Полусинтетический антибиотик группы макролидов. Подавляет си... Инструкция
Показания к применению
Клабакс применяют в лечении пациентов с заболеваниями бактериальной этиологии, которые ассоциированы с микроорганизмами, чувствительными к кларитромицину. В частности Клабакс эффективен в терапии пациентов с синуситами, фарингитами, отитами, пневмонией, бронхитом (включая хроническую и острую форму), а также вторично инфицированными дерматозами, рожей ...
Клабакс не назначают пациентам с непереносимостью кларитромицина и других макролидных препаратов. В педиатрической практике препарат Клабакс используют только у детей, достигших двухлетнего возраста. Клабакс с осторожностью назначают пациентам с почечной и печеночной недостаточностью. Не рекомендуется управлять автомобилем и потенциально опасными механизмами ...
Полусинтетический антибиотик группы макролидов. Подавляет синтез белков в микробной клетке, взаимодействуя с 50S рибосомальной субъединицей бактерий. Действует в основном бактериостатически, а также бактерицидно. Активен в отношении грамположительных бактерий: Streptococcus spp., Staphylococcus spp., Listeria monocytogenes, Corynebacterium spp. . грамотрицательных бактерий: Helicobacter pylori, Haemophilus influenzae, Haemophilus ducreyi, Moraxella catarrhalis, Bordetella pertussis, Neisseria gonorrhoeae, Neisseria meningitidis, Borrelia burgdorferi . анаэробных бактерий: Eubacterium spp., Peptococcus spp., Propionibacterium spp., Clostridium perfringens, Bacteroides melaninogenicus . внутриклеточных микроорганизмов: Legionella pneumophila, Chlamydia trachomatis, Chlamydophila pneumoniae, Ureaplasma urealyticum, Mycoplasma pneumoniae. Активен также в отношении Toxoplasma gondii, Mycobacterium spp. (кроме Mycobacterium tuberculosis).
Показания к применению
Клабакс применяют в лечении пациентов с заболеваниями бактериальной этиологии, которые ассоциированы с микроорганизмами, чувствительными к кларитромицину. В частности Клабакс эффективен в терапии пациентов с синуситами, фарингитами, отитами, пневмонией, бронхитом (включая хроническую и острую форму), а также вторично инфицированными дерматозами, рожей и фолликулитом. Клабакс также применяют при диссеминированных микобактериальных инфекциях, ассоциированных с Mycobacterium avium и Mycobacterium intracellulare, микоплазмозе, хламидиозе и уреаплазмозе. Клабакс может быть рекомендован в схемах антихеликобактерной терапии. Кларитромицин также используют в лечении пациентов с токсоплазмозом и лепрой.
Противопоказания
Клабакс не назначают пациентам с непереносимостью кларитромицина и других макролидных препаратов. В педиатрической практике препарат Клабакс используют только у детей, достигших двухлетнего возраста. Клабакс с осторожностью назначают пациентам с почечной и печеночной недостаточностью. Не рекомендуется управлять автомобилем и потенциально опасными механизмами во время приема препарата Клабакс.
Применение при беременности и в период грудного вскармливания
Применение в I триместре беременности противопоказано. Применение во II и III триместрах беременности возможно только в тех случаях, когда предполагаемая польза для матери превышает потенциальный риск для плода. При необходимости применения в период лактации следует прекратить грудное вскармливание.
Способ применения и дозы
Клабакс предназначен для приема перорально. Суточную дозу препарата Клабакс следует делить на 2 приема с равными интервалами. Таблетки рекомендуется глотать целиком, не нарушая целостность оболочки, во время приема пищи. Продолжительность лечения, дозы кларитромицина и схему приема препарата Клабакс определяет врач. При заболеваниях средней степени тяжести подросткам и взрослым обычно назначают прием 1 таблетки препарата Клабакс 250 дважды в сутки. При тяжелых формах заболеваний, а также болезнях, ассоциированных с Mycobacterium avium, взрослым и подросткам назначают прием 1 таблетки Клабакс 500 дважды в сутки. Средняя продолжительность лечения от 7 до 14 дней. Пациентам с язвенными поражениями слизистой оболочки желудка и двенадцатиперстной кишки, как правило, назначают прием 500 мг кларитромицина трижды в сутки сочетано с другой антихеликобактерной терапией. Продолжительность приема 14 дней. Детям, как правило, назначают прием кларитромицина в дозе 7,5 мг на каждый килограмм массы тела (но не более 250 мг) дважды в сутки. Продолжительность лечения составляет от 5 до 10 дней. Пациентам с нарушениями функций почек необходима коррекция дозы кларитромицина: При клиренсе креатинина менее 30 мл/мин максимальная рекомендованная доза составляет 250 мг в сутки (при тяжелых инфекциях дозу можно повысить до 500 мг в сутки под строгим контролем врача).
Побочное действие
Клабакс редко вызывает развитие нежелательных эффектов. Во время терапии кларитромицином нельзя исключать возможность развития таких побочных действий: Влияние на нервную систему головная боль, тревожность, галлюцинации, нарушения сна, спутанность сознания. Влияние на пищеварительную систему боль в абдоминальной области, стоматит, рвота, тошнота, диспепсические явления, жидкий стул, изменение вкусовых ощущений. Также возможно развитие желтухи, холестаза, гепатита и печеночной недостаточности. Влияние на систему крови, сосуды и сердце тромбоцитопения. Аллергические реакции крапивница, анафилактический шок, синдром Стивенса-Джонсона, ангионевротический отек. Как и при применении других противомикробных средств, при терапии кларитромицином возможно развитие псевдомембранозного колита различной степени тяжести (о легкой формы до тяжелой с угрозой для жизни пациента). При продолжительной или повторной терапии кларитромицином возможно развитие суперинфекции, которая требует специфического лечения.
Особые указания
Клабакс редко вызывает развитие нежелательных эффектов. Во время терапии кларитромицином нельзя исключать возможность развития таких побочных действий: Влияние на нервную систему головная боль, тревожность, галлюцинации, нарушения сна, спутанность сознания. Влияние на пищеварительную систему боль в абдоминальной области, стоматит, рвота, тошнота, диспепсические явления, жидкий стул, изменение вкусовых ощущений. Также возможно развитие желтухи, холестаза, гепатита и печеночной недостаточности. Влияние на систему крови, сосуды и сердце тромбоцитопения. Аллергические реакции крапивница, анафилактический шок, синдром Стивенса-Джонсона, ангионевротический отек. Как и при применении других противомикробных средств, при терапии кларитромицином возможно развитие псевдомембранозного колита различной степени тяжести (о легкой формы до тяжелой с угрозой для жизни пациента). При продолжительной или повторной терапии кларитромицином возможно развитие суперинфекции, которая требует специфического лечения.
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