Дозировка действующего вещества Состав 1 мл азаметония бромид 50 мг Фармакокинетика Фармакологическое действие Ганглиоблокатор, бисчетвертичное аммониевое соединение. Оказывает гипотензивное, артерио- и венодилатирующее действие. Блокирует н-холинорецепторы вегетативных ганглиев и в связи с этим тормозит передачу нервного возбуждения с преганглионарных на постганглионарные волокна вегетативных нервов. Вегетативные ганглии становятся также малочувствительными к возбуждающему действию ряда холинергических раздражителей (в т.ч. ацетилхолина, никотина, лобелина, цитизина). Прерывая проведение нервных импульсов через вегетативные ганглии, ганглиоблокаторы изменяют функции органов, снабженных вегетативной иннервацией. При этом происходит понижение АД, что связано преимущественно с уменьшением поступления сосудосуживающих импульсов к кровеносным сосудам и расширением периферического сосудистого русла (в первую очередь артериол). Торможение проведения импульсов по холинергическим нервным волокнам приводит к нарушению аккомодации, расширению бронхов, уменьшению моторики органов ЖКТ, угнетению секреции желез, повышению ЧСС, понижению тонуса мочевого пузыря. Угнетение н-холинорецепторов хромаффинной ткани надпочечников приводит к уменьшению выделения адренергических веществ и ослаблению рефлекторных прессорных реакций. В высоких дозах может блокировать н-холинорецепторы скелетных мышц и ЦНС. Азаметония бромид несколько уступает бензогексонию по активности и продолжительности действия. Показания к применению Заболевания и состояния, обусловленные спазмами периферических сосудов (в т.ч. эндартериит, перемежающаяся хромота). В составе комбинированной терапии при гипертоническом кризе, отеке легких, отеке мозга. В анестезиологической практике - для управляемой артериальной гипотензии. В урологической практике - при цистоскопии у мужчин (для облегчения прохождения цистоскопа через уретру). Способ применения и дозы Применяют в/м или в/в. Дозу устанавливают индивидуально в зависимости от показаний и конкретной клинической ситуации. Максимальные дозы: при в/м введении разовая доза - 150 мг, суточная доза - 450 мг. Противопоказания Закрытоугольная глаукома, острая фаза инфаркта миокарда, выраженная артериальная гипотензия, шок, нарушения функции печени и/или почек, феохромоцитома, дегенеративные заболевания ЦНС, повышенная чувствительность к азаметония бромиду. Меры предосторожности Применение при нарушениях функции печени Противопоказание: нарушения функции печени. Применение при нарушениях функции почек Противопоказание: нарушения функции почек. Применение у пожилых пациентов С осторожностью применяют азаметония бромид у пациентов пожилого возраста. Взаимодействие с другими препаратами При одновременном применении ганглиоблокаторы усиливают действие адреномиметиков. Антихолинэстеразные препараты являются антагонистами ганглиоблокаторов. При одновременном применении с трициклическими антидепрессантами уменьшается гипотензивное действие ганглиоблокаторов. Побочное действие Со стороны сердечно-сосудистой системы: возможны учащение пульса, ортостатический коллапс (в связи с угнетением рефлекторных механизмов, поддерживающих постоянный уровень АД). Со стороны пищеварительной системы: сухость во рту . при применении в течение длительного времени в повышенных дозах возможна атония кишечника (вплоть до паралитической непроходимости кишечника). Со стороны ЦНС: возможны общая слабость, головокружение. Со стороны органа зрения: мидриаз, парез аккомодации, инъекция сосудов склер. Со стороны мочевыделительной системы: при применении в течение длительного времени в повышенных дозах возможна атония мочевого пузыря с анурией. Передозировка Особые указания С осторожностью применяют азаметония бромид при бронхиальной астме с затрудненным отделением мокроты, атонии кишечника и мочевого пузыря различной этиологии, при тромбозах, тромбофлебите, дегенеративных заболеваниях ЦНС, бронхиальной астме (с затруднением отхождения мокроты), у пациентов пожилого возраста. Лечение ганглиоблокаторами следует проводить под тщательным наблюдением врача. Во избежание развития ортостатического коллапса рекомендуется, чтобы до введения азаметония бромида и в течение 1-2 ч после инъекции пациент находился в положении лежа. Рекомендуется в начале лечения проверить реакцию пациента на малые дозы азаметония бромида: вводят 1/2 средней дозы и следят за состоянием пациента. Следует иметь в виду, что при повышенном АД гипотензивное действие носит более резкий характер. При открытоугольной глаукоме может наблюдаться понижение внутриглазного давления, что обусловлено уменьшением под влиянием ганглиоблокаторов продукции водянистой влаги. Применение при беременности и кормлении грудью Данные о безопасности применения азаметония бромида при беременности и в период лактации (грудного вскармливания) отсутствуют. Тип: Лекарственное средство Срок годности: 60 мес Действующее вещество: Азаметония бромид (Azamethonium bromide) Путь введения: Внутримышечно, Внутривенно Порядок отпуска: По рецепту Форма выпуска: По рецепту Фармакологическая группа: C02BC Бисчетвертичные аммониевые соединения Нозологическая классификация (МКБ-10): I73.1 Облитерирующий тромбоангиит [болезнь Бергера], I79.2 Периферическая ангиопатия при болезнях, классифицированных в других рубриках (в т.ч. диабетическая ангиопатия), I73.0 Синдром Рейно, I73.9 Болезнь периферических сосудов неуточненная (перемежающаяся хромота), G93.6 Отек мозга, Z51.4 Подготовительные процедуры для последующего лечения или обследования, не классифицированные в других рубриках, J81 Легочный отек, I10 Эссенциальная [первичная] гипертензия
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действующего вещества Состав 1 мл азаметония бромид 50 мг Фармакокинетика Фармакологическое действие Ганглиоблокатор, бисчетвертичное аммониевое соединение. Оказывает гипотензивное, артерио- и венодилатирующее действие. Блокирует н-холинорецепторы вегетативных ганглиев и в связи с этим тормозит передачу нервного возбуждения с преганглионарных на постганглионарные волокна вегетативных нервов. Вегетативные ганглии становятся также малочувствительными к возбуждающему действию ряда холинергических раздражителей (в т.ч. ацетилхолина, никотина, лобелина, цитизина). Прерывая проведение нервных импульсов через вегетативные ганглии, ганглиоблокаторы изменяют функции органов, снабженных вегетативной иннервацией. При этом происходит понижение АД, что связано преимущественно с уменьшением поступления сосудосуживающих импульсов к кровеносным сосудам и расширением периферического сосудистого русла (в первую очередь артериол). Торможение проведения импульсов по холинергическим нервным волокнам приводит к нарушению аккомодации, расширению бронхов, уменьшению моторики органов ЖКТ, угнетению секреции желез, повышению ЧСС, понижению тонуса мочевого пузыря. Угнетение н-холинорецепторов хромаффинной ткани надпочечников приводит к уменьшению выделения адренергических веществ и ослаблению рефлекторных прессорных реакций. В высоких дозах может блокировать н-холинорецепторы скелетных мышц и ЦНС. Азаметония бромид несколько уступает бензогексонию по активности и продолжительности действия. Показания к применению Заболевания и состояния, обусловленные спазмами периферических сосудов (в т.ч. эндартериит, перемежающаяся хромота). В составе комбинированной терапии при гипертоническом кризе, отеке легких, отеке мозга. В анестезиологической практике - для управляемой артериальной гипотензии. В урологической практике - при цистоскопии у мужчин (для облегчения прохождения цистоскопа через уретру). Способ применения и дозы Применяют в/м или в/в. Дозу устанавливают индивидуально в зависимости от показаний и конкретной клинической ситуации. Максимальные дозы: при в/м введении разовая доза - 150 мг, суточная доза - 450 мг. Противопоказания Закрытоугольная глаукома, острая фаза инфаркта миокарда, выраженная артериальная гипотензия, шок, нарушения функции печени и/или почек, феохромоцитома, дегенеративные заболевания ЦНС, повышенная чувствительность к азаметония бромиду. Меры предосторожности Применение при нарушениях функции печени Противопоказание: нарушения функции печени. Применение при нарушениях функции почек Противопоказание: нарушения функции почек. Применение у пожилых пациентов С осторожностью применяют азаметония бромид у пациентов пожилого возраста. Взаимодействие с другими препаратами При одновременном применении ганглиоблокаторы усиливают действие адреномиметиков. Антихолинэстеразные препараты являются антагонистами ганглиоблокаторов. При одновременном применении с трициклическими антидепрессантами уменьшается гипотензивное действие ганглиоблокаторов. Побочное действие Со стороны сердечно-сосудистой системы: возможны учащение пульса, ортостатический коллапс (в связи с угнетением рефлекторных механизмов, поддерживающих постоянный уровень АД). Со стороны пищеварительной системы: сухость во рту . при применении в течение длительного времени в повышенных дозах возможна атония кишечника (вплоть до паралитической непроходимости кишечника). Со стороны ЦНС: возможны общая слабость, головокружение. Со стороны органа зрения: мидриаз, парез аккомодации, инъекция сосудов склер. Со стороны мочевыделительной системы: при применении в течение длительного времени в повышенных дозах возможна атония мочевого пузыря с анурией. Передозировка Особые указания С осторожностью применяют азаметония бромид при бронхиальной астме с затрудненным отделением мокроты, атонии кишечника и мочевого пузыря различной этиологии, при тромбозах, тромбофлебите, дегенеративных заболеваниях ЦНС, бронхиальной астме (с затруднением отхождения мокроты), у пациентов пожилого возраста. Лечение ганглиоблокаторами следует проводить под тщательным наблюдением врача. Во избежание развития ортостатического коллапса рекомендуется, чтобы до введения азаметония бромида и в течение 1-2 ч после инъекции пациент находился в положении лежа. Рекомендуется в начале лечения проверить реакцию пациента на малые дозы азаметония бромида: вводят 1/2 средней дозы и следят за состоянием пациента. Следует иметь в виду, что при повышенном АД гипотензивное действие носит более резкий характер. При открытоугольной глаукоме может наблюдаться понижение внутриглазного давления, что обусловлено уменьшением под влиянием ганглиоблокаторов продукции водянистой влаги. Применение при беременности и кормлении грудью Данные о безопасности применения азаметония бромида при беременности и в период лактации (грудного вскармливания) отсутствуют. Тип: Лекарственное средство Срок годности: 60 мес Действующее вещество: Азаметония бромид (Azamethonium bromide) Путь введения: Внутримышечно, Внутривенно Порядок отпуска: По рецепту Форма выпуска: По рецепту Фармакологическая группа: C02BC Бисчетвертичные аммониевые соединения Нозологическая классификация (МКБ-10): I73.1 Облитерирующий тромбоангиит [болезнь Бергера], I79.2 Периферическая ангиопатия при болезнях, классифицированных в других рубриках (в т.ч. диабетическая ангиопатия), I73.0 Синдром Рейно, I73.9 Болезнь периферических сосудов неуточненная (перемежающаяся хромота), G93.6 Отек мозга, Z51.4 Подготовительные процедуры для последующего лечения или обследования, не классифицированные в других рубриках, J81 Легочный отек, I10 Эссенциальная [первичная] гипертензия"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Дозировка действующего вещества Состав 1 мл азаметония бромид 50 мг Фармакокинетика Фармакологическое действие Ганглиоблокатор, бисчетвертичное аммониевое соединение. Оказывает гипотензивное, артерио- и венодилатирующее действие. Блокирует н-холинорецепторы вегетативных ганглиев и в связи с этим тормозит передачу нервного возбуждения с преганглионарных на постганглионарные волокна вегетативных нервов. Вегетативные ганглии становятся также малочувствительными к возбуждающему действию ряда холинергических раздражителей (в т.ч. ацетилхолина, никотина, лобелина, цитизина). Прерывая проведение нервных импульсов через вегетативные ганглии, ганглиоблокаторы изменяют функции органов, снабженных вегетативной иннервацией. При этом происходит понижение АД, что связано преимущественно с уменьшением поступления сосудосуживающих импульсов к кровеносным сосудам и расширением периферического сосудистого русла (в первую очередь артериол). Торможение проведения импульсов по холинергическим нервным волокнам приводит к нарушению аккомодации, расширению бронхов, уменьшению моторики органов ЖКТ, угнетению секреции желез, повышению ЧСС, понижению тонуса мочевого пузыря. Угнетение н-холинорецепторов хромаффинной ткани надпочечников приводит к уменьшению выделения адренергических веществ и ослаблению рефлекторных прессорных реакций. В высоких дозах может блокировать н-холинорецепторы скелетных мышц и ЦНС. Азаметония бромид несколько уступает бензогексонию по активности и продолжительности действия. Показания к применению Заболевания и состояния, обусловленные спазмами периферических сосудов (в т.ч. эндартериит, перемежающаяся хромота). В составе комбинированной терапии при гипертоническом кризе, отеке легких, отеке мозга. В анестезиологической практике - для управляемой артериальной гипотензии. В урологической практике - при цистоскопии у мужчин (для облегчения прохождения цистоскопа через уретру). Способ применения и дозы Применяют в/м или в/в. Дозу устанавливают индивидуально в зависимости от показаний и конкретной клинической ситуации. Максимальные дозы: при в/м введении разовая доза - 150 мг, суточная доза - 450 мг. Противопоказания Закрытоугольная глаукома, острая фаза инфаркта миокарда, выраженная артериальная гипотензия, шок, нарушения функции печени и/или почек, феохромоцитома, дегенеративные заболевания ЦНС, повышенная чувствительность к азаметония бромиду. Меры предосторожности Применение при нарушениях функции печени Противопоказание: нарушения функции печени. Применение при нарушениях функции почек Противопоказание: нарушения функции почек. Применение у пожилых пациентов С осторожностью применяют азаметония бромид у пациентов пожилого возраста. Взаимодействие с другими препаратами При одновременном применении ганглиоблокаторы усиливают действие адреномиметиков. Антихолинэстеразные препараты являются антагонистами ганглиоблокаторов. При одновременном применении с трициклическими антидепрессантами уменьшается гипотензивное действие ганглиоблокаторов. Побочное действие Со стороны сердечно-сосудистой системы: возможны учащение пульса, ортостатический коллапс (в связи с угнетением рефлекторных механизмов, поддерживающих постоянный уровень АД). Со стороны пищеварительной системы: сухость во рту . при применении в течение длительного времени в повышенных дозах возможна атония кишечника (вплоть до паралитической непроходимости кишечника). Со стороны ЦНС: возможны общая слабость, головокружение. Со стороны органа зрения: мидриаз, парез аккомодации, инъекция сосудов склер. Со стороны мочевыделительной системы: при применении в течение длительного времени в повышенных дозах возможна атония мочевого пузыря с анурией. Передозировка Особые указания С осторожностью применяют азаметония бромид при бронхиальной астме с затрудненным отделением мокроты, атонии кишечника и мочевого пузыря различной этиологии, при тромбозах, тромбофлебите, дегенеративных заболеваниях ЦНС, бронхиальной астме (с затруднением отхождения мокроты), у пациентов пожилого возраста. Лечение ганглиоблокаторами следует проводить под тщательным наблюдением врача. Во избежание развития ортостатического коллапса рекомендуется, чтобы до введения азаметония бромида и в течение 1-2 ч после инъекции пациент находился в положении лежа. Рекомендуется в начале лечения проверить реакцию пациента на малые дозы азаметония бромида: вводят 1/2 средней дозы и следят за состоянием пациента. Следует иметь в виду, что при повышенном АД гипотензивное действие носит более резкий характер. При открытоугольной глаукоме может наблюдаться понижение внутриглазного давления, что обусловлено уменьшением под влиянием ганглиоблокаторов продукции водянистой влаги. Применение при беременности и кормлении грудью Данные о безопасности применения азаметония бромида при беременности и в период лактации (грудного вскармливания) отсутствуют. 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