В состав препарата входят неактивные компоненты - гиалуроновая кислота (в форме натрия гиалуроната), глицерол и сорбитол, которые являются увлажнителями, позволяющими препарату уменьшать симптомы раздражения и сухости слизистой оболочки носа.
Действие наступает через 2 мин после применения и продолжается в течение 12 часов.
Фармакокинетика
При местном применении практически не абсорбируется, концентрации в плазме настолько малы, что их невозможно определить современными аналитическими методами.
У человека фармакокинетические исследования не проводились.
пациенты с тяжелыми сердечно-сосудистыми заболеваниями (например, ишемической болезнью сердца, стенокардией, тахикардией, артериальной гипертензией, выраженным атеросклерозом);
пациенты с хирургическими вмешательствами на мозговых оболочках в анамнезе;
пациенты, получающие ингибиторы моноаминооксидазы (МАО) или другие препараты, способные вызвать повышение артериального давления;
пациенты с повышенным внутриглазным давлением, особенно с закрытоугольной глаукомой;
состояние после транссфеноидальной гипофизэктомии.
С осторожностью
В следующих случаях «Тизин Эксперт» можно применять, только тщательно взвесив пользу и риск лечения:
пациенты с повышенной чувствительностью к адренергическим препаратам, сопровождающейся бессонницей, головокружением, аритмией, тремором, повышением артериального давления;
пациенты с феохромоцитомой;
пациенты с эндокринными заболеваниями (например, гипертиреозом, сахарным диабетом);
пациенты с гиперплазией предстательной железы;
пациенты с порфирией.
Применение при беременности и в период грудного вскармливания
Ксилометазолин не следует применять во время беременности, так как воздействие этого препарата на плод в клинических исследованиях не изучалось. Препарат не следует применять во время кормления грудью, так как неизвестно, выводится ли активное вещество с грудным молоком.
Способ применения и дозы
Взрослые и дети старше 6 лет - 0,1 %
• До 3-х раз в сутки вводят по одной дозе препарата в виде 0,1 % дозированного спрея в каждую ноздрю. Доза зависит от индивидуальной чувствительности пациента и клинического эффекта.
Дети в возрасте 2–6 лет - 0,05 %
• Если не назначено иное, то использовать по одной дозе препарата в виде 0,05 % дозированного спрея в каждую ноздрю 1–2 раза в сутки.
Ксилометазолин в виде дозированного спрея не следует применять более 5–7 дней, если врач не рекомендовал иную длительность лечения.
После завершения терапии препарат можно назначать повторно только через несколько дней.
По поводу длительности применения у детей всегда советуйтесь с врачом.
В случае хронического ринита препарат «Тизин Эксперт» 0,05 % и 0,1 % можно применять только под контролем врача, учитывая риск атрофии слизистой оболочки носа.
Побочное действие
Дыхательные пути
«ТизинЭксперт» может вызвать преходящее легкое раздражение носа (жжение) у восприимчивых людей, чихание.
Часто (> 1– < 10%) после прекращения действия препарата может наблюдаться повышенная отечность слизистой оболочки носа (реактивная гиперемия).
Длительное или слишком частое использование ксилометазолина, или применение его в высоких дозах может привести к появлению жжения в носу или сухости слизистой оболочки, а также реактивной заложенности носа, с развитием медикаментозного ринита, парестезии, чихания, гиперсекреции. Этот эффект может наблюдаться даже через 5–7 дней после завершения лечения, а при длительном применении может быть причиной хронического воспаления слизистой оболочки с образованием корок (сухой ринит).
Нервная система
В редких случаях (> 0,01% – < 1%) могут наблюдаться головная боль, бессонница, нарушение зрения, утомление и депрессия (при длительном применении в высоких дозах).
Сердечно-сосудистая система
В единичных случаях (0,1% – < 1%) местное интраназальное применение симпатомиметиков может сопровождаться системными эффектами, такими как сердцебиение, тахикардия, аритмия и повышение артериального давления.
Передозировка
Симптомы
Передозировка или случайный прием препарата внутрь может привести к следующим симптомам: расширение зрачков, тошнота, рвота, цианоз, лихорадка, судороги, тахикардия, аритмия, коллапс, остановка сердца, гипертония, отек легких, нарушение дыхания, психические нарушения.
Кроме того, могут наблюдаться следующие симптомы: подавление функции центральной нервной системы, сопровождающееся сонливостью, снижением температуры тела, брадикардией, гипотенизией, апноэ и комой.
Лечение
Применение активированного угля, промывание желудка, искусственное дыхание с введением кислорода. Для снижения артериального давления применяют фентоламин 5 мг на физиологическом растворе внутривенно медленно или 100 мг внутрь.
Вазопрессорные средства противопоказаны. При необходимости применяют жаропонижающие и противосудорожные средства.
Взаимодействие с другими лекарственными средствами
Одновременное применение ингибиторов МАО типа транилципромина или трициклических антидепрессантов может привести к повышению артериального давления вследствие сердечно-сосудистых эффектов этих веществ.
Особые указания
Длительное применение (более 7 дней) и передозировка симпатомиметиков, оказывающих деконгестивное действие, может привести к реактивной гиперемии слизистой оболочки носа. В результате возникает затруднение носового дыхания, которое приводит к тому, что пациент начинает пользоваться препаратом повторно или даже постоянно. Это может приводить к хронической отечности (медикаментозному риниту), а в итоге даже к атрофии слизистой оболочки носа (озене).
В более легких случаях для улучшения состояния пациента вначале можно прекратить введение симпатомиметика в одну ноздрю, а после уменьшения жалоб продолжить вводить его в другую ноздрю, чтобы по крайней мере частично обеспечить носовое дыхание.
Не следует превышать рекомендованные дозы, особенно у детей и пожилых людей.
Не рекомендуется применять препарат в непрерывном режиме более 7 дней.
Если лекарственное средство пришло в негодность или истек срок годности – не выбрасывайте его в сточные воды и на улицу! Поместите лекарственное средство в пакет и положите в мусорный контейнер. Эти меры помогут защитить окружающую среду!
Влияние на способность управлять автомобилем и движущимися механизмами
При длительном лечении или применении препарата «Тизин Эксперт» в более высоких дозах нельзя исключить возможность его системного действия на сердечно-сосудистую систему. В таких случаях способность к вождению и пользованию техникой может нарушаться.
Форма выпуска
Спрей назальный дозированный 005% и 01%. По 10 мл во флаконе из полиэтилена высокой плотности белого цвета с дозирующим устройством и полиэтиленовой крышкой. По 1 флакону вместе с инструкцией по применению в картонной пачке.
Количество доз во флаконе 10 мл: не менее 140 доз.
Условия хранения
Хранить при температуре не выше 25°С.
Хранить в недоступном для детей месте.
Срок годности
2 года.
Условия отпуска
Без рецепта.
Производитель
«Фамар Хелc Кейр Сервисез Мадрид, С.А.У.», Испания/Famar Health Care Services Madrid, S.A.U., Spain
Организация, принимающая претензии потребителей
ООО «Джонсон & Джонсон», Россия, 121614, г. Москва, ул. Крылатская, д. 17, корп. 2, тел. (495) 726-55-55
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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название препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Тизин Ксило БИО"}}]},{"id":2,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"спрей назальный дозированный"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"В 1 мл раствора содержится:"}},{"type":"paragraph","data":{"text":"действующее вещество: \u003ca href=\"https://www.tyzine.ru/polezno-znat/kak-rabotaet-tizin/ksilometazolin\"\u003eксилометазолина \u003c/a\u003eгидрохлорид 0,5 мг (0,05 %) или 1 мг (0,1 %); количество активного компонента в одной дозе для 0,05 % – 0,035 мг ксилометазолина гидрохлорида; для 0,1 % – 0,14 мг ксилометазолина гидрохлорида;"}},{"type":"paragraph","data":{"text":"вспомогательные вещества: глицерол – 8,5 мг, сорбитол – 5 мг, натрия дигидрофосфата дигидрат – 4 мг, натрия хлорид – 3 мг, натрия фосфата дигидрат – 0,628 мг, натрия гиалуронат – 0,2 мг, вода для инъекций – до 1 мл. "}}]},{"id":3,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"прозрачный или слегка опалесцирующий, бесцветный или слегка желтоватого цвета раствор."}}]},{"id":5,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"противоконгестивное средство – вазоконстриктор."}}]},{"id":6,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Фармакодинамика"}},{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.tyzine.ru/polezno-znat/kak-rabotaet-tizin/ksilometazolin\"\u003eКсилометазолин\u003c/a\u003e (производное имидазола) — альфа-адреностимулятор, сужает кровеносные сосуды слизистой оболочки полости носа, устраняя отек и гиперемию слизистой оболочки. Облегчает носовое дыхание при ринитах."}},{"type":"paragraph","data":{"text":"В состав препарата входят неактивные компоненты - гиалуроновая кислота (в форме натрия гиалуроната), глицерол и сорбитол, которые являются увлажнителями, позволяющими препарату уменьшать симптомы раздражения и сухости слизистой оболочки носа."}},{"type":"paragraph","data":{"text":"Действие наступает через 2 мин после применения и продолжается в течение 12 часов."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"При местном применении практически не абсорбируется, концентрации в плазме настолько малы, что их невозможно определить современными аналитическими методами."}},{"type":"paragraph","data":{"text":"У человека фармакокинетические исследования не проводились."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["Уменьшение \u003ca href=\"https://www.tyzine.ru/zabolevaniya-nosa/otek-pazukh-nosa\"\u003eотечности слизистой оболочки носа\u003c/a\u003e при рините, в том числе аллергическом рините, ОРЗ с явлениями ринита, поллинозе.","Облегчение отхождения выделений из носа при параназальном синусите и воспалении среднего уха, вызванном простудой.","Подготовка пациентов к диагностическим манипуляциям в носовых ходах."]}},{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.tyzine.ru/preparaty/tyzine-expert-dlya-detey\"\u003e«Тизин Эксперт», cпрей назальный\u003c/a\u003e дозированный 0,05 % предназначен для детей в возрасте от 2 до 6 лет."}},{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.tyzine.ru/preparaty/tyzine-expert\"\u003e«Тизин Эксперт», cпрей назальный\u003c/a\u003e дозированный 0,1 % предназначен для взрослых и детей старше 6 лет."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["Повышенная чувствительность к любому из компонентов препарата;","атрофический ринит, тиреотоксикоз;","новорожденные и дети в возрасте до 2 лет (\u003ca href=\"https://www.tyzine.ru/preparaty/tyzine-expert-dlya-detey\"\u003eдля спрея назального дозированного 0,05 %\u003c/a\u003e); дети в возрасте до 6 лет (\u003ca href=\"https://www.tyzine.ru/preparaty/tyzine-expert\"\u003eдля спрея назального дозированного 0,1 %\u003c/a\u003e);","пациенты с тяжелыми сердечно-сосудистыми заболеваниями (например, ишемической болезнью сердца, стенокардией, тахикардией, артериальной гипертензией, выраженным атеросклерозом);","пациенты с хирургическими вмешательствами на мозговых оболочках в анамнезе;","пациенты, получающие ингибиторы моноаминооксидазы (МАО) или другие препараты, способные вызвать повышение артериального давления;","пациенты с повышенным внутриглазным давлением, особенно с закрытоугольной глаукомой;","состояние после транссфеноидальной гипофизэктомии."]}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"В следующих случаях \u003ca href=\"https://www.tyzine.ru/preparaty/tyzine-expert\"\u003e«Тизин Эксперт»\u003c/a\u003e можно применять, только тщательно взвесив пользу и риск лечения:"}},{"type":"list","data":{"style":"ordered","items":["пациенты с повышенной чувствительностью к адренергическим препаратам, сопровождающейся бессонницей, головокружением, аритмией, тремором, повышением артериального давления;","пациенты с феохромоцитомой;","пациенты с эндокринными заболеваниями (например, гипертиреозом, сахарным диабетом);","пациенты с гиперплазией предстательной железы;","пациенты с порфирией."]}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.tyzine.ru/polezno-znat/kak-rabotaet-tizin/ksilometazolin\"\u003eКсилометазолин\u003c/a\u003e не следует применять во время беременности, так как воздействие этого препарата на плод в клинических исследованиях не изучалось. Препарат не следует применять во время кормления грудью, так как неизвестно, выводится ли активное вещество с грудным молоком. "}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Взрослые и дети старше 6 лет - 0,1 %"}},{"type":"paragraph","data":{"text":"• До 3-х раз в сутки вводят по одной дозе \u003ca href=\"https://www.tyzine.ru/preparaty/tyzine-expert\"\u003eпрепарата\u003c/a\u003e в виде 0,1 % дозированного спрея в каждую ноздрю. Доза зависит от индивидуальной чувствительности пациента и клинического эффекта."}},{"type":"paragraph","data":{"text":"Дети в возрасте 2–6 лет - 0,05 %"}},{"type":"paragraph","data":{"text":"• Если не назначено иное, то использовать по одной дозе \u003ca href=\"https://www.tyzine.ru/preparaty/tyzine-expert-dlya-detey\"\u003eпрепарата\u003c/a\u003e в виде 0,05 % дозированного спрея в каждую ноздрю 1–2 раза в сутки."}},{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.tyzine.ru/polezno-znat/kak-rabotaet-tizin/ksilometazolin\"\u003eКсилометазолин\u003c/a\u003e в виде дозированного спрея не следует применять более 5–7 дней, если врач не рекомендовал иную длительность лечения."}},{"type":"paragraph","data":{"text":"После завершения терапии препарат можно назначать повторно только через несколько дней."}},{"type":"paragraph","data":{"text":"По поводу длительности применения у детей всегда советуйтесь с врачом."}},{"type":"paragraph","data":{"text":"В случае хронического ринита препарат «Тизин Эксперт» 0,05 % и 0,1 % можно применять только под контролем врача, учитывая риск атрофии слизистой оболочки носа."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Дыхательные пути"}},{"type":"paragraph","data":{"text":"«Тизин\u003csup\u003e \u003c/sup\u003eЭксперт» может вызвать преходящее легкое раздражение носа (жжение) у восприимчивых людей, чихание."}},{"type":"paragraph","data":{"text":"Часто (> 1– < 10%) после прекращения действия препарата может наблюдаться повышенная \u003ca href=\"https://www.tyzine.ru/zabolevaniya-nosa/otek-pazukh-nosa\"\u003eотечность слизистой оболочки носа\u003c/a\u003e (реактивная гиперемия)."}},{"type":"paragraph","data":{"text":"Длительное или слишком частое использование \u003ca href=\"https://www.tyzine.ru/polezno-znat/kak-rabotaet-tizin/ksilometazolin\"\u003eксилометазолина\u003c/a\u003e, или применение его в высоких дозах может привести к появлению жжения в носу или сухости слизистой оболочки, а также реактивной \u003ca href=\"https://www.tyzine.ru/zabolevaniya-nosa/prichini-zalozhennosti-nosa\"\u003eзаложенности носа\u003c/a\u003e, с развитием медикаментозного ринита, парестезии, чихания, гиперсекреции. Этот эффект может наблюдаться даже через 5–7 дней после завершения лечения, а при длительном применении может быть причиной хронического воспаления слизистой оболочки с образованием корок (сухой ринит)."}},{"type":"paragraph","data":{"text":"Нервная система"}},{"type":"paragraph","data":{"text":"В редких случаях (> 0,01% – < 1%) могут наблюдаться головная боль, бессонница, нарушение зрения, утомление и депрессия (при длительном применении в высоких дозах)."}},{"type":"paragraph","data":{"text":"Сердечно-сосудистая система"}},{"type":"paragraph","data":{"text":"В единичных случаях (0,1% – < 1%) местное интраназальное применение симпатомиметиков может сопровождаться системными эффектами, такими как сердцебиение, тахикардия, аритмия и повышение артериального давления."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы"}},{"type":"paragraph","data":{"text":"Передозировка или случайный прием препарата внутрь может привести к следующим симптомам: расширение зрачков, тошнота, рвота, цианоз, лихорадка, судороги, тахикардия, аритмия, коллапс, остановка сердца, гипертония, отек легких, нарушение дыхания, психические нарушения."}},{"type":"paragraph","data":{"text":"Кроме того, могут наблюдаться следующие симптомы: подавление функции центральной нервной системы, сопровождающееся сонливостью, снижением температуры тела, брадикардией, гипотенизией, апноэ и комой."}},{"type":"paragraph","data":{"text":"Лечение"}},{"type":"paragraph","data":{"text":"Применение активированного угля, промывание желудка, искусственное дыхание с введением кислорода. Для снижения артериального давления применяют фентоламин 5 мг на физиологическом растворе внутривенно медленно или 100 мг внутрь."}},{"type":"paragraph","data":{"text":"Вазопрессорные средства противопоказаны. При необходимости применяют жаропонижающие и противосудорожные средства."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Одновременное применение ингибиторов МАО типа транилципромина или трициклических антидепрессантов может привести к повышению артериального давления вследствие сердечно-сосудистых эффектов этих веществ."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Длительное применение (более 7 дней) и передозировка симпатомиметиков, оказывающих деконгестивное действие, может привести к реактивной \u003ca href=\"https://www.tyzine.ru/zabolevaniya-nosa/otek-pazukh-nosa\"\u003eгиперемии слизистой оболочки носа\u003c/a\u003e. В результате возникает затруднение носового дыхания, которое приводит к тому, что пациент начинает пользоваться препаратом повторно или даже постоянно. Это может приводить к хронической отечности (медикаментозному риниту), а в итоге даже к атрофии слизистой оболочки носа (озене)."}},{"type":"paragraph","data":{"text":"В более легких случаях для улучшения состояния пациента вначале можно прекратить введение симпатомиметика в одну ноздрю, а после уменьшения жалоб продолжить вводить его в другую ноздрю, чтобы по крайней мере частично обеспечить носовое дыхание."}},{"type":"paragraph","data":{"text":"Не следует превышать рекомендованные дозы, особенно у детей и пожилых людей."}},{"type":"paragraph","data":{"text":"Не рекомендуется применять препарат в непрерывном режиме более 7 дней."}},{"type":"paragraph","data":{"text":"Если лекарственное средство пришло в негодность или истек срок годности – не выбрасывайте его в сточные воды и на улицу! Поместите лекарственное средство в пакет и положите в мусорный контейнер. Эти меры помогут защитить окружающую среду!"}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":" При длительном лечении или применении препарата «Тизин Эксперт» в более высоких дозах нельзя исключить возможность его системного действия на сердечно-сосудистую систему. В таких случаях способность к вождению и пользованию техникой может нарушаться. "}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Спрей назальный дозированный 005% и 01%. По 10 мл во флаконе из полиэтилена высокой плотности белого цвета с дозирующим устройством и полиэтиленовой крышкой. По 1 флакону вместе с инструкцией по применению в картонной пачке."}},{"type":"paragraph","data":{"text":"Количество доз во флаконе 10 мл: не менее 140 доз."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25°С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"«Фамар Хелc Кейр Сервисез Мадрид, С.А.У.», Испания/Famar Health Care Services Madrid, S.A.U., Spain"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Джонсон & Джонсон», Россия, 121614, г. Москва, ул. Крылатская, д. 17, корп. 2, тел. (495) 726-55-55"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаКсилометазолин(производное имидазола) — альфа-адреностимулятор, сужает кровеносные сосуды слизистой оболочки полости носа, устраняя отек и гиперемию слизистой оболочки. Облегчает носовое дыхание при ринитах. В состав препарата входят неактивные компоненты - гиалуроновая кислота (в форме натрия гиалуроната), глицерол и сорбитол, которые являются увлажнителями, позволяющими препарату уменьшать симптомы раздражения и сухости слизистой оболочки носа. Действие наступает через 2 мин после применения и продолжается в течение 12 часов. Фармакокинетика При местном применении практически не абсорбируется, концентрации в плазме настолько малы, что их невозможно определить современными аналитическими методами. 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