Острые и хронические заболевания дыхательных путей, сопровождающиеся нарушением образования и отхождения мокроты.
Противопоказания
повышенная чувствительность к амброксолу или к одному из вспомогательных веществ; применение у детей до 6 лет; беременность (I триместр); непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция.
С осторожностью: Нарушение моторной функции бронхов и повышенное образование мокроты (при синдроме неподвижных ресничек), язвенная болезнь ...
Муколитический и отхаркивающий препарат.; Амброксол представляет собой бензиламин - метаболит бромгексина. Отличается от бромгексина отсутствием метильной группы и наличием гидроксильной группы в пара-транс положении циклогексильного кольца. Обладает секретомоторным, секретолитическим и отхаркивающим действием.; После приема внутрь действие наступает через 30 мин и продолжается в течение 6-12 ч (в зависимости от принятой дозы). Доклинические исследования показали, что амброксол стимулирует серозные клетки желез слизистой оболочки бронхов. Активируя клетки реснитчатого эпителия и снижая вязкость мокроты, улучшает мукоцилиарный транспорт.; Амброксол активирует образование сурфактанта, оказывая прямое воздействие на альвеолярные пневмоциты 2 типа и клетки Клара мелких дыхательных путей.; Исследования на клеточных культурах и исследования in vivo на животных показали, что амброксол стимулирует образование и секрецию вещества (сурфактанта), активного на поверхности альвеол и бронхов эмбриона и взрослого.; Также при доклинических исследованиях был доказан антиоксидантный эффект амброксола. Амброксол при совместном применении с антибиотиками (амоксициллин, цефуроксим, эритромицин и доксициклин) увеличивает их концентрацию в мокроте и бронхиальном секрете.
Показания к применению
Острые и хронические заболевания дыхательных путей, сопровождающиеся нарушением образования и отхождения мокроты.
Противопоказания
повышенная чувствительность к амброксолу или к одному из вспомогательных веществ; применение у детей до 6 лет; беременность (I триместр); непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция.
С осторожностью: Нарушение моторной функции бронхов и повышенное образование мокроты (при синдроме неподвижных ресничек), язвенная болезнь желудка и 12-перстной кишки в период обострения, беременность (II-III триместр), период лактации.
Пациенты с нарушениями функции почек или тяжелыми заболевания печени должны принимать Амбробене с особой осторожностью, соблюдая большие интервалы между приемами или принимая препарат в меньшей дозе.
Применение при беременности и в период грудного вскармливания
Беременность: Недостаточно данных относительно применения амброксола в период беременности. В частности, это касается первых 28 недель беременности. Исследования, проводимые на животных, не выявили тератогенного эффекта.; Применение Амбробене при беременности (II-III триместр) возможно только по назначению врача, после тщательной оценки соотношения риск/польза.; Период кормления грудью: Исследования, проводимые на животных, показали, что амброксол проникает в грудное молоко. В связи с недостаточным изучением применения препарата у женщин в период кормления грудью применение Амбробене возможно только по назначению врача, после тщательной оценки соотношения риск/польза.
Способ применения и дозы
Таблетки следует проглатывать целиком, не разжевывая, после еды, запивая большим количеством жидкости.; Детям от 6 до 12 лет следует принимать по 1/2 таблетки 2-3 раза в день (15 мг амброксола 2-3 раза в день).; Взрослым и детям старше 12 лет в первые 2-3 дня лечения следует принимать по 1 таблетке 3 раза в день (30 мг амброксола 3 раза в день). При неэффективности терапии взрослые могут увеличить дозу до 2 таблеток 2 раза в день (120 мг амброксола в день). В последующие дни следует принимать по 1 таблетке 2 раза в день (30 мг амброксола 2 раза в день).; Длительность лечения подбирается индивидуально в зависимости от течения заболевания. Не рекомендуется принимать Амбробене без назначения врача более чем в течение 4-5 дней. Муколитический эффект препарата проявляется при приеме большого количества жидкости. Поэтому во время лечения рекомендуется обильное питье.
Побочное действие
Общие нарушения: Редко (от больше 0,1 % до меньше 1 %): аллергические реакции (крапивница, кожная сыпь, ангионевротический отек лица, одышка, зуд), лихорадка, слабость, головная боль.; Очень редко (меньше 0,01 %): анафилактические реакции, в том числе анафилактический шок.; Со стороны желудочно-кишечного тракта: Редко (от больше 0,1 % до меньше 1 %): тошнота, боли в животе, рвота, диарея, запоры.; Прочие: Редко (от больше 0,1 % до меньше 1 %): сухость слизистой оболочки полости рта и дыхательных путей, экзантема, ринорея, дизурия.
Передозировка
Симптомы: Признаков интоксикации при передозировке амброксола не выявлено. Имеются сведения о нервном возбуждении и диарее.; Амброксол хорошо переносится при приеме внутрь в дозе до 25 мг/кг/день. В случае тяжелой передозировки возможны повышенное слюноотделение, тошнота, рвота, снижение артериального давления.; Лечение: Методы интенсивной терапии, такие как вызывание рвоты, промывание желудка, должны применяться только в случаях тяжелой передозировки, в первые 1-2 часа после приема препарата. Показано симптоматическое лечение.
Особые указания
Не следует комбинировать с противокашлевыми лекарственными средствами, затрудняющими выведение мокроты.; Крайне редко при применении Амбробене наблюдались кожные реакции в тяжелой форме, такие как синдром Стивенса-Джонсона и синдром Лайелла. При изменении кожных покровов или слизистых оболочек, необходимо срочно обратиться к врачу и прекратить прием препарата. Влияние на способность вождения транспорта и на управление машинами и механизмами до настоящего момента не известно.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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Отличается от бромгексина отсутствием метильной группы и наличием гидроксильной группы в пара-транс положении циклогексильного кольца. Обладает секретомоторным, секретолитическим и отхаркивающим действием.; После приема внутрь действие наступает через 30 мин и продолжается в течение 6-12 ч (в зависимости от принятой дозы). Доклинические исследования показали, что амброксол стимулирует серозные клетки желез слизистой оболочки бронхов. Активируя клетки реснитчатого эпителия и снижая вязкость мокроты, улучшает мукоцилиарный транспорт.; Амброксол активирует образование сурфактанта, оказывая прямое воздействие на альвеолярные пневмоциты 2 типа и клетки Клара мелких дыхательных путей.; Исследования на клеточных культурах и исследования in vivo на животных показали, что амброксол стимулирует образование и секрецию вещества (сурфактанта), активного на поверхности альвеол и бронхов эмбриона и взрослого.; Также при доклинических исследованиях был доказан антиоксидантный эффект амброксола. Амброксол при совместном применении с антибиотиками (амоксициллин, цефуроксим, эритромицин и доксициклин) увеличивает их концентрацию в мокроте и бронхиальном секрете."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Острые и хронические заболевания дыхательных путей, сопровождающиеся нарушением образования и отхождения мокроты."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"повышенная чувствительность к амброксолу или к одному из вспомогательных веществ; применение у детей до 6 лет; беременность (I триместр); непереносимость лактозы, дефицит лактазы или глюкозо-галактозная мальабсорбция."}},{"type":"paragraph","data":{"text":"С осторожностью: Нарушение моторной функции бронхов и повышенное образование мокроты (при синдроме неподвижных ресничек), язвенная болезнь желудка и 12-перстной кишки в период обострения, беременность (II-III триместр), период лактации."}},{"type":"paragraph","data":{"text":"Пациенты с нарушениями функции почек или тяжелыми заболевания печени должны принимать Амбробене с особой осторожностью, соблюдая большие интервалы между приемами или принимая препарат в меньшей дозе."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Беременность: Недостаточно данных относительно применения амброксола в период беременности. 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