психомоторные реакции и способность к концентрации внимания. Это может представлять собой определенный риск в ситуациях, когда эти способности имеют особое значение (например, при управлении автомобилем, при обслуживании машин и механизмов, при выполнении работ в неустойчивом положении).
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